Actas urologicas espanolas最新文献

{"title":"Masa renal secundaria a la enfermedad de Rosai-Dorfman: reporte de caso clínico","authors":"A. Romero Crespo , R. España Navarro , E. Prieto Sanchez , E. Garcia Galisteo","doi":"10.1016/j.acuro.2025.501750","DOIUrl":"10.1016/j.acuro.2025.501750","url":null,"abstract":"","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"50 1","pages":"Article 501750"},"PeriodicalIF":1.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145898169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perspectiva internacional sobre el diagnóstico y tratamiento de la enuresis nocturna: estudio basado en una encuesta del Grupo de Trabajo de Urología Pediátrica de la Sección de Jóvenes Urólogos Académicos (YAU) de la Asociación Europea de Urología (EAU)","authors":"N. Baydilli ,&nbsp;M.İ. Dönmez ,&nbsp;Y. Quiroz Madarriaga ,&nbsp;B. Banuelos Marco ,&nbsp;İ. Selvi ,&nbsp;E. Bindi ,&nbsp;R. Lammers ,&nbsp;S. Sforza ,&nbsp;L.A. ’tHoen ,&nbsp;en representación del Grupo de Trabajo de Urología Pediátrica de la Sección de Jóvenes Urólogos Académicos – Asociación Europea de Urología (EAU-YAU)","doi":"10.1016/j.acuro.2025.501822","DOIUrl":"10.1016/j.acuro.2025.501822","url":null,"abstract":"<div><h3>Objective</h3><div>This study assessed global diagnostic and therapeutic approaches to nocturnal enuresis (NE), highlighting current practices and variations.</div></div><div><h3>Materials and methods</h3><div>An 18-question survey by the European Association of Urology (EAU) Young Academic Urologist (YAU) Paediatric Urology Working Group targeted clinicians managing NE. Distributed online, it reached Urologists, Pediatric Urologists, Pediatricians, Nephrologists, and Urotherapists. The survey collected demographic data and details on diagnostic and treatment practices. Responses were analyzed using descriptive statistics.</div></div><div><h3>Results</h3><div>Most respondents worked in university or government hospitals, with pediatric urologists forming the largest group (43.6%). A significant portion had 11-20 years of NE management experience. Initial treatment favored behavioral strategies and urotherapy (84.5%), with desmopressin as a common first-line medication (23.8%). Most clinicians initiated treatment at ages 5-6. Bladder diaries were widely used (82.0%), while airway assessments were inconsistent (52.1%). Diagnostic test usage varied, with urinary tract ultrasonography (53.65%) and urinalysis (51.5%) employed to identify underlying abnormalities. Psychological referrals were common for secondary enuresis (58.9%).</div></div><div><h3>Conclusion</h3><div>NE management varies globally due to regional practices, clinician experience, and specialty focus. The findings emphasize the need for standardized guidelines and education on comprehensive assessments, including sleep-related factors. International collaboration and guideline development could enhance consistency and improve patient outcomes.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"50 1","pages":"Article 501822"},"PeriodicalIF":1.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145898161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluación de la eficacia del tratamiento según los criterios RECIP 1.0 en el cáncer de próstata sensible a la castración","authors":"I. Gulturk ,&nbsp;C. Kapar ,&nbsp;E. Arslan ,&nbsp;M. Polat ,&nbsp;G.B. Sonmezoz ,&nbsp;D. Tural","doi":"10.1016/j.acuro.2025.501837","DOIUrl":"10.1016/j.acuro.2025.501837","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the relationship between treatment response and radiological progression-free survival (rPFS) in patients with metastatic castration-sensitive prostate cancer (mCSPC) assessed by PSMA-PET/CT using Response Evaluation Criteria on PSMA (RECIP 1.0) criteria.</div></div><div><h3>Methods</h3><div>In this study, 116 patients were analyzed retrospectively. At the beginning of the treatment and week 12 were PSMA PET/CT images evaluated for changes in total tumor volüme and new lesions. Patients were divided into four groups according to RECIP criteria; complete response (CR), partial response (PR), stable disease (SD) and progressive disease (PD). The primary outcome was the correlation of RECIP criteria with rPFS.</div></div><div><h3>Results</h3><div>Mean age of the patients was 67 years (IQR: 62-72]). Total of 116 patients; 65 (56%) had PR, 17 (14,6%) SD, 19 (16,3%) PD, and 15 (12%) CR. rPFS was found to be statistically significantly different among these four groups (<em>P</em>&lt;.001). RECIP PD was found to be significantly shorter rPFS compared with non-PD (<em>P</em>&lt;.001), with an rPFS of 7 months (95% CI: 3.45-10.56). PSA values were measured at nadir in 40 patients and no patient in this group was evaluated as having PD.</div></div><div><h3>Conclusion</h3><div>RECIP criteria have been shown to have prognostic significance in terms of evaluating treatment response and rPFS in mCSPC patients.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"50 1","pages":"Article 501837"},"PeriodicalIF":1.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145898165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heminefroureterectomía laparoscópica en riñón en herradura con sospecha de carcinoma urotelial empleando un modelo virtual 3 D de hiperprecisión","authors":"A. Garcia-Segui,&nbsp;M. Ferrández-Jimenez,&nbsp;N. García-Cárceles,&nbsp;C. Soler-López","doi":"10.1016/j.acuro.2025.501747","DOIUrl":"10.1016/j.acuro.2025.501747","url":null,"abstract":"","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"50 1","pages":"Article 501747"},"PeriodicalIF":1.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145898168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Manejo de la incontinencia tras el cierre de la extrofia vesical clásica","authors":"K. Godlewski,&nbsp;M. Davis,&nbsp;D. Weiss,&nbsp;A. Shukla","doi":"10.1016/j.acuro.2025.501818","DOIUrl":"10.1016/j.acuro.2025.501818","url":null,"abstract":"<div><h3>Introduction</h3><div>Classic bladder exstrophy presents a unique challenge for reconstructive surgeons given the significant alternations it has on normal pelvic anatomy. The ultimate goal of surgery, whether in one stage or more, is simple; close the bladder, reconstruct the bladder neck and urethra, and place the unit into a more orthotopic position deep in the pelvis, and establish normal genitalia. Despite significant improvements with the success of bladder exstrophy closure, a patient's ability to volitionally void and achieve urinary continence after initial closure remain an elusive «holy grail» for bladder exstrophy surgeons. After closure many patients will endure persistent urinary incontinence post exstrophy closure. In this review, we will discuss the conservative strategies and surgical options to facilitate continence in our bladder exstrophy patients. Regardless of surgical approach or initial outcome, all patients with bladder exstrophy require lifelong urologic follow-up.</div></div><div><h3>Methods</h3><div>A comprehensive search of electronic databases (Medline, PubMed, Embase, PsycINFO and CINAHL), and citation tracking platforms (Google Scholar and Web of Science) was performed. Keywords included classic bladder exstrophy, incontinence, behavioral therapy, urotherapy, biofeedback, bulking agents, artificial urinary sphincter, bladder neck reconstruction, bladder neck closure, urinary diversion.</div></div><div><h3>Results</h3><div>Conservative measures such as behavioral therapy, physical therapy and uropsychological counseling should be first line for the treatment of urinary incontinence after exstrophy closure. These interventions along with maturation of the child and bladder growth can improve incontinence without surgery. Patients should be counseled on the limited success of bulking agents and significant risk of erosion with sphincters. Although success after bladder neck reconstruction or bladder neck closure with or without augmentation and catheterizable channel can be variable, these surgical options can be offered to patients that have exhausted conservative treatment strategies.</div></div><div><h3>Conclusions</h3><div>A patient's ability to volitionally void and achieve urinary continence remain an elusive goal for bladder exstrophy surgeons with many experiencing persistent urinary incontinence following exstrophy closure. Behavioral therapy, physical therapy and pyschological support should be provided to all bladder exstrophy patients and families. Giving children time to grow and mature can potentially facilitate continence without surgical intervention. If surgical intervention is pursued lifelong follow-up and monitoring is critical.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 10","pages":"Article 501818"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145623407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Terapia hormonal para el testículo no descendido: resultados de un cuestionario internacional","authors":"R.J.M. Lammers ,&nbsp;L.A.’t Hoen ,&nbsp;F. O’Kelly ,&nbsp;I. Selvi ,&nbsp;Y. Quiroz Madarriaga ,&nbsp;N. Baydilli ,&nbsp;B. Bañuelos Marco ,&nbsp;M.I. Dönmez ,&nbsp;S. Sforza ,&nbsp;E. Bindi ,&nbsp;B. Haid ,&nbsp;en representación del Grupo de Trabajo de Urología Pediátrica de la Sección de Jóvenes Urólogos Académicos (YAU) - Asociación Europea de Urología (EAU)","doi":"10.1016/j.acuro.2025.501820","DOIUrl":"10.1016/j.acuro.2025.501820","url":null,"abstract":"<div><div>The objective of this study was to provide an overview of current practices on hormonal therapy (HT) in children with undescended testes (UDT).</div><div>An online questionnaire about HT, referral patterns, and orchidopexy was spread via several (social media) networks involved in pediatric urology.</div><div>A total of 283 individuals responded, with 54 countries sampled. The majority (84%) did not prescribe HT for UDT, predominantly due to a paucity of scientific evidence (76%). Among those who use HT, main reason was bilateral UDT (62%). There was no clear preference in administration type (50% intramuscular injection, 50% nasal spray). GnRH was slightly more favoured over HCG (50% vs. 32%). No standardized schedule was used. Most respondents (67%) felt all forms of UDT should be treated by either a pediatric urologist or -surgeon. Eighty-seven percent follow the current guidelines and perform orchidopexy between 6-18 months of age.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 10","pages":"Article 501820"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145623408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasonido focalizado de alta intensidad con el dispositivo Focal One para el cáncer de próstata localizado: revisión sistemática de resultados oncológicos, preservación funcional y evolución de la tecnología","authors":"K. Eskandar","doi":"10.1016/j.acuro.2025.501869","DOIUrl":"10.1016/j.acuro.2025.501869","url":null,"abstract":"<div><h3>Introduction</h3><div>Focal therapy offers a middle-ground approach for localized prostate cancer, preserving the prostate while avoiding the morbidity of radical treatment. High-Intensity Focused Ultrasound (HIFU) is the most studied focal modality, with FocalONE representing the most widely adopted modern platform enabling precise image-guided ablation.</div></div><div><h3>Objective</h3><div>To systematically assess the oncologic control, functional outcomes, safety, and technological advancements of focal and hemiablation HIFU with an emphasis on the FocalONE platform.</div></div><div><h3>Methodology</h3><div>This systematic review followed PRISMA guidelines and was registered in PROSPERO. A comprehensive search of PubMed, Embase, and Cochrane databases identified prospective studies using FocalONE or earlier-generation transrectal HIFU devices for focal or hemiablation in localized prostate cancer. Key outcomes included biopsy negativity, salvage-free survival, urinary continence, erectile function, and complications. Study quality was appraised using the JBI tool.</div></div><div><h3>Results</h3><div>Five prospective studies involving 701 patients were included. Biopsy negativity ranged from 84% to 95%, with salvage-free survival reaching up to 92% at mid-term follow-up. Urinary continence was preserved in 96–100% of patients, and erectile function in 74–95%, with the most favorable functional outcomes consistently observed in FocalONE-based cohorts. Most adverse events were minor (grade I–II), with few serious complications. Compared to focal cryotherapy and irreversible electroporation, HIFU showed comparable cancer control and better or similar functional preservation. PSA density and MRI-visible lesions were strong predictors of success.</div></div><div><h3>Conclusions</h3><div>FocalONE-based focal HIFU provides effective cancer control with excellent functional preservation in selected patients. While evidence from earlier-generation devices supports these trends, generalizability across all HIFU platforms remains to be validated. Its precision and safety profile make it a promising alternative between active surveillance and radical therapies, especially in favorable intermediate-risk cases.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 10","pages":"Article 501869"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145623410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparación entre la biopsia prostática dirigida por fusión cognitiva y la biopsia estándar después de resonancia magnética multiparamétrica de próstata (RMmp) y valor diagnóstico de RMmp","authors":"Ö. Faruk Akgün ,&nbsp;A. Altunkol ,&nbsp;E. Alma ,&nbsp;Ü. Uysal ,&nbsp;B. Aksay ,&nbsp;Y.E. Kök","doi":"10.1016/j.acuro.2025.501839","DOIUrl":"10.1016/j.acuro.2025.501839","url":null,"abstract":"<div><h3>Objectives</h3><div>To compare the diagnostic performance of cognitive fusion biopsy and/or standard systematic biopsy performed following multiparametric magnetic resonance imaging (mpMRI) in the detection of prostate cancer (PCa), and to assess the standalone diagnostic value of mpMRI.</div></div><div><h3>Materials and methods</h3><div>Initially, 1153 patients undergoing PBx from 2017 to 2022 were chosen. Patients were divided into three groups: those with standard PBx without mpMRI (1<!--> <!-->st group), those with standard PBx after mpMRI (2<!--> <!-->nd group) and those with standard and cognitive fusion PBx after mpMRI (3<!--> <!-->rd group). The correlations of general PCa and clinically significant PCa (csPCa) detection rates and Prostate Imaging Reporting and Data System version 2.1 (PI-RADS v2.1) scores were evaluated.</div></div><div><h3>Results</h3><div>The overall PCa detection rate was highest in group 2 (47%). Additionally, the malignancy rate in group 3 was significantly higher compared to group 1 (p&lt;<!--> <!-->0.05). Though the csPCa rate was higher in the third group (40%) compared to the other groups, no significant difference was identified. As the PI-RADS score increased, the malignancy rates appeared to increase. The rate of high-risk patients in the group with cognitive fusion biopsy performed (11, 17%) was higher compared to the second group (p&lt;<!--> <!-->0.05).</div></div><div><h3>Conclusions</h3><div>Multiparametric MRI is valuable in prostate cancer diagnosis, particularly for lesion detection and biopsy guidance in patients with high PI-RADS scores. However, in our study, the addition of cognitive fusion biopsy did not significantly increase the detection rate of csPCa. Further prospective randomized studies are needed to clarify its diagnostic value.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 10","pages":"Article 501839"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145623405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resultados del tratamiento quirúrgico de quistes parauretrales grandes","authors":"N. Kulchenko ,&nbsp;G. Demyashkin ,&nbsp;A. Mansur ,&nbsp;A. Strachuk ,&nbsp;E. Korovyakova ,&nbsp;R. Frantsev ,&nbsp;K. Neklyudov ,&nbsp;A. Mirontsev ,&nbsp;V. Rostovskaya ,&nbsp;K. Silakov","doi":"10.1016/j.acuro.2025.501865","DOIUrl":"10.1016/j.acuro.2025.501865","url":null,"abstract":"<div><h3>Introduction</h3><div>Paraurethral cysts are rare in females and are often incidental findings during routine medical examinations. To date, no standardized approach exists for the surgical management of large cysts, which tend to cause the most discomfort to patients.</div></div><div><h3>Objective</h3><div>To evaluate the effectiveness of surgical treatment for large paraurethral cysts through excision and laser vaporization.</div></div><div><h3>Method</h3><div>The study included 49 female patients diagnosed with paraurethral cysts larger than 4<!--> <!-->cm in diameter. The patients were divided into 2 groups: group 1 (n<!--> <!-->=<!--> <!-->26) underwent excision of the paraurethral cyst, and group 2 (n<!--> <!-->=<!--> <!-->23) underwent laser vaporization. All patients were monitored throughout their hospitalization. The parameters assessed included operation time, the number and type of intraoperative complications, the duration of bladder catheterization, and the length of hospital stay.</div></div><div><h3>Results</h3><div>Laser vaporization was, on average, 8.6<!--> <!-->min shorter than excision (p<!--> <!-->&lt;<!--> <!-->0.05), with a strong correlation between the surgical method and operation time (r<!--> <!-->=<!--> <!-->0.70). Intraoperative complications (bleeding, urethral injury, cyst rupture) occurred 2.8 times less frequently in group 2 compared to group 1. The length of hospital stay was 1.3 days shorter following laser vaporization. The correlation between hospital stay duration and surgical method was moderate (r<!--> <!-->=<!--> <!-->0.31).</div></div><div><h3>Conclusions</h3><div>Laser vaporization offers significant advantages for the treatment of large paraurethral cysts, including shorter operation time, fewer intraoperative complications, and a faster recovery period. Therefore, laser vaporization should be considered the treatment of choice for large paraurethral cysts.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 10","pages":"Article 501865"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145623423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Valor de la longitud de biopsia por unidad de volumen en la biopsia prostática","authors":"J. Tang ,&nbsp;T. Wu ,&nbsp;K. Zhang ,&nbsp;Z. Wen","doi":"10.1016/j.acuro.2025.501862","DOIUrl":"10.1016/j.acuro.2025.501862","url":null,"abstract":"<div><h3>Introduction</h3><div>Prostate cancer is a significant global health issue. Prostate biopsy remains the gold standard for diagnosis. However, the impact of biopsy tissue length on diagnostic performance remains controversial. This study investigates the relationship between biopsy tissue length and diagnostic efficacy, introducing a new parameter, “unit volume biopsy length”, to optimize clinical practice.</div></div><div><h3>Methods</h3><div>A retrospective analysis was conducted on the clinical data of 301 patients who underwent prostate biopsy. The biopsy tissue length and unit volume biopsy length were compared between patients with positive and negative results, and their impact on the detection rate of prostate cancer was analyzed to obtain the optimal threshold for unit volume biopsy length.</div></div><div><h3>Results</h3><div>Among the 301 patients, 130 (43.19%) had positive results, while 171 had negative results. The median unit volume biopsy length in the positive group was 0.39<!--> <!-->cm/ml, which was significantly higher than that in the negative group (0.28<!--> <!-->cm/ml; <em>P</em>&lt;.05). When the unit volume biopsy length exceeded 0.39<!--> <!-->cm/ml, the detection rate of prostate cancer significantly increased (OR: 2.879, 95% CI: 1.728-4.796), with positive rates of 58.58% and 32.94% in the groups above and below the threshold, respectively (<em>P</em>&lt;.05).</div></div><div><h3>Conclusion</h3><div>Unit volume biopsy length significantly affects the detection rate of prostate cancer. It is recommended that at least 0.39<!--> <!-->cm of biopsy tissue be obtained per milliliter of prostate tissue to ensure adequate screening.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 10","pages":"Article 501862"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145623409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}