Pub Date : 2023-01-01DOI: 10.23893/1307-2080.aps6112
O. E. Thomas, O. Alabi, Patience E. Osharode
{"title":"Characterization, antimicrobial and catalytic activities of silver nanoparticles biosynthesized using aqueous extract of euphorbia graminea","authors":"O. E. Thomas, O. Alabi, Patience E. Osharode","doi":"10.23893/1307-2080.aps6112","DOIUrl":"https://doi.org/10.23893/1307-2080.aps6112","url":null,"abstract":"<jats:p xml:lang=\"tr\" />","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68932777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.23893/1307-2080.aps6125
Yalcin Erzurumlu, Hatice Kubra Dogan
{"title":"Dbeq-mediated pharmacological modulation of the retrotranslocation step of erad may exhibit a potent therapeutic approach against colorectal cancer","authors":"Yalcin Erzurumlu, Hatice Kubra Dogan","doi":"10.23893/1307-2080.aps6125","DOIUrl":"https://doi.org/10.23893/1307-2080.aps6125","url":null,"abstract":"<jats:p xml:lang=\"tr\" />","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134884569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.23893/1307-2080.aps6117
G. İşcan, M. Kürkçüoǧlu, F. Tosun, M. Miski
{"title":"Biological activity and chemical composition of the essential oil from the fruits of ferula rigidula fisch. ex dc.","authors":"G. İşcan, M. Kürkçüoǧlu, F. Tosun, M. Miski","doi":"10.23893/1307-2080.aps6117","DOIUrl":"https://doi.org/10.23893/1307-2080.aps6117","url":null,"abstract":"<jats:p xml:lang=\"tr\" />","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68933078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.23893/1307-2080.aps6121
Oluyemisi Adebowale Bamiro, L. Bakre, O. Adeleye
{"title":"Assessment of compressional, mechanical and release properties of terminalia randii gum in paracetamol tablet formulation","authors":"Oluyemisi Adebowale Bamiro, L. Bakre, O. Adeleye","doi":"10.23893/1307-2080.aps6121","DOIUrl":"https://doi.org/10.23893/1307-2080.aps6121","url":null,"abstract":"<jats:p xml:lang=\"tr\" />","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68933291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.23893/1307-2080.aps6110
Şule Nur Karavuş, A. Caskurlu, A. Karadaǧ, Fatih Demirci
{"title":"Bioautography for evaluation of several lavandula l. and origanum species antimicrobial and antioxidant activity","authors":"Şule Nur Karavuş, A. Caskurlu, A. Karadaǧ, Fatih Demirci","doi":"10.23893/1307-2080.aps6110","DOIUrl":"https://doi.org/10.23893/1307-2080.aps6110","url":null,"abstract":"<jats:p xml:lang=\"tr\" />","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68932744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.23893/1307-2080.aps6114
N. Taner, Betül Şirin
{"title":"Evaluation of venous thromboembolism prophylaxis in cancer patients: a retrospective study","authors":"N. Taner, Betül Şirin","doi":"10.23893/1307-2080.aps6114","DOIUrl":"https://doi.org/10.23893/1307-2080.aps6114","url":null,"abstract":"<jats:p xml:lang=\"tr\" />","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68932838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.23893/1307-2080.aps6102
O. Horodnycha, A. Zimenkovsky
{"title":"Antibiotic therapy of adult inpatients with community-acquired pneumonia: a retrospective hospital-based study in ukraine","authors":"O. Horodnycha, A. Zimenkovsky","doi":"10.23893/1307-2080.aps6102","DOIUrl":"https://doi.org/10.23893/1307-2080.aps6102","url":null,"abstract":"<jats:p xml:lang=\"en\" />","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68932910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-18eCollection Date: 2022-05-01DOI: 10.1093/eurheartj/suac015
David Mocini, Stefania Angela Di Fusco, Leonardo De Luca, Pasquale Caldarola, Manlio Cipriani, Marco Corda, Andrea Di Lenarda, Alfredo De Nardo, Giuseppina Maura Francese, Cosimo Napoletano, Alessandro Navazio, Carmine Riccio, Loris Roncon, Emanuele Tizzani, Federico Nardi, Stefano Urbinati, Serafina Valente, Michele Massimo Gulizia, Domenico Gabrielli, Fabrizio Oliva, Furio Colivicchi
The appropriateness of prescribing direct oral anticoagulants [dabigatran, rivaroxaban, apixaban, and edoxaban (DOACs)] is regulated on the criteria established in Phase III trials. These criteria are reported in the summary of the product characteristics of the four DOACs. In clinical practice, prescriptions are not always in compliance with established indications. In particular, the use of lower doses than those recommended in drug data sheets is not uncommon. Literature data show that the inappropriate prescription of reduced doses causes drug underexposure and up to a three-fold increase in the risk of stroke/ischaemic transient attack, systemic thromboembolism, and hospitalization. Possible causes of the deviation between the dose that should be prescribed and that prescribed in the real world include erroneous prescription, an overstated haemorrhagic risk perception, and the presence of frail and complex patients in clinical practice who were not included in pivotal trials, which makes it difficult to apply study results to the real world. For these reasons, we summarize DOAC indications and contraindications. We also suggest the appropriate use of DOACs in common clinical scenarios, in accordance with what international guidelines and national and international health regulatory bodies recommend.
直接口服抗凝药[达比加群、利伐沙班、阿哌沙班和依度沙班（DOACs）]的处方适宜性是根据 III 期试验中制定的标准进行管理的。这些标准已在四种 DOAC 的产品特性摘要中报告。在临床实践中，处方并不总是符合既定的适应症。特别是，使用低于药物数据表推荐剂量的情况并不少见。文献数据显示，不适当地减少处方剂量会导致药物暴露不足，中风/缺血性短暂发作、全身性血栓栓塞和住院治疗的风险最多会增加三倍。造成应处方剂量与实际处方剂量之间偏差的可能原因包括错误处方、夸大出血风险认知，以及临床实践中存在未纳入关键试验的体弱和复杂患者，这使得研究结果难以应用于实际情况。因此，我们总结了 DOAC 的适应症和禁忌症。我们还根据国际指南以及国家和国际卫生监管机构的建议，提出了在常见临床情况下如何合理使用 DOAC 的建议。
{"title":"ANMCO position paper 'Appropriateness of prescribing direct oral anticoagulants in stroke and systemic thromboembolism prevention in adult patients with non-valvular atrial fibrillation'.","authors":"David Mocini, Stefania Angela Di Fusco, Leonardo De Luca, Pasquale Caldarola, Manlio Cipriani, Marco Corda, Andrea Di Lenarda, Alfredo De Nardo, Giuseppina Maura Francese, Cosimo Napoletano, Alessandro Navazio, Carmine Riccio, Loris Roncon, Emanuele Tizzani, Federico Nardi, Stefano Urbinati, Serafina Valente, Michele Massimo Gulizia, Domenico Gabrielli, Fabrizio Oliva, Furio Colivicchi","doi":"10.1093/eurheartj/suac015","DOIUrl":"10.1093/eurheartj/suac015","url":null,"abstract":"<p><p>The appropriateness of prescribing direct oral anticoagulants [dabigatran, rivaroxaban, apixaban, and edoxaban (DOACs)] is regulated on the criteria established in Phase III trials. These criteria are reported in the summary of the product characteristics of the four DOACs. In clinical practice, prescriptions are not always in compliance with established indications. In particular, the use of lower doses than those recommended in drug data sheets is not uncommon. Literature data show that the inappropriate prescription of reduced doses causes drug underexposure and up to a three-fold increase in the risk of stroke/ischaemic transient attack, systemic thromboembolism, and hospitalization. Possible causes of the deviation between the dose that should be prescribed and that prescribed in the real world include erroneous prescription, an overstated haemorrhagic risk perception, and the presence of frail and complex patients in clinical practice who were not included in pivotal trials, which makes it difficult to apply study results to the real world. For these reasons, we summarize DOAC indications and contraindications. We also suggest the appropriate use of DOACs in common clinical scenarios, in accordance with what international guidelines and national and international health regulatory bodies recommend.</p>","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":"C278-C288"},"PeriodicalIF":1.7,"publicationDate":"2022-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90918413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.23893/1307-2080.aps.6010
B. Bakchiche, A. Gören, Z. Aydoğmuş, Emel Mataracikara, M. Ghareeb
{"title":"Artemisia campestris and artemisia herbaalba: lc-hresi-ms profile alongside their antioxidant and antimicrobial evaluation","authors":"B. Bakchiche, A. Gören, Z. Aydoğmuş, Emel Mataracikara, M. Ghareeb","doi":"10.23893/1307-2080.aps.6010","DOIUrl":"https://doi.org/10.23893/1307-2080.aps.6010","url":null,"abstract":"<jats:p xml:lang=\"tr\" />","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68931876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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