Introduction: Patients with OSCC in India (oral squamous cell carcinoma) presents at a later stage with approximately 28% presenting at stage III and 64% at stage IV disease. In this retrospective study we have reviewed the treatment modalities rendered and outcomes associated for the management of locally advanced oral squamous cell carcinoma in our Institute. We evaluated the survival data and the factors effecting survival. Methods: Kaplan Meir method was used to evaluate OS and DFS rate and log rank test was used to compare the survival amongst groups. Cox regression analysis (univariate and multivariate) was used to evaluate the hazard ratio to find out the possible factors influencing risk of death and disease. Results: The median OS and DFS in our study were 32 and 24 months respectively. On a subset analysis of only T4b patients who underwent either upfront surgery or induction chemotherapy followed by surgery there was no significant difference in OS and DFS. All patients with TURD had partial response after induction chemotherapy and were subjected to surgical resection followed by adjuvant therapy. Conclusion: Extracapsular spread, bone involvement, skin infiltration, treatments, surgical margins and Lymph node size are the prime predictors of survival.Upfront surgery remains the standard of care for resectable LAOSCC. Induction chemotherapy might improve the resectability in technically unresectable OSCC. There is no difference in survival between concurrent chemoradiation, sequential chemoradiation and radical radiotherapy in the management of unresectable disease.
Supplementary information: The online version contains supplementary material available at 10.1007/s12070-023-04168-4.
简介：印度的口腔鳞状细胞癌（OSCC）患者发病较晚，约 28% 的患者处于 III 期，64% 的患者处于 IV 期。在这项回顾性研究中，我们回顾了本研究所在治疗局部晚期口腔鳞状细胞癌时所采用的治疗方法和相关结果。我们还评估了生存数据和影响生存的因素。方法采用 Kaplan Meir 法评估 OS 和 DFS 率，采用对数秩检验比较各组间的生存率。采用 Cox 回归分析（单变量和多变量）评估危险比，以找出影响死亡和疾病风险的可能因素。结果我们研究的中位 OS 和 DFS 分别为 32 个月和 24 个月。仅对接受先期手术或诱导化疗后再手术的 T4b 患者进行子集分析，结果显示 OS 和 DFS 没有显著差异。所有 TURD 患者在接受诱导化疗后都出现了部分反应，并接受了手术切除和辅助治疗。结论囊外扩散、骨受累、皮肤浸润、治疗方法、手术切缘和淋巴结大小是预测生存率的主要因素。对于技术上无法切除的 OSCC，诱导化疗可能会提高其切除率。在治疗无法切除的疾病时，同时化疗、连续化疗和根治性放疗的生存率没有差异：在线版本包含补充材料，可在10.1007/s12070-023-04168-4网站上查阅。
{"title":"Locally Advanced oral Squamous cell Carcinomas: Auditing and Outcome Appraisal.","authors":"Rathindra Nath Bera, Richik Tripathi, Sapna Tandon, Mohd Adil, Sanober Sohail, Shashank, Avishek Chakraborty","doi":"10.1007/s12070-023-04168-4","DOIUrl":"10.1007/s12070-023-04168-4","url":null,"abstract":"<p><p>Introduction: Patients with OSCC in India (oral squamous cell carcinoma) presents at a later stage with approximately 28% presenting at stage III and 64% at stage IV disease. In this retrospective study we have reviewed the treatment modalities rendered and outcomes associated for the management of locally advanced oral squamous cell carcinoma in our Institute. We evaluated the survival data and the factors effecting survival. Methods: Kaplan Meir method was used to evaluate OS and DFS rate and log rank test was used to compare the survival amongst groups. Cox regression analysis (univariate and multivariate) was used to evaluate the hazard ratio to find out the possible factors influencing risk of death and disease. Results: The median OS and DFS in our study were 32 and 24 months respectively. On a subset analysis of only T4b patients who underwent either upfront surgery or induction chemotherapy followed by surgery there was no significant difference in OS and DFS. All patients with TURD had partial response after induction chemotherapy and were subjected to surgical resection followed by adjuvant therapy. Conclusion: Extracapsular spread, bone involvement, skin infiltration, treatments, surgical margins and Lymph node size are the prime predictors of survival.Upfront surgery remains the standard of care for resectable LAOSCC. Induction chemotherapy might improve the resectability in technically unresectable OSCC. There is no difference in survival between concurrent chemoradiation, sequential chemoradiation and radical radiotherapy in the management of unresectable disease.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s12070-023-04168-4.</p>","PeriodicalId":55483,"journal":{"name":"Archiv Fur Mikroskopische Anatomie Und Entwicklungsmechanik","volume":"101 1","pages":"380-391"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10937854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73345627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Untersuchungen zur Genetik der geographischen Variation I","authors":"Richard Goldschmidt, J. Seiler, H. Poppelbaum","doi":"10.1007/BF02108170","DOIUrl":"https://doi.org/10.1007/BF02108170","url":null,"abstract":"","PeriodicalId":55483,"journal":{"name":"Archiv Fur Mikroskopische Anatomie Und Entwicklungsmechanik","volume":"101 1","pages":"92-337"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02108170","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51719939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Achsenverhältnisse und Entwicklungspotenzen der Urodelenextremitäten an Modellen zu Harrisons Transplantationsversuchen","authors":"H. Przibram","doi":"10.1007/BF02292963","DOIUrl":"https://doi.org/10.1007/BF02292963","url":null,"abstract":"","PeriodicalId":55483,"journal":{"name":"Archiv Fur Mikroskopische Anatomie Und Entwicklungsmechanik","volume":"102 1","pages":"604-623"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02292963","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51850885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Die Akromelanie der Russenkaninchen und ihre Bedeutung für unsere Auffassung der Akromegalie","authors":"Dr. WaI t he r Schultz","doi":"10.1007/BF02107650","DOIUrl":"https://doi.org/10.1007/BF02107650","url":null,"abstract":"","PeriodicalId":55483,"journal":{"name":"Archiv Fur Mikroskopische Anatomie Und Entwicklungsmechanik","volume":"102 1","pages":"499-500"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02107650","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51719145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2001-11-01DOI: 10.1177/014107680109401114
L Turner
{"title":"Medical ethics in a multicultural society.","authors":"L Turner","doi":"10.1177/014107680109401114","DOIUrl":"10.1177/014107680109401114","url":null,"abstract":"","PeriodicalId":55483,"journal":{"name":"Archiv Fur Mikroskopische Anatomie Und Entwicklungsmechanik","volume":"99 1","pages":"592-4"},"PeriodicalIF":17.3,"publicationDate":"2001-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1282251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74060145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Beeinflussung des Fischfarbwechsels durch Chemikalien","authors":"Leo Abolin","doi":"10.1007/BF02254276","DOIUrl":"https://doi.org/10.1007/BF02254276","url":null,"abstract":"","PeriodicalId":55483,"journal":{"name":"Archiv Fur Mikroskopische Anatomie Und Entwicklungsmechanik","volume":"104 1","pages":"667-698"},"PeriodicalIF":0.0,"publicationDate":"1925-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02254276","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52564080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Quando si forma la Dopa nei bozzoli di Lophyrus Pini L.","authors":"I. Sciacchitano","doi":"10.1007/BF02254275","DOIUrl":"https://doi.org/10.1007/BF02254275","url":null,"abstract":"","PeriodicalId":55483,"journal":{"name":"Archiv Fur Mikroskopische Anatomie Und Entwicklungsmechanik","volume":"104 1","pages":"664-666"},"PeriodicalIF":0.0,"publicationDate":"1925-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02254275","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52564028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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