American Journal of the Medical Sciences最新文献

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59 Novel mutations of the cytochrome B5 reductase gene in a patient with recessive congenital methemoglobinemia type II

IF 2.3 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

American Journal of the Medical Sciences

Pub Date : 2025-02-01 DOI: 10.1016/S0002-9629(25)00068-0

R Mayo, G Aixa, D Fry, JM Mack, JE Farrar

引用次数: 0

60 Acute urinary retention in a 17-year-old male

IF 2.3 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

American Journal of the Medical Sciences

Pub Date : 2025-02-01 DOI: 10.1016/S0002-9629(25)00069-2

T Le

引用次数: 0

82 Hypertrophic obstructive cardiomyopathy mimicking aortic stenosis: diagnostic challenges and therapeutic outcomes

IF 2.3 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

American Journal of the Medical Sciences

Pub Date : 2025-02-01 DOI: 10.1016/S0002-9629(25)00091-6

M Abubaker, P Adrejiya, RN Khouzam

引用次数: 0

76 When the lumps aren't mumps

IF 2.3 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

American Journal of the Medical Sciences

Pub Date : 2025-02-01 DOI: 10.1016/S0002-9629(25)00085-0

EL Nichols, JI Hampton, CL Wu

引用次数: 0

63 PCR vs. clinical judgment: is my tool accurate?

IF 2.3 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

American Journal of the Medical Sciences

Pub Date : 2025-02-01 DOI: 10.1016/S0002-9629(25)00072-2

C Johnson, S Khan, K Parsell, B Estrada

引用次数: 0

Systemic investigation of the mechanism underlying the therapeutic effect of Astragalus membranaceus in ulcerative colitis 系统研究黄芪对溃疡性结肠炎的治疗作用机制。

IF 2.3 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

American Journal of the Medical Sciences

Pub Date : 2025-02-01 DOI: 10.1016/j.amjms.2024.07.019

Jingxin Mao PhD , Lihong Tan MD , Cheng Tian MD , Wenxiang Wang PhD , YanLin Zou MD , Zhaojing Zhu PhD , Yan Li MD

Background

Whether Astragalus membranaceus is an effective drug in the treatment of ulcerative colitis (UC) is unknown and how it exhibits activity in UC is unclear.

Methods

TCMSP, GeneCards, String, and DAVID databases were used to screen target genes in PPI network and we performed GO and KEGG pathway enrichment analysis. Molecular docking and animal experiments were performed. The body weight and disease activity index (DAI) of mice were recorded. ELISA kits were used to detect the levels of CAT, SOD, MDA and IL-6, IL-10, TNF-α in the blood of mice. Western blot kits were utilized to measure the expression of MAPK14, RB1, MAPK1, JUN, ATK1, and IL2 proteins.

Results

The active components of Astragalus membranaceus mainly include 7-O-methylisomucronulatol, quercetin, kaempferol, formononetin and isrhamnetin. Astragalus membranaceus may inhibit the expression of TNF-α, IL-6, MDA, while promoting the expression of CAT, SOD, and IL-10. The expression levels of MAPK14, RB1, MAPK1, JUN and ATK1 proteins were significantly decreased while IL2 protein increased after administration of Astragalus membranaceus.

Conclusions

Astragalus membranaceus may be an effective drug in the treatment of UC by acting on targets with anti-UC effect via its antioxidant action and by regulating the balance of pro-inflammatory and anti-inflammatory factors.

背景：黄芪是治疗溃疡性结肠炎（UC）的有效药物吗？黄芪是否是治疗溃疡性结肠炎（UC）的有效药物及其对UC的活性作用尚不清楚：方法：利用 TCMSP、GeneCards、String 和 DAVID 数据库筛选构建 PPI 网络的靶基因，并分别进行 GO 和 KEGG 通路富集分析。进行了分子对接和动物实验。记录小鼠的体重和疾病活动指数（DAI）。用 ELISA 试剂盒检测小鼠血液中 CAT、SOD、MDA 和 IL-6、IL-10、TNF-α 的水平。用Western印迹试剂盒检测MAPK14、RB1、MAPK1、JUN、ATK1和IL2蛋白的表达：结果：黄芪的有效成分主要包括7-O-甲基异黄芪醇、槲皮素、山柰醇、甲萘素和异鼠李素。黄芪可抑制 TNF-α、IL-6、MDA 的表达，促进 CAT、SOD、IL-10 的表达。服用黄芪后，MAPK14、RB1、MAPK1、JUN和ATK1蛋白的表达水平明显下降，而IL2蛋白的表达水平上升：根据上述靶点，黄芪是一种治疗UC的有效药物，可通过其抗氧化途径和调节促炎因子与抗炎因子的平衡发挥抗UC作用。

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引用次数: 0

29 From throat to thorax: an unusual case of mediastinitis after streptococcal pharyngitis infection

IF 2.3 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

American Journal of the Medical Sciences

Pub Date : 2025-02-01 DOI: 10.1016/S0002-9629(25)00038-2

A Anderson, T Tran, MK Olejniczak, V Nijjar, O Ajibola, S Sanne, B DeBoisblanc

引用次数: 0

Effect of different shock conditions on mesenteric hemodynamics 不同冲击条件对肠系膜血液动力学的影响。

IF 2.3 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

American Journal of the Medical Sciences

Pub Date : 2025-02-01 DOI: 10.1016/j.amjms.2024.08.018

Hao Pu MSc, Wen Li MSc, Gui Wang MSc, ShuJun Zhou MSc

Background

Reduced effective circulating blood volume and impaired peripheral tissue perfusion play an important role in the pathophysiology of shock. However, there have been no studies examining the relationship between Doppler ultrasound of the superior mesenteric artery (SMA) under different shock conditions.

Methods

We evaluated a total of 85 patients, including 63 patients with different types of shock and 22 in the control group. we included patients who were diagnosed with shock upon admission or developed shock during their hospital stay. At the same time, patients with stable hemodynamics, no use of vasoactive drugs and normal lactate levels were used as a control group. We collected SMA Doppler ultrasound parameters, including Peak Systolic Velocity (PSV), End Diastolic Velocity (EDV), Resistance Index (RI), pulsatility index (PI), Time-Averaged Mean Velocity (TAMV), and Blood Flow (BF).

Results

In the cardiac shock group, SMA PSV, TAMV, and BF were lower compared to the other groups. There was no significant difference in SMA RI and PI between the different types of shock groups, but both were significantly lower than the control group. Cardiac index (CI) is correlated with SMA PSV (r = 0.487, P = 0.000) and TAMV (r = 0.538, P = 0.000), whereas SVRI is not correlated with SMA RI and PI. Lactate levels was correlation with SMA RI (r = -0.307, P = 0.000) and PI (r = -0.287, P = 0.000). The area under the ROC curve of SMA RI and PI to predict hyperlactatemia was 0.85[0.78–0.91] and 0.83[0.76–0.90].

Conclusions

The velocity parameters of SMA Doppler ultrasound such as TAMV and PSV can reflect cardiac function. The measurements of SMA RI and PI are correlated with lactate levels, having a positive predictive value for hyperlactatemia and provide guidance for fluid resuscitation in patients with shock in the future.

背景：有效循环血容量减少和外周组织灌注受损在休克的病理生理学中起着重要作用。然而，目前还没有研究探讨在不同休克条件下肠系膜上动脉（SMA）多普勒超声之间的关系：我们共对 85 名患者进行了评估，其中包括 63 名不同类型的休克患者和 22 名对照组患者。同时，将血液动力学稳定、未使用血管活性药物且乳酸水平正常的患者作为对照组。我们收集了SMA多普勒超声参数，包括收缩峰值速度（PSV）、舒张末期速度（EDV）、阻力指数（RI）、搏动指数（PI）、时间平均平均速度（TAMV）和血流量（BF）：在心脏休克组，SMA PSV、TAMV 和 BF 均低于其他组。不同类型休克组的 SMA RI 和 PI 无明显差异，但均明显低于对照组。心脏指数（CI）与 SMA PSV（r = 0.487，P = 0.000）和 TAMV（r = 0.538，P = 0.000）相关，而 SVRI 与 SMA RI 和 PI 无关。乳酸水平与 SMA RI（r = -0.307，P = 0.000）和 PI（r = -0.287，P = 0.000）相关。SMA RI 和 PI 预测高乳酸血症的 ROC 曲线下面积分别为 0.85[0.78-0.91] 和 0.83[0.76-0.90]：结论：SMA多普勒超声的速度参数，如TAMV和PSV，可以反映心脏功能。SMA的RI和PI测量值与乳酸水平相关，对高乳酸血症具有积极的预测价值，可为今后休克患者的液体复苏提供指导。

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引用次数: 0

70 A complex case of gastroparesis, severe feeding intolerance, and malnutrition in a 2-month-old

IF 2.3 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

American Journal of the Medical Sciences

Pub Date : 2025-02-01 DOI: 10.1016/S0002-9629(25)00079-5

P Escalona, A Sarkar, S Prudencio

引用次数: 0

7 La ribonucleoprotein 6 regulates skeletal muscle fibrotic response in congestive heart failure

IF 2.3 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

American Journal of the Medical Sciences

Pub Date : 2025-02-01 DOI: 10.1016/S0002-9629(25)00016-3

CS Lott, S Sukhanov, P Delafontaine, T Yoshida

引用次数: 0

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