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Meanings of thinness and dysfunctional eating in black South African females: a qualitative study. 南非黑人女性消瘦和饮食失调的意义:一项定性研究。
Pub Date : 2013-09-01 DOI: 10.4314/ajpsy.v16i5.45
P F Morris, C P Szabo

Objective: This study qualitatively explored local meanings of thinness and dysfunctional eating in black adolescent females in the rapidly westernizing socio-cultural context of post-apartheid South Africa.

Methods: Four (n=4) urban state highschools in KwaZulu-Natal were selected from which 40 subjects were sampled from Grades 9-12. Focus groups were conducted following a semi-structured interview and analysed using Constant Comparative Analysis.

Results: Subjects reported a wide range of different meanings for thinness, which included traditional idioms of distress and typically western pressures towards thinness, which was particularly evident in the multicultural schools. Subjects also reported a wide range of dysfunctional eating practices (such as purging) which were underscored by a wide range of motivations, including traditional practices and western body image concern; and which did not tend to follow patterns of 'dieting' that are typical in affluent, western societies.

Conclusion: Western pressures towards thinness may be blending with traditional idioms of distress and culturally sanctioned rituals of remedial purging and social over-eating, thereby placing this group at particular risk for a range of dysfunctional eating patterns that may not follow typically western paradigms or diagnostic systems.

目的:本研究定性地探讨了后种族隔离时代南非迅速西化的社会文化背景下黑人青少年女性的瘦和饮食失调的地方意义。方法:选取夸祖鲁-纳塔尔省4所城市公立高中(n=4),从9-12年级抽取40名被试。焦点小组在半结构化访谈之后进行,并使用恒定比较分析进行分析。结果:研究对象对“瘦”有不同的含义,包括传统习语中的“痛苦”和典型的西方对“瘦”的压力,这在多元文化学校中尤为明显。研究对象还报告了各种各样的不正常饮食习惯(如泻食),这些习惯被各种各样的动机所强调,包括传统习惯和西方身体形象的担忧;他们也不倾向于遵循富裕的西方社会典型的“节食”模式。结论:西方对瘦的压力可能与传统的痛苦习语和文化认可的补救净化仪式以及社会暴饮暴食混合在一起,从而使这一群体处于一系列功能失调的饮食模式的特殊风险中,这些模式可能不遵循典型的西方范式或诊断系统。
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引用次数: 14
The role of spirituality in specialist psychiatry: a review of the medical literature. 精神在专科精神病学中的作用:医学文献综述。
Pub Date : 2013-07-01 DOI: 10.4314/ajpsy.v16i4.33
A B Janse van Rensburg, C P Myburgh, C P Szabo, M Poggenpoel

A review of the international medical literature was undertaken on the role of spirituality in the discipline of psychiatry, within the context that a perceived change is taking place in the health care environment in South Africa. Revitalized interest in spirituality was evident from the literature partly because Western societies have, through the migration of people, become more heterogeneous in recent years. The literature concurred that spirituality must be incorporated into the current approach to the practice and training of psychiatry, but within the professional scope of the discipline, while all faith traditions and belief systems should be regarded equally. Beyond South Africa, it is envisaged that the review has implications for the practice of psychiatry in Africa.

在南非保健环境正在发生明显变化的背景下,对精神病学学科中的作用进行了国际医学文献审查。从文学作品中可以明显看出,人们对灵性的兴趣重新燃起,部分原因是近年来,由于人口的迁移,西方社会变得更加异质。文献一致认为,精神病学必须纳入当前的精神病学实践和培训方法,但在该学科的专业范围内,而所有的信仰传统和信仰体系都应被平等对待。除南非外,预计该审查对非洲的精神病学实践也有影响。
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引用次数: 15
Psychosocial rehabilitation in a chronic care hospital in South Africa: views of clinical staff. 南非一家慢性病医院的心理社会康复:临床工作人员的看法。
Pub Date : 2013-07-01 DOI: 10.4314/ajpsy.v16i4.37
A L Pillay, A L Kramers-Olen

Objective: The study was based at a South African hospital providing inpatient care for people with chronic mental disorders, and aimed at investigating the multidisciplinary team (MDT) members' views, understanding and attitudes towards psychosocial rehabilitation (PSR).

Method: A survey method was used, with the MDT members completing a questionnaire that tapped, inter alia, their understanding of PSR, perceived aims and goals of PSR, adequacy of their professional training to implement PSR, availability of resources to implement PSR, and their views of chronic mentally ill patients, including their functional skills, needs and prognosis.

Results: Of 114 respondents, 19.3% felt they had sufficient knowledge of PSR practice, 53.5% reported that their professional training included teaching on PSR, 90.4% wanted to undertake further training in PSR, 64.9% believed that the hospital environment lends itself to PSR, and 23.7% felt the hospital had sufficient resources to perform PSR. Most (93%) believed that patients with chronic mental disorders can improve their functioning, and 65.8% thought that such patients could make decisions for themselves.

Conclusion: It is not surprising that most of the clinical staff in this investigation do not feel sufficiently equipped to perform PSR interventions, considering that past mental health policies and training failed to emphasize this component of mental health care. The need for training programmes to address this deficit is evident.

目的:本研究以南非一家为慢性精神障碍患者提供住院治疗的医院为基础,旨在调查多学科团队(MDT)成员对心理社会康复(PSR)的看法、理解和态度。方法:采用问卷调查的方法,让MDT成员填写问卷,了解他们对PSR的理解、感知的PSR目的和目标、实施PSR的专业培训是否足够、实施PSR的资源是否可用,以及他们对慢性精神病患者的看法,包括他们的功能技能、需求和预后。结果:114名受访者中,19.3%的人认为自己对PSR实践有足够的了解,53.5%的人表示他们的专业培训包括PSR教学,90.4%的人希望接受进一步的PSR培训,64.9%的人认为医院环境适合PSR, 23.7%的人认为医院有足够的资源来实施PSR。大多数(93%)认为慢性精神障碍患者可以改善他们的功能,65.8%的人认为这些患者可以自己做决定。结论:考虑到过去的精神卫生政策和培训未能强调精神卫生保健的这一组成部分,本次调查中的大多数临床工作人员认为没有足够的能力进行PSR干预,这并不奇怪。显然有必要制定培训方案来解决这一缺陷。
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引用次数: 1
Psychiatric classification, stigma, and mental health. 精神病学分类、病耻感和精神健康。
Pub Date : 2013-07-01 DOI: 10.4314/ajpsy.v16i4.29
D J Stein
Work on DSM-5 and ICD-11, and the simultaneous development of alternative approaches to psychiatric classification such as the Research Domain Criteria of the National Institute of Mental Health, has led to renewed interest of colleagues, patients, decision-makers, and the lay media in psychiatric diagnosis. Psychiatrists find themselves reading rationales for these classification systems by those who have worked on them, as well as strong criticisms by those who have perceived key weaknesses. How should we respond?
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引用次数: 1
Sublingual atropine for the treatment of severe and hyoscine-resistant clozapine-induced sialorrhea. 舌下阿托品治疗重度氯氮平引起的唾液漏。
Pub Date : 2013-07-01 DOI: 10.4314/ajpsy.v16i4.32
F A Mustafa, A Khan, J Burke, M Cox, S Sherif
1, which may increase the risk of aspiration pneumonia 2 , a potentially life threatening condition. M4 agonism, α2 antagonism and impaired deglutition have been hypothesised as probable underlying mechanisms. 3 A few previous case reports have shown topical atropine, an antimuscarinic agent, to be effective in the management of clozapine induced sialorrhea (CIS). 4-6 Informed consent was received for publication of the following case material. A 46 year old Afro-Caribbean male with chronic refractory schizophrenia, was compulsorily hospitalised after experiencing an acute psychotic relapse. His relapse was precipitated by clozapine discontinuation. During his hospital treatment, the patient failed to respond to olanzapine up to a dose of 40 mg/day (plasma level 59 mcg/L) and was therefore cross tapered to clozapine over a period of 3 weeks. Clozapine was gradually titrated up to 400 mg/day (plasma level 0.26 mg/L) and the patient subsequently developed severe sialorrhea. He was constantly drooling and his speech was impaired due to the copious amount of saliva in his mouth. The patient found this adverse effect very distressing. Oral hyoscine hydrobromide was administered for 4 weeks (titrated gradually up to 900 mcg/day) without notable improvement in the patient’s hypersalivation. This restricted any further increase in the dose of clozapine, despite the patient’s continued psychotic symptoms. Sublingual atropine solution (1%) was commenced (one drop up to 3 times/day), to which the patient instantaneously responded, and hyoscine hydrobromide was gradually reduced to 300 mcg at bed time. The drooling stopped and the patient’s speech normalised. The clozapine dose was increased to 450 mg/day and his mental state started improving steadily. Sialorrhea did not recur following the discontinuation of atropine by the patient after 7 days. In this case, sublingual administration of atropine led to dramatic resolution of severe CIS, which had not responded to previous treatment with hyoscine. Atropine treatment provided instantaneous relief from CIS and allowed further increase in the clozapine dose until a therapeutic response was achieved. However, at the end of the 7 day atropine trial, the patient was still receiving hyoscine 300 mcg at bed time. Hence, it could be argued that CIS resolution may have been due to the combined treatment with atropine and hyoscine. CIS did not recur after atropine was discontinued, which suggests that in this patient CIS was a transient adverse effect. This case further supports the use of sublingual atropine in the management of CIS and this should be robustly evaluated using a randomised controlled trial.
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引用次数: 19
The experiences of parents of children with mental disability regarding access to mental health care. 精神残疾儿童的父母在获得精神保健方面的经验。
Pub Date : 2013-07-01 DOI: 10.4314/ajpsy.v16i4.36
R A Coomer

Objective: The aim of this qualitative study was to describe the problems that parents or caregivers of children with mental health disabilities and disorders in Namibia experience when accessing healthcare resources for their children.

Method: Data was collected through focus group discussions with the participants and individual interviews with the key informants. Overall, a total of 41 people provided information for this study. Thematic data analysis was used to assess the data.

Results: The main barriers experienced by the parents were poor service provision, transport and money, whilst access to education services facilitated access to healthcare services.

Conclusion: The challenges go beyond commonly-reported problems such as sub-optimal service provision and include the basic challenge of lack of transportation to reach healthcare services. Many of the barriers identified in this study have been related to general problems with the healthcare system in Namibia. Therefore there is a need to address general concerns about healthcare provision as well as improve specific services for children with mental health disabilities and disorders in Namibia.

目的:本定性研究的目的是描述纳米比亚精神健康残疾和障碍儿童的父母或照顾者在为其子女获取医疗资源时遇到的问题。方法:通过与参与者的焦点小组讨论和对主要举报人的个别访谈收集资料。总的来说,共有41人为这项研究提供了信息。采用专题数据分析对数据进行评估。结果:父母遇到的主要障碍是服务条件差、交通和金钱,而获得教育服务有助于获得医疗保健服务。结论:这些挑战超出了常见的服务提供不佳等问题,还包括缺乏交通工具来获得医疗服务的基本挑战。本研究中确定的许多障碍与纳米比亚医疗保健系统的一般问题有关。因此,有必要解决对保健服务提供的普遍关切,并改善对纳米比亚患有精神健康残疾和障碍儿童的具体服务。
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引用次数: 20
The role of psycho-education in improving outcome at a general hospital psychiatry clinic in Uganda. 乌干达一家综合医院精神病诊所心理教育在改善结果中的作用。
Pub Date : 2013-07-01 DOI: 10.4314/ajpsy.v16i4.35
E Prost, S Musisi, E S Okello, W M Hopman

Objective: While psychoeducation has been shown to positively affect outcomes in psychiatric disorders, its utility has been little studied in developing countries. The current study sought to examine the role of psychoeducation at a general psychiatric outpatient clinic in Kampala, Uganda in improving clinic attendance, treatment adherence, and clinical outcomes.

Method: A prospective case-control study using a quasi-experimental design was conducted in 117 patients suffering various psychiatric disorders. Participants were recruited for two months and then followed for a further three months after recruitment ended. Participants in the intervention group received formalized psychoeducation sessions at each clinic visit in addition to the usual psychiatric evaluation and care. Participants in the control group received the usual clinical care. Measured outcomes were knowledge of mental illness, compliance with medications and follow-up, and Clinical Global Impression (CGI).

Results: The groups did not differ with respect to sociodemographic characteristics or attendance at scheduled follow-up visits. Both groups significantly improved on the CGI, but with no significant difference between the groups. However, the intervention group was more likely to adhere to medication, and their knowledge of mental illness was significantly higher at follow-up.

Conclusion: These data suggest that psychoeducation is a beneficial mental health intervention in a developing country that may increase compliance with medication and result in greater knowledge of mental illness. However, other factors such as distance from a centralized clinic or cost of treatment may impact outcomes, including attendance at scheduled follow-up visits.

目的:虽然心理教育已被证明对精神疾病的预后有积极影响,但在发展中国家对其效用的研究很少。目前的研究试图在乌干达坎帕拉的一家普通精神病门诊诊所检查心理教育在提高诊所出勤率、治疗依从性和临床结果方面的作用。方法:采用准实验设计对117例不同类型精神障碍患者进行前瞻性病例对照研究。参与者被招募了两个月,然后在招募结束后又被跟踪了三个月。干预组的参与者在每次就诊时除了接受常规的精神评估和护理外,还接受正式的心理教育。对照组接受常规临床护理。测量的结果是对精神疾病的了解,对药物的依从性和随访,以及临床总体印象(CGI)。结果:两组在社会人口学特征或参加预定随访方面没有差异。两组在CGI上都有显著改善,但两组之间没有显著差异。然而,干预组更有可能坚持药物治疗,他们对精神疾病的了解在随访中明显更高。结论:这些数据表明,在发展中国家,心理教育是一种有益的心理健康干预措施,可以增加对药物的依从性,并提高对精神疾病的认识。然而,其他因素,如与集中诊所的距离或治疗费用可能会影响结果,包括参加预定的随访。
{"title":"The role of psycho-education in improving outcome at a general hospital psychiatry clinic in Uganda.","authors":"E Prost,&nbsp;S Musisi,&nbsp;E S Okello,&nbsp;W M Hopman","doi":"10.4314/ajpsy.v16i4.35","DOIUrl":"https://doi.org/10.4314/ajpsy.v16i4.35","url":null,"abstract":"<p><strong>Objective: </strong>While psychoeducation has been shown to positively affect outcomes in psychiatric disorders, its utility has been little studied in developing countries. The current study sought to examine the role of psychoeducation at a general psychiatric outpatient clinic in Kampala, Uganda in improving clinic attendance, treatment adherence, and clinical outcomes.</p><p><strong>Method: </strong>A prospective case-control study using a quasi-experimental design was conducted in 117 patients suffering various psychiatric disorders. Participants were recruited for two months and then followed for a further three months after recruitment ended. Participants in the intervention group received formalized psychoeducation sessions at each clinic visit in addition to the usual psychiatric evaluation and care. Participants in the control group received the usual clinical care. Measured outcomes were knowledge of mental illness, compliance with medications and follow-up, and Clinical Global Impression (CGI).</p><p><strong>Results: </strong>The groups did not differ with respect to sociodemographic characteristics or attendance at scheduled follow-up visits. Both groups significantly improved on the CGI, but with no significant difference between the groups. However, the intervention group was more likely to adhere to medication, and their knowledge of mental illness was significantly higher at follow-up.</p><p><strong>Conclusion: </strong>These data suggest that psychoeducation is a beneficial mental health intervention in a developing country that may increase compliance with medication and result in greater knowledge of mental illness. However, other factors such as distance from a centralized clinic or cost of treatment may impact outcomes, including attendance at scheduled follow-up visits.</p>","PeriodicalId":55549,"journal":{"name":"African Journal of Psychiatry","volume":"16 4","pages":"264-70"},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4314/ajpsy.v16i4.35","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31745997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Pattern of attendance and predictors of default among Nigerian outpatients with schizophrenia. 尼日利亚精神分裂症门诊患者的出勤模式和违约预测因素。
Pub Date : 2013-07-01 DOI: 10.4314/ajpsy.v16i4.38
A O Adelufosi, A Ogunwale, A B Adeponle, O Abayomi

Objective: To assess the pattern of and factors associated with outpatient clinic attendance among patients diagnosed with schizophrenia at a Nigerian psychiatric hospital.

Methods: This was a cross-sectional descriptive study of 313 consecutive outpatients with diagnosis of schizophrenia confirmed with the Structured Clinical Interview for Diagnosis (SCID). Data was collected on sociodemographics, clinic attendance, perceived social support, perceived satisfaction with hospital care and illness severity (assessed using the Brief Psychiatric Rating Scale, BPRS). Logistic regression analysis was used to identify factors associated with outpatient clinic default.

Results: Overall, 20.4% respondents were defaulters, with a median duration of clinic non-attendance of 8 weeks. Outpatient clinic defaulters had significantly higher BPRS scores and had missed more outpatient clinic appointments compared with non-defaulters. A significantly higher proportion of defaulters resided more than 20 km away from the hospital and reported "not satisfied" with their outpatient care. Being financially constrained was the commonest reason given by defaulters for missing their clinic appointments. The significant predictors of outpatient clinic default included residing more than 20 km from the hospital, missing previous appointments and dissatisfaction with outpatient care.

Conclusion: Outpatient clinic non-attendance is common among patients with schizophrenia, and is significantly associated with demographic, clinical and service related factors. Interventions targeted at addressing the risk factors for defaulting peculiar to developing country settings similar to the location of this study, could significantly improve treatment outcome.

目的:评估尼日利亚一家精神病院诊断为精神分裂症的患者的门诊就诊模式和相关因素。方法:本研究是一项横断面描述性研究,对313例经结构化临床诊断访谈(SCID)确诊为精神分裂症的连续门诊患者进行研究。收集的数据包括社会人口统计学、诊所就诊、感知到的社会支持、感知到的医院护理满意度和疾病严重程度(使用简短精神病评定量表,BPRS进行评估)。采用Logistic回归分析确定门诊诊所违约的相关因素。结果:总体而言,20.4%的应答者为违约者,平均缺席时间为8周。门诊失约者的BPRS评分显著高于非失约者,且失诊次数较多。有更高比例的违约者住在离医院20公里以上的地方,他们对门诊服务“不满意”。经济拮据是违约者错过诊所预约的最常见原因。门诊缺席的显著预测因子包括居住距离医院超过20公里、错过以前的预约和对门诊服务的不满。结论:精神分裂症患者门诊缺勤现象普遍存在,且与人口统计学、临床及服务相关因素显著相关。针对与本研究地点相似的发展中国家环境特有的违约风险因素的干预措施可以显著改善治疗结果。
{"title":"Pattern of attendance and predictors of default among Nigerian outpatients with schizophrenia.","authors":"A O Adelufosi,&nbsp;A Ogunwale,&nbsp;A B Adeponle,&nbsp;O Abayomi","doi":"10.4314/ajpsy.v16i4.38","DOIUrl":"https://doi.org/10.4314/ajpsy.v16i4.38","url":null,"abstract":"<p><strong>Objective: </strong>To assess the pattern of and factors associated with outpatient clinic attendance among patients diagnosed with schizophrenia at a Nigerian psychiatric hospital.</p><p><strong>Methods: </strong>This was a cross-sectional descriptive study of 313 consecutive outpatients with diagnosis of schizophrenia confirmed with the Structured Clinical Interview for Diagnosis (SCID). Data was collected on sociodemographics, clinic attendance, perceived social support, perceived satisfaction with hospital care and illness severity (assessed using the Brief Psychiatric Rating Scale, BPRS). Logistic regression analysis was used to identify factors associated with outpatient clinic default.</p><p><strong>Results: </strong>Overall, 20.4% respondents were defaulters, with a median duration of clinic non-attendance of 8 weeks. Outpatient clinic defaulters had significantly higher BPRS scores and had missed more outpatient clinic appointments compared with non-defaulters. A significantly higher proportion of defaulters resided more than 20 km away from the hospital and reported \"not satisfied\" with their outpatient care. Being financially constrained was the commonest reason given by defaulters for missing their clinic appointments. The significant predictors of outpatient clinic default included residing more than 20 km from the hospital, missing previous appointments and dissatisfaction with outpatient care.</p><p><strong>Conclusion: </strong>Outpatient clinic non-attendance is common among patients with schizophrenia, and is significantly associated with demographic, clinical and service related factors. Interventions targeted at addressing the risk factors for defaulting peculiar to developing country settings similar to the location of this study, could significantly improve treatment outcome.</p>","PeriodicalId":55549,"journal":{"name":"African Journal of Psychiatry","volume":"16 4","pages":"283-7"},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4314/ajpsy.v16i4.38","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31746000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 27
Deserves a hearing? A case report of remitting tinnitus with N-acetyl cysteine. 值得听证?用n -乙酰半胱氨酸治疗耳鸣1例。
Pub Date : 2013-07-01 DOI: 10.4314/ajpsy.v16i4.31
O M Dean, S Jeavons, G S Malhi, S M Cotton, M Tanious, K Kohlmann, K Hewitt, K Moss, C Allwang, I Schapkaitz, J Robbins, H Cobb, S Dodd, A Bush, M Berk
238The known pharmacokinetic profile of a medication doesnot always point to its therapeutic potential. Manytreatments were discovered serendipitously as aconsequence of careful clinical observation, often in thecontext of treatment of apparently unrelated conditions.Consequently, many widely-used therapies have currentuses well removed from their initial indications, forinstance the use of aspirin in cardiovascular protection.
{"title":"Deserves a hearing? A case report of remitting tinnitus with N-acetyl cysteine.","authors":"O M Dean,&nbsp;S Jeavons,&nbsp;G S Malhi,&nbsp;S M Cotton,&nbsp;M Tanious,&nbsp;K Kohlmann,&nbsp;K Hewitt,&nbsp;K Moss,&nbsp;C Allwang,&nbsp;I Schapkaitz,&nbsp;J Robbins,&nbsp;H Cobb,&nbsp;S Dodd,&nbsp;A Bush,&nbsp;M Berk","doi":"10.4314/ajpsy.v16i4.31","DOIUrl":"https://doi.org/10.4314/ajpsy.v16i4.31","url":null,"abstract":"238The known pharmacokinetic profile of a medication doesnot always point to its therapeutic potential. Manytreatments were discovered serendipitously as aconsequence of careful clinical observation, often in thecontext of treatment of apparently unrelated conditions.Consequently, many widely-used therapies have currentuses well removed from their initial indications, forinstance the use of aspirin in cardiovascular protection.","PeriodicalId":55549,"journal":{"name":"African Journal of Psychiatry","volume":"16 4","pages":"238, 240"},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4314/ajpsy.v16i4.31","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31746098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Clozapine- induced recurrent and transient parotid gland swelling. 氯氮平引起的复发性和短暂性腮腺肿胀。
Pub Date : 2013-07-01 DOI: 10.4314/ajpsy.v16i4.30
A Vohra
Clozapine is a novel dibenzodiazepine derivative, atypical antipsychotic which exhibits antagonistic activity on 5HT2, alpha 1, alpha 2, H1 and M1, M2, M3 and M5 receptors; agonist activity at the M4 muscarinic receptor and modest antagonistic effect on D2-like receptors. Clozapine is known to be superior to other antipsychotics and is effective in 30-50% of patients diagnosed with treatment-resistant schizophrenia. However, its use is restricted mainly due to its side effect of agranulocytosis.
{"title":"Clozapine- induced recurrent and transient parotid gland swelling.","authors":"A Vohra","doi":"10.4314/ajpsy.v16i4.30","DOIUrl":"https://doi.org/10.4314/ajpsy.v16i4.30","url":null,"abstract":"Clozapine is a novel dibenzodiazepine derivative, atypical antipsychotic which exhibits antagonistic activity on 5HT2, alpha 1, alpha 2, H1 and M1, M2, M3 and M5 receptors; agonist activity at the M4 muscarinic receptor and modest antagonistic effect on D2-like receptors. Clozapine is known to be superior to other antipsychotics and is effective in 30-50% of patients diagnosed with treatment-resistant schizophrenia. However, its use is restricted mainly due to its side effect of agranulocytosis.","PeriodicalId":55549,"journal":{"name":"African Journal of Psychiatry","volume":"16 4","pages":"236, 238"},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4314/ajpsy.v16i4.30","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31746097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
期刊
African Journal of Psychiatry
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