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Response to paper by Douxfils et al. Oestradiol is not the Holy Grail in the quest for the ideal oestrogen therapy. 对Douxfils等人论文的回应。在寻求理想的雌激素疗法时,雌二醇不是圣杯。
IF 1.8 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-09-01 Epub Date: 2023-09-25 DOI: 10.5114/pm.2023.131374
Małgorzata Bińkowska, Artur Jakimiuk, Tomasz Paszkowski, Leszek Pawelczyk, Violetta Skrzypulec-Plinta
We express our deep thanks to all distinguished colleagues for their careful reading of our paper (Menopause Rev 2022; 21: 197-199) and for writing their thoughtful and valuable commentary (Menopause Rev 2023; 22: 117-119). We would like to take this opportunity to address some of the issues they have raised. The aim of our paper was to present the most recently published clinical data on the safety profile of oral oestrogen-progestogen hormone therapies with respect to the venous system provided by studies conducted in standard real-world clinical practice. We did not address in our paper estetrol-containing drugs simply because no such studies exist, and the presentation and detailed discussion of basic science findings was out of our paper’s scope. The end-point of both studies discussed by us was exclusively the thromboembolism risk measured by epidemiological and not biochemical Response to paper by Douxfils et al. Oestradiol is not the Holy Grail in the quest for the ideal oestrogen therapy
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引用次数: 0
A rare case of bilateral distal segmental absence of fallopian tubes in a patient presenting with hydrosalpinx. 输卵管积水患者双侧输卵管远端节段缺失的罕见病例。
IF 1.8 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-09-01 Epub Date: 2023-09-20 DOI: 10.5114/pm.2023.131308
Karolina Wiśniewska, Michał Wojciechowski

Isolated fallopian tube anomalies are a rare group of disorders, usually observed in otherwise asymptomatic patients. If symptomatic, the patients may present with infertility or unspecified abdominal pains. Various aetiologies have been proposed to explain this phenomenon, ranging from congenital to vascular events. Diagnosis is very challenging because in most cases those abnormalities are not easily seen on ultrasound, computed tomography, or even magnetic resonance imaging. The most objective and certain diagnosis, however, can be obtained through laparoscopy with an associated histopathological examination performed if necessary. Management of this rare group of disorders remains unclear - because the number of cases is relatively small, there is no consensus on treatment. We present a case of a 22-year-old woman with no relevant clinical history and no sexual activity with large bilateral hydrosalpinx that developed as a result of bilateral distal fallopian tube segmental absence with associated occlusion and concomitant endometriotic implants in the vicinity of the left ovarian fossa and the peritoneum of the rectouterine pouch. To our best knowledge, only a few similar cases have been described in the literature. We summarise the available descriptions of this group of pathologies, present theories that have been proposed to explain this phenomenon, and provide various classifications of those disorders.

孤立性输卵管异常是一组罕见的疾病,通常在其他无症状的患者中观察到。如果有症状,患者可能会出现不孕或不明原因的腹痛。人们提出了各种病因来解释这种现象,从先天性到血管性事件。诊断是非常具有挑战性的,因为在大多数情况下,这些异常不容易在超声波、计算机断层扫描甚至磁共振成像中看到。然而,最客观和确定的诊断可以通过腹腔镜检查获得,必要时进行相关的组织病理学检查。这类罕见疾病的治疗仍不清楚,因为病例数量相对较少,在治疗方面没有达成共识。我们报告了一例22岁女性,无相关临床病史,也无性活动,双侧输卵管积水是由于双侧远侧输卵管节段缺失,并伴有左卵巢窝和直肠子宫袋腹膜附近的子宫内膜异位植入物。据我们所知,文献中只描述了少数类似的案例。我们总结了这组病理学的现有描述,提出了解释这一现象的理论,并提供了这些疾病的各种分类。
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引用次数: 0
Use of botulinum toxin in aesthetic medicine and gynaecology: current approaches, controversies, and future directions. 肉毒杆菌毒素在美容医学和妇科中的应用:目前的方法、争议和未来的方向。
IF 1.8 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-09-01 Epub Date: 2023-09-25 DOI: 10.5114/pm.2023.131457
Andrea Etrusco, Maurina Geru, Antonio Simone Laganà, Vito Chiantera, Andrea Giannini, Giovanni Buzzaccarini

This review looks at the use of botulinum toxin in the gynaecological field with the aim of determining what needs to be further investigated to achieve a standardized application. Numerous studies have been conducted to explore how botulinum toxins (BoNT) can be applied, and it is becoming popular for treating various disorders such as chronic pelvic pain, vestibulodynia, and vaginism. However, the exact dosage and ideal location for injections still need to be clarified. The objective of this study is to point out which aspects need to be more carefully studied to ensure a consistent use of BoNT in gynaecology.

这篇综述着眼于肉毒杆菌毒素在妇科领域的应用,目的是确定需要进一步研究才能实现标准化应用。已经进行了大量的研究来探索肉毒杆菌毒素(BoNT)是如何应用的,它在治疗慢性盆腔疼痛、前庭痛和阴道病等各种疾病方面越来越受欢迎。然而,注射的确切剂量和理想位置仍需澄清。本研究的目的是指出哪些方面需要更仔细地研究,以确保BoNT在妇科中的一致使用。
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引用次数: 0
Early-stage cervical cancer treatment - what's new? 早期子宫颈癌的治疗有什么新进展?
IF 1.8 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-06-01 DOI: 10.5114/pm.2023.127774
Camilla Di Dio, Ilham Azenkoud, Angelo Trezza, Emanuele Lentini, Tullio Golia D'Augè, Ilaria Cuccu, Giorgia Di Bartolomeo, Ilaria Firulli, Andrea Canicchio, Ludovica Sgamba, Ludovico Muzii

The gold standard of treatment for patients with early-stage cervical cancer is radical hysterectomy, in agreement with the entire scientific community. During the last decade, growing evidence has supported the minimally invasive approach. Several studies have suggested that the minimally invasive approach could improve surgical and perioperative outcomes. Because of these findings, ESCO/ESTRO/ESP guidelines state that a "minimally invasive approach is favoured" in comparison with open surgery, as a grade B recommendation. Because of the lack of a grade A recommendation, this randomized Laparoscopic Approach to Cervical Cancer trial evaluated open vs. minimally invasive approach in the early stage. It demonstrated an increase in mortality among patients treated with minimally invasive surgery, revolutionizing current thinking on the primary surgical approach to early cervical cancer. The aim of this study is to analyse which is the best treatment for early cervical cancer and which approach is the most effective at the moment. Further studies are needed to state with certainty the appropriateness of the treatments offered to patients with early cervical cancer.

治疗早期宫颈癌患者的黄金标准是根治性子宫切除术,这与整个科学界一致。在过去十年中,越来越多的证据支持微创方法。一些研究表明,微创入路可以改善手术和围手术期的预后。由于这些发现,ESCO/ESTRO/ESP指南指出,与开放手术相比,“微创手术更受欢迎”,作为B级推荐。由于缺乏a级推荐,这项随机的宫颈癌腹腔镜入路试验在早期评估了开放与微创入路。研究表明,在接受微创手术治疗的患者中,死亡率有所增加,这彻底改变了目前对早期宫颈癌的主要手术方法的看法。本研究的目的是分析早期宫颈癌的最佳治疗方法和目前最有效的治疗方法。需要进一步的研究来确定为早期宫颈癌患者提供的治疗是否适当。
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引用次数: 0
Epidemiology and risk factors for ovarian cancer. 卵巢癌的流行病学和危险因素。
IF 1.8 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-06-01 DOI: 10.5114/pm.2023.128661
Aus Tariq Ali, Osamah Al-Ani, Faisal Al-Ani

Ovarian cancer is a complex disease, mostly observed in postmenopausal women, and is associated with poor survival rates. It is the sixth most common cancer and the fifth most common cause of death due to cancer among women in developed countries. Thus, despite representing less than one third of all gynaecologic cancers, deaths due to ovarian cancer account for more than two thirds of deaths due to gynaecologic cancers. Its prevalence is higher in Western Europe and Northern America than Asia and Africa. In sub-Saharan Africa, there is a considerably lower prevalence of ovarian cancer than other parts of Africa. Ovarian cancer is multifaceted, involving many factors, complex biological processes and unpredictable consequences. Unlike other female cancers that have early warning symptoms, ovarian cancer's symptoms are non-specific. As a result, ovarian cancers are normally undetected until advanced stages (III or IV). The major risk factors for ovarian cancer include older age, genetics, family history, hormone replacement therapy, nulliparity, and dietary fat. Controversial factors include obesity, infertility, talc powder, radiation exposure, fertility medications and in vitro fertilization. The current review discusses the aetiology, epidemiology and risk factors for ovarian cancer. Nevertheless, identification of the main risk factors for ovarian cancer may increase the awareness among women of the general population. This should help to decrease the incidence rate of ovarian cancer and increase the five-year survival rate.

卵巢癌是一种复杂的疾病,主要发生在绝经后妇女,与生存率低有关。它是发达国家妇女癌症死亡的第六大常见癌症和第五大常见原因。因此,尽管卵巢癌在所有妇科癌症中所占的比例不到三分之一,但卵巢癌造成的死亡占妇科癌症死亡人数的三分之二以上。它在西欧和北美的流行率高于亚洲和非洲。在撒哈拉以南非洲,卵巢癌的发病率比非洲其他地区低得多。卵巢癌是多面性的,涉及诸多因素,生物学过程复杂,后果难以预测。与其他有早期预警症状的女性癌症不同,卵巢癌的症状是非特异性的。因此,卵巢癌通常要到晚期(III或IV期)才会被发现。卵巢癌的主要危险因素包括年龄较大、遗传、家族史、激素替代疗法、不孕和饮食脂肪。有争议的因素包括肥胖、不孕症、滑石粉、辐射暴露、生育药物和体外受精。本文综述了卵巢癌的病因、流行病学和危险因素。然而,确定卵巢癌的主要危险因素可能会提高普通人群中妇女的认识。这将有助于降低卵巢癌的发病率,提高五年生存率。
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引用次数: 0
Communication skills training with the transactional analysis approach developed menopausal women's marital adjustment - a quasi-experimental study. 交易分析方法下的沟通技巧训练促进了更年期妇女的婚姻调整——一项准实验研究。
IF 1.8 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-06-01 DOI: 10.5114/pm.2023.127772
Behnaz Enjezab, Fatemeh Yousofvand, Hamid Nasiri Dehsorkhi, Tayebeh Mokhtari Sorkhani

Introduction: Communication skills help people have a better life. Due to the changes caused by menopause and their effects on interpersonal communication, it is essential to reinforce communication skills during this period. This study aimed to investigate the effect of communication skills training (CST) using the transactional analysis (TA) approach on menopausal women's marital adjustment.

Material and methods: This quasi-experimental study with a parallel design was performed by the availability sampling method with participation of 46 married menopausal women. Participants were randomly assigned to two groups. The intervention group participated in eight CST sessions with a TA approach. The control group did not receive any psychosocial or educational services. Participants completed the demographic information, Queen Dam communication skills, and Spinner's marital adjustment questionnaire before, at the end of, and one month after the training period. Data were analyzed by descriptive and analytical tests with SPSS22 software.

Results: There was no significant difference in demographics between the groups (p < 0.05). The mean marital adjustment scores were 53.48 ±12.24, 117.70 ±11.15, and 116.52 ±10.73 before, at the end of, and one month after the intervention, respectively. The marital adjustment scores before the intervention did not differ between the two groups but significantly increased after training and in the follow-up period (p < 0.001).

Conclusions: Communication skills training with a TA approach in postmenopausal women improves marital adjustment. Therefore, it is suggested that midwives use this method in comprehensive health centers as an effective method for improving the lives of postmenopausal women.

沟通技巧帮助人们拥有更好的生活。由于更年期引起的变化及其对人际交往的影响,在此期间加强沟通技巧是至关重要的。本研究旨在探讨沟通技巧训练(CST)对更年期妇女婚姻调整的影响。材料与方法:本研究采用准实验设计,采用可得性抽样方法,纳入46名已婚绝经妇女。参与者被随机分为两组。干预组采用TA方法参加了8次CST会议。对照组没有接受任何社会心理或教育服务。参与者在培训前、培训结束时和培训结束后一个月分别填写了人口统计信息、女王坝沟通技巧和斯宾纳婚姻调整问卷。采用SPSS22软件进行描述性检验和分析性检验。结果:两组间统计学差异无统计学意义(p < 0.05)。干预前、干预结束、干预后1个月的平均婚姻适应得分分别为53.48±12.24、117.70±11.15、116.52±10.73。两组在干预前的婚姻适应得分无显著差异,但在训练后和随访期间显著升高(p < 0.001)。结论:采用TA方法进行沟通技巧训练可改善绝经后妇女的婚姻调节。因此,建议助产士在综合保健中心使用这种方法,作为改善绝经后妇女生活的有效方法。
{"title":"Communication skills training with the transactional analysis approach developed menopausal women's marital adjustment - a quasi-experimental study.","authors":"Behnaz Enjezab,&nbsp;Fatemeh Yousofvand,&nbsp;Hamid Nasiri Dehsorkhi,&nbsp;Tayebeh Mokhtari Sorkhani","doi":"10.5114/pm.2023.127772","DOIUrl":"https://doi.org/10.5114/pm.2023.127772","url":null,"abstract":"<p><strong>Introduction: </strong>Communication skills help people have a better life. Due to the changes caused by menopause and their effects on interpersonal communication, it is essential to reinforce communication skills during this period. This study aimed to investigate the effect of communication skills training (CST) using the transactional analysis (TA) approach on menopausal women's marital adjustment.</p><p><strong>Material and methods: </strong>This quasi-experimental study with a parallel design was performed by the availability sampling method with participation of 46 married menopausal women. Participants were randomly assigned to two groups. The intervention group participated in eight CST sessions with a TA approach. The control group did not receive any psychosocial or educational services. Participants completed the demographic information, Queen Dam communication skills, and Spinner's marital adjustment questionnaire before, at the end of, and one month after the training period. Data were analyzed by descriptive and analytical tests with SPSS22 software.</p><p><strong>Results: </strong>There was no significant difference in demographics between the groups (<i>p</i> < 0.05). The mean marital adjustment scores were 53.48 ±12.24, 117.70 ±11.15, and 116.52 ±10.73 before, at the end of, and one month after the intervention, respectively. The marital adjustment scores before the intervention did not differ between the two groups but significantly increased after training and in the follow-up period (<i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>Communication skills training with a TA approach in postmenopausal women improves marital adjustment. Therefore, it is suggested that midwives use this method in comprehensive health centers as an effective method for improving the lives of postmenopausal women.</p>","PeriodicalId":55643,"journal":{"name":"Przeglad Menopauzalny","volume":"22 2","pages":"64-70"},"PeriodicalIF":1.8,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ed/46/MR-22-50762.PMC10477762.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10181372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response to paper by Binkowska et al. Risk of venous thromboembolism during the use of oral estrogen-progestogen hormone therapies in light of most recent research findings. Commentary: Oestradiol is not the holy grail in the quest for the ideal oestrogen therapy. 对Binkowska等人论文的回应。根据最近的研究结果,口服雌激素-孕激素治疗期间静脉血栓栓塞的风险。评论:雌二醇不是追求理想雌激素治疗的圣杯。
IF 1.8 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-06-01 DOI: 10.5114/pm.2023.128815
Jonathan Douxfils, Jean-Michel Foidart, Ulysse Gaspard, Guillaume Chatel, Mélanie Taziaux, Maud Jost, Céline Gérard, Laure Morimont
{"title":"Response to paper by Binkowska <i>et al</i>. Risk of venous thromboembolism during the use of oral estrogen-progestogen hormone therapies in light of most recent research findings. Commentary: Oestradiol is not the holy grail in the quest for the ideal oestrogen therapy.","authors":"Jonathan Douxfils,&nbsp;Jean-Michel Foidart,&nbsp;Ulysse Gaspard,&nbsp;Guillaume Chatel,&nbsp;Mélanie Taziaux,&nbsp;Maud Jost,&nbsp;Céline Gérard,&nbsp;Laure Morimont","doi":"10.5114/pm.2023.128815","DOIUrl":"https://doi.org/10.5114/pm.2023.128815","url":null,"abstract":"","PeriodicalId":55643,"journal":{"name":"Przeglad Menopauzalny","volume":"22 2","pages":"117-119"},"PeriodicalIF":1.8,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/84/3a/MR-22-50886.PMC10477764.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10533742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The burden of paraovarian cysts - a case series and review of the literature. 卵巢旁囊肿的负担-一个病例系列和文献回顾。
IF 1.8 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-06-01 DOI: 10.5114/pm.2023.128054
Sweta Singh, Ishita Agarwal, Jasmina Begum, Bhavya Bhardwaj

Introduction: A paraovarian cyst (POC) is a cyst in the broad ligament or mesosalpinx. Paraovarian cysts have an estimated prevalence of 5-20% amongst the adnexal masses. Despite the high prevalence and availability of advanced imaging modalities, an accurate pre-operative diagnosis of POC is still made in less than 50% of patients.

Case reports: Two females with suspected ovarian torsion underwent laparotomy and had POCs. A 42-year-old hysterectomized female underwent surgery for a suspected POC which turned out to be a mesenteric cyst. Two females underwent laparotomy for suspected mesenteric cysts which turned out to be POCs. A nulliparous female with infertility conceived spontaneously after cystectomy of POC.

Results: Optimal management of an adnexal mass depends on the knowledge of the origin and the exact nature of the mass. No clear-cut guidelines exist for the management of POCs despite their high prevalence. There is a need for further research on this topic to formulate clear-cut guidelines for their management.

Conclusions: Radiologists and gynaecologists need to keep them in mind as differentials for patients with adnexal masses to ensure a correct pre-operative diagnosis in order to achieve an optimal outcome for these females. Gynaecologists need to be aware of the cases which can be managed conservatively and those that need surgery, along with the extent of the surgery required, taking care to protect the ovary at all costs, particularly in benign cases.

简介:卵巢旁囊肿(POC)是一种发生在宽韧带或输卵管系膜的囊肿。据估计,卵巢旁囊肿在附件肿块中的患病率为5-20%。尽管先进的成像方式非常普遍和可用,但对POC的准确术前诊断仍然不到50%。病例报告:两名女性疑似卵巢扭转行剖腹手术,并有POCs。一个42岁的子宫切除女性接受手术怀疑POC,结果是一个肠系膜囊肿。两名女性因怀疑肠系膜囊肿而接受剖腹手术,结果发现是POCs。一例无生育女性在POC膀胱切除术后自然受孕。结果:附件肿块的最佳处理取决于对肿块起源和确切性质的了解。尽管POCs的发病率很高,但目前尚无明确的治疗指南。有必要对这一课题进行进一步研究,为其管理制定明确的指导方针。结论:放射科医生和妇科医生需要将其作为附件肿块患者的鉴别指标,以确保正确的术前诊断,从而为这些女性患者获得最佳结果。妇科医生需要了解哪些病例可以保守治疗,哪些病例需要手术治疗,以及手术的范围,注意不惜一切代价保护卵巢,尤其是良性病例。
{"title":"The burden of paraovarian cysts - a case series and review of the literature.","authors":"Sweta Singh,&nbsp;Ishita Agarwal,&nbsp;Jasmina Begum,&nbsp;Bhavya Bhardwaj","doi":"10.5114/pm.2023.128054","DOIUrl":"https://doi.org/10.5114/pm.2023.128054","url":null,"abstract":"<p><strong>Introduction: </strong>A paraovarian cyst (POC) is a cyst in the broad ligament or mesosalpinx. Paraovarian cysts have an estimated prevalence of 5-20% amongst the adnexal masses. Despite the high prevalence and availability of advanced imaging modalities, an accurate pre-operative diagnosis of POC is still made in less than 50% of patients.</p><p><strong>Case reports: </strong>Two females with suspected ovarian torsion underwent laparotomy and had POCs. A 42-year-old hysterectomized female underwent surgery for a suspected POC which turned out to be a mesenteric cyst. Two females underwent laparotomy for suspected mesenteric cysts which turned out to be POCs. A nulliparous female with infertility conceived spontaneously after cystectomy of POC.</p><p><strong>Results: </strong>Optimal management of an adnexal mass depends on the knowledge of the origin and the exact nature of the mass. No clear-cut guidelines exist for the management of POCs despite their high prevalence. There is a need for further research on this topic to formulate clear-cut guidelines for their management.</p><p><strong>Conclusions: </strong>Radiologists and gynaecologists need to keep them in mind as differentials for patients with adnexal masses to ensure a correct pre-operative diagnosis in order to achieve an optimal outcome for these females. Gynaecologists need to be aware of the cases which can be managed conservatively and those that need surgery, along with the extent of the surgery required, taking care to protect the ovary at all costs, particularly in benign cases.</p>","PeriodicalId":55643,"journal":{"name":"Przeglad Menopauzalny","volume":"22 2","pages":"105-110"},"PeriodicalIF":1.8,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/44/14/MR-22-50826.PMC10477768.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10533741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A paradigm of higher success rate of intracytoplasmic sperm injection - preovulatory human chorionic gonadotropin-day serum oestradiol. 卵泡内单精子注射高成功率的范例-排卵前人绒毛膜促性腺激素日血清雌二醇。
IF 1.8 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-06-01 DOI: 10.5114/pm.2023.127964
Ahmed Elsayad, Wael Khafagy, Walaa ElBassioune, Mahmoud Rady, Ahmed Abdeltawab, Muhammad Altoraky, Mahmoud Hegazy, Waled Ayad, Moatazza Alghazaly, Ahmed Elshorbagy, Ahmed Shafik Almorsy, Ahmed Saeed, Elmetwally Farouk, Ehab Elhelw, Hamada Abuelmatti, Mohammed El-Husseny Elkadosi

Introduction: The aim of the study is to evaluate the correlation between the level of serum oestradiol (E2) on the day of human chorionic gonadotropin (hCG-day) administration and successful intracytoplasmic sperm injection (ICSI) outcome.

Material and methods: This prospective study was performed during the period from January 2019 to September 2021, at Zagazig Obstetrics and Gynecology Department, and Al-Azhar Obstetrics and Gynecology Department, and private ART centers. One hundred and fifty women attending the infertility clinic for ICSI cycles. All women were divided into 5 groups according to the serum E2 level on the day of hCG administration: Group A - serum E2 < 1000 pg/ml; Group B - serum E2 1000 to < 2000 pg/ml; Group C - serum E2 2000 to < 3000 pg/ml;Group D - serum E2 3000 to < 4000 pg/ml; Group E - serum E2 ≥ 4000 pg/ml.

Results: The highest fertilization rate (58.1%) was among women with E2 ≥ 4000 pg/ml, while the lowest (37%) was in women with E2 1000 to < 2000 pg/ml. Also, the highest pregnancy rate (21.5%) was among women with E2 > 4000 pg/ml, while the lowest (5.3%) was in women with E2 < 1000 pg/ml. In the current study the median serum E2 level on the day of hCG administration was highly significant in women who became pregnant when compared to women who did not. The best cut-off value of serum E2 at hCG administration was ≥ 3682.3 pg/ml.

Conclusions: this study suggests that the optimal range of E2 level for achieving a successful pregnancy is > 4000 pg/ml.

前言:本研究的目的是评估人绒毛膜促性腺激素(hCG-day)给药当天血清雌二醇(E2)水平与成功的卵浆内单精子注射(ICSI)结果之间的相关性。材料和方法:本前瞻性研究于2019年1月至2021年9月在Zagazig妇产科和Al-Azhar妇产科以及私立ART中心进行。150名妇女在不孕不育诊所接受ICSI周期。根据给药当日血清E2水平分为5组:A组-血清E2 < 1000 pg/ml;B组:E2 1000 ~ < 2000 pg/ml;C组血清E2 2000 ~ < 3000 pg/ml; D组血清E2 3000 ~ < 4000 pg/ml;E组-血清E2≥4000 pg/ml。结果:E2≥4000 pg/ml受精率最高(58.1%),E2 1000 ~ < 2000 pg/ml受精率最低(37%)。E2 > 4000 pg/ml的孕妇妊娠率最高(21.5%),E2 < 1000 pg/ml的孕妇妊娠率最低(5.3%)。在目前的研究中,与未怀孕的妇女相比,怀孕妇女在服用hCG当天的血清E2水平中位数非常显著。给药时血清E2的最佳临界值为≥3682.3 pg/ml。结论:本研究提示E2水平的最佳范围为> 4000 pg/ml。
{"title":"A paradigm of higher success rate of intracytoplasmic sperm injection - preovulatory human chorionic gonadotropin-day serum oestradiol.","authors":"Ahmed Elsayad,&nbsp;Wael Khafagy,&nbsp;Walaa ElBassioune,&nbsp;Mahmoud Rady,&nbsp;Ahmed Abdeltawab,&nbsp;Muhammad Altoraky,&nbsp;Mahmoud Hegazy,&nbsp;Waled Ayad,&nbsp;Moatazza Alghazaly,&nbsp;Ahmed Elshorbagy,&nbsp;Ahmed Shafik Almorsy,&nbsp;Ahmed Saeed,&nbsp;Elmetwally Farouk,&nbsp;Ehab Elhelw,&nbsp;Hamada Abuelmatti,&nbsp;Mohammed El-Husseny Elkadosi","doi":"10.5114/pm.2023.127964","DOIUrl":"https://doi.org/10.5114/pm.2023.127964","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of the study is to evaluate the correlation between the level of serum oestradiol (E<sub>2</sub>) on the day of human chorionic gonadotropin (hCG-day) administration and successful intracytoplasmic sperm injection (ICSI) outcome.</p><p><strong>Material and methods: </strong>This prospective study was performed during the period from January 2019 to September 2021, at Zagazig Obstetrics and Gynecology Department, and Al-Azhar Obstetrics and Gynecology Department, and private ART centers. One hundred and fifty women attending the infertility clinic for ICSI cycles. All women were divided into 5 groups according to the serum E<sub>2</sub> level on the day of hCG administration: Group A - serum E<sub>2</sub> < 1000 pg/ml; Group B - serum E<sub>2</sub> 1000 to < 2000 pg/ml; Group C - serum E<sub>2</sub> 2000 to < 3000 pg/ml;Group D - serum E<sub>2</sub> 3000 to < 4000 pg/ml; Group E - serum E<sub>2</sub> ≥ 4000 pg/ml.</p><p><strong>Results: </strong>The highest fertilization rate (58.1%) was among women with E<sub>2</sub> ≥ 4000 pg/ml, while the lowest (37%) was in women with E<sub>2</sub> 1000 to < 2000 pg/ml. Also, the highest pregnancy rate (21.5%) was among women with E<sub>2</sub> > 4000 pg/ml, while the lowest (5.3%) was in women with E<sub>2</sub> < 1000 pg/ml. In the current study the median serum E<sub>2</sub> level on the day of hCG administration was highly significant in women who became pregnant when compared to women who did not. The best cut-off value of serum E<sub>2</sub> at hCG administration was ≥ 3682.3 pg/ml.</p><p><strong>Conclusions: </strong>this study suggests that the optimal range of E<sub>2</sub> level for achieving a successful pregnancy is > 4000 pg/ml.</p>","PeriodicalId":55643,"journal":{"name":"Przeglad Menopauzalny","volume":"22 2","pages":"83-86"},"PeriodicalIF":1.8,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ad/e7/MR-22-50807.PMC10477759.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10181373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The shift in COVID-19 vaccination policy for pregnant women, from restricted to required, and the confusion that ensued. 孕妇COVID-19疫苗接种政策的转变,从限制到要求,以及随之而来的混乱。
IF 1.8 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-06-01 DOI: 10.5114/pm.2023.127773
Kamil Mosa Fram, Shawqi Saleh, Rand Fram, Taiba Khalaf, Shrouq Almasoud, Bader Almukaimi, Sondos Tawasfshy Tawasfshy, May Aladrah, Majd Kharabsheh

Introduction: The aim was to investigate the response of pregnant women when the COVID-19 vaccination policy shifted from restricted to required, and the confusion that ensued during pregnancy, bearing in mind that women undergo unique physiological and immunological changes during pregnancy, making them at risk of developing a more severe course of COVID-19 infection compared to their non-pregnant peers.

Material and methods: A cross-sectional study was carried out at the outpatient clinics at Jordan University Hospital for all pregnant women during the period of the survey from 1st October 2021 to 31st December 2021, focusing on the source of information about the vaccine, receiving the vaccine, and the reasons for rejecting the vaccine, especially during pregnancy.

Results: In total, 468 pregnant women were interviewed. The single primary source of information about the COVID-19 vaccine was the traditional media, audio-visual and print media being the most important as reported by 191 women (40.81%), while possible harm to the fetus was the single main reason for refusal of vaccination during pregnancy as reported by 111 women (23.72%).

Conclusions: Reluctance toward vaccination is primarily driven by the fierce media campaign that portrayed its initially ambiguous effects on the pregnancy and fetus in a negative light, in conjunction with the open media platforms that enabled semi-experts to issue medically inaccurate statements and information and further complicated the matter by planting the seed of fear and mistrust of the public in the health care system and providers. More public healthcare awareness regarding the safety of the COVID-19 vaccine is needed.

前言:目的是调查当COVID-19疫苗接种政策从限制转变为要求时孕妇的反应,以及怀孕期间随之而来的困惑,考虑到妇女在怀孕期间经历独特的生理和免疫变化,使她们比未怀孕的同龄人面临更严重的COVID-19感染过程的风险。材料和方法:在2021年10月1日至2021年12月31日的调查期间,在约旦大学医院的门诊诊所对所有孕妇进行了横断面研究,重点是关于疫苗的信息来源、接种疫苗和拒绝接种疫苗的原因,特别是在怀孕期间。结果:共访谈468名孕妇。关于COVID-19疫苗的单一主要信息来源是传统媒体,其中视听和印刷媒体是最重要的,有191名妇女(40.81%)报告,而111名妇女(23.72%)报告,可能对胎儿有害是怀孕期间拒绝接种疫苗的单一主要原因。结论:对疫苗接种的不情愿主要是由激烈的媒体宣传推动的,这些媒体宣传从负面的角度描述了疫苗最初对妊娠和胎儿的模糊影响,再加上开放的媒体平台使半专家能够发布医学上不准确的声明和信息,并通过在卫生保健系统和提供者中播下恐惧和不信任的种子,使问题进一步复杂化。需要提高公众对COVID-19疫苗安全性的卫生保健意识。
{"title":"The shift in COVID-19 vaccination policy for pregnant women, from restricted to required, and the confusion that ensued.","authors":"Kamil Mosa Fram,&nbsp;Shawqi Saleh,&nbsp;Rand Fram,&nbsp;Taiba Khalaf,&nbsp;Shrouq Almasoud,&nbsp;Bader Almukaimi,&nbsp;Sondos Tawasfshy Tawasfshy,&nbsp;May Aladrah,&nbsp;Majd Kharabsheh","doi":"10.5114/pm.2023.127773","DOIUrl":"https://doi.org/10.5114/pm.2023.127773","url":null,"abstract":"<p><strong>Introduction: </strong>The aim was to investigate the response of pregnant women when the COVID-19 vaccination policy shifted from restricted to required, and the confusion that ensued during pregnancy, bearing in mind that women undergo unique physiological and immunological changes during pregnancy, making them at risk of developing a more severe course of COVID-19 infection compared to their non-pregnant peers.</p><p><strong>Material and methods: </strong>A cross-sectional study was carried out at the outpatient clinics at Jordan University Hospital for all pregnant women during the period of the survey from 1<sup>st</sup> October 2021 to 31<sup>st</sup> December 2021, focusing on the source of information about the vaccine, receiving the vaccine, and the reasons for rejecting the vaccine, especially during pregnancy.</p><p><strong>Results: </strong>In total, 468 pregnant women were interviewed. The single primary source of information about the COVID-19 vaccine was the traditional media, audio-visual and print media being the most important as reported by 191 women (40.81%), while possible harm to the fetus was the single main reason for refusal of vaccination during pregnancy as reported by 111 women (23.72%).</p><p><strong>Conclusions: </strong>Reluctance toward vaccination is primarily driven by the fierce media campaign that portrayed its initially ambiguous effects on the pregnancy and fetus in a negative light, in conjunction with the open media platforms that enabled semi-experts to issue medically inaccurate statements and information and further complicated the matter by planting the seed of fear and mistrust of the public in the health care system and providers. More public healthcare awareness regarding the safety of the COVID-19 vaccine is needed.</p>","PeriodicalId":55643,"journal":{"name":"Przeglad Menopauzalny","volume":"22 2","pages":"71-76"},"PeriodicalIF":1.8,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/89/e7/MR-22-50763.PMC10477761.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10181376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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