Acta neurologica Belgica最新文献

英文中文

Myoclonus with Bilateral Basal Ganglia Hyperintensities in Subacute Sclerosing Panencephalitis: A Case Report. 亚急性硬化性全脑炎伴双侧基底神经节高信号的肌阵挛1例。

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Acta neurologica Belgica

Pub Date : 2025-11-28 DOI: 10.1007/s13760-025-02957-y

Shreyashi Jha, Santosh Kumar Pendyala, Mona Tiwari

引用次数: 0

Intracranial hypotension following post-dural puncture: a case report of a severe neurological emergency. 硬脑膜穿刺后颅内低血压：一例严重神经系统急症报告。

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Acta neurologica Belgica

Pub Date : 2025-11-28 DOI: 10.1007/s13760-025-02956-z

Maurizio Giorelli, Marilisa Pasquale, Donatella Accavone, Sarah Idrissi, Rita Vitobello

引用次数: 0

Intraventricular glioblastoma in Lynch syndrome: a case report. Lynch综合征脑室内胶质母细胞瘤1例报告。

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Acta neurologica Belgica

Pub Date : 2025-11-27 DOI: 10.1007/s13760-025-02953-2

Armindo Picão Fernandes, Sérgio Sousa, Sérgio Moreira, Alfredo Calheiros, Margarida Calejo

引用次数: 0

Pain in neuromyelitis optica spectrum disorder: determination of prevalence and characteristics. 视神经脊髓炎谱系障碍的疼痛：患病率和特征的测定。

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Acta neurologica Belgica

Pub Date : 2025-11-27 DOI: 10.1007/s13760-025-02958-x

Asiye Tuba Ozdogar, Pervin Yesiloglu, Gozde Deniz Unal, Veysel Engenc, Ela Simay Zengin, Vedat Cilingir, Serkan Ozakbas

Introduction: The aim was to determine the prevalence and characteristics of pain in people with neuromyelitis optica spectrum disorders (pwNMOSD).

Methods: The Nordic Musculoskeletal Questionnaire (NMQ) was used to determine the participants' pain levels and pain localization. The PainDETECT Questionnaire (PD-Q) was used to differentiate between nociceptive and neuropathic pain. The scores ≤ 12 were considered as presence of musculoskeletal pain (MSP) and > 12 as neuropathic pain (NP). The Preference-Based Multiple Sclerosis Index (PBMSI) was used to measure health-related quality of life. Information such as Expanded Disability Status Scale (EDSS), disease duration and age of the participants were also recorded.

Results: The 62 participants included in the study were divided into 3 groups: 14 without pain, 17 with MSP and 31 with NP. There was no difference between the groups in terms of age, disease duration and EDSS scores (p > .05). When the pain distribution was analyzed, the regions with the most pain complaints in the last 12 months were neck (n = 22, 34.9%), foot-ankle (n = 16, 25.4%) and back (n = 15, 25.8%), respectively. When the quality of life of the three groups were compared, there was a difference between PBMSI-Walk, PBMSI-Fatigue and total score.

Conclusion: The results of this study showed that the neck, back, and foot-ankle were the most common and most disabling pain areas in pwNMOSD, regardless of the age, disease duration, and EDSS score of the participant. However, there was a difference between the groups in the parameters related to gait, fatigue and total quality of life against NP.

前言：目的是确定视神经脊髓炎谱系障碍（pwNMOSD）患者疼痛的患病率和特征。方法：采用北欧肌肉骨骼问卷（NMQ）确定参与者的疼痛水平和疼痛定位。疼痛检测问卷（PD-Q）用于区分伤害性疼痛和神经性疼痛。评分≤12分为存在肌肉骨骼疼痛（MSP），评分≤12分为神经性疼痛（NP）。采用基于偏好的多发性硬化症指数（pbsi）来衡量与健康相关的生活质量。还记录了参与者的扩展残疾状态量表（EDSS）、疾病持续时间和年龄等信息。结果：将62例受试者分为3组：无疼痛组14例，MSP组17例，NP组31例。两组患者年龄、病程、EDSS评分差异无统计学意义（p < 0.05）。对疼痛分布进行分析，近12个月疼痛主叫最多的部位分别为颈部（n = 22, 34.9%）、足踝部（n = 16, 25.4%）和背部（n = 15, 25.8%）。比较三组患者的生活质量，pmsi - walk、pmsi - fatigue及总分均有差异。结论：本研究结果显示，无论参与者的年龄、病程和EDSS评分如何，颈部、背部和足踝是pwNMOSD中最常见和最致残的疼痛区域。然而，两组之间在步态、疲劳和总体生活质量等参数上存在差异。

{"title":"Pain in neuromyelitis optica spectrum disorder: determination of prevalence and characteristics.","authors":"Asiye Tuba Ozdogar, Pervin Yesiloglu, Gozde Deniz Unal, Veysel Engenc, Ela Simay Zengin, Vedat Cilingir, Serkan Ozakbas","doi":"10.1007/s13760-025-02958-x","DOIUrl":"https://doi.org/10.1007/s13760-025-02958-x","url":null,"abstract":"Introduction: The aim was to determine the prevalence and characteristics of pain in people with neuromyelitis optica spectrum disorders (pwNMOSD).Methods: The Nordic Musculoskeletal Questionnaire (NMQ) was used to determine the participants' pain levels and pain localization. The PainDETECT Questionnaire (PD-Q) was used to differentiate between nociceptive and neuropathic pain. The scores ≤ 12 were considered as presence of musculoskeletal pain (MSP) and > 12 as neuropathic pain (NP). The Preference-Based Multiple Sclerosis Index (PBMSI) was used to measure health-related quality of life. Information such as Expanded Disability Status Scale (EDSS), disease duration and age of the participants were also recorded.Results: The 62 participants included in the study were divided into 3 groups: 14 without pain, 17 with MSP and 31 with NP. There was no difference between the groups in terms of age, disease duration and EDSS scores (p > .05). When the pain distribution was analyzed, the regions with the most pain complaints in the last 12 months were neck (n = 22, 34.9%), foot-ankle (n = 16, 25.4%) and back (n = 15, 25.8%), respectively. When the quality of life of the three groups were compared, there was a difference between PBMSI-Walk, PBMSI-Fatigue and total score.Conclusion: The results of this study showed that the neck, back, and foot-ankle were the most common and most disabling pain areas in pwNMOSD, regardless of the age, disease duration, and EDSS score of the participant. However, there was a difference between the groups in the parameters related to gait, fatigue and total quality of life against NP.","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145627398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PRES-like MRI findings in sporadic Creutzfeldt-Jakob disease: a case report. 散发性克雅氏病的press样MRI表现1例。

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Acta neurologica Belgica

Pub Date : 2025-11-27 DOI: 10.1007/s13760-025-02961-2

J Wijnand, E Vereecke, T Van Langenhove, G Laureys

引用次数: 0

Longstanding histological colitis following ocrelizumab therapy: a case report. ocrelizumab治疗后的长期组织学结肠炎1例报告

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Acta neurologica Belgica

Pub Date : 2025-11-26 DOI: 10.1007/s13760-025-02955-0

Frédéric London, Firas Sellami, Mouna Messaoudi, Marie-Cécile Nollevaux, Jean-François Rahier

引用次数: 0

Apraxia of eyelid-closure in cortico-basal degeneration. 皮质基底变性患者闭眼睑失用。

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Acta neurologica Belgica

Pub Date : 2025-11-24 DOI: 10.1007/s13760-025-02949-y

Sweety Kumari, Niraj Kumar

引用次数: 0

Postpartum hypernatremic osmotic demyelination syndrome. 产后高钠血症渗透性脱髓鞘综合征。

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Acta neurologica Belgica

Pub Date : 2025-11-21 DOI: 10.1007/s13760-025-02951-4

Farsana Mustafa, Navneeta Menoki, Suraj Patre, Ajay Garg, Divyani Garg, Manish Soneja, Naval K Vikram, Achal Kumar Srivastava, Ayush Agarwal

引用次数: 0

Neurofilament light chain levels as a biomarker in idiopathic intracranial hypertension: correlations with papilledema and radiological findings. 神经丝轻链水平作为特发性颅内高压的生物标志物：与乳头水肿和影像学表现的相关性

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Acta neurologica Belgica

Pub Date : 2025-11-20 DOI: 10.1007/s13760-025-02936-3

Ahmed Hamdy, Shimaa Elgamal, Reem Algamal, Hadeer Elsaeed AboElfarh, Muhammad Abdelshafi Elsayed, Ahmed Reda Abdelmeguid Moustafa, Yasmeena Abdelall Kozaa, Hossam Egila, Osama Elshafei

Background: Idiopathic intracranial hypertension (IIH) is marked by elevated intracranial pressure with risk of vision loss. Neurofilament light chain (NfL), a marker of axonal injury, may reflect optic nerve damage in IIH.

Objective: To assess the relationship between cerebrospinal fluid (CSF) and serum NfL levels, papilledema severity, and radiological findings in patients with IIH.

Methods: A cross-sectional study was performed on 34 women with IIH and 34 age- and sex-matched healthy controls. Demographics, clinical features, ophthalmological evaluation, lumbar puncture opening pressure measurement, brain MRI/MRV, and ONSD ultrasound were performed. NfL levels were measured in CSF and serum using ELISA. Correlations with papilledema grade (Frisén scale) and radiological findings were analyzed.

Results: IIH patients had higher BMI (34.2 vs. 27.3 kg/m², p < 0.001) and ONSD (6.39 vs. 5.40 mm, p < 0.001). CSF NfL levels were elevated (median 79.8 ng/L) and positively correlated with papilledema grade (r = 0.383, p = 0.031) but negatively with ONSD (r = -0.352, p = 0.041). ONSD correlated strongly with papilledema (r = 0.456, p = 0.009) and lumbar puncture pressure (r = 0.502, p = 0.002). Serum NfL showed no significant difference between patients and controls (p = 0.562) and no correlation with disease severity.

Conclusion: CSF NfL correlates with papilledema grade and may serve as an objective biomarker of optic nerve damage in IIH. Its complementary role alongside ONSD suggests potential for a dual biomarker approach, combining acute pressure assessment with cumulative axonal injury monitoring.

背景：特发性颅内高压（IIH）以颅内压升高为特征，伴有视力丧失的危险。神经丝轻链（Neurofilament light chain, NfL）是轴突损伤的标志，可以反映视神经损伤。目的：评估脑脊液（CSF）和血清NfL水平、乳头水肿严重程度以及IIH患者影像学表现之间的关系。方法：对34名IIH妇女和34名年龄和性别匹配的健康对照进行横断面研究。进行了人口统计学、临床特征、眼科评价、腰椎穿刺开口压力测量、脑MRI/MRV和ONSD超声检查。采用ELISA法测定脑脊液和血清中NfL水平。分析其与乳头水肿等级（frissamn量表）和影像学表现的相关性。结果：IIH患者的BMI更高（34.2 vs. 27.3 kg/m²，p）。结论：脑脊液NfL与视神经水肿分级相关，可作为IIH视神经损伤的客观生物标志物。它与ONSD的互补作用表明了双重生物标志物方法的潜力，将急性压力评估与累积轴索损伤监测相结合。

{"title":"Neurofilament light chain levels as a biomarker in idiopathic intracranial hypertension: correlations with papilledema and radiological findings.","authors":"Ahmed Hamdy, Shimaa Elgamal, Reem Algamal, Hadeer Elsaeed AboElfarh, Muhammad Abdelshafi Elsayed, Ahmed Reda Abdelmeguid Moustafa, Yasmeena Abdelall Kozaa, Hossam Egila, Osama Elshafei","doi":"10.1007/s13760-025-02936-3","DOIUrl":"https://doi.org/10.1007/s13760-025-02936-3","url":null,"abstract":"Background: Idiopathic intracranial hypertension (IIH) is marked by elevated intracranial pressure with risk of vision loss. Neurofilament light chain (NfL), a marker of axonal injury, may reflect optic nerve damage in IIH.Objective: To assess the relationship between cerebrospinal fluid (CSF) and serum NfL levels, papilledema severity, and radiological findings in patients with IIH.Methods: A cross-sectional study was performed on 34 women with IIH and 34 age- and sex-matched healthy controls. Demographics, clinical features, ophthalmological evaluation, lumbar puncture opening pressure measurement, brain MRI/MRV, and ONSD ultrasound were performed. NfL levels were measured in CSF and serum using ELISA. Correlations with papilledema grade (Frisén scale) and radiological findings were analyzed.Results: IIH patients had higher BMI (34.2 vs. 27.3 kg/m², p < 0.001) and ONSD (6.39 vs. 5.40 mm, p < 0.001). CSF NfL levels were elevated (median 79.8 ng/L) and positively correlated with papilledema grade (r = 0.383, p = 0.031) but negatively with ONSD (r = -0.352, p = 0.041). ONSD correlated strongly with papilledema (r = 0.456, p = 0.009) and lumbar puncture pressure (r = 0.502, p = 0.002). Serum NfL showed no significant difference between patients and controls (p = 0.562) and no correlation with disease severity.Conclusion: CSF NfL correlates with papilledema grade and may serve as an objective biomarker of optic nerve damage in IIH. Its complementary role alongside ONSD suggests potential for a dual biomarker approach, combining acute pressure assessment with cumulative axonal injury monitoring.","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145562210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Herpes simplex encephalitis in pregnancy: a case report. 妊娠期单纯疱疹脑炎1例报告。

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Acta neurologica Belgica

Pub Date : 2025-11-20 DOI: 10.1007/s13760-025-02940-7

Kamilė Piesliakaitė, Arminas Jasionis, Daiva Radzišauskienė, Jelena Volochovič

引用次数: 0

首页上一页

下一页尾页

类型

全部化学•材料生命科学医学物理工程技术环境•农林材料科学地球科学法学管理学化学环境科学与生态学计算机科学教育学经济学农林科学人文科学生物学数学物理与天体物理心理学综合性期刊其他工业工程理学历史学农学文学信息工程

数据库

全部 ACS Publications Elsevier ieeexplore Springer The Royal Society of Chemistry Wiley

期刊

Acta neurologica Belgica

全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.

﹀