Pub Date : 2025-11-01Epub Date: 2025-10-08DOI: 10.1177/02611929251383029
Gilly Griffin
Real progress has been made towards replacing animals for risk assessment purposes, particularly given the recent announcement of comprehensive roadmaps by regulatory agencies. However, given the vast number of animals that continue to be used for biomedical purposes, perhaps now is the time to place greater emphasis on replacing animals in biomedical research. Scientific journals have a key role to play in encouraging the uptake of new approach methodologies and providing a supportive environment for a cultural shift to humane, sustainable Three Rs-based science.
{"title":"Charting a new path, replacing animals in biomedical research.","authors":"Gilly Griffin","doi":"10.1177/02611929251383029","DOIUrl":"10.1177/02611929251383029","url":null,"abstract":"<p><p>Real progress has been made towards replacing animals for risk assessment purposes, particularly given the recent announcement of comprehensive roadmaps by regulatory agencies. However, given the vast number of animals that continue to be used for biomedical purposes, perhaps now is the time to place greater emphasis on replacing animals in biomedical research. Scientific journals have a key role to play in encouraging the uptake of new approach methodologies and providing a supportive environment for a cultural shift to humane, sustainable Three Rs-based science.</p>","PeriodicalId":55577,"journal":{"name":"Atla-Alternatives To Laboratory Animals","volume":" ","pages":"335-339"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01Epub Date: 2025-10-21DOI: 10.1177/02611929251388320
Songyi Kim, Keonyeong Min, Changgyu Lim, Hearang Lim, Sunghoon Jeon, Byungjin Kim, Jinhwa Chang, Sang-Hwan Hyun, Dongwoo Chang, Namsoon Lee
Minimally invasive catheter-based techniques for cardiac diseases, such as patent ductus arteriosus occlusion, pulmonic stenosis balloon valvuloplasty, atrial septal defect occlusion and transseptal approaches, have gained popularity in veterinary cardiology owing to their high success and low complication rates. However, the technical complexity of these procedures and the lack of accessible training opportunities have limited their widespread adoption in clinical practice. In this study, we evaluated the effectiveness of a 3D-printed canine cardiac model as a simulator-based training tool for improving proficiency in these interventional procedures. The 3D model was developed by using computed tomography (CT) data of a dog diagnosed with type IIa patent ductus arteriosus. A virtual prototype of the model was created by segmenting the CT data. A hard-type photopolymer resin was used for 3D printing the model to ensure durability. To enhance the structural stability and applicability of the model, iterative optimisation was carried out by incorporating feedback from testers who used it for the different procedural simulations. The model accurately replicated cardiovascular structures and artificial defects, such as atrial and ventricular septal defects. Patent ductus arteriosus occlusion, pulmonic stenosis balloon valvuloplasty, atrial septal defect occlusion and transseptal approaches were performed, in order to evaluate the compatibility of the model with fluoroscopy. To assess the effectiveness of the model as a training tool, time-trial assessments and pre- and post-training evaluations involving six participants were conducted. The 3D-printed canine cardiac model improved procedural efficiency and understanding of cardiac anatomy. The 3D-printed model of canine cardiac diseases introduced here is scalable and valuable as a teaching tool in veterinary interventional cardiology.
{"title":"Development of a 3D-printed canine cardiac disease model for interventional procedure training.","authors":"Songyi Kim, Keonyeong Min, Changgyu Lim, Hearang Lim, Sunghoon Jeon, Byungjin Kim, Jinhwa Chang, Sang-Hwan Hyun, Dongwoo Chang, Namsoon Lee","doi":"10.1177/02611929251388320","DOIUrl":"10.1177/02611929251388320","url":null,"abstract":"<p><p>Minimally invasive catheter-based techniques for cardiac diseases, such as patent ductus arteriosus occlusion, pulmonic stenosis balloon valvuloplasty, atrial septal defect occlusion and transseptal approaches, have gained popularity in veterinary cardiology owing to their high success and low complication rates. However, the technical complexity of these procedures and the lack of accessible training opportunities have limited their widespread adoption in clinical practice. In this study, we evaluated the effectiveness of a 3D-printed canine cardiac model as a simulator-based training tool for improving proficiency in these interventional procedures. The 3D model was developed by using computed tomography (CT) data of a dog diagnosed with type IIa patent ductus arteriosus. A virtual prototype of the model was created by segmenting the CT data. A hard-type photopolymer resin was used for 3D printing the model to ensure durability. To enhance the structural stability and applicability of the model, iterative optimisation was carried out by incorporating feedback from testers who used it for the different procedural simulations. The model accurately replicated cardiovascular structures and artificial defects, such as atrial and ventricular septal defects. Patent ductus arteriosus occlusion, pulmonic stenosis balloon valvuloplasty, atrial septal defect occlusion and transseptal approaches were performed, in order to evaluate the compatibility of the model with fluoroscopy. To assess the effectiveness of the model as a training tool, time-trial assessments and pre- and post-training evaluations involving six participants were conducted. The 3D-printed canine cardiac model improved procedural efficiency and understanding of cardiac anatomy. The 3D-printed model of canine cardiac diseases introduced here is scalable and valuable as a teaching tool in veterinary interventional cardiology.</p>","PeriodicalId":55577,"journal":{"name":"Atla-Alternatives To Laboratory Animals","volume":" ","pages":"314-325"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145338302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01Epub Date: 2025-10-17DOI: 10.1177/02611929251390811
{"title":"Spotlight on Three Rs Progress.","authors":"","doi":"10.1177/02611929251390811","DOIUrl":"10.1177/02611929251390811","url":null,"abstract":"","PeriodicalId":55577,"journal":{"name":"Atla-Alternatives To Laboratory Animals","volume":" ","pages":"307-309"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145314286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01Epub Date: 2025-08-17DOI: 10.1177/02611929251369699
{"title":"Spotlight on Three Rs Progress.","authors":"","doi":"10.1177/02611929251369699","DOIUrl":"10.1177/02611929251369699","url":null,"abstract":"","PeriodicalId":55577,"journal":{"name":"Atla-Alternatives To Laboratory Animals","volume":" ","pages":"243-245"},"PeriodicalIF":3.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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