B. Krishnan, Rathi Muthaiyan Ahalliya, Nirmaladevi N, Narayanasamy Kandasamay, S. Nehru, Ashly George, Vinuchakravarthi Subaramanian
Medicinal plant research includes much more than the discovery of new drugs. This field has been expanded to also include diverse subjects as negotiation of power based on medicinal plant knowledge (Garro,1986). Plants generally contain both primary metabolites as well as secondary metabolites. The different phytoconstituents present in plants include anthraglycosides, arbutin, bitter drugs, flavonoids, alkaloids, saponins, coumarins, phenol carboxylic acids, terpenes and valepotriates. These phytoconstituents confer specific characteristics and properties of plants. Therefore, the analysis of these constituents would help in determining various biological activities of plants. Natural products, either as pure compounds or as standardized plant extracts, provide unlimited opportunities for new drug (Parekh and Chanda, 2007). It is one of the most widely used methods to identify the chemical constituents and elucidate the structural compounds and has been used as a requisite method to identify medicines in pharmacopoeia of many countries. However, some adulterants come out in the medicinal market along with the high value medicinal materials. At present, the chromatography is the main tool used to identify the adulterants from the medicinal materials and extract products based on the chemical profile. It is well known that the medicinal materials comprise hundreds of components, and produce their curative effects through mutual effects of many ingredients, so the limited numbers of specific components cannot availably reflect the real qualities of the herbal Phytochemical investigations of Tribulus terrestris and Solanum torvum by FT-IR analysis
{"title":"Phytochemical investigations of Tribulus terrestris and Solanum torvum by FT-IR analysis","authors":"B. Krishnan, Rathi Muthaiyan Ahalliya, Nirmaladevi N, Narayanasamy Kandasamay, S. Nehru, Ashly George, Vinuchakravarthi Subaramanian","doi":"10.31024/apj.2019.4.3.4","DOIUrl":"https://doi.org/10.31024/apj.2019.4.3.4","url":null,"abstract":"Medicinal plant research includes much more than the discovery of new drugs. This field has been expanded to also include diverse subjects as negotiation of power based on medicinal plant knowledge (Garro,1986). Plants generally contain both primary metabolites as well as secondary metabolites. The different phytoconstituents present in plants include anthraglycosides, arbutin, bitter drugs, flavonoids, alkaloids, saponins, coumarins, phenol carboxylic acids, terpenes and valepotriates. These phytoconstituents confer specific characteristics and properties of plants. Therefore, the analysis of these constituents would help in determining various biological activities of plants. Natural products, either as pure compounds or as standardized plant extracts, provide unlimited opportunities for new drug (Parekh and Chanda, 2007). It is one of the most widely used methods to identify the chemical constituents and elucidate the structural compounds and has been used as a requisite method to identify medicines in pharmacopoeia of many countries. However, some adulterants come out in the medicinal market along with the high value medicinal materials. At present, the chromatography is the main tool used to identify the adulterants from the medicinal materials and extract products based on the chemical profile. It is well known that the medicinal materials comprise hundreds of components, and produce their curative effects through mutual effects of many ingredients, so the limited numbers of specific components cannot availably reflect the real qualities of the herbal Phytochemical investigations of Tribulus terrestris and Solanum torvum by FT-IR analysis","PeriodicalId":7190,"journal":{"name":"Advance Pharmaceutical Journal","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73325927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
It is well known that the main goal of drug delivery is effective and safe delivery of a drug to its target tissues, organs and cells. However, transport of a drug to its specific targets represents one of the major challenges for an effective drug delivery (Mainardesand Silva, 2004). Conventional enteral or parenteral drug delivery methods of systemic drug administration include the formulation of a drug into suitable dosage forms for oral/gastrointestinal administration (e. g. tablets, capsules, solutions, suspensions, syrups, etc.) or sterile drug preparations (solutions, suspensions, emulsions, or reconstituted lyophilized powders) suitable for administration by injection (intravenous, epidural, intramuscular, subcutaneous, etc.) (Robinson and Mauger, 1991). Nevertheless, these systemic drug delivery methods are associated with several limitations such as relatively low site specific bioavailability of administered drugs, unfavorable distribution of drugs throughout the body and, in most cases, low accumulation in the target site, adverse side effects, etc. (Bardal et al., 2011). Besides, these drug delivery systems can't fulfill the ever-growing need of the modern medicine such as personalized medicine and targeted therapies. Therefore, there was an urgent need to develop novel drug delivery systems for localized and targeted delivery of therapeutics. Over the decades, researchers have extensively studied development of carrier-based drug delivery systems with truly targeted features towards specific disease as well as to prevent drug degradation, resistance, drug side effects and also improve the potential of individualized medicine. Various surface markers and cytokines such as integrins, folate, growth factors etc., which are known to express on disease cells and their microenvironments, were explored for developing counter marker functionalized drug carrier to recognize the target disease cells. Carrier-based targeted and localized drug delivery systems, e.g. supramolecular gels (Oneto et al., 2016), nanocarriers such as different types of nanoparticles (Garbuzenko et al., 2014; Chen et al., 2010), liposomes (Zhang et al., 2012; Saad et al., 2008), Nano drug delivery systems: Targeted and site specific tool for therapeutic management
众所周知，药物传递的主要目标是有效和安全地将药物传递到其靶组织、器官和细胞。然而，将药物运送到其特定靶点是有效给药的主要挑战之一(Mainardesand Silva, 2004)。传统的全身给药的肠内或肠外给药方法包括将药物配制成适合口服/胃肠道给药的剂量形式(如片剂、胶囊、溶液、悬浮液、糖浆等)或适合注射给药的无菌药物制剂(溶液、悬浮液、乳剂或重组冻干粉剂)(静脉注射、硬膜外、肌肉注射、皮下注射等)(Robinson和Mauger, 1991)。然而，这些全身给药方法有一些局限性，如给药部位特异性生物利用度相对较低，药物在全身的分布不利，在大多数情况下，靶部位的蓄积低，不良副作用等(Bardal et al.， 2011)。此外，这些给药系统不能满足个性化医疗和靶向治疗等现代医学日益增长的需求。因此，迫切需要开发新的药物递送系统，用于局部和靶向递送治疗。几十年来，研究人员广泛研究了基于载体的药物输送系统的发展，这些系统具有针对特定疾病的真正靶向特征，以及防止药物降解，耐药性，药物副作用，并提高个体化医疗的潜力。探索已知在疾病细胞及其微环境上表达的各种表面标记物和细胞因子，如整合素、叶酸、生长因子等，开发反标记功能化药物载体，以识别目标疾病细胞。基于载体的靶向和局部药物递送系统，如超分子凝胶(Oneto等人，2016)，纳米载体，如不同类型的纳米颗粒(Garbuzenko等人，2014;Chen et al.， 2010)，脂质体(Zhang et al.， 2012;Saad et al.， 2008)，纳米药物输送系统:治疗管理的靶向和特定部位工具
{"title":"Nano drug delivery systems: Targeted and site specific tool for therapeutic management","authors":"A. Garg, V. Tiwari","doi":"10.31024/apj.2019.4.3.2","DOIUrl":"https://doi.org/10.31024/apj.2019.4.3.2","url":null,"abstract":"It is well known that the main goal of drug delivery is effective and safe delivery of a drug to its target tissues, organs and cells. However, transport of a drug to its specific targets represents one of the major challenges for an effective drug delivery (Mainardesand Silva, 2004). Conventional enteral or parenteral drug delivery methods of systemic drug administration include the formulation of a drug into suitable dosage forms for oral/gastrointestinal administration (e. g. tablets, capsules, solutions, suspensions, syrups, etc.) or sterile drug preparations (solutions, suspensions, emulsions, or reconstituted lyophilized powders) suitable for administration by injection (intravenous, epidural, intramuscular, subcutaneous, etc.) (Robinson and Mauger, 1991). Nevertheless, these systemic drug delivery methods are associated with several limitations such as relatively low site specific bioavailability of administered drugs, unfavorable distribution of drugs throughout the body and, in most cases, low accumulation in the target site, adverse side effects, etc. (Bardal et al., 2011). Besides, these drug delivery systems can't fulfill the ever-growing need of the modern medicine such as personalized medicine and targeted therapies. Therefore, there was an urgent need to develop novel drug delivery systems for localized and targeted delivery of therapeutics. Over the decades, researchers have extensively studied development of carrier-based drug delivery systems with truly targeted features towards specific disease as well as to prevent drug degradation, resistance, drug side effects and also improve the potential of individualized medicine. Various surface markers and cytokines such as integrins, folate, growth factors etc., which are known to express on disease cells and their microenvironments, were explored for developing counter marker functionalized drug carrier to recognize the target disease cells. Carrier-based targeted and localized drug delivery systems, e.g. supramolecular gels (Oneto et al., 2016), nanocarriers such as different types of nanoparticles (Garbuzenko et al., 2014; Chen et al., 2010), liposomes (Zhang et al., 2012; Saad et al., 2008), Nano drug delivery systems: Targeted and site specific tool for therapeutic management","PeriodicalId":7190,"journal":{"name":"Advance Pharmaceutical Journal","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88989034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"In-vivo anticancer activity of Curcumin-Hyaluronic acid conjugate","authors":"M. P. Mudagal, S. Janadri, N. Taj","doi":"10.31024/apj.2019.4.3.3","DOIUrl":"https://doi.org/10.31024/apj.2019.4.3.3","url":null,"abstract":"","PeriodicalId":7190,"journal":{"name":"Advance Pharmaceutical Journal","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88533003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A brief review on pharmacological and phytochemical studies of Capparis decidua","authors":"R. Dahiya, J. Vaghela, R. Singh","doi":"10.31024/apj.2019.4.6.1","DOIUrl":"https://doi.org/10.31024/apj.2019.4.6.1","url":null,"abstract":"","PeriodicalId":7190,"journal":{"name":"Advance Pharmaceutical Journal","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73024788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Antioxidant potential of Solanum torvum (L.) seed extract using in-vitro models","authors":"K. Baskaran, N. Nirmaladevi, M. Rathi","doi":"10.31024/apj.2019.4.1.3","DOIUrl":"https://doi.org/10.31024/apj.2019.4.1.3","url":null,"abstract":"","PeriodicalId":7190,"journal":{"name":"Advance Pharmaceutical Journal","volume":" 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91415935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. D. Baviskar, Tanvir Y. Shaikh, K. Patil, Rahul Baviskar, S. Lodhi
{"title":"Role of hyaluronic acid based hydrogel in management of wound healing effect","authors":"K. D. Baviskar, Tanvir Y. Shaikh, K. Patil, Rahul Baviskar, S. Lodhi","doi":"10.31024/apj.2019.4.6.3","DOIUrl":"https://doi.org/10.31024/apj.2019.4.6.3","url":null,"abstract":"","PeriodicalId":7190,"journal":{"name":"Advance Pharmaceutical Journal","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73592541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparative investigation on anthelmintic activities of Azadirachta indica and Areca catechu leaves","authors":"P. Vikram, S. Mishra, R. Vishwakarma, A. Shukla","doi":"10.31024/apj.2019.4.5.3","DOIUrl":"https://doi.org/10.31024/apj.2019.4.5.3","url":null,"abstract":"","PeriodicalId":7190,"journal":{"name":"Advance Pharmaceutical Journal","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78987634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Preliminary phytochemical study and antibacterial activity of Tamarindus indica leaves","authors":"P. Vikram, S. Mishra, R. Vishwakarma, A. Shukla","doi":"10.31024/apj.2019.4.5.2","DOIUrl":"https://doi.org/10.31024/apj.2019.4.5.2","url":null,"abstract":"","PeriodicalId":7190,"journal":{"name":"Advance Pharmaceutical Journal","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81202255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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