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Impaired albumin function: a novel potential indicator for liver function damage? 白蛋白功能受损:肝功能损伤的新潜在指标?
IF 4.9 Pub Date : 2019-11-01 Epub Date: 2019-11-21 DOI: 10.1080/07853890.2019.1693056
Lejia Sun, Huanhuan Yin, Meixi Liu, Gang Xu, Xiaoxiang Zhou, Penglei Ge, Huayu Yang, Yilei Mao

Albumin is the most abundant plasma protein and albumin infusion is commonly used. Conventionally, the biologic and therapeutic effects of albumin have been thought to be due to its oncotic properties. However, albumin has a variety of biologic functions, including molecular transport, anti-oxidation, anti-inflammation, endothelial stabilisation, anti-thrombotic effects, and the adjustment of capillary permeability. Despite this, the functions of albumin have not been thoroughly investigated. Recent studies have shown non-alcoholic fatty liver disease (NAFLD), viral hepatitis, cirrhosis, and liver failure to be associated with impairments in albumin function, which are associated with impairments in liver function and disease prognosis. Post-translational modifications of albumin cause structural modifications that affect protein function. Recently, the concentration of albumin associated with normal function, the 'efficient albumin concentration', has been attracting more interest. In addition, although many biologic markers, including albumin concentration, are widely used for the assessment of early liver dysfunction in patients with liver diseases, the predictive values are unsatisfactory. However, clinical evidence has suggested that albumin function may represent a novel biomarker of early impairment in liver function. In this review, we summarise the factors affecting albumin function and discuss the clinical significance of impairments in albumin function in various liver diseases.Key messagesThe importance of albumin depends not only on its concentration, but also on its various physiological functions.Impaired albumin function has been reported in a variety of liver diseases, and is associated with disease severity and prognosis, thereby proposing the concept of 'effective albumin concentration'.Albumin dysfunction occurs earlier than other conventional indicators, and albumin dysfunction may be a new biomarker of early impairment in liver function.Many exogenous and endogenous factors lead to post-translational modifications of albumin, which alters the three-dimensional structure of albumin, resulting in a decrease in its biological activity.

白蛋白是最丰富的血浆蛋白,白蛋白输注也很常用。传统上,人们认为白蛋白的生物和治疗作用是由于其抗肿瘤特性。然而,白蛋白具有多种生物功能,包括分子转运、抗氧化、抗炎、稳定内皮、抗血栓作用和调节毛细血管通透性。尽管如此,白蛋白的功能尚未得到深入研究。最近的研究表明,非酒精性脂肪肝(NAFLD)、病毒性肝炎、肝硬化和肝功能衰竭与白蛋白功能损害有关,而白蛋白功能损害又与肝功能损害和疾病预后有关。白蛋白的翻译后修饰会导致结构改变,从而影响蛋白质的功能。最近,与正常功能相关的白蛋白浓度,即 "有效白蛋白浓度",引起了越来越多的关注。此外,尽管包括白蛋白浓度在内的许多生物标记物被广泛用于评估肝病患者的早期肝功能异常,但其预测值并不令人满意。然而,临床证据表明,白蛋白功能可能是早期肝功能损害的新型生物标志物。在这篇综述中,我们总结了影响白蛋白功能的因素,并讨论了白蛋白功能受损在各种肝病中的临床意义。白蛋白的重要性不仅取决于其浓度,还取决于其各种生理功能。白蛋白功能受损在多种肝病中均有报道,并与疾病的严重程度和预后相关,因此提出了 "有效白蛋白浓度 "的概念。许多外源性和内源性因素导致白蛋白翻译后修饰,从而改变了白蛋白的三维结构,导致其生物活性下降。
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引用次数: 0
Retrieval of Total Suspended Matter in the Lower of Minjiang River based on PSO-RBF 基于PSO-RBF的岷江下游总悬浮物反演
Pub Date : 2019-03-01 DOI: 10.11873/J.ISSN.1004-0323.2018.5.0900
Xie Xu, Chen Yunzhi
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引用次数: 1
Algorithms Comparison of Land Surface Temperature Retrieval from Landsat Series Data:A Case Study in Qiqihar,China 利用Landsat系列数据反演地表温度的算法比较——以齐齐哈尔市为例
Pub Date : 2019-03-01 DOI: 10.11873/J.ISSN.1004-0323.2018.5.0830
Jin Dian-Dian, Gong Zhaoning
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引用次数: 7
Study on Differences between Sentinel-2A and Landsat-8 Images in Rape Identification Sentinel-2A与Landsat-8图像在油菜识别中的差异研究
Pub Date : 2019-03-01 DOI: 10.11873/J.ISSN.1004-0323.2018.5.0890
Han Tao, Pan Jian-jun, Zhang Peiyu, Cao Luodan
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引用次数: 2
Information Measure of Polarimetric SAR Coherence Matrix based on A Shannon Entropy 基于Shannon熵的极化SAR相干矩阵信息度量
Pub Date : 2019-03-01 DOI: 10.11873/j.issn.1004-0323.2018.5.0842〖
Li Jiaojiao, Liu Yu, Chen Kunshan
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引用次数: 0
Simulation of Solar Radiation based on BP Neural Network andIts Spatio-temporal Change Analysis in East China 基于BP神经网络的华东地区太阳辐射模拟及其时空变化分析
Pub Date : 2019-03-01 DOI: 10.11873/j.issn.1004-0323.2018.5.0881
Feng Jiaojiao, Wang Weizhen, Li Jing, Liuwenwen
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引用次数: 1
Study on Dynamic Remote Sensing Monitoring of LUCC and Soilwind Erosion Intensity in the Beijing-Tianjin Sandstorm Source Control Project Region 京津沙源治理区土地利用变化与土壤风蚀强度动态遥感监测研究
Pub Date : 2019-03-01 DOI: 10.11873/J.ISSN.1004-0323.2018.5.0965
Chi Wenfeng, Kuang Wenhui, Jia Jing, L. Zhengjia
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引用次数: 6
Land Surface Temperature Retrieval and Its Spatial Heterogeneity in Summer in Chongqing 重庆夏季地表温度反演及其空间分异特征
Pub Date : 2019-02-22 DOI: 10.11873/J.ISSN.1004-0323.2018.5.0820
Li Jun, Gong Wei, Xin Xiaozhou, Gao Yanghua
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引用次数: 0
Distribution and Variation of Glacier Velocity in Himalayas based on ALOS PALSAR 基于ALOS PALSAR的喜马拉雅山冰川速度分布与变化
Pub Date : 2019-02-22 DOI: 10.11873/j.issn.1004-0323.2018.5.0942
Ke Changqing Wang Shizhe
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引用次数: 0
Error Analysis of Change Detection based on Land Cover in High Resolution Remote Sensing Images in Urban Areas 基于城市高分辨率遥感影像土地覆盖变化检测的误差分析
Pub Date : 2019-02-22 DOI: 10.11873/J.ISSN.1004-0323.2018.5.0932
Wei Yuchun Wang Wenyao Fang Hong Ji Xinying
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引用次数: 0
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