Pub Date : 1959-04-01DOI: 10.1001/ARCHNEURPSYC.1959.02340160111016
J. Satterfield
Introduction There has long been a search for a physiological test which would predict response to therapy in psychiatric disease. Gold, 1 in 1943, and, later, Funkenstein 2-7 described such a test. The test as usually described consists of following the blood pressure response to either epinephrine and methacholine (Mecholyl), given at different times, preferably on different days, or to methacholine alone. On the basis of the blood pressure response to these drugs, patients may be divided into two categories: those with favorable and those with unfavorable prognosis. Because of the importance of having a physiological test of predictive value, I decided to extend the studies thus far reported by repeating the original ones and by a long-term study, which, as far as I know, is the first such investigation reported. Procedure and Results Attempt at Confirmation of the Epinephrine-Methacholine Test In an effort to evaluate the autonomic test described
{"title":"Prediction of improvement by use of epinephrine-methacholine (mecholyl) test; study of immediate response in twenty-six treated patients and one-year follow-up of forty-eight treated patients.","authors":"J. Satterfield","doi":"10.1001/ARCHNEURPSYC.1959.02340160111016","DOIUrl":"https://doi.org/10.1001/ARCHNEURPSYC.1959.02340160111016","url":null,"abstract":"Introduction There has long been a search for a physiological test which would predict response to therapy in psychiatric disease. Gold, 1 in 1943, and, later, Funkenstein 2-7 described such a test. The test as usually described consists of following the blood pressure response to either epinephrine and methacholine (Mecholyl), given at different times, preferably on different days, or to methacholine alone. On the basis of the blood pressure response to these drugs, patients may be divided into two categories: those with favorable and those with unfavorable prognosis. Because of the importance of having a physiological test of predictive value, I decided to extend the studies thus far reported by repeating the original ones and by a long-term study, which, as far as I know, is the first such investigation reported. Procedure and Results Attempt at Confirmation of the Epinephrine-Methacholine Test In an effort to evaluate the autonomic test described","PeriodicalId":6866,"journal":{"name":"A.M.A. archives of neurology and psychiatry","volume":"15 1","pages":"513-6"},"PeriodicalIF":0.0,"publicationDate":"1959-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83097432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1959-04-01DOI: 10.1001/ARCHNEURPSYC.1959.02340160056008
F. Samson, D. Dahl, N. Dahl, H. Himwich
A deficiency of glucose supply to the brain is followed by a gradual reduction in carbohydrate reserves, a decrease in oxygen uptake, 1,2 and a reduction in the high-energy phosphates of that organ. 1 In this situation, the compounds which are considered to be the usual free-energy sources have been depleted, and the question becomes: "What are the chemical consequences of this state?" The evidence presented indicates that deep hypoglycemia in the cat or rat does not result in any appreciable change in the quantity of cerebral deoxyribonucleic acid (DNA) or pentose nucleic acid (PNA). However, it does produce alterations in the pattern of the free amino acids, and during profound hypoglycemia a decline in practically all of the amino acids. The total nitrogen and acid-soluble nitrogen content remain practically the same; and the side-group ionization of the proteins is not significantly altered. Method Twelve adult cats were made hypoglycemic
{"title":"Studies of the hypoglycemic brain; amino acids, nucleic acids, total nitrogen, and side-group ionization of proteins in cat brain during insulin coma.","authors":"F. Samson, D. Dahl, N. Dahl, H. Himwich","doi":"10.1001/ARCHNEURPSYC.1959.02340160056008","DOIUrl":"https://doi.org/10.1001/ARCHNEURPSYC.1959.02340160056008","url":null,"abstract":"A deficiency of glucose supply to the brain is followed by a gradual reduction in carbohydrate reserves, a decrease in oxygen uptake, 1,2 and a reduction in the high-energy phosphates of that organ. 1 In this situation, the compounds which are considered to be the usual free-energy sources have been depleted, and the question becomes: \"What are the chemical consequences of this state?\" The evidence presented indicates that deep hypoglycemia in the cat or rat does not result in any appreciable change in the quantity of cerebral deoxyribonucleic acid (DNA) or pentose nucleic acid (PNA). However, it does produce alterations in the pattern of the free amino acids, and during profound hypoglycemia a decline in practically all of the amino acids. The total nitrogen and acid-soluble nitrogen content remain practically the same; and the side-group ionization of the proteins is not significantly altered. Method Twelve adult cats were made hypoglycemic","PeriodicalId":6866,"journal":{"name":"A.M.A. archives of neurology and psychiatry","volume":"46 1","pages":"458-65"},"PeriodicalIF":0.0,"publicationDate":"1959-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83614892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1959-03-01DOI: 10.1001/archneurpsyc.1959.02340150102012
M D ALTSCHULE
{"title":"Effects of electroconvulsive therapy on blood carbonic anhydrase activity in man.","authors":"M D ALTSCHULE","doi":"10.1001/archneurpsyc.1959.02340150102012","DOIUrl":"https://doi.org/10.1001/archneurpsyc.1959.02340150102012","url":null,"abstract":"","PeriodicalId":6866,"journal":{"name":"A.M.A. archives of neurology and psychiatry","volume":"81 3","pages":"370-2"},"PeriodicalIF":0.0,"publicationDate":"1959-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archneurpsyc.1959.02340150102012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23219520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1959-03-01DOI: 10.1001/archneurpsyc.1959.02340150124016
M M SEGAL, K L SHAPIRO
{"title":"A clinical comparison study of the effects of reserpine and placebo on anxiety.","authors":"M M SEGAL, K L SHAPIRO","doi":"10.1001/archneurpsyc.1959.02340150124016","DOIUrl":"https://doi.org/10.1001/archneurpsyc.1959.02340150124016","url":null,"abstract":"","PeriodicalId":6866,"journal":{"name":"A.M.A. archives of neurology and psychiatry","volume":"81 3","pages":"392-8"},"PeriodicalIF":0.0,"publicationDate":"1959-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archneurpsyc.1959.02340150124016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23219524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Illusions of comparative interpretation and emotion; production by epileptic discharge and by electrical stimulation in the temporal cortex.","authors":"S MULLAN, W PENFIELD","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":6866,"journal":{"name":"A.M.A. archives of neurology and psychiatry","volume":"81 3","pages":"269-84"},"PeriodicalIF":0.0,"publicationDate":"1959-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23219510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1959-03-01DOI: 10.1001/archneurpsyc.1959.02340150067007
C L YOUNG
{"title":"A therapeutic community with an open door in a psychiatric receiving service.","authors":"C L YOUNG","doi":"10.1001/archneurpsyc.1959.02340150067007","DOIUrl":"https://doi.org/10.1001/archneurpsyc.1959.02340150067007","url":null,"abstract":"","PeriodicalId":6866,"journal":{"name":"A.M.A. archives of neurology and psychiatry","volume":"81 3","pages":"335-40"},"PeriodicalIF":0.0,"publicationDate":"1959-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archneurpsyc.1959.02340150067007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23219515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1959-03-01DOI: 10.1001/archneurpsyc.1959.02340150080009
E L BLISS, L D CLARK, C D WEST
{"title":"Studies of sleep deprivation-relationship to schizophrenia.","authors":"E L BLISS, L D CLARK, C D WEST","doi":"10.1001/archneurpsyc.1959.02340150080009","DOIUrl":"https://doi.org/10.1001/archneurpsyc.1959.02340150080009","url":null,"abstract":"","PeriodicalId":6866,"journal":{"name":"A.M.A. archives of neurology and psychiatry","volume":"81 3","pages":"348-59"},"PeriodicalIF":0.0,"publicationDate":"1959-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archneurpsyc.1959.02340150080009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23219517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1959-03-01DOI: 10.1001/archneurpsyc.1959.02340150024003
A J VALCOURT
{"title":"Study of excretion of 5-hydroxyindoleacetic acid in mental patients.","authors":"A J VALCOURT","doi":"10.1001/archneurpsyc.1959.02340150024003","DOIUrl":"https://doi.org/10.1001/archneurpsyc.1959.02340150024003","url":null,"abstract":"","PeriodicalId":6866,"journal":{"name":"A.M.A. archives of neurology and psychiatry","volume":"81 3","pages":"292-8"},"PeriodicalIF":0.0,"publicationDate":"1959-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archneurpsyc.1959.02340150024003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23219512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1959-03-01DOI: 10.1001/archneurpsyc.1959.02340150031004
V MEYER
{"title":"Cognitive changes following temporal lobectomy for relief of temporal lobe epilepsy.","authors":"V MEYER","doi":"10.1001/archneurpsyc.1959.02340150031004","DOIUrl":"https://doi.org/10.1001/archneurpsyc.1959.02340150031004","url":null,"abstract":"","PeriodicalId":6866,"journal":{"name":"A.M.A. archives of neurology and psychiatry","volume":"81 3","pages":"299-309"},"PeriodicalIF":0.0,"publicationDate":"1959-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archneurpsyc.1959.02340150031004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23219513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1959-03-01DOI: 10.1001/archneurpsyc.1959.02340150109014
R H GEERTSMA, C MACANDREW, R J STOLLER
{"title":"Medical student orientations toward the emotionally III.","authors":"R H GEERTSMA, C MACANDREW, R J STOLLER","doi":"10.1001/archneurpsyc.1959.02340150109014","DOIUrl":"https://doi.org/10.1001/archneurpsyc.1959.02340150109014","url":null,"abstract":"","PeriodicalId":6866,"journal":{"name":"A.M.A. archives of neurology and psychiatry","volume":"81 3","pages":"377-83"},"PeriodicalIF":0.0,"publicationDate":"1959-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archneurpsyc.1959.02340150109014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23219522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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