Pub Date : 2019-01-01DOI: 10.1016/BS.ANT.2018.10.006
C. M. Mitchell, Omar El Jordi, B. Yamamoto
{"title":"Inflammatory mechanisms of abused drugs","authors":"C. M. Mitchell, Omar El Jordi, B. Yamamoto","doi":"10.1016/BS.ANT.2018.10.006","DOIUrl":"https://doi.org/10.1016/BS.ANT.2018.10.006","url":null,"abstract":"","PeriodicalId":72100,"journal":{"name":"Advances in neurotoxicology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/BS.ANT.2018.10.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54049252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.1016/BS.ANT.2018.10.008
A. D’Angiulli
{"title":"The role of neuroinflammation in developmental neurotoxicity, tackling complexity in children's exposures and outcomes","authors":"A. D’Angiulli","doi":"10.1016/BS.ANT.2018.10.008","DOIUrl":"https://doi.org/10.1016/BS.ANT.2018.10.008","url":null,"abstract":"","PeriodicalId":72100,"journal":{"name":"Advances in neurotoxicology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/BS.ANT.2018.10.008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54049398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.1016/BS.ANT.2018.10.001
N. Filipov
{"title":"Overview of peripheral and central inflammatory responses and their contribution to neurotoxicity","authors":"N. Filipov","doi":"10.1016/BS.ANT.2018.10.001","DOIUrl":"https://doi.org/10.1016/BS.ANT.2018.10.001","url":null,"abstract":"","PeriodicalId":72100,"journal":{"name":"Advances in neurotoxicology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/BS.ANT.2018.10.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54048703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.1016/BS.ANT.2018.10.002
G. Harry, G. Childers, C. McPherson
{"title":"An introduction to innate immunity in the central nervous system","authors":"G. Harry, G. Childers, C. McPherson","doi":"10.1016/BS.ANT.2018.10.002","DOIUrl":"https://doi.org/10.1016/BS.ANT.2018.10.002","url":null,"abstract":"","PeriodicalId":72100,"journal":{"name":"Advances in neurotoxicology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/BS.ANT.2018.10.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54048724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.1016/BS.ANT.2018.10.010
T. Young, K. Zychowski, J. L. Denson, M. Campen
{"title":"Blood-brain barrier at the interface of air pollution-associated neurotoxicity and neuroinflammation","authors":"T. Young, K. Zychowski, J. L. Denson, M. Campen","doi":"10.1016/BS.ANT.2018.10.010","DOIUrl":"https://doi.org/10.1016/BS.ANT.2018.10.010","url":null,"abstract":"","PeriodicalId":72100,"journal":{"name":"Advances in neurotoxicology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/BS.ANT.2018.10.010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54049038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.1016/BS.ANT.2018.10.009
C. Guerri, M. Pascual
{"title":"Role of neuroinflammation in ethanol neurotoxicity","authors":"C. Guerri, M. Pascual","doi":"10.1016/BS.ANT.2018.10.009","DOIUrl":"https://doi.org/10.1016/BS.ANT.2018.10.009","url":null,"abstract":"","PeriodicalId":72100,"journal":{"name":"Advances in neurotoxicology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/BS.ANT.2018.10.009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54049015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01Epub Date: 2018-05-24DOI: 10.1016/bs.ant.2018.03.005
Cláudia S Oliveira, Pablo A Nogara, Daniel M P Ardisson-Araújo, Michael Aschner, João B T Rocha, José G Dórea
The toxicology of mercury (Hg) is of concern since this metal is ubiquitously distributed in the environment, and living organisms are routinely exposed to Hg at low to high levels. The toxic effects of Hg are well studied and it is known that they may differ depending on the Hg chemical species. In this chapter, we emphasize the neurotoxic effects of Hg during brain development. The immature brain is more susceptible to Hg exposure, since all the Hg chemical forms, not only the organic ones, can harm it. The possible consequences of Hg exposure during the early stages of development, the additive effects with other co-occurring neurotoxicants, and the known mechanisms of action and targets will be addressed in this chapter.
{"title":"Neurodevelopmental Effects of Mercury.","authors":"Cláudia S Oliveira, Pablo A Nogara, Daniel M P Ardisson-Araújo, Michael Aschner, João B T Rocha, José G Dórea","doi":"10.1016/bs.ant.2018.03.005","DOIUrl":"10.1016/bs.ant.2018.03.005","url":null,"abstract":"<p><p>The toxicology of mercury (Hg) is of concern since this metal is ubiquitously distributed in the environment, and living organisms are routinely exposed to Hg at low to high levels. The toxic effects of Hg are well studied and it is known that they may differ depending on the Hg chemical species. In this chapter, we emphasize the neurotoxic effects of Hg during brain development. The immature brain is more susceptible to Hg exposure, since all the Hg chemical forms, not only the organic ones, can harm it. The possible consequences of Hg exposure during the early stages of development, the additive effects with other co-occurring neurotoxicants, and the known mechanisms of action and targets will be addressed in this chapter.</p>","PeriodicalId":72100,"journal":{"name":"Advances in neurotoxicology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188190/pdf/nihms-1580310.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37882913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01Epub Date: 2017-09-01DOI: 10.1016/bs.ant.2017.07.003
Nancy L Parmalee, Michael Aschner
Circadian rhythms describe the behavioral and physiological changes that occur in living organisms in order to attune to a 24 hour cycle of day and night. The most striking aspect of circadian function is the sleep-wake cycle, however many other physiological processes are regulated in 24 hour oscillations, including blood pressure, body temperature, appetite, urine production, and the transcription and translation of thousands of circadian dependent genes. Circadian disruption and sleep disorders are strongly connected to neurodegenerative diseases including Parkinson's disease, Alzheimer's disease, and Huntington's disease as well as others. Metal exposures have been implicated in neurodegenerative diseases, in some cases involving metals that are essential micronutrients but are toxic at high levels of exposure (such as manganese, copper, and zinc), and in other cases involving metals that have no biological role but are toxic to living systems (such as lead, mercury, and aluminum). In this review, we examine the evidence for circadian and sleep disorders with exposures to these metals and review the literature for possible mechanisms. We suggest that giving the aging population, the prevalence of environmental exposures to metals, and the increasing prevalence of neurodegenerative disease in the aged, more research into the mechanisms of circadian disruption subsequent to metal exposures is warranted.
{"title":"Metals and Circadian Rhythms.","authors":"Nancy L Parmalee, Michael Aschner","doi":"10.1016/bs.ant.2017.07.003","DOIUrl":"https://doi.org/10.1016/bs.ant.2017.07.003","url":null,"abstract":"<p><p>Circadian rhythms describe the behavioral and physiological changes that occur in living organisms in order to attune to a 24 hour cycle of day and night. The most striking aspect of circadian function is the sleep-wake cycle, however many other physiological processes are regulated in 24 hour oscillations, including blood pressure, body temperature, appetite, urine production, and the transcription and translation of thousands of circadian dependent genes. Circadian disruption and sleep disorders are strongly connected to neurodegenerative diseases including Parkinson's disease, Alzheimer's disease, and Huntington's disease as well as others. Metal exposures have been implicated in neurodegenerative diseases, in some cases involving metals that are essential micronutrients but are toxic at high levels of exposure (such as manganese, copper, and zinc), and in other cases involving metals that have no biological role but are toxic to living systems (such as lead, mercury, and aluminum). In this review, we examine the evidence for circadian and sleep disorders with exposures to these metals and review the literature for possible mechanisms. We suggest that giving the aging population, the prevalence of environmental exposures to metals, and the increasing prevalence of neurodegenerative disease in the aged, more research into the mechanisms of circadian disruption subsequent to metal exposures is warranted.</p>","PeriodicalId":72100,"journal":{"name":"Advances in neurotoxicology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.ant.2017.07.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36937059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01Epub Date: 2017-09-01DOI: 10.1016/bs.ant.2017.07.002
Marcelo Farina, Michael Aschner, João Batista Teixeira da Rocha
{"title":"The catecholaminergic neurotransmitter system in methylmercury-induced neurotoxicity.","authors":"Marcelo Farina, Michael Aschner, João Batista Teixeira da Rocha","doi":"10.1016/bs.ant.2017.07.002","DOIUrl":"https://doi.org/10.1016/bs.ant.2017.07.002","url":null,"abstract":"","PeriodicalId":72100,"journal":{"name":"Advances in neurotoxicology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.ant.2017.07.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37882523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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