Frontiers in Integrative Neuroscience最新文献

Introduction: Sex difference in latency for cervical vestibular-evoked myogenic potential (VEMP) has been reported in Brown Norway rats. Human investigations of sex difference in VEMP latency have shown inconsistent results, although there are indicators of sexual dimorphism in vestibular function and a higher reporting rate for vestibular disorder in women than in men.

Methods: Sex effects in human VEMP were re-evaluated here using a procedure adapting clinical protocols for higher sensitivity. VEMP was compared between 24 women and 24 men using a novel procedure that (1) controlled neck tension with biofeedback and a padded head bar; (2) used body-conducted stimuli to eliminate sound exposure concerns and collect appreciably more data than is feasible with air-conducted stimuli; which in turn (3) increased statistical power because there were sufficient data for a linear mixed effects regression modelling analysis.

Results: Women had significantly shorter VEMP peak to trough latency than men. The sex difference of 2.4 ms (95% CI [-0.9, -3.9], p = 0.0020) was 21% of the mean 11.4 ms VEMP peak to trough latency measured across women and men. There was no significant sex difference in VEMP peak to trough amplitude. These findings are a reversal of several prior studies in humans, reviewed here with a simulation indicating the studies may have been underpowered.

Discussion: Findings are consistent with those in Brown Norway Rats, for which a study design featuring a custom rodent holder to control neck tension, extension of test sequences in comparison to those typically used in VEMP protocols for humans, and insertion of electrodes subcutaneously will have increased sensitivity compared to that achievable with clinical VEMP protocols for humans. Findings are interpreted as sex hormones affecting myelination or synaptic response; sexual dimorphism in neck/head size may also have contributed. The vestibular periphery and brainstem are highly conserved across vertebrates with similar findings in rat and human supporting use of VEMP as a reliable, non-invasive indicator of vestibular function. VEMP measures in humans may require higher sensitivity than is achievable using current clinical protocols in order to produce consistent results.

Arecoline, a biologically active alkaloid extracted from the areca nut, serves as the primary psychoactive ingredient in betel quid, one of the most widely consumed psychoactive substances worldwide. Despite its extensive use, the central nervous system (CNS) effects of arecoline remain inadequately understood. This study aims to investigate the central actions of arecoline through a comprehensive, multi-dimensional approach that integrates behavioral assays, neuroimaging techniques, calcium signaling analysis, and transcriptomic profiling. Our findings demonstrate dose-dependent addictive properties of arecoline, alongside distinct behavioral alterations that highlight its potential for addiction. Neuroimaging and calcium signaling data revealed region-specific alterations in neural activity, particularly in areas associated with learning, memory, and reward processing. Furthermore, transcriptomic analysis identified significant changes in gene expression, particularly in pathways related to synaptic plasticity, calcium signaling, and metal ion transport. These results provide valuable insights into the addictive potential of arecoline and its underlying neurobiological mechanisms, offering crucial information for understanding its broader impact on CNS function. The study's findings hold significant implications for informing public health strategies aimed at addressing arecoline misuse and its potential role in addiction-related disorders.

School mathematics mainly embraces algorithmic problem solving, pays less attention to strategic reasoning, and rarely contains insightful problem solving. Based on our previous research, we hypothesize that success in solving insight problems correlates strongly with general giftedness, while mathematical expertise is essential for strategy-based problem solving. Furthermore, we employ a phenomenon of greater ERP amplitudes in PO4/8 electrodes associated with insightful problem solving. In this study, 114 high school students (aged 16-18) with varying degrees of general giftedness and mathematical expertise were asked to solve mathematical problem of three distinct type: (1) function problems, whose solutions are memory-based; (2) area problems that necessitate strategic thinking; and (3) insight problems, that necessitate insight for their resolution. The problem solving process was accompanied by ERP recording. We demonstrate that variations in accuracy of solutions and reaction time for correct responses between tasks are influenced by students' general giftedness and mathematical expertise. Our ERP analyses partly supported our hypotheses regarding the relationship between PO electrode activation, insight-based problem solving processes, and participants' levels of giftedness and mathematical expertise.

This article presents the theoretical foundation of two well established movement-based methods that represent a fundamental departure from most current interventions and are applied globally with children and adults experiencing diverse motoric, cognitive, and social challenges as well as with high functioning individuals: the Feldenkrais method and Anat Baniel Method^® NeuroMovement^®. These methods are based on leveraging neuroplasticity through the utilization of movement, not as "exercise" or externally imposed motor sequences, but as a means for effective, two-way felt communication with the recipient and their brain. Through connecting with the recipient, starting where they are-motorically, emotionally, and cognitively, we follow their unique responses, moment-by-moment, creating a dance-like dyadic process of self-discovery that mimics the spontaneous, organic way typically developing children play, learn, and grow. Practitioners in these methods, by joining and creating mutual connection with the recipient, help turn the subjective experience of the recipient into a reliable means of attaining spontaneous, mutually generated emergent learning in the recipient. In this process the autonomy of the recipient is respected and enhanced. Our work will be described through direct applications to autism seen as a neuro-motor-sensing disorder where those challenges can be transcended through the dyadic dance embodied in our techniques. Since 87% of children with autism spectrum disorder have significant movement challenges, we propose that movement, as a means for effective two-way communication with the child and their brain, needs to play a central role in autism intervention. In this article we outline how our interventions take place through case studies, vignettes and discussion, separately for each of the two methods. This article will also include recommendations for conducting investigations that characterize some of the basic components of these two methods, utilizing experimental designs and recently developed technologies and biometrics that generate unique individual profiles of both the receiver and the provider of the intervention, and of the interbrain synchrony, correlate them with changes in movement organization, cognitive functioning and coherence, and track changes in the signal-to-noise ratio. These methods should enable refinement and scalability of tracking and assessing the mechanisms and effectiveness of the interventions.

Introduction: Anticipating distractors during working memory maintenance is critical to reduce their disruptive effects. In this study, we aimed to identify the oscillatory correlates of this process across different spatial scales of neural activity.

Methods: We simultaneously recorded local field potentials (LFP) from the lateral prefrontal cortex (LPFC) and electroencephalograms (EEG) from the scalp of monkeys performing a modified memory-guided saccade (MGS) task. The monkeys were required to remember the location of a target visual stimulus while anticipating distracting visual stimulus, flashed at 50% probability during the delay period.

Results: We found significant theta-band activity across spatial scales during anticipation of a distractor, closely linked with underlying working memory dynamics, through decoding and cross-temporal generalization analyses. EEG particularly reflected reactivation of memory around the anticipated time of a distractor, even in the absence of stimuli. During this anticipated time, beta-band activity exhibited transiently enhanced intrahemispheric communication between the LPFC and occipitoparietal brain areas. These oscillatory phenomena were observed only when the monkeys successfully performed the task, implicating their possible functional role in mitigating anticipated distractors.

Discussion: Our results demonstrate that distractor anticipation recruits multiple oscillatory processes across the brain during working memory maintenance, with a key activity observed predominantly in the theta and beta bands.

NaiKan Therapy, a method of self-reflection and introspection, has garnered considerable interest for its psychological benefits. However, its physiological impacts, particularly on hormonal regulation, remain underexplored. In this study, we aimed to investigate the effects of NaiKan Therapy on salivary oxytocin and cortisol release, shedding light on the psychophysiological mechanisms underlying this introspective practice. Sixty participants underwent Naikan Therapy sessions over five consecutive days, during which salivary samples were collected at multiple time points. Salivary oxytocin and cortisol levels were measured using enzyme-linked immunosorbent assay (ELISA) kits. Our results revealed significant increases in salivary oxytocin levels following NaiKan Therapy, suggesting a potential role of this practice in enhancing social bonding and emotional regulation. Conversely, salivary cortisol levels exhibited a decrease post-therapy, indicating a reduction in stress reactivity. These findings provide novel insights into the neuroendocrine mechanisms underlying NaiKan Therapy and highlight its potential as a holistic approach to improving mental wellbeing. Further research exploring the long-term effects of NaiKan Therapy and its implications for clinical practice is warranted.

The phase slips are generally extracted from the EEG using Hilbert transforms but could also be extracted from the derivatives of EEG, providing additional information about the formation of cortical phase transitions. We examined this from the 30 s long, 256-channel resting state, eyes open EEG data of a 30-year-old male subject. The phase slip rates, PSR1 from EEG, PSR2 from the first-order derivative of EEG, and PSR3 from the second-order derivative of EEG, respectively, were extracted. The study was performed in the alpha (7-12 Hz) band only. The spatiotemporal plots of the EEG and phase slip rates over a 3.0 s period with a 0.5 s resolution were made with a montage layout of the 256 electrode positions. The spatiotemporal patterns of EEG and its derivatives exhibited shifting activity from posterior visual areas to the central and frontal regions over the 3.0 s period. The PSR1, PSR2, and PSR3 activity areas were different from the EEG and were distributed in larger areas as compared with the EEG and its derivatives. Also, the PSR2 and PSR3 activity areas and magnitudes were significantly different as compared with the PSR1 alone. This was also confirmed (p < 0.01) by the one-way ANOVA analysis of the means of PSR1, PSR2, and PSR3. These results show that PSR2 and PSR3 carry additional information that could potentially be biomarkers for studying the rate of formation of phase slips and the related cortical activity from the derivatives of EEG data.

Since the pivotal studies of neurophysiologists in the early 20th century, research on brain functions in non-human primates has provided valuable insights into the neural mechanisms subserving neurological function. By using data acquired on non-human primates as a reference, important progress in knowledge of the human brain and its functions has been achieved. The translational impact allowed by this scientific effort must be recognized in the implementation of the current surgical techniques particularly in support of the neurosurgical approach to brain tumors. In the surgical treatment of brain tumors, the ability to maximally extend the resection allows an improvement in overall survival, progression-free survival, and quality of life of patients. The main goal, and, at the same time, the main challenge, of oncological neurological surgery is to avoid permanent neurological deficit while reaching maximal resection, particularly when the tumor infiltrates the neural network subserving motor functions. Brain mapping techniques were developed using neurophysiological probes to identify the areas and tracts subserving sensorimotor function, ensuring their preservation during the resection. During the last 20 years, starting from the classical "Penfield" technique, brain mapping has been progressively implemented. Among the major advancements was the introduction of high-frequency direct electrical stimulation. Its refinement, along with the complementary use of low-frequency stimulation, allowed a further refinement of stimulation protocols. In this narrative review, we propose an analysis of the process through which the knowledge acquired through experiments on non-human primates influenced and changed the current approach to neurosurgical procedures. We then describe the main brain mapping techniques used in the resection of tumors located within sensorimotor circuits. We also detail how these techniques allowed the acquisition of new data on the properties of areas and tracts underlying sensorimotor control, in turn fostering the design of new tools to navigate within cortical and subcortical areas, that were before deemed to be "sacred and untouchable."

In this study we propose an architecture (bauplan) for the growth and form of behavior in vertebrates and arthropods. We show in what sense behavior is an extension of anatomy. Then we show that movement-based behavior shares linearity and modularity with the skeletal body plan, and with the Hox genes; that it mirrors the geometry of the physical environment; and that it reveals the animal's understanding of the animate and physical situation, with implications for perception, attention, emotion, and primordial cognition. First we define the primitives of movement in relational terms, as in comparative anatomy, yielding homological primitives. Then we define modules, generative rules and the architectural plan of behavior in terms of these primitives. In this way we expose the homology of behaviors, and establish a rigorous trans-phyletic comparative discipline of the morphogenesis of movement-based behavior. In morphogenesis, behavior builds up and narrows incessantly according to strict geometric rules. The same rules apply in moment-to-moment behavior, in ontogenesis, and partly also in phylogenesis. We demonstrate these rules in development, in neurological recovery, with drugs (dopamine-stimulated striatal modulation), in stressful situations, in locomotor behavior, and partly also in human pathology. The buildup of movement culminates in free, undistracted, exuberant behavior. It is observed in play, in superior animals during agonistic interactions, and in humans in higher states of functioning. Geometrization promotes the study of genetics, anatomy, and behavior within one and the same discipline. The geometrical bauplan portrays both already evolved dimensions, and prospective dimensional constraints on evolutionary behavioral innovations.