Pub Date : 2024-11-01DOI: 10.1016/j.acuro.2024.05.004
{"title":"Cáncer testicular en Iberoamérica: estrategias para una adecuada prevención y diagnóstico","authors":"","doi":"10.1016/j.acuro.2024.05.004","DOIUrl":"10.1016/j.acuro.2024.05.004","url":null,"abstract":"","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"48 9","pages":"Pages 621-622"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141275831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/j.acuro.2024.05.003
Objective
This descriptive study examines quality of life in women undergoing placement of a midurethral sling for stress urinary incontinence.
Material and methods
This was a retrospective cohort study based on data from 51 women consecutively undergoing this procedure at a tertiary hospital in the years 2014 and 2015. The main outcome variable was quality of life assessed through the Sandvick severity test and International Consultation on Incontinence Short Form quality of life questionnaire (ICIQ-UI-SF) at the time points baseline or presurgery, and 6 months and 5 years postsurgery. Factors associated with treatment failure were determined through binary logistic regression.
Results
At 5-year follow-up we obtained an absolute reduction of 8.78 points (95% CI 6.43-11.14; p < 0.001) in the ICIQ-UI-SF and 4.54 (95% CI 3.25-5.83; p < 0.001) in the Sandvick severity test score, compared to baseline, in the 35 patients that completed follow-up. Out of the 51 patients that were followed, the rate of success in incontinence correction was 86.3% (44/50) with a failure rate of 12% (6/50). Multiparity and previous gynaecological surgery were identified as predisposing factors for treatment failure. Obesity was associated with a worse treatment outcome.
Conclusion
Sling treatment for incontinence was successful in 86.3% (44/50) of participants and remained effective 5 years after surgery in terms of quality of life.
{"title":"Calidad de vida en pacientes intervenidas quirúrgicamente mediante malla transobturadora para la corrección de incontinencia urinaria de esfuerzo","authors":"","doi":"10.1016/j.acuro.2024.05.003","DOIUrl":"10.1016/j.acuro.2024.05.003","url":null,"abstract":"<div><h3>Objective</h3><div>This descriptive study examines quality of life in women undergoing placement of a midurethral sling for stress urinary incontinence.</div></div><div><h3>Material and methods</h3><div>This was a retrospective cohort study based on data from 51 women consecutively undergoing this procedure at a tertiary hospital in the years 2014 and 2015. The main outcome variable was quality of life assessed through the Sandvick severity test and International Consultation on Incontinence Short Form quality of life questionnaire (ICIQ-UI-SF) at the time points baseline or presurgery, and 6 months and 5 years postsurgery. Factors associated with treatment failure were determined through binary logistic regression.</div></div><div><h3>Results</h3><div>At 5-year follow-up we obtained an absolute reduction of 8.78 points (95% CI 6.43-11.14; p<!--> <!--><<!--> <!-->0.001) in the ICIQ-UI-SF and 4.54 (95% CI 3.25-5.83; p<!--> <!--><<!--> <!-->0.001) in the Sandvick severity test score, compared to baseline, in the 35 patients that completed follow-up. Out of the 51 patients that were followed, the rate of success in incontinence correction was 86.3% (44/50) with a failure rate of 12% (6/50). Multiparity and previous gynaecological surgery were identified as predisposing factors for treatment failure. Obesity was associated with a worse treatment outcome.</div></div><div><h3>Conclusion</h3><div>Sling treatment for incontinence was successful in 86.3% (44/50) of participants and remained effective 5 years after surgery in terms of quality of life.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"48 9","pages":"Pages 651-657"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141277507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/j.acuro.2024.04.004
Introduction and objectives
A Consensus document on the management of patients with neurogenic detrusor overactivity (NDO) was published in 2018. The present document aims to update its recommendations regarding treatment considering the new evidence available, and to contribute to the standardization of the management of this disorder.
Methods
The methodology used was based on a systematic review and the Nominal Group Technique. The clinical coordinator (CC) and the Consensus update group (CUG) defined the questions to be updated and carried out a systematic review to identify the new available evidence. After being evaluated by the expert panel, the relevant recommendations were updated and agreed in a consensus meeting.
Results
A total of 3,210 publications were identified and 26 publications that met the inclusion criteria were included. The CUG updated 18 recommendations on the therapeutic approach to NDO. Unanimous consensus was reached on all of them.
Conclusions
Previous recommendations need to be revised due to the availability of new drugs, the increasing evidence on the use of botulinum toxin or neuromodulation procedures, and new surgical options.
{"title":"Actualización del consenso sobre el abordaje terapéutico del paciente con hiperactividad neurógena del detrusor","authors":"","doi":"10.1016/j.acuro.2024.04.004","DOIUrl":"10.1016/j.acuro.2024.04.004","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>A Consensus document on the management of patients with neurogenic detrusor overactivity (NDO) was published in 2018. The present document aims to update its recommendations regarding treatment considering the new evidence available, and to contribute to the standardization of the management of this disorder.</div></div><div><h3>Methods</h3><div>The methodology used was based on a systematic review and the Nominal Group Technique. The clinical coordinator (CC) and the Consensus update group (CUG) defined the questions to be updated and carried out a systematic review to identify the new available evidence. After being evaluated by the expert panel, the relevant recommendations were updated and agreed in a consensus meeting.</div></div><div><h3>Results</h3><div>A total of 3,210 publications were identified and 26 publications that met the inclusion criteria were included. The CUG updated 18 recommendations on the therapeutic approach to NDO. Unanimous consensus was reached on all of them.</div></div><div><h3>Conclusions</h3><div>Previous recommendations need to be revised due to the availability of new drugs, the increasing evidence on the use of botulinum toxin or neuromodulation procedures, and new surgical options.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"48 9","pages":"Pages 674-682"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141028370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/j.acuro.2024.02.007
G. Basile , A. Gallioli , A. Territo , P. Verri , J.M. Gaya , L. Afferi , P. Diana , I. Sanz , L. Dieguez , A. Uleri , C. Berquin , P. Gavrilov , F. Algaba , J. Palou , A. Breda
Objective
To assess complications after ureteroscopy (URS) for upper tract urothelial carcinoma (UTUC) management and to assess its postoperative cumulative morbidity burden using the Comprehensive Complication Index (CCI).
Materials and methods
Single center retrospective study including patients submitted to URS for UTUC suspicion. URSs were both diagnostic and operative. Postoperative complications were recorded according to the EAU Guidelines and graded according to Clavien-Dindo Classification (CDC). The cumulative postoperative morbidity burden developed by patients experiencing multiple events was assessed using the CCI. Multivariable logistic regression (MLR) analyses identified factors independently associated with the development of any grade and major postoperative complications.
Results
Overall, 360 patients with UTUC suspicion were included with a total of 575 URSs performed. The cumulative number of all postoperative complications recorded was 111. In 86 (15%) procedures, patients experienced at least one postoperative complication, while 25 (4.3%) experienced more than one complication. Of these, 16 (14%) were severe (CDC ≥ IIIa). The most frequent type of complications were urinary (34%), bleeding (30%) and infectious (30%). The higher the CDC grade, the higher the median CCI, with a statistically significant increase in median CCI from CDC II to major complications. Patients who experienced intraoperative complications were at higher risk of developing any grade and major postoperative complications at MLR.
Conclusions
Complications after ureteroscopy for UTUC are relatively uncommon events. Patients who experience intraoperative complications are at higher risk of developing postoperative complications. The CCI appeared more representative of the cumulative postoperative morbidity rather than the Clavien-Dindo classification.
目的评估输尿管镜检查（URS）治疗上尿路上皮癌（UTUC）后的并发症，并使用综合并发症指数（CCI）评估其术后累积发病率。URS包括诊断性URS和手术性URS。根据 EAU 指南记录术后并发症，并根据 Clavien-Dindo 分类法（CDC）进行分级。使用 CCI 评估了发生多次并发症的患者的累积术后发病负担。多变量逻辑回归（MLR）分析确定了与术后任何等级和主要并发症的发生独立相关的因素。 结果共纳入了360名疑似UTUC患者，进行了575次URS手术。所有术后并发症的累计记录为 111 例。在86例（15%）手术中，患者至少出现了一种术后并发症，25例（4.3%）出现了一种以上的并发症。其中，16 例（14%）为严重并发症（CDC ≥ IIIa）。最常见的并发症类型是泌尿系统（34%）、出血（30%）和感染（30%）。CDC 等级越高，CCI 中位数越高，从 CDC II 到主要并发症，CCI 中位数有显著的统计学增长。出现术中并发症的患者在MLR时出现任何级别和主要术后并发症的风险更高。术中出现并发症的患者术后出现并发症的风险更高。CCI似乎比Clavien-Dindo分类更能代表术后累积发病率。
{"title":"Morbilidad acumulada tras la ureteroscopia para el carcinoma urotelial del tracto superior","authors":"G. Basile , A. Gallioli , A. Territo , P. Verri , J.M. Gaya , L. Afferi , P. Diana , I. Sanz , L. Dieguez , A. Uleri , C. Berquin , P. Gavrilov , F. Algaba , J. Palou , A. Breda","doi":"10.1016/j.acuro.2024.02.007","DOIUrl":"10.1016/j.acuro.2024.02.007","url":null,"abstract":"<div><h3>Objective</h3><div>To assess complications after ureteroscopy (URS) for upper tract urothelial carcinoma (UTUC) management and to assess its postoperative cumulative morbidity burden using the Comprehensive Complication Index (CCI).</div></div><div><h3>Materials and methods</h3><div>Single center retrospective study including patients submitted to URS for UTUC suspicion. URSs were both diagnostic and operative. Postoperative complications were recorded according to the EAU Guidelines and graded according to Clavien-Dindo Classification (CDC). The cumulative postoperative morbidity burden developed by patients experiencing multiple events was assessed using the CCI. Multivariable logistic regression (MLR) analyses identified factors independently associated with the development of any grade and major postoperative complications.</div></div><div><h3>Results</h3><div>Overall, 360 patients with UTUC suspicion were included with a total of 575 URSs performed. The cumulative number of all postoperative complications recorded was 111. In 86 (15%) procedures, patients experienced at least one postoperative complication, while 25 (4.3%) experienced more than one complication. Of these, 16 (14%) were severe (CDC<!--> <!-->≥<!--> <!-->IIIa). The most frequent type of complications were urinary (34%), bleeding (30%) and infectious (30%). The higher the CDC grade, the higher the median CCI, with a statistically significant increase in median CCI from CDC II to major complications. Patients who experienced intraoperative complications were at higher risk of developing any grade and major postoperative complications at MLR.</div></div><div><h3>Conclusions</h3><div>Complications after ureteroscopy for UTUC are relatively uncommon events. Patients who experience intraoperative complications are at higher risk of developing postoperative complications. The CCI appeared more representative of the cumulative postoperative morbidity rather than the Clavien-Dindo classification.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"48 9","pages":"Pages 665-673"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142573476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/j.acuro.2024.01.012
Introduction
The microbiota is defined as the microorganisms in a particular environment. Conversely, the term microbiome is less firmly defined and is used to reference the habitat.
Objective
To identify the association between the microbiome and the penile cancer.
Evidence Acquisition
We performed this scoping review according to the recommendations of the Joanna Briggs Institute. We found five articles that fulfilled the inclusion criteria. We focused on oncogenesis and factors that alter the penile microbiome. We were not limited to language or setting. We searched MEDLINE (Ovid), Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and LILACS from inception to the present day.
Evidence Synthesis
We found nine studies describing multiple factors that could disturb the microbiome, such as sexual behavior, anatomic alterations including circumcision, and inflammatory factors: lichen sclerosus, poor genital hygiene, compromised immune system, smoking, and HPV infection.
Conclusion
Overall, knowledge of the composition of the penile microbiota and its role in penile cancer oncogenesis is minimal.
Patient Summary
Future studies should focus on the relationship between the microbiome and penile cancer to broaden this field of knowledge.
引言微生物群被定义为特定环境中的微生物。证据获取我们根据乔安娜-布里格斯研究所（Joanna Briggs Institute）的建议进行了此次范围界定综述。我们找到了五篇符合纳入标准的文章。我们的研究重点是阴茎癌的发病机制和改变阴茎微生物组的因素。我们不受语言或环境的限制。我们检索了 MEDLINE (Ovid)、Embase、Cochrane Central Register of Controlled Trials (CENTRAL) 和 LILACS（从开始到现在）。证据综述我们发现九项研究描述了可能干扰微生物组的多种因素，如性行为、包括包皮环切术在内的解剖学改变和炎症因素：硬皮病、生殖器卫生不良、免疫系统受损、吸烟和 HPV 感染。患者小结未来的研究应关注微生物组与阴茎癌之间的关系，以拓宽这一知识领域。
{"title":"¿Cuál es la relación entre el cáncer de pene y el microbioma? Una revisión exploratoria","authors":"","doi":"10.1016/j.acuro.2024.01.012","DOIUrl":"10.1016/j.acuro.2024.01.012","url":null,"abstract":"<div><h3>Introduction</h3><div>The microbiota is defined as the microorganisms in a particular environment. Conversely, the term microbiome is less firmly defined and is used to reference the habitat.</div></div><div><h3>Objective</h3><div>To identify the association between the microbiome and the penile cancer.</div></div><div><h3>Evidence Acquisition</h3><div>We performed this scoping review according to the recommendations of the Joanna Briggs Institute. We found five articles that fulfilled the inclusion criteria. We focused on oncogenesis and factors that alter the penile microbiome. We were not limited to language or setting. We searched MEDLINE (Ovid), Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and LILACS from inception to the present day.</div></div><div><h3>Evidence Synthesis</h3><div>We found nine studies describing multiple factors that could disturb the microbiome, such as sexual behavior, anatomic alterations including circumcision, and inflammatory factors: lichen sclerosus, poor genital hygiene, compromised immune system, smoking, and HPV infection.</div></div><div><h3>Conclusion</h3><div>Overall, knowledge of the composition of the penile microbiota and its role in penile cancer oncogenesis is minimal.</div></div><div><h3>Patient Summary</h3><div>Future studies should focus on the relationship between the microbiome and penile cancer to broaden this field of knowledge.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"48 9","pages":"Pages 632-641"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139965865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/j.acuro.2024.05.006
C. Romojaro-Pérez , B. Navarro-Brazález , J. Bailón-Cerezo , M. Torres-Lacomba
Introduction
Prostate cancer is the tumor with the highest incidence in Spanish men. The implementation of health literacy and therapeutic education programs adapted to the needs of the population could be a resource to minimize the sequelae derived from the treatments used to combat this pathology. To this end, it would be necessary to know the level of health literacy about prostate cancer.
Objective
To determine the level of health literacy in prostate cancer in the Spanish male population using the validated version of the PCKQ-12 for the Spanish population.
Methodology
Cross-sectional, population-based, descriptive study. Spanish-speaking men of legal age were included. To carry out the study, an ad hoc questionnaire was designed on the Google Forms platform, which was distributed via WhatsApp. Previously, it was necessary to validate the PCKQ-12 to the Spanish population in 2 phases, a first phase for translation and cross-cultural adaptation and a second phase to test the measurement properties.
Results
The Spanish version of the PCKQ-12 showed good language, conceptual, semantic and content equivalence and could be used to assess health literacy in prostate cancer. Three hundred and seventy Spanish men with a mean age of 43.87 (SD 13.65) years responded to the questionnaire. The level of prostate cancer health literacy found was low (6.72 points), being 2 points higher in health men.
Conclusion
Health literacy about prostate cancer in the Spanish male population is low.
{"title":"Alfabetización en salud en cáncer de próstata: ¿qué saben los varones españoles sobre el cáncer de próstata? Estudio descriptivo transversal","authors":"C. Romojaro-Pérez , B. Navarro-Brazález , J. Bailón-Cerezo , M. Torres-Lacomba","doi":"10.1016/j.acuro.2024.05.006","DOIUrl":"10.1016/j.acuro.2024.05.006","url":null,"abstract":"<div><h3>Introduction</h3><div>Prostate cancer is the tumor with the highest incidence in Spanish men. The implementation of health literacy and therapeutic education programs adapted to the needs of the population could be a resource to minimize the sequelae derived from the treatments used to combat this pathology. To this end, it would be necessary to know the level of health literacy about prostate cancer<strong>.</strong></div></div><div><h3>Objective</h3><div>To determine the level of health literacy in prostate cancer in the Spanish male population using the validated version of the PCKQ-12 for the Spanish population<strong>.</strong></div></div><div><h3>Methodology</h3><div>Cross-sectional, population-based, descriptive study. Spanish-speaking men of legal age were included. To carry out the study, an ad hoc questionnaire was designed on the Google Forms platform, which was distributed via WhatsApp. Previously, it was necessary to validate the PCKQ-12 to the Spanish population in 2<!--> <!-->phases, a first phase for translation and cross-cultural adaptation and a second phase to test the measurement properties.</div></div><div><h3>Results</h3><div>The Spanish version of the PCKQ-12 showed good language, conceptual, semantic and content equivalence and could be used to assess health literacy in prostate cancer. Three hundred and seventy Spanish men with a mean age of 43.87 (SD 13.65) years responded to the questionnaire. The level of prostate cancer health literacy found was low (6.72 points), being 2 points higher in health men<strong>.</strong></div></div><div><h3>Conclusion</h3><div>Health literacy about prostate cancer in the Spanish male population is low<strong>.</strong></div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"48 9","pages":"Pages 642-650"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142573475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/j.acuro.2024.05.005
Introduction and objectives
Long-term use of an indwelling catheter is associated with complications such as catheter encrustation and infection. Canoxidin® is a novel oral treatment that can potentially prevent catheter encrustation, as it contains a urine acidifier and a combination of two crystallization inhibitors. This study aimed to evaluate the effects of Canoxidin® on catheter encrustation in patients with indwelling Foley catheters.
Patients and methods
This was a single-center, double-blind, randomized, placebo-controlled study. Neuro-urology patients aged ≥ 18 years with an indwelling catheter (urethral or suprapubic) were randomized to treatment consisting of either Canoxidin® or placebo for one month. Foley catheters (two per patient, one before treatment and one after treatment) were removed for analysis of the presence and degree of encrustation.
Results
A total of 40 patients were enrolled and randomized, 28 of whom had analyzable catheters (13 assigned to Canoxidin® and 15 assigned to placebo). The patients had a mean age of 51.8 years, and eight (28.6%) were female. Two patients (13.3%) in the placebo group and eight patients (61.5%) in the Canoxidin® group experienced an improvement (less encrustation). There was a significant association between Canoxidin® and improvement (odds ratio: 10.4, 95% confidence interval: 1.6 to 66.9, P = .016). No adverse effects attributable to the treatment were reported.
Conclusions
The overall rate of catheter encrustation was high among those with indwelling Foley catheters. One-month treatment with Canoxidin® reduced the formation of these encrustations, with an excellent short-term safety profile.
{"title":"Estudio piloto unicéntrico, doble ciego, aleatorizado y controlado con placebo para evaluar el uso de Canoxidin® en la prevención de la incrustación de la sonda en pacientes portadores de sonda permanente","authors":"","doi":"10.1016/j.acuro.2024.05.005","DOIUrl":"10.1016/j.acuro.2024.05.005","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Long-term use of an indwelling catheter is associated with complications such as catheter encrustation and infection. Canoxidin® is a novel oral treatment that can potentially prevent catheter encrustation, as it contains a urine acidifier and a combination of two crystallization inhibitors. This study aimed to evaluate the effects of Canoxidin® on catheter encrustation in patients with indwelling Foley catheters.</div></div><div><h3>Patients and methods</h3><div>This was a single-center, double-blind, randomized, placebo-controlled study. Neuro-urology patients aged ≥<!--> <!-->18<!--> <!-->years with an indwelling catheter (urethral or suprapubic) were randomized to treatment consisting of either Canoxidin® or placebo for one month. Foley catheters (two per patient, one before treatment and one after treatment) were removed for analysis of the presence and degree of encrustation.</div></div><div><h3>Results</h3><div>A total of 40 patients were enrolled and randomized, 28 of whom had analyzable catheters (13 assigned to Canoxidin® and 15 assigned to placebo). The patients had a mean age of 51.8<!--> <!-->years, and eight (28.6%) were female. Two patients (13.3%) in the placebo group and eight patients (61.5%) in the Canoxidin® group experienced an improvement (less encrustation). There was a significant association between Canoxidin® and improvement (odds ratio: 10.4, 95% confidence interval: 1.6 to 66.9, <em>P</em> <!-->=<!--> <!-->.016). No adverse effects attributable to the treatment were reported.</div></div><div><h3>Conclusions</h3><div>The overall rate of catheter encrustation was high among those with indwelling Foley catheters. One-month treatment with Canoxidin® reduced the formation of these encrustations, with an excellent short-term safety profile.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"48 9","pages":"Pages 658-664"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141395792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/j.acuro.2024.03.002
The standard treatment for metastatic hormone-sensitive prostate cancer (mHSPC) is now a combination of androgen deprivation therapy plus an androgen receptor-targeted therapy (abiraterone, apalutamide, enzalutamide or darolutamide), with or without chemotherapy (docetaxel). The selection of suitable patients for each therapeutic approach has become a determining factor to ensure efficacy and minimize side effects. This article combines recent clinical evidence with the accumulated experience of experts in medical oncology, radiation oncology and urology, to provide a comprehensive view and therapeutic recommendations for mHSPC.
{"title":"Recomendaciones de tratamiento en el cáncer de próstata hormonosensible metastásico: selección de pacientes","authors":"","doi":"10.1016/j.acuro.2024.03.002","DOIUrl":"10.1016/j.acuro.2024.03.002","url":null,"abstract":"<div><div>The standard treatment for metastatic hormone-sensitive prostate cancer (mHSPC) is now a combination of androgen deprivation therapy plus an androgen receptor-targeted therapy (abiraterone, apalutamide, enzalutamide or darolutamide), with or without chemotherapy (docetaxel). The selection of suitable patients for each therapeutic approach has become a determining factor to ensure efficacy and minimize side effects. This article combines recent clinical evidence with the accumulated experience of experts in medical oncology, radiation oncology and urology, to provide a comprehensive view and therapeutic recommendations for mHSPC.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"48 9","pages":"Pages 623-631"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140776855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/j.acuro.2024.04.003
{"title":"Cornada envainada: la paradoja de un trauma contuso-penetrante. Caso clínico","authors":"","doi":"10.1016/j.acuro.2024.04.003","DOIUrl":"10.1016/j.acuro.2024.04.003","url":null,"abstract":"","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"48 9","pages":"Pages 683-684"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141032209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-01DOI: 10.1016/j.acuro.2024.03.005
Objective
To analyze the predictive capacity of the nephrolithometry scoring systems (GSS, STONE, CROES and S-ReSC) and stone surface regarding success and complications following percutaneous nephrolithotomy (PCNL).
Methods
We studied 392 patients who had undergone PCNL in our center. Only patients with a non-contrast CT (n = 240) were finally included for analysis. The predictive capacities for success and complications of the different scoring systems were evaluated using ROC curves and their area under the curve (AUC).
Results
Regarding success, the S-ReSC system had the highest predictive capacity with an AUC of 0.681 (95% CI 0.610 - 0.751), followed by the CROES with 0.667 (95% CI 0.595 - 0.738), the STONE with 0.654 (95% CI 0.579 - 0.728) and finally the GSS with 0.626 (95% CI 0.555 - 0.698). The stone surface as a single variable had an AUC of 0.641 (95% CI 0.565 - 0.718). As for complications, the S-ReSC had the highest AUC with 0.664 (95% CI 0.57 - 0.758), followed by STONE with 0.663 (95% CI 0.572 - 0.755), GSS with 0.626 (95% CI 0.555). - 0.698) and CROES with 0.614 (95% CI 0.518 - 0.7). The stone surface alone had an AUC of 0.616 (95% CI 0.522 - 0.715).
Conclusion
The nephrolithometry scales analyzed show a moderate predictive capacity for success and complications in patients undergoing PCNL in our center. Moreover, stone surface as an independent variable demonstrates moderate predictive capacity for both outcomes.
目的 分析肾石测量评分系统（GSS、STONE、CROES 和 S-ReSC）和结石表面对经皮肾镜取石术（PCNL）的成功率和并发症的预测能力。我们对本中心接受 PCNL 的 392 例患者进行了研究，最终只分析了接受非对比 CT 检查的患者（240 例）。结果在成功率方面，S-ReSC 系统的预测能力最高，其 AUC 为 0.681（95% CI 0.610 - 0.751），其次是 CROES，为 0.667（95% CI 0.595 - 0.738），再次是 STONE，为 0.654（95% CI 0.579 - 0.728），最后是 GSS，为 0.626（95% CI 0.555 - 0.698）。结石表面作为单一变量的 AUC 为 0.641（95% CI 0.565 - 0.718）。在并发症方面，S-ReSC 的 AUC 最高，为 0.664 (95% CI 0.57 - 0.758)，其次是 STONE，为 0.663 (95% CI 0.572 - 0.755)，GSS 为 0.626 (95% CI 0.555).- 0.698），CROES 为 0.614（95% CI 0.518 - 0.7）。结石表面的 AUC 为 0.616 (95% CI 0.522 - 0.715)。此外，结石表面作为一个独立变量，对这两种结果的预测能力适中。
{"title":"¿Depende el éxito en nefrolitotomía percutánea solo del tamaño litiásico? Análisis de la capacidad predictiva de éxito y complicaciones de los actuales sistemas de puntuación de nefrolitometría y su relación con la superficie litiásica","authors":"","doi":"10.1016/j.acuro.2024.03.005","DOIUrl":"10.1016/j.acuro.2024.03.005","url":null,"abstract":"<div><h3>Objective</h3><div>To analyze the predictive capacity of the nephrolithometry scoring systems (GSS, STONE, CROES and S-ReSC) and stone surface regarding success and complications following percutaneous nephrolithotomy (PCNL).</div></div><div><h3>Methods</h3><div>We studied 392 patients who had undergone PCNL in our center. Only patients with a non-contrast CT (n<!--> <!-->=<!--> <!-->240) were finally included for analysis. The predictive capacities for success and complications of the different scoring systems were evaluated using ROC curves and their area under the curve (AUC).</div></div><div><h3>Results</h3><div>Regarding success, the S-ReSC system had the highest predictive capacity with an AUC of 0.681 (95% CI 0.610 - 0.751), followed by the CROES with 0.667 (95% CI 0.595 - 0.738), the STONE with 0.654 (95% CI 0.579 - 0.728) and finally the GSS with 0.626 (95% CI 0.555 - 0.698). The stone surface as a single variable had an AUC of 0.641 (95% CI 0.565 - 0.718). As for complications, the S-ReSC had the highest AUC with 0.664 (95% CI 0.57 - 0.758), followed by STONE with 0.663 (95% CI 0.572 - 0.755), GSS with 0.626 (95% CI 0.555). - 0.698) and CROES with 0.614 (95% CI 0.518 - 0.7). The stone surface alone had an AUC of 0.616 (95% CI 0.522 - 0.715).</div></div><div><h3>Conclusion</h3><div>The nephrolithometry scales analyzed show a moderate predictive capacity for success and complications in patients undergoing PCNL in our center. Moreover, stone surface as an independent variable demonstrates moderate predictive capacity for both outcomes.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"48 8","pages":"Pages 603-610"},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140791705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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