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Pityrosporum ovale in healthy children, infantile seborrhoeic dermatitis and atopic dermatitis. 健康儿童、婴儿脂溢性皮炎和特应性皮炎中的卵圆囊孢。
A Broberg

The occurrence of Pityrosporum ovale was studied in healthy children, children with infantile seborrhoeic dermatitis (ISD) and in patients with atopic dermatitis (AD). Twenty children with ISD and twenty healthy infants were subjected to culture for P. ovale. Positive cultures were found in 18 of 20 infants with ISD, compared with 4 of 20 controls. The same culture medium containing olive oil as one of the lipids was used to evaluate the frequency of positive P. ovale cultures in 60 patients with AD, 40 patients with rhinoconjunctivitis and/or asthma (RA) and 40 children and young adults with no atopic history (HC). The results of the quantitative cultures from the forehead did not differ between the groups. P. ovale cultures were positive in 0-20% of children aged 0-10 years and in 60-90% of the 11-20-year-old subjects. Positive P. ovale cultures were found in 87% of 138 healthy children aged 2 months to 15 years when cultures were performed on a medium containing whole fat cows' milk as one lipid source. The largest number of colonies was found among children aged 2-23 months and among children older than 9 years. The occurrence of specific IgE antibodies to P. ovale was evaluated with a skin prick test (SPT) and RAST and compared in 3 groups (AD, RA, HC) of patients aged 0-20 years. Specific IgE were found most often in patients with AD. In patients with AD on different parts of the body, 15% had a positive SPT to P. ovale. In another group of patients, aged 14-53 years, with AD localised mainly to the head and neck area, the SPT was positive in 55% of the patients. Sera from 13 patients with positive SPT to P. ovale were further analysed with IgE immunoblotting using both P. ovale and C. albicans antigens. Simultaneous IgE-binding to both these yeasts was found in 5 sera and these were analysed with RAST-inhibition. Cross-reacting IgE antibodies to P. ovale and C. albicans were found in two of these sera. Cross-reacting sera were pooled and used as an IgE probe in crossed radioimmunoelectrophoresis and Tandem-crossed immunoelectrophoresis. Cross-reacting epitopes were suggested to be located in the mannan polysaccharide of C. albicans and in a high molecular weight fraction of P. ovale.(ABSTRACT TRUNCATED AT 400 WORDS)

研究了健康儿童、小儿脂溢性皮炎(ISD)患儿和特应性皮炎(AD)患儿卵形糠秕孢子菌的发生情况。对20例ISD患儿和20例健康婴儿进行卵圆杆菌培养。20名患有ISD的婴儿中有18名培养阳性,而20名对照组中有4名培养阳性。使用含有橄榄油和其中一种脂质的相同培养基来评估60例AD患者、40例鼻结膜炎和/或哮喘(RA)患者和40例无特应性史的儿童和年轻人(HC)中卵形假体阳性培养的频率。前额定量培养的结果在两组之间没有差异。0-10岁儿童中0-20%卵形假单胞菌培养呈阳性,11-20岁儿童中60-90%呈阳性。138名2个月至15岁的健康儿童中,87%的人在含有全脂牛奶作为脂质来源的培养基上进行卵形假单胞菌培养。在2-23个月的儿童和9岁以上的儿童中发现的菌落最多。采用皮肤点刺试验(SPT)和RAST评估卵形假单抗特异性IgE抗体的发生情况,并比较3组(AD、RA、HC) 0 ~ 20岁患者的情况。特异性IgE最常见于AD患者。在身体不同部位的AD患者中,15%的人对卵形疟原虫的SPT呈阳性。在另一组14-53岁的患者中,AD主要局限于头颈部,55%的患者SPT呈阳性。对13例卵形假单胞菌SPT阳性患者的血清进行卵形假单胞菌和白色假单胞菌抗原的IgE免疫印迹分析。在5种血清中发现了与这两种酵母同时结合的ige,并用rast抑制法对它们进行了分析。在其中两种血清中发现卵形假单胞菌和白色假单胞菌交叉反应的IgE抗体。收集交叉反应血清作为IgE探针,用于交叉放射免疫电泳和串联交叉免疫电泳。交叉反应的表位被认为位于白色念珠菌的甘露聚糖多糖和卵形念珠菌的高分子量部分。(摘要删节为400字)
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引用次数: 0
Biophysical properties of dry atopic and normal skin with special reference to effects of skin care products. 干性特应性和正常皮肤的生物物理特性,特别参考护肤品的效果。
Pub Date : 1995-01-01 DOI: 10.2340/00015555192148
M Lodén

During recent years several highly developed non-invasive methods for evaluation of skin physiology and pathology have been introduced. Against this background, the present studies were undertaken with the primary aim of assessing the effects of various skin care products on some properties of the skin. Skin topography was measured by profilometry on skin replicas, friction with a newly developed friction instrument, capacitance with a Corneometer, and barrier function both with an Evaporimeter to assess transepidermal water loss (TEWL) and by application of an irritant followed by measurement of the resulting irritative reaction. Initially some of the techniques were used to further characterize the differences between dry atopic skin and normal skin. Dry skin exhibits increased values of roughness parameters and a reduced number of topographical peaks. TEWL is increased, indicating impaired barrier function. The friction and capacitance are lower and correlate significantly to each other, whereas TEWL does not appear to relate to either of these parameters. The use of a scrub cream removes the outermost part of the stratum corneum, resulting in a smoother skin. Application of moisturizers modifies the frictional response of the skin. The friction instrument gave results comparable to those of panelists trained in sensory evaluation. The study suggests that measurement of skin friction can be used to predict the degree of liking of moisturizers. Furthermore, moisturizers increase the skin hydration. They provide water directly to the skin from their water phase. Skin hydration also increases with increased degree of occlusion, as measured as a decrease in TEWL. Moisturizers may also alter the diffusional resistance of the stratum corneum and reduce the skin susceptibility to the surfactant sodium lauryl sulphate (SLS). Lipids in moisturizers may influence already developed SLS-induced irritation. A significantly lower degree of irritation was found in areas treated with canola oil and its sterol-enriched fraction than in an area treated with water. These findings emphasize that skin care products do not only form an inert, epicutaneous layer, but that they may penetrate and influence the structure and function of the skin.

近年来介绍了几种高度发达的非侵入性皮肤生理和病理评估方法。在此背景下,本研究的主要目的是评估各种护肤品对皮肤某些特性的影响。皮肤形貌的测量方法是在皮肤模型上使用异型仪测量,使用新开发的摩擦仪测量摩擦,使用Corneometer测量电容,使用蒸发仪测量屏障功能,以评估经皮失水(TEWL),并通过使用刺激物测量产生的刺激反应。最初,一些技术被用来进一步表征干性特应性皮肤和正常皮肤之间的差异。干燥的皮肤表现出粗糙度参数值的增加和地形峰数量的减少。TEWL增加,表明屏障功能受损。摩擦和电容较低且彼此显著相关,而TEWL似乎与这些参数中的任何一个都无关。使用磨砂膏可以去除角质层的最外层,使皮肤更光滑。使用润肤霜可以改变皮肤的摩擦反应。摩擦仪器给出的结果与经过感官评估培训的小组成员的结果相当。研究表明,皮肤摩擦的测量可以用来预测对保湿霜的喜爱程度。此外,保湿霜可以增加皮肤的水分。它们从水相直接向皮肤提供水分。皮肤水合作用也随着闭塞程度的增加而增加,以TEWL的减少来衡量。润肤霜还可以改变角质层的扩散阻力,降低皮肤对表面活性剂十二烷基硫酸钠(SLS)的敏感性。润肤霜中的脂质可能会影响已经形成的sls诱导的刺激。用菜籽油及其富含甾醇的部分处理的区域的刺激程度明显低于用水处理的区域。这些发现强调,护肤品不仅会形成一种惰性的表皮层,而且还可能渗透并影响皮肤的结构和功能。
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引用次数: 85
Hereditary palmoplantar keratoderma and dermatophytosis in the northernmost county of Sweden (Norrbotten). 遗传性掌跖角化病和皮肤病在瑞典最北部的县(Norrbotten)。
Pub Date : 1994-06-14 DOI: 10.2340/00015555188160
Povl Gamborg Nielsen
Clinical reports of hereditary palmoplantar keratoderma are generally based on a limited number of patients. In 1967 the prevalence in the northernmost county of Sweden (Norrbotten) was shown to be 0.55%. In 1982 it was possible to trace half of the original propositi from that study. Among these families, a severe clinical form with a presumed recessive inheritance could be distinguished. The clinical pictures in relatives of the original propositi were described, and other diseases were listed together with those in patients from previously performed studies. The frequency of dermatophytosis was 36.2%, which was equal to a prevalence of 37.6%. T. mentagrophytes occurred significantly more often and immunological factors, such as increased presence of blood group A, specific dermatophyte IgG antibodies, precipitating antibodies and an immunological in vitro reaction to keratin, supported differences in the distribution of dermatophytes. However, the amount of keratin was considered the most important factor for the affinity of dermatophytes to the palms and soles. A vesicular eruption along the hyperkeratotic border and a mononuclear cell infiltrate were often reported. Such reactions were interpreted as immunological reactions to dermatophytosis. Scaling and fissuring were considered clinical signs of dermatophyte infections and not a part of the originally reported clinical picture. Results of the histopathological study corresponded to previously reported descriptions of the Unna-Thost variety. However, it has recently been reported that the histopathological picture of this variety was based on histopathological features of epidermolytic palmoplantar keratoderma. The existence on the Continent of the Unna-Thost variety was therefore questioned. Histopathological features of epidermolytic palmoplantar keratoderma were not found in the County of Norrbotten and the designation "Diffuse HPPK type Norrbotten" has therefore been proposed. The histopathological picture of the presumed recessive variety did not differ from that of the dominant variety but ultrastructural characteristics differentiated it from Mal de Meleda and the dominant variety. It was therefore concluded that a new variety with a presumed recessive inheritance was found.
遗传性掌跖角化病的临床报告通常基于有限数量的患者。1967年,瑞典最北端县(Norrbotten)的患病率为0.55%。1982年,从该研究中可以追溯出一半的原始提议。在这些家庭中,严重的临床形式与假定的隐性遗传可以区分。描述了原始受试者亲属的临床表现,并将其他疾病与先前进行的研究中患者的疾病列在一起。皮肤癣的发生率为36.2%,相当于37.6%的患病率。T. mentagrophytes的发生频率明显更高,免疫因素,如血型A的增加、特异性皮肤真菌IgG抗体、沉淀抗体和对角蛋白的体外免疫反应,支持了皮肤真菌分布的差异。然而,角蛋白的数量被认为是皮肤真菌对手掌和鞋底亲和力的最重要因素。沿角化过度边界的水泡性爆疹和单个核细胞浸润常被报道。这些反应被解释为对皮肤真菌病的免疫反应。结垢和裂裂被认为是皮肤真菌感染的临床症状,而不是最初报道的临床症状的一部分。组织病理学研究的结果与先前报道的Unna-Thost品种的描述相符。然而,最近有报道称,该品种的组织病理学图是基于表皮松解性掌跖角化病的组织病理学特征。因此,乌纳-托斯特品种在大陆上的存在受到了质疑。在Norrbotten郡未发现表皮松解性掌跖角化病的组织病理学特征,因此提出了“弥漫性HPPK型Norrbotten”的命名。隐性品种的组织病理学图与显性品种没有差异,但超微结构特征将其与Mal de Meleda和显性品种区分开来。因此得出结论,发现了一个假定具有隐性遗传的新品种。
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引用次数: 20
An epidemiological study of hand eczema. III. Characterization of hairdressers with and without hand eczema, regarding demographic factors and medical histories. 手部湿疹流行病学研究。3有和没有手湿疹的理发师的特征,关于人口因素和病史。
Pub Date : 1994-06-14 DOI: 10.2340/000155551871517
J. Holm, M. Veierød
The aim of this study was to compare, by stratification, subgroups of hairdressers. Three groups were considered: Group I (102 persons) consisted of hairdressers reporting skin affection at the time of completing an earlier mailed questionnaire (point prevalence). Group II reported exanthema prior to completing, while group III reported not having had exanthema at all (51 and 50 persons, respectively). No significant difference was found between these groups with regard to age and duration in work. The mean number of months since start of disease was significantly higher for group I (64 (range: 0.5-552)) than group II (7 (range: 0.6-38)). The frequency of atopic dermatitis was 12.7% (C.I: 6.3-19.2) in group I, compared with 3.9% (C.I: 0.0-9.2) in group II and none in group III. This difference between groups was significant. A significantly higher extent of sick leave was found in group I, compared to group II.
本研究的目的是通过分层比较理发师的亚组。分为三组:第一组(102人)由美发师组成,他们在完成早期邮寄的问卷(点患病率)时报告对皮肤的喜爱。第二组报告在完成之前有痛风,而第三组报告根本没有痛风(分别为51人和50人)。在年龄和工作时间方面,这些组之间没有显著差异。I组的平均发病月数(64个月,范围0.5-552个月)明显高于II组(7个月,范围0.6-38个月)。ⅰ组特应性皮炎发生率为12.7% (c.i.: 6.3 ~ 19.2),ⅱ组为3.9% (c.i.: 0.0 ~ 9.2),ⅲ组无。两组之间的差异是显著的。与第二组相比,第一组的病假程度要高得多。
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引用次数: 4
An epidemiological study of hand eczema. IV. Degree and pattern of eczema in affected hairdressers, with and without atopic symptoms, compared with a control group of affected teachers. 手部湿疹流行病学研究。与受影响的教师对照组相比,受影响的理发师有或没有特应性症状的湿疹程度和类型。
Pub Date : 1994-06-14 DOI: 10.2340/000155551871822
J. Holm, M. Veierød
The aim of this study was to show degree and pattern of hand eczema in affected hairdressers (n = 69), compared with a control group of teachers (n = 19). Both groups consisted of employees having eczema, confirmed by the visit of a doctor at the working place. The mean age for the affected hairdressers was 27 years (range: 17-63) and for the teachers 43 years (range: 27-57). The mean duration of employment was 96 months for the hairdressers (range: 2-552) and 182 months for the teachers (range: 25-336). The localization of eczematous lesions, presence of efflorescenses and extent of skin affection were recorded by constructing scores for these variables. The mean number of localizations was significantly higher in hairdressers than in teachers; this was caused by greater affection of fingers in hairdressers compared to teachers. Seventy-five percent of the hairdressers and 79% of the teachers had only modest or very moderate erythema. Fourteen percent and 5%, respectively, had vesicular dermatitis. The right upper limb was most affected in both hairdressers and teachers. Three subgroups of hairdressers were considered: hairdressers with atopic dermatitis, those with only atopic mucosal symptoms and those without atopic symptoms. No significant differences were found between these groups, except a significant higher finger involvement in atopics compared to non-atopics.
本研究的目的是显示受影响的理发师(n = 69)与对照组教师(n = 19)相比手部湿疹的程度和模式。两组都由患有湿疹的员工组成,经工作地点的医生检查证实。受影响的理发师的平均年龄为27岁(范围:17-63),教师的平均年龄为43岁(范围:27-57)。理发师的平均工作时间为96个月(范围:2-552),教师的平均工作时间为182个月(范围:25-336)。通过构建这些变量的分数来记录湿疹病变的定位,是否存在癣和皮肤影响的程度。理发师的平均定位数显著高于教师;这是因为理发师比老师更喜欢用手指。75%的美发师和79%的教师只有中度或非常中度的红斑。分别有14%和5%的人患有水疱性皮炎。理发师和教师的右上肢受影响最大。理发师的三个亚组被考虑:有特应性皮炎的理发师,只有特应性粘膜症状的理发师和没有特应性症状的理发师。这些组之间没有发现显著差异,除了与非特应性相比,特应性手指受累明显更高。
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引用次数: 5
An epidemiological study of hand eczema. I. Prevalence and cumulative prevalence among hairdressers compared with a control group of teachers. 手部湿疹流行病学研究。1 .美发师与对照组教师的患病率及累计患病率比较。
Pub Date : 1994-06-14 DOI: 10.2340/00015555187811
J. Holm, M. Veierød
The aim of this cross-sectional study was to estimate the prevalence of dermatitis of the hands and/or forearms among hairdressers compared with a control group of elementary school teachers. Questionnaires were sent to 818 hairdressers and 816 teachers. The response rates were 83% and 65%, respectively. The mean age for those completing the questionnaire, was 28 years (range: 17-71) for the hairdressers and 45 years (range: 20-70) for the teachers. The mean number of months employed in these occupations was 105 (range: 1-672) and 186 (range: 0-516), respectively. Forty-two per cent of the hairdressers and 23% of the teachers suffered or had been suffering from exanthema of the hands and/or forearms. Sixty-one and 15%, respectively, related the skin disease to work.
本横断面研究的目的是估计发型师的手和/或前臂皮炎的患病率,并与对照组的小学教师进行比较。共向818名美发师和816名教师发放了问卷。应答率分别为83%和65%。理发师的平均年龄为28岁(范围17-71岁),教师的平均年龄为45岁(范围20-70岁)。这些职业的平均受雇月数分别为105个(范围:1-672)和186个(范围:0-516)。42%的美发师和23%的教师患有或曾经患有手部和/或前臂的疹子。分别有61%和15%的人认为皮肤疾病与工作有关。
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引用次数: 9
An epidemiological study of hand eczema. 手部湿疹流行病学研究。
Pub Date : 1994-06-14 DOI: 10.2340/00015555187127
J. Holm
No abstract available
没有摘要
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引用次数: 15
An epidemiological study of hand eczema. VI. A follow-up of hairdresser trainees, with the focus on various health complaints. 手部湿疹流行病学研究。六、对理发师学员进行跟踪调查,重点关注各种健康投诉。
Pub Date : 1994-06-14 DOI: 10.2340/000155551872627
J. Holm
The aim of this follow up study was to show how career dropouts among young hairdressers are related to various health complaints. Questionnaires were sent to 286 hairdressers, who had been registered as trainees three to five years earlier. The forms were returned from 124 hairdressers, of whom 26 (21%) reported that they stopped working as hairdressers because of various health complaints. Eight (6.5%) left their job because of skin conditions.
这项后续研究的目的是显示年轻美发师的职业辍学与各种健康问题之间的关系。研究人员向286名在三至五年前注册为培训生的理发师发送了调查问卷。124名美发师退回了表格,其中26名(21%)报告称,由于各种健康问题,他们停止了美发师的工作。8人(6.5%)因皮肤问题离职。
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引用次数: 10
An epidemiological study of hand eczema. II. Prevalence of atopic diathesis in hairdressers, compared with a control group of teachers. 手部湿疹流行病学研究。2与对照组教师比较理发师特应性素质的患病率。
Pub Date : 1994-06-14 DOI: 10.2340/000155551871214
J. Holm, M. Veierød
The aim of this cross-sectional study was to estimate the prevalence of atopic dermatitis in hairdressers compared with a control group of elementary school teachers. Both groups consisted of employees who reported exanthema on the hands and/or forearms at the time of completing a questionnaire. The mean age for the affected hairdressers was 26 years (range: 17-63) and for the teachers 44 years (range: 28-65). The mean duration of employment was 85 months for the hairdressers (range: 2-552) and 177 months for the teachers (range: 24-360). The frequency of atopic dermatitis was 12.7% (C.I.: 6.3-19.2) in the group of hairdressers and 25% (C.I.: 7.7-42.3) in the group of teachers. No difference was observed between the groups regarding atopic mucosal symptoms or familial atopy.
本横断面研究之目的在于评估理发师与小学教师之特应性皮炎患病率。两组员工都在填写问卷时报告手和/或前臂有湿疹。受影响的理发师的平均年龄为26岁(范围17-63岁),教师的平均年龄为44岁(范围28-65岁)。理发师的平均工作时间为85个月(范围:2-552),教师的平均工作时间为177个月(范围:24-360)。发型师组特应性皮炎发生率为12.7% (c.i.: 6.3 ~ 19.2),教师组为25% (c.i.: 7.7 ~ 42.3)。在特应性粘膜症状或家族性特应性方面,组间无差异。
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引用次数: 2
An epidemiological study of hand eczema. V. Prevalence among hairdresser trainees, compared with a general population of hairdressers. 手部湿疹流行病学研究。V.与一般发型师人群相比,理发学员的患病率。
Pub Date : 1994-06-14 DOI: 10.2340/000155551872325
J. Holm, M. Veierød
The aim of this study was to show degree and pattern of hand eczema in affected hairdresser trainees (n = 52), compared with a general population of affected hairdressers (n = 69). The mean ages were 18 years (range: 16-25) for the trainees and 27 years (range: 17-63) for the hairdressers. For the latter group, the mean number of months spent in profession was 96 (range: 2-552) and the number of working hours per week was 36 (range: 4-50). Twenty-seven per cent of all trainees (67/246) were reported to have had initial of eczematous lesions on the hands and/or forearms during their apprenticeship. The extent of skin affection, as assessed by scores for localization and distribution of eczema, was significantly lower in trainees, compared with the general population of hairdressers. Patch test revealed sensitization to nickel to be prominent in both groups; 34% among affected hairdressers and 26% among affected and non-affected trainees. Of the hairdressers, 3% had allergy to hair dye (2.5-toluenediamine), while 8% were sensitized to glyceryl monothioglycolate. None of the trainees were sensitized to those two chemicals.
本研究的目的是显示受影响的理发师培训生(n = 52)与受影响的理发师一般人群(n = 69)相比手部湿疹的程度和模式。学员的平均年龄为18岁(范围16-25岁),美发师的平均年龄为27岁(范围17-63岁)。后一组的平均工作时间为96个月(范围:2-552),每周工作时间为36个小时(范围:4-50)。据报道,27%的学员(67/246)在学徒期间手部和/或前臂有最初的湿疹病变。通过湿疹的局部和分布评分来评估,受训者对皮肤的影响程度明显低于普通美发师。斑贴试验显示两组对镍的致敏性显著;受影响的理发师占34%,受影响及未受影响的学员占26%。在发型师中,3%的人对染发剂(2.5-甲苯二胺)过敏,8%的人对单巯基甘油酯敏感。没有一个受训者对这两种化学物质过敏。
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引用次数: 12
期刊
Acta dermato-venereologica. Supplementum
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