David J Hunt, Nathan Y Chu, Donna Kuipers, Jomana Morkous, Kyra West, Christopher E Uy, Mohammad Alhalabi, Ana-Luiza Sayao, Anthony Traboulsee, Robert L Carruthers, Virginia Devonshire, Alice J Schabas
{"title":"A Retrospective Evaluation of Ocrelizumab and Rituximab Discontinuation in a Real-World Patient Cohort.","authors":"David J Hunt, Nathan Y Chu, Donna Kuipers, Jomana Morkous, Kyra West, Christopher E Uy, Mohammad Alhalabi, Ana-Luiza Sayao, Anthony Traboulsee, Robert L Carruthers, Virginia Devonshire, Alice J Schabas","doi":"10.1017/cjn.2025.10520","DOIUrl":"https://doi.org/10.1017/cjn.2025.10520","url":null,"abstract":"","PeriodicalId":56134,"journal":{"name":"Canadian Journal of Neurological Sciences","volume":" ","pages":"1-24"},"PeriodicalIF":2.2,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Preoperative Management of Patients with Myasthenia Gravis: A Review of the Evidence.","authors":"Salwa Alhammadi, Colin Chalk","doi":"10.1017/cjn.2025.10524","DOIUrl":"https://doi.org/10.1017/cjn.2025.10524","url":null,"abstract":"","PeriodicalId":56134,"journal":{"name":"Canadian Journal of Neurological Sciences","volume":" ","pages":"1-12"},"PeriodicalIF":2.2,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145913933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reviewer Comment on Injar et al. \"Screening and management of depression and anxiety in people with epilepsy: A quality improvement study\".","authors":"Jonah Fox","doi":"10.1017/cjn.2025.10492","DOIUrl":"https://doi.org/10.1017/cjn.2025.10492","url":null,"abstract":"","PeriodicalId":56134,"journal":{"name":"Canadian Journal of Neurological Sciences","volume":" ","pages":"1"},"PeriodicalIF":2.2,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145913883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kenneth Ong, David Chang, Kelsey Cruz, Alexander D Rebchuk, Serge Makarenko
{"title":"Early versus Late Mobilization Following Chronic Subdural Hematoma Surgery: A Systematic Review.","authors":"Kenneth Ong, David Chang, Kelsey Cruz, Alexander D Rebchuk, Serge Makarenko","doi":"10.1017/cjn.2025.10514","DOIUrl":"https://doi.org/10.1017/cjn.2025.10514","url":null,"abstract":"","PeriodicalId":56134,"journal":{"name":"Canadian Journal of Neurological Sciences","volume":" ","pages":"1-22"},"PeriodicalIF":2.2,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145906793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jean-Simon Dallaire, Marie-Pier Bachand, Jonathan Shaul, Émilie Lareau-Trudel
{"title":"Mortality and Complications of Percutaneous Gastrostomy in Amyotrophic Lateral Sclerosis Patients.","authors":"Jean-Simon Dallaire, Marie-Pier Bachand, Jonathan Shaul, Émilie Lareau-Trudel","doi":"10.1017/cjn.2025.10510","DOIUrl":"https://doi.org/10.1017/cjn.2025.10510","url":null,"abstract":"","PeriodicalId":56134,"journal":{"name":"Canadian Journal of Neurological Sciences","volume":" ","pages":"1-23"},"PeriodicalIF":2.2,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145913944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reviewer Comment on Injar et al. \"Screening and management of depression and anxiety in people with epilepsy: A quality improvement study\".","authors":"Richa Saxena, Heidi M Munger Clary","doi":"10.1017/cjn.2025.10493","DOIUrl":"https://doi.org/10.1017/cjn.2025.10493","url":null,"abstract":"","PeriodicalId":56134,"journal":{"name":"Canadian Journal of Neurological Sciences","volume":" ","pages":"1-2"},"PeriodicalIF":2.2,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145913914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reviewer Comment on Setayeshgar et al. \"Trends and Drivers of Declining Stroke Mortality in British Columbia: A Population-Based Study (2002-2022)\".","authors":"Noreen Kamal","doi":"10.1017/cjn.2025.10484","DOIUrl":"https://doi.org/10.1017/cjn.2025.10484","url":null,"abstract":"","PeriodicalId":56134,"journal":{"name":"Canadian Journal of Neurological Sciences","volume":" ","pages":"1"},"PeriodicalIF":2.2,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145906872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Arun Mathai Mani, Mandar S Jog, Christopher O'Brien
{"title":"Impact of DaTscan on the Management of Clinically Uncertain Parkinsonian Syndromes: A Retrospective Canadian Cohort Study.","authors":"Arun Mathai Mani, Mandar S Jog, Christopher O'Brien","doi":"10.1017/cjn.2025.10516","DOIUrl":"https://doi.org/10.1017/cjn.2025.10516","url":null,"abstract":"","PeriodicalId":56134,"journal":{"name":"Canadian Journal of Neurological Sciences","volume":" ","pages":"1-17"},"PeriodicalIF":2.2,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145906896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Özge Özdemir, İsa Tuncay Batuk, Ayla Fil Balkan, Pınar Acar Özen, Aslı Tuncer, Yeliz Salcı
Background: The aim of this study was to investigate the effects of central vestibular dysfunction on physical functionality and cognitive function in individuals with multiple sclerosis (MS).
Methods: Fifty-two fully ambulatory individuals with MS (Expanded Disability Status Scale [EDSS] ≤ 4) were included and divided into two groups: those with central vestibular involvement (Group 1; n = 25) and those without (Group 2; n = 27). Central vestibular involvement was assessed using videonystagmography. Physical and cognitive functions were evaluated in all participants using the Glittre Activities of Daily Living (ADL) test, Godin Leisure-Time Exercise Questionnaire (GLTEQ), and the physical dimension of the MSQoL-54 for physical functionality, and the BICAMS, Trail Making Test (TMT), Word List Generation test and the cognitive dimension of the MSQoL-54 for cognitive function.
Results: According to the physical functionality assessment results, the time required to complete the Glittre ADL test was longer in group 1 than in group 2 (p = 0.01). The score for the physical dimension of the MSQoL-54 was lower in group 1 (p = 0.045). In the BICAMS Symbol Digit Modalities Test, Group 1 scored lower than Group 2 (p = 0.013). A significant difference between the groups was also observed in the time taken to complete the TMT (p = 0.017). Additionally, Group 1 exhibited lower scores on the cognitive dimension of the MSQoL-54 (p = 0.012).
Conclusion: Physical functionality and specific cognitive domains differed between MS participants with and without central vestibular involvement. It should be considered that vestibular dysfunction may adversely impact cognitive and physical functionality, even in low-moderate disability level.
背景：本研究的目的是探讨前庭中枢功能障碍对多发性硬化症（MS）患者身体功能和认知功能的影响。方法：选取52例完全活动能力的MS患者（扩展残疾状态量表[EDSS]≤4），分为前庭中枢受累组（1组，n = 25）和未受累组（2组，n = 27）。中央前庭受累情况用视震图评估。采用格里特日常生活活动（ADL）测试、戈丁休闲运动问卷（GLTEQ）和MSQoL-54的物理维度对所有参与者的身体和认知功能进行评估，并使用BICAMS、Trail Making test （TMT）、Word List Generation test和MSQoL-54的认知维度对所有参与者的认知功能进行评估。结果：根据身体功能评估结果，1组完成Glittre ADL测试所需时间比2组长（p = 0.01）。MSQoL-54生理维度得分1组低于对照组（p = 0.045）。在BICAMS符号数字模式测试中，1组得分低于2组（p = 0.013）。在完成TMT所需的时间上，两组之间也存在显著差异（p = 0.017）。此外，组1在MSQoL-54的认知维度上得分较低（p = 0.012）。结论：有和没有前庭中枢受累的MS参与者的身体功能和特定认知领域存在差异。应考虑到前庭功能障碍可能对认知和身体功能产生不利影响，即使在中低度残疾水平。
{"title":"The Role of Central Vestibular Dysfunction in Cognitive and Physical Impairment in Ambulatory Multiple Sclerosis.","authors":"Özge Özdemir, İsa Tuncay Batuk, Ayla Fil Balkan, Pınar Acar Özen, Aslı Tuncer, Yeliz Salcı","doi":"10.1017/cjn.2025.10502","DOIUrl":"https://doi.org/10.1017/cjn.2025.10502","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to investigate the effects of central vestibular dysfunction on physical functionality and cognitive function in individuals with multiple sclerosis (MS).</p><p><strong>Methods: </strong>Fifty-two fully ambulatory individuals with MS (Expanded Disability Status Scale [EDSS] ≤ 4) were included and divided into two groups: those with central vestibular involvement (Group 1; <i>n</i> = 25) and those without (Group 2; <i>n</i> = 27). Central vestibular involvement was assessed using videonystagmography. Physical and cognitive functions were evaluated in all participants using the Glittre Activities of Daily Living (ADL) test, Godin Leisure-Time Exercise Questionnaire (GLTEQ), and the physical dimension of the MSQoL-54 for physical functionality, and the BICAMS, Trail Making Test (TMT), Word List Generation test and the cognitive dimension of the MSQoL-54 for cognitive function.</p><p><strong>Results: </strong>According to the physical functionality assessment results, the time required to complete the Glittre ADL test was longer in group 1 than in group 2 (<i>p</i> = 0.01). The score for the physical dimension of the MSQoL-54 was lower in group 1 (<i>p</i> = 0.045). In the BICAMS Symbol Digit Modalities Test, Group 1 scored lower than Group 2 (<i>p</i> = 0.013). A significant difference between the groups was also observed in the time taken to complete the TMT (<i>p</i> = 0.017). Additionally, Group 1 exhibited lower scores on the cognitive dimension of the MSQoL-54 (<i>p</i> = 0.012).</p><p><strong>Conclusion: </strong>Physical functionality and specific cognitive domains differed between MS participants with and without central vestibular involvement. It should be considered that vestibular dysfunction may adversely impact cognitive and physical functionality, even in low-moderate disability level.</p>","PeriodicalId":56134,"journal":{"name":"Canadian Journal of Neurological Sciences","volume":" ","pages":"1-8"},"PeriodicalIF":2.2,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145890615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christina Toma, David Fortin, Sébastien Chénier, Marie-Christine Guiot, Stéphanie Corriveau-Désilets, Laurence Masson-Cote
{"title":"Adult Patient with Primary Intracranial Sarcoma DICER1 Mutated: Therapy Leading to Prolonged Survival and Local Control.","authors":"Christina Toma, David Fortin, Sébastien Chénier, Marie-Christine Guiot, Stéphanie Corriveau-Désilets, Laurence Masson-Cote","doi":"10.1017/cjn.2025.10486","DOIUrl":"https://doi.org/10.1017/cjn.2025.10486","url":null,"abstract":"","PeriodicalId":56134,"journal":{"name":"Canadian Journal of Neurological Sciences","volume":" ","pages":"1-3"},"PeriodicalIF":2.2,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145851316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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