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Streptococcal Meningitis Associated With Cerebello-Pontine Angle Meningioma.
IF 1 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2025-01-24 DOI: 10.1097/PAF.0000000000001022
Sabrina Gribble, Walter L Kemp
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引用次数: 0
Kounis Syndrome Following a Wasp Sting.
IF 1 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2025-01-22 DOI: 10.1097/PAF.0000000000001013
Ryan Blumenthal, Paula Troskie, Seduma Suzan Mabotja
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引用次数: 0
AJFMP 2024 Reviewer Thank You.
IF 1 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2025-01-22 DOI: 10.1097/PAF.0000000000001023
{"title":"AJFMP 2024 Reviewer Thank You.","authors":"","doi":"10.1097/PAF.0000000000001023","DOIUrl":"https://doi.org/10.1097/PAF.0000000000001023","url":null,"abstract":"","PeriodicalId":55535,"journal":{"name":"American Journal of Forensic Medicine and Pathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fatal Ludwig Angina in the Setting of Alcohol Withdrawal: A Rare Cause of Death With Postmortem Computed Tomography and Autopsy Correlation. 酒精戒断后致死性路德维希型心绞痛:一种罕见的死因,与死后计算机断层扫描和尸检相关。
IF 1 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2025-01-21 DOI: 10.1097/PAF.0000000000001015
Miranda Hanson, Alistair Soon, Alex Forrest, Jessica Vidler, Nathan Milne, Jack Garland
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引用次数: 0
Homemade Fentanyl Suicide Machine Used in Experiment to Prove Existence of the Multiverse: A Case Report. 自制芬太尼自杀机用于证明多元宇宙存在的实验:一个案例报告。
IF 1 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2025-01-20 DOI: 10.1097/PAF.0000000000001016
John-Luke Rivera, Claire Sorensen, Lorenzo Gitto

Abstract: Deaths by homemade suicide machines naturally capture public attention given the sensationalism of the subject matter and the complexity of the mechanisms involved. In this case, a self-made apparatus designed to administer a fatal dose of fentanyl, leading to an intentional acute toxicity, was used. As detailed in his 19-page manifesto discovered posthumously, the decedent engineered this device with the express purpose of testing the Many-Worlds Interpretation of quantum mechanics. This interpretation posits that for every time one outcome is observed, there are "parallel universes" in which a different outcome becomes reality; these "parallel universes" are collectively called the "multiverse." By programming his homemade device to kill the versions of himself in the "parallel universes" where he did not achieve a desired outcome-that is, having the winning numbers of a Powerball lottery drawing-the decedent sought to experience a reality where he did win the lottery, which would somehow through his convoluted logic thereby prove the existence of the "multiverse."Initially, the bizarre details of the scene led investigators to consider possibilities like intentional electrocution or even homicide executed by remote means. Thorough death scene and background investigation was critical to determine that it was an elaborate act of suicide.

摘要:自制自杀机器引发的死亡事件由于其主题的耸人听闻性和机制的复杂性,自然会引起公众的关注。在这个案例中,使用了一种自制的装置来施用致命剂量的芬太尼,导致故意的急性毒性。正如他在死后发现的19页宣言中所详述的那样,这位死者设计这个装置的明确目的是测试量子力学的多世界解释。这种解释假定,每当观察到一种结果时,就存在“平行宇宙”,其中不同的结果成为现实;这些“平行宇宙”统称为“多元宇宙”。通过给他自制的装置编程,杀死他在“平行宇宙”中没有得到预期结果的自己的版本——也就是说,他没有得到强力球彩票的中奖号码——死者试图体验一个他确实中了彩票的现实,这将以某种方式通过他复杂的逻辑证明“多元宇宙”的存在。最初,现场的奇怪细节让调查人员考虑到故意触电甚至是远程杀人的可能性。彻底的死亡现场和背景调查对于确定这是一起精心策划的自杀行为至关重要。
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引用次数: 0
An Autopsy Case of Polymicrobial Cardiac Abscesses With Cultured Klebsiella pneumonaie in the Setting of Hyperosmolar Hyperglycemic State.
IF 1 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2025-01-06 DOI: 10.1097/PAF.0000000000001011
Thomas Auen, Erin Linde
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引用次数: 0
An Unusual Death From Penetrating Cranial Trauma: The Importance of Investigating the Primary Scene of Injury.
IF 1 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2025-01-06 DOI: 10.1097/PAF.0000000000001012
Kelli Oxborrow, Laura D Knight

Abstract: A 65-year-old man with a history of hypertension and coronary artery disease was found dead at home after having fallen about 6 days prior. Autopsy examination revealed unexplained penetrating trauma of the skull with a circular defect in the frontal bone with associated cerebral laceration and organizing subdural hemorrhage. As the cause of the penetrating injury was unknown, the forensic pathologist instigated further investigation. Through interviews, the medicolegal death investigator identified the primary scene of injury, which was different from the scene of death; she elucidated the injury scenario, including the culprit object, which she photographed during the follow-up investigation. The etiology of the injury allowed the medical examiner to correctly certify manner of death. This case represents an interesting example of penetrating cranial injury, with minimal external injury and extensive internal lethal damage to the brain. Furthermore, it highlights the importance of investigating the primary scene of injury, especially when death is delayed and the deceased is no longer at the injury location.

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引用次数: 0
Brain Findings in Deceased COVID-19 Patients.
IF 1 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2025-01-06 DOI: 10.1097/PAF.0000000000001010
Armaan Shergill, Bennet Omalu, Peter Conner, Machelle Wilson

Abstract: As COVID-19 continues to infect millions of people globally, it is essential to understand how SARS-CoV-2 affects the brain. The purpose of this study is to determine if there are any associations or patterns of gross and microscopic neuropathological autopsy findings in the brains of patients who died from COVID-19. We analyzed 32 autopsy cases that met 3 requirements: (1) positive polymerase chain reaction (PCR) SARS-CoV-2 test at autopsy; (2) pulmonary histological features of SARS-CoV-2; (3) complete autopsies conducted during the COVID-19 pandemic from 2020 to 2023. We accounted for the presence of the following gross and microscopic neuropathological findings: cerebral edema (CE), cerebral cortical atrophy (CCA), chronic cerebrovascular disease (CCD), cerebral ischemic injury (CII), cerebral inflammation (CIN), and/or cerebral parenchymal hemorrhage (CPH) in every case. We found that CE, CCA, and CII diagnoses had a statistically significant association with age. There were no distinctive or recurrent neuropathological alterations in the autopsied brains that may be interpreted to be pathognomonic of SARS-CoV-2 infection in our cohort. These findings may suggest that SARS-CoV-2 infection is not associated with any distinct histomorphologic abnormalities that are diagnostic of COVID-19 in the brains of autopsied patients.

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引用次数: 0
A Multidisciplinary Approach to Navigating Variants of Uncertain Significance in Sudden Infant Deaths: A Case Report of 2 Siblings With an SCN10A VUS. 一种多学科方法来导航婴儿猝死中不确定意义的变异:两名患有SCN10A VUS的兄弟姐妹的病例报告
IF 1 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2025-01-02 DOI: 10.1097/PAF.0000000000001008
Renee Dumm, Austin Pagani, Lydia Hellwig, Mark Haigney, Mauricio De Castro, Joel Hughes, John Paul Schacht, William McClain, John Walsh

Abstract: The sudden death of a previously healthy infant is a devastating event for a family-the death of 2 even more unimaginable. Prior to the debunking of Meadow's law, a legal concept attributing multiple unexplained infant deaths to Munchausen by proxy, these events could lead to the wrongful prosecution of those who had lost their children to "sudden unexpected infant death (SUID)." Today, these cases, wherein multiple infants within one family pass inexplicably, raise suspicion for a possible genetic cause and point toward a need for postmortem genetic testing.We present the case of 2 siblings who passed suddenly in infancy, with no structural cause of death identified at autopsy. Genetic testing in both infants found the same variant of uncertain significance, a heterozygous single nucleotide substitution, denoted c.3191C>T, in SCN10A, which encodes a sodium channel with pathogenic variants possibly implicated in sudden cardiac death syndromes. Although it is unclear at this time if the variant of uncertain significance identified was a contributing factor in the deaths, the case emphasized the importance of involving a multidisciplinary team to ensure appropriate pretest and posttest counseling, interpretation of nuanced testing results, and medical follow-up for surviving family members of SUID.

摘要:一个原本健康的婴儿突然死亡对一个家庭来说是一个毁灭性的事件,两个孩子的死亡更是难以想象。在梅多定律(Meadow’s law)被揭穿之前,这一法律概念将多起无法解释的婴儿死亡归咎于Munchausen的代理人,这些事件可能导致对那些因“婴儿猝死(SUID)”而失去孩子的人的错误起诉。今天,这些病例中,一个家庭中的多个婴儿莫名其妙地去世,引起了对可能的遗传原因的怀疑,并指出需要进行死后基因检测。我们提出的情况下,2兄弟姐妹谁突然去世在婴儿期,没有结构性死亡原因确定在尸检。在这两个婴儿中进行的基因检测发现了意义不确定的相同变异,即SCN10A中的杂合单核苷酸替代,标记为c.3191C>T,该变异编码一个钠通道,其致病变异可能与心源性猝死综合征有关。虽然目前尚不清楚所确定的不确定意义的变异是否是导致死亡的一个因素,但该病例强调了涉及多学科团队的重要性,以确保适当的测试前和测试后咨询,解释细微的测试结果,并对SUID的幸存家庭成员进行医疗随访。
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引用次数: 0
Green Tip 5.56 × 45-mm (NATO M855) Ammunition: Structural Composition, Radiological Features, and Autopsy Findings. 5.56 × 45毫米(北约M855)弹药:结构组成、放射学特征和尸检结果。
IF 1 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2024-12-31 DOI: 10.1097/PAF.0000000000001006
Wijesinghe Arachchilage Chamila Lakmali, Lorenzo Gitto
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引用次数: 0
期刊
American Journal of Forensic Medicine and Pathology
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