In this paper, we replace the standard numerical approach of estimating parameters in a mathematical model using numerical solvers for differential equations with a physics-informed neural network (PINN). This neural network requires a sequence of time instances as direct input of the network and the numbers of susceptibles, vaccinated, infected, hospitalized, and recovered individuals per time instance to learn certain parameters of the underlying model, which are used for the loss calculations. The established model is an extended susceptible-infected-recovered (SIR) model in which the transitions between disease-related population groups, called compartments, and the physical laws of epidemic transmission dynamics are expressed by a system of ordinary differential equations (ODEs). The system of ODEs and its time derivative are included in the residual loss function of the PINN in addition to the data error between the current network output and the time series data of the compartment sizes. Further, we illustrate how this PINN approach can also be used for differential equation-based models such as the proposed extended SIR model, called SVIHR model. In a validation process, we compare the performance of the PINN with results obtained with the numerical technique of non-standard finite differences (NSFD) in generating future COVID-19 scenarios based on the parameters identified by the PINN. The used training data set covers the time between the outbreak of the pandemic in Germany and the last week of the year 2021. We obtain a two-step or hybrid approach, as the PINN is then used to generate a future COVID-19 outbreak scenario describing a possibly next pandemic wave. The week at which the prediction starts is chosen in mid-April 2022.
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