Pub Date : 2021-08-26DOI: 10.1109/atigb50996.2021.9423389
{"title":"Organizing Committee Information","authors":"","doi":"10.1109/atigb50996.2021.9423389","DOIUrl":"https://doi.org/10.1109/atigb50996.2021.9423389","url":null,"abstract":"","PeriodicalId":6690,"journal":{"name":"2020 Applying New Technology in Green Buildings (ATiGB)","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86921095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-12DOI: 10.1109/ATiGB50996.2021.9423225
Mi Do Hoang Ngan, Dung Le Tien, Quang Nguyen Phung
Chaos can lead to self-oscillation, which affect thequality of induction motor drive system?. This effect happens with nonlinear systems, which are sensitive to the initial conditions, but governed by deterministic laws unlike random. to The present study aims to investigate the chaos that occur in the nonlinear systems - three phase AC drives using induction motor by the rotor of flux oriented control. After analyzing the phenomena based on a mathematical model, simulation will prove chaotic behavior when parameters fall into period doubling bifurcation regions. It showed clearly the chaotic behaviors through time response, phase diagram, Fourier spectrum, Poincaré section, bifurcation diagrams, and Lyapunov exponents. Besides, the sensitivity of the initial condition of the system was also well presented. This is the typical characteristic of a chaotic system. In conclusion, this is a suitable algorithm - sliding mode control put forward to suppress the chaotic oscillations quickly and return the system to the normal working, therefore, could improve the quality of the system.)
{"title":"Period Doubling Bifurcations and Its Control in Induction Motor Drives","authors":"Mi Do Hoang Ngan, Dung Le Tien, Quang Nguyen Phung","doi":"10.1109/ATiGB50996.2021.9423225","DOIUrl":"https://doi.org/10.1109/ATiGB50996.2021.9423225","url":null,"abstract":"Chaos can lead to self-oscillation, which affect thequality of induction motor drive system?. This effect happens with nonlinear systems, which are sensitive to the initial conditions, but governed by deterministic laws unlike random. to The present study aims to investigate the chaos that occur in the nonlinear systems - three phase AC drives using induction motor by the rotor of flux oriented control. After analyzing the phenomena based on a mathematical model, simulation will prove chaotic behavior when parameters fall into period doubling bifurcation regions. It showed clearly the chaotic behaviors through time response, phase diagram, Fourier spectrum, Poincaré section, bifurcation diagrams, and Lyapunov exponents. Besides, the sensitivity of the initial condition of the system was also well presented. This is the typical characteristic of a chaotic system. In conclusion, this is a suitable algorithm - sliding mode control put forward to suppress the chaotic oscillations quickly and return the system to the normal working, therefore, could improve the quality of the system.)","PeriodicalId":6690,"journal":{"name":"2020 Applying New Technology in Green Buildings (ATiGB)","volume":"106 1","pages":"6-11"},"PeriodicalIF":0.0,"publicationDate":"2021-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77277510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-12DOI: 10.1109/ATiGB50996.2021.9423440
Nguyen Van Nam, Huynh Ba Tan, Nguyen Duc Quan
This paper presents the image processing based control approach for an industrial arm. Firstly, the dynamics of 3-DOF robot arm is developed. Then, a controller combined with image processing method on Matlab software is proposed. Finally, the robot arm is designed by using the Solidwork tool, which then is embedded in Matlab software to simulate the closed-loop system. The simulation results show that the robot arms work more reliably and accurately. From this result, the controller can be applied on an industrial robot arm to serve in industrial and agricultural production with high intelligence.
{"title":"An Image Processing Based Controller for a Three Degrees of Freedom Robotic Arm","authors":"Nguyen Van Nam, Huynh Ba Tan, Nguyen Duc Quan","doi":"10.1109/ATiGB50996.2021.9423440","DOIUrl":"https://doi.org/10.1109/ATiGB50996.2021.9423440","url":null,"abstract":"This paper presents the image processing based control approach for an industrial arm. Firstly, the dynamics of 3-DOF robot arm is developed. Then, a controller combined with image processing method on Matlab software is proposed. Finally, the robot arm is designed by using the Solidwork tool, which then is embedded in Matlab software to simulate the closed-loop system. The simulation results show that the robot arms work more reliably and accurately. From this result, the controller can be applied on an industrial robot arm to serve in industrial and agricultural production with high intelligence.","PeriodicalId":6690,"journal":{"name":"2020 Applying New Technology in Green Buildings (ATiGB)","volume":"3 1","pages":"146-154"},"PeriodicalIF":0.0,"publicationDate":"2021-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74955397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
There has been a rapid increase in the demand for aggregates used in construction activities, in which, natural aggregate is the most common one. However, the exploitation of natural aggregates caused the depletion of natural resources and environmental pollution. Therefore, this study aims to investigate the feasibility of manufacturing artificial coarse and fine aggregates by alkaline activation of fly ash-slag blends. In this study, a mixture of 50% fly ash and 50% slag was activated by an alkaline solution including NaOH 10M and Na2SiO3. The effects of different alkali equivalent (AE) and alkali modulus (Ms) on the characteristics of the produced aggregates. Characteristics of the 28-day-old artificial aggregates (AA), including grain size distribution, density, water absorption, and crushing strength were then tested according to the TCVN 7572-2006 Vietnamese standard. A comparison between the characteristics of artificial and natural aggregates was also performed in this study. Experimental results pointed out that the grain size distribution of the AAs was adjustable simply by the crusher. Both AE and Ms slightly affected the AAs’ properties. The strength of the AAs developed rapidly as increasing AE from 5 to 9% and rising Ms from 0.6 to 0.8 had an advantageous impact on the aggregates’ strength. However, the strength value dropped as the Ms increased further. However, the crushing strength of the AAs was comparable to that of the natural aggregate. The values of density and water absorption of the AAs ranged from 2291-2474 kg/m3 and 14.1-19.2%, respectively. This study found that the AAs prepared with the AE of 9% and Ms of 0.8 exhibited a better performance among the samples and the proposed AAs can be applied successfully in the construction activities.
{"title":"Feasibility of Producing Artificial Aggregates by Alkaline Activation of Fly Ash-Slag Blends","authors":"Trong‐Phuoc Huynh, Trong-Binh Pham, Tri-Khang Lam, Tien-Dat Tran, Van-Thien Nguyen","doi":"10.1109/ATiGB50996.2021.9423427","DOIUrl":"https://doi.org/10.1109/ATiGB50996.2021.9423427","url":null,"abstract":"There has been a rapid increase in the demand for aggregates used in construction activities, in which, natural aggregate is the most common one. However, the exploitation of natural aggregates caused the depletion of natural resources and environmental pollution. Therefore, this study aims to investigate the feasibility of manufacturing artificial coarse and fine aggregates by alkaline activation of fly ash-slag blends. In this study, a mixture of 50% fly ash and 50% slag was activated by an alkaline solution including NaOH 10M and Na2SiO3. The effects of different alkali equivalent (AE) and alkali modulus (Ms) on the characteristics of the produced aggregates. Characteristics of the 28-day-old artificial aggregates (AA), including grain size distribution, density, water absorption, and crushing strength were then tested according to the TCVN 7572-2006 Vietnamese standard. A comparison between the characteristics of artificial and natural aggregates was also performed in this study. Experimental results pointed out that the grain size distribution of the AAs was adjustable simply by the crusher. Both AE and Ms slightly affected the AAs’ properties. The strength of the AAs developed rapidly as increasing AE from 5 to 9% and rising Ms from 0.6 to 0.8 had an advantageous impact on the aggregates’ strength. However, the strength value dropped as the Ms increased further. However, the crushing strength of the AAs was comparable to that of the natural aggregate. The values of density and water absorption of the AAs ranged from 2291-2474 kg/m3 and 14.1-19.2%, respectively. This study found that the AAs prepared with the AE of 9% and Ms of 0.8 exhibited a better performance among the samples and the proposed AAs can be applied successfully in the construction activities.","PeriodicalId":6690,"journal":{"name":"2020 Applying New Technology in Green Buildings (ATiGB)","volume":"97 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2021-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85313107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-12DOI: 10.1109/ATiGB50996.2021.9423160
Xuan Bao Nguyen, H. Truong
In this study, a novel adaptive controller of the Omnidirectional Mobile Robot (OMR) is proposed for a certain class of unknown nonlinear dynamical systems. The proposed controller was designed by incorporating 2 types of control methods. One is an adaptive controller, and the other is an adaptive tuner. While the adaptive controller is designed using a back-stepping controller that would act as the main tracking controller, the adaptive tuner derived in the sense of Lyapunov stability theorem was utilized to adjust the parameter on-line for further assuring robust and optimal performance. To verify its effectiveness and extend its application, the proposed controller was applied to the path tracking of an Omnidirectional Mobile Robot, whose salient performance is verified by numerical simulation and whose advantages are presented compared with conventional controller scheme under the same environment.
{"title":"Dynamics and Robust Adaptive Controller of Three Wheel Omnidirectional Mobile Robot","authors":"Xuan Bao Nguyen, H. Truong","doi":"10.1109/ATiGB50996.2021.9423160","DOIUrl":"https://doi.org/10.1109/ATiGB50996.2021.9423160","url":null,"abstract":"In this study, a novel adaptive controller of the Omnidirectional Mobile Robot (OMR) is proposed for a certain class of unknown nonlinear dynamical systems. The proposed controller was designed by incorporating 2 types of control methods. One is an adaptive controller, and the other is an adaptive tuner. While the adaptive controller is designed using a back-stepping controller that would act as the main tracking controller, the adaptive tuner derived in the sense of Lyapunov stability theorem was utilized to adjust the parameter on-line for further assuring robust and optimal performance. To verify its effectiveness and extend its application, the proposed controller was applied to the path tracking of an Omnidirectional Mobile Robot, whose salient performance is verified by numerical simulation and whose advantages are presented compared with conventional controller scheme under the same environment.","PeriodicalId":6690,"journal":{"name":"2020 Applying New Technology in Green Buildings (ATiGB)","volume":"235 1","pages":"110-114"},"PeriodicalIF":0.0,"publicationDate":"2021-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77281571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-12DOI: 10.1109/ATiGB50996.2021.9423213
Luong Duong Trong, Duc Nguyen Minh, Ha Nguyen Thai
Pneumatic compression systems have been becoming the favorable compression method for treating venous stasis, or chronic venous efficiency (CVI), for the last 20 years. However, a standard routine for different venous stasis’s complications is still missing due to lack of clinical evidences, while many commercial devices only offer fixed treatment routine. In this paper, a design of a customizable pneumatic compression device is proposed. The purpose is to provide both common routines currently used in clinical therapeutics and a fine degree of customization between routines to serve clinicians in search of more clinical evidences to optimize the treatment. The proposed system is also made to be portable for home treatment with an easy but adequate user interaction. The resulted outcome was a customizable 4-chambered device that is able to offer 3 common treatment routines and 3 adjustable options of (1) amount of pressure in each chamber, (2) selecting chamber to be air pumped for compression and (3) the compression time. Compared with one of the most upto-date commercial devices, the proposed system is capable to perform equally in terms of functions while costing much less. The proposed system is planned to be tested at National Geriatric hospital, Hanoi, Vietnam in the near future.
{"title":"Design of a customizable and portable pneumatic compression device","authors":"Luong Duong Trong, Duc Nguyen Minh, Ha Nguyen Thai","doi":"10.1109/ATiGB50996.2021.9423213","DOIUrl":"https://doi.org/10.1109/ATiGB50996.2021.9423213","url":null,"abstract":"Pneumatic compression systems have been becoming the favorable compression method for treating venous stasis, or chronic venous efficiency (CVI), for the last 20 years. However, a standard routine for different venous stasis’s complications is still missing due to lack of clinical evidences, while many commercial devices only offer fixed treatment routine. In this paper, a design of a customizable pneumatic compression device is proposed. The purpose is to provide both common routines currently used in clinical therapeutics and a fine degree of customization between routines to serve clinicians in search of more clinical evidences to optimize the treatment. The proposed system is also made to be portable for home treatment with an easy but adequate user interaction. The resulted outcome was a customizable 4-chambered device that is able to offer 3 common treatment routines and 3 adjustable options of (1) amount of pressure in each chamber, (2) selecting chamber to be air pumped for compression and (3) the compression time. Compared with one of the most upto-date commercial devices, the proposed system is capable to perform equally in terms of functions while costing much less. The proposed system is planned to be tested at National Geriatric hospital, Hanoi, Vietnam in the near future.","PeriodicalId":6690,"journal":{"name":"2020 Applying New Technology in Green Buildings (ATiGB)","volume":"5 1","pages":"49-52"},"PeriodicalIF":0.0,"publicationDate":"2021-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85622654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-12DOI: 10.1109/ATiGB50996.2021.9423263
P. Le, P. Pham
The Built Operate Transfer (BOT) method has been used popularly to invest into infrastructure system in Vietnam, especially in transportation sector. This investment method has been confronted with a high level of risks due to the complexity of stakeholders’ involvements and a lengthy concession period. However, risk management application in these projects is still inadequate. This study aims at finding out what is the most suitable risk allocation mechanism and investigating the differences in the perception between public and private sector regarding risk allocation in BOT transportation projects in Vietnam. A mixed-method was adopted including interviews and a questionnaire survey to collected relevant data which then were analyzed through descriptive and inferential statistical analysis. The result of descriptive statistical analysis showed that from the viewpoint of both sectors, only one risk namely "changes in government policies" was suggested to be allocated to public sector while the number of risks supposed to allocate to private sector was twelve. Meanwhile, a majority of risks (27 risks) were suggested to be shared between public and private sector. Moreover, inferential statistical analysis indicated that there is no statistical significant difference in the perception of public and private sector in terms of risk allocation, except the risk of "poor decision-making process". As a result, a risk allocation recommendation in BOT transportation projects was established as an outcome of the research, which contributes to assist authorities in order to provide suitable laws and policies related to these projects. Also, the research results appear to be useful in contributing to the body of knowledge related to PPP procurement.
{"title":"Risk allocation in BOT transportation projects in Vietnam from different viewpoints","authors":"P. Le, P. Pham","doi":"10.1109/ATiGB50996.2021.9423263","DOIUrl":"https://doi.org/10.1109/ATiGB50996.2021.9423263","url":null,"abstract":"The Built Operate Transfer (BOT) method has been used popularly to invest into infrastructure system in Vietnam, especially in transportation sector. This investment method has been confronted with a high level of risks due to the complexity of stakeholders’ involvements and a lengthy concession period. However, risk management application in these projects is still inadequate. This study aims at finding out what is the most suitable risk allocation mechanism and investigating the differences in the perception between public and private sector regarding risk allocation in BOT transportation projects in Vietnam. A mixed-method was adopted including interviews and a questionnaire survey to collected relevant data which then were analyzed through descriptive and inferential statistical analysis. The result of descriptive statistical analysis showed that from the viewpoint of both sectors, only one risk namely \"changes in government policies\" was suggested to be allocated to public sector while the number of risks supposed to allocate to private sector was twelve. Meanwhile, a majority of risks (27 risks) were suggested to be shared between public and private sector. Moreover, inferential statistical analysis indicated that there is no statistical significant difference in the perception of public and private sector in terms of risk allocation, except the risk of \"poor decision-making process\". As a result, a risk allocation recommendation in BOT transportation projects was established as an outcome of the research, which contributes to assist authorities in order to provide suitable laws and policies related to these projects. Also, the research results appear to be useful in contributing to the body of knowledge related to PPP procurement.","PeriodicalId":6690,"journal":{"name":"2020 Applying New Technology in Green Buildings (ATiGB)","volume":"36 1","pages":"80-86"},"PeriodicalIF":0.0,"publicationDate":"2021-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81994822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-12DOI: 10.1109/ATiGB50996.2021.9423329
Thi Minh Phuong Ngo
This study aims to develop hydration properties of pectin/nanochitosan films at different pectin: nanochitosan ratios (100:0; 75:25; 50:50; 25:75 and 0:100). The blending of pectin with nanochitosan at ratio of 50:50 (P/NaCS2) reduced moisture content, swelling degree, water solubility. Moisture sorption isotherms for all P/NaCS films had a sigmoidal shape. Moisture sorption isotherms indicated hydrophobic character of P/NaCS films. Moisture sorption isotherm showed that P/NaCS films should be used at lower than 86%RH. Some models such as GAB, BET, Peleg and Oswin were investigated for predicting the equilibrium moisture content of P/NaCS films. The results showed that the GAB model was the best estimator. SEM micrographs of cross - section morphology of P/NaCS films indicated that certain interactions between pectin and nanochitosan matrix were formed. Therefore, P/NaCS2 films can be used as active packaging to extend the shelf life of food.
{"title":"Improvement of hydration properties of pectin/nanochitosan films","authors":"Thi Minh Phuong Ngo","doi":"10.1109/ATiGB50996.2021.9423329","DOIUrl":"https://doi.org/10.1109/ATiGB50996.2021.9423329","url":null,"abstract":"This study aims to develop hydration properties of pectin/nanochitosan films at different pectin: nanochitosan ratios (100:0; 75:25; 50:50; 25:75 and 0:100). The blending of pectin with nanochitosan at ratio of 50:50 (P/NaCS2) reduced moisture content, swelling degree, water solubility. Moisture sorption isotherms for all P/NaCS films had a sigmoidal shape. Moisture sorption isotherms indicated hydrophobic character of P/NaCS films. Moisture sorption isotherm showed that P/NaCS films should be used at lower than 86%RH. Some models such as GAB, BET, Peleg and Oswin were investigated for predicting the equilibrium moisture content of P/NaCS films. The results showed that the GAB model was the best estimator. SEM micrographs of cross - section morphology of P/NaCS films indicated that certain interactions between pectin and nanochitosan matrix were formed. Therefore, P/NaCS2 films can be used as active packaging to extend the shelf life of food.","PeriodicalId":6690,"journal":{"name":"2020 Applying New Technology in Green Buildings (ATiGB)","volume":"17 1","pages":"120-124"},"PeriodicalIF":0.0,"publicationDate":"2021-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77122764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
As public space, not only does street space play an important role in terms of traffic, but it also serves as a crucial venue for daily activities of human beings. Accompanying the social development, the demand for upgrading and improving street space is inevitable but how to design the space still remains a concern among many individuals. This research investigates the interaction of human beings with street space. This is a pivotal basis for helping designers and administrators develop suitable space for human demands and concurrently preserve sociocultural values of local residents through the theory of environment behavior study. By using Danang city as a case study, this research identifies eight elements that people pay the most attention to both negative and positive sides. Further analyses identify the properties and characteristics of emerged elements that caught users’ attention. Each element is associated with its own characteristics. The details are performed in this paper.
{"title":"How people interact with street environment: A case study of Da Nang city","authors":"Duy Thinh Do, Thi Vy Phuong Vo, Thi Thuy Trang Nguyen","doi":"10.1109/ATiGB50996.2021.9423123","DOIUrl":"https://doi.org/10.1109/ATiGB50996.2021.9423123","url":null,"abstract":"As public space, not only does street space play an important role in terms of traffic, but it also serves as a crucial venue for daily activities of human beings. Accompanying the social development, the demand for upgrading and improving street space is inevitable but how to design the space still remains a concern among many individuals. This research investigates the interaction of human beings with street space. This is a pivotal basis for helping designers and administrators develop suitable space for human demands and concurrently preserve sociocultural values of local residents through the theory of environment behavior study. By using Danang city as a case study, this research identifies eight elements that people pay the most attention to both negative and positive sides. Further analyses identify the properties and characteristics of emerged elements that caught users’ attention. Each element is associated with its own characteristics. The details are performed in this paper.","PeriodicalId":6690,"journal":{"name":"2020 Applying New Technology in Green Buildings (ATiGB)","volume":"100 1","pages":"134-141"},"PeriodicalIF":0.0,"publicationDate":"2021-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79329943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-12DOI: 10.1109/ATiGB50996.2021.9423402
Chiuyen Phan, N. Huynh, H. Nguyen, T. N. Do
Salt formation is the most commonly method for increasing the solubility of drug. Sorafenib (Sor), a multikinase inhibitor active in the treatment a board of human cancers, has a very low solubility. In this study, sorafenib sulfate monohydrate (Sor-S) has been prepared for improving its solubility. The simulated powder X-ray diffraction (PXRD) was different from experimental PXRD of free Sor. The crystal structure of Sor-S was characterized. The hydrogen bond system, topology, and the superposition of the molecular conformations of sorafenib in base form and protonated cation in salt form were analyzed. The Hirshfeld surfaces plotted with dnorm was conducted for investigating the hydrogen bonds. Shape index and curvedness maps presented two rings with π π interplanar stacking. The tabletability was predicted using an energy framework.
{"title":"Preparation and crystal structure of sorafenib sulfate monohydrate","authors":"Chiuyen Phan, N. Huynh, H. Nguyen, T. N. Do","doi":"10.1109/ATiGB50996.2021.9423402","DOIUrl":"https://doi.org/10.1109/ATiGB50996.2021.9423402","url":null,"abstract":"Salt formation is the most commonly method for increasing the solubility of drug. Sorafenib (Sor), a multikinase inhibitor active in the treatment a board of human cancers, has a very low solubility. In this study, sorafenib sulfate monohydrate (Sor-S) has been prepared for improving its solubility. The simulated powder X-ray diffraction (PXRD) was different from experimental PXRD of free Sor. The crystal structure of Sor-S was characterized. The hydrogen bond system, topology, and the superposition of the molecular conformations of sorafenib in base form and protonated cation in salt form were analyzed. The Hirshfeld surfaces plotted with dnorm was conducted for investigating the hydrogen bonds. Shape index and curvedness maps presented two rings with π π interplanar stacking. The tabletability was predicted using an energy framework.","PeriodicalId":6690,"journal":{"name":"2020 Applying New Technology in Green Buildings (ATiGB)","volume":"4 1","pages":"65-69"},"PeriodicalIF":0.0,"publicationDate":"2021-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91201478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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