{"title":"Synergistic Value from Real-Life Registry Studies and Randomized Controlled Trials in Testosterone Therapy of Testosterone-Deficient Men","authors":"M. Zitzmann","doi":"10.1089/ANDRO.2020.0016","DOIUrl":"https://doi.org/10.1089/ANDRO.2020.0016","url":null,"abstract":"","PeriodicalId":72197,"journal":{"name":"Androgens: clinical research and therapeutics","volume":"206 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76068410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-01DOI: 10.1089/ANDRO.2021.29002.INT
A. Morgentaler
{"title":"ANDROGENS: Interview with Paresh Dandona, MD","authors":"A. Morgentaler","doi":"10.1089/ANDRO.2021.29002.INT","DOIUrl":"https://doi.org/10.1089/ANDRO.2021.29002.INT","url":null,"abstract":"","PeriodicalId":72197,"journal":{"name":"Androgens: clinical research and therapeutics","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75739596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiao Zhang, Ke Huang, F. Saad, K. Haider, A. Haider, Xiaohui Xu
Background: Low testosterone level has been associated with predictors of cardiovascular disease (CVD); however, controversies exist regarding the role of testosterone therapy, a treatment to impro...
{"title":"Testosterone Therapy Reduces Cardiovascular Risk Among Hypogonadal Men: A Prospective Cohort Study in Germany","authors":"Xiao Zhang, Ke Huang, F. Saad, K. Haider, A. Haider, Xiaohui Xu","doi":"10.1089/ANDRO.2020.0015","DOIUrl":"https://doi.org/10.1089/ANDRO.2020.0015","url":null,"abstract":"Background: Low testosterone level has been associated with predictors of cardiovascular disease (CVD); however, controversies exist regarding the role of testosterone therapy, a treatment to impro...","PeriodicalId":72197,"journal":{"name":"Androgens: clinical research and therapeutics","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72399855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Understanding the Controversy Regarding Treatment of Age-Related Testosterone Deficiency","authors":"A. Morgentaler","doi":"10.1089/ANDRO.2021.0006","DOIUrl":"https://doi.org/10.1089/ANDRO.2021.0006","url":null,"abstract":"","PeriodicalId":72197,"journal":{"name":"Androgens: clinical research and therapeutics","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91278376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The negative effects of testosterone deficiency (TD) on human health and quality of life are well demonstrated, including signs, symptoms, metabolic syndrome, obesity, and increased mortality. Rece...
{"title":"Age-Related Testosterone Deficiency Merits Treatment","authors":"A. Traish","doi":"10.1089/ANDRO.2020.0019","DOIUrl":"https://doi.org/10.1089/ANDRO.2020.0019","url":null,"abstract":"The negative effects of testosterone deficiency (TD) on human health and quality of life are well demonstrated, including signs, symptoms, metabolic syndrome, obesity, and increased mortality. Rece...","PeriodicalId":72197,"journal":{"name":"Androgens: clinical research and therapeutics","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85393408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01Epub Date: 2021-07-21DOI: 10.1089/andro.2021.0015
Jesse Ory, Ranjith Ramasamy
Accepted practice surrounding the use of exogenous testosterone in the presence of treated or untreated localized prostate cancer has changed dramatically over the past decade. Recent evidence has failed to show an increased risk of de novo disease in the general population,1 or of progression or recurrence in men after definitive therapy or on active surveillance for localized disease.2 This has culminated in recent American Urological Association guidelines on testosterone therapy (TT) reinforcing the lack of evidence connecting TT to de novo prostate cancer, and supporting the safety of TT in men with treated prostate cancer— primarily in men with low or intermediate risk disease.1
{"title":"Testosterone Therapy in Men with Advanced Prostate Cancer: Too Many Unknowns for Safe Use.","authors":"Jesse Ory, Ranjith Ramasamy","doi":"10.1089/andro.2021.0015","DOIUrl":"https://doi.org/10.1089/andro.2021.0015","url":null,"abstract":"Accepted practice surrounding the use of exogenous testosterone in the presence of treated or untreated localized prostate cancer has changed dramatically over the past decade. Recent evidence has failed to show an increased risk of de novo disease in the general population,1 or of progression or recurrence in men after definitive therapy or on active surveillance for localized disease.2 This has culminated in recent American Urological Association guidelines on testosterone therapy (TT) reinforcing the lack of evidence connecting TT to de novo prostate cancer, and supporting the safety of TT in men with treated prostate cancer— primarily in men with low or intermediate risk disease.1","PeriodicalId":72197,"journal":{"name":"Androgens: clinical research and therapeutics","volume":"2 1","pages":"131-132"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39328496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-08-01DOI: 10.1089/andro.2020.29001.cfp
A. Traish
{"title":"Call for Papers: Androgens: Clinical Research and Therapeutics Now Open for Submissions","authors":"A. Traish","doi":"10.1089/andro.2020.29001.cfp","DOIUrl":"https://doi.org/10.1089/andro.2020.29001.cfp","url":null,"abstract":"","PeriodicalId":72197,"journal":{"name":"Androgens: clinical research and therapeutics","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75998821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Obese men can have testosterone deficiency (TD) but the etiology is uncertain. Leptin is a 16-kDa protein produced primarily by adipose tissue and, therefore, is positively associated with the amount of body fat and can affect testosterone (T) production. We hypothesized that increased leptin can be independently associated with low T.
Materials and methods: We performed a cross-sectional analysis of men from National Health and Nutrition Examination III database to evaluate the association of leptin with serum T and calculated free testosterone (cFT). Linear regression was performed with leptin, age, waist circumference, hypertension, and diabetes as independent variables predicting cFT/T. Multiple linear regression was used to determine predictors for cFT and T using variables previously significant in the univariate analysis.
Results: A total of 1193 men were analyzed. As expected, older and obese men were associated with having lower T. Interestingly, increasing leptin levels were an independent predictor of decreasing T and cFT on multivariable analysis. Increasing 1ng/mL in leptin resulted in a decrease of 5.13 and 0.11 ng/dL of T and cFT, respectively (p < 0.05). Also, every additional year of life led to a T and cFT reduction of 2.87 and 0.13 ng/dL, respectively, and increasing 1 cm in waist circumference corresponded to decrease of 4ng/dL in T (p < 0.05).
Conclusions: We concluded that increasing leptin, age, and waist circumference were associated with decreasing of T and cFT. Elevated leptin levels could be one of the potential etiologies of TD.
{"title":"Association of Leptin with Total and Free Testosterone: Results from the National Health and Nutrition Examination Surveys.","authors":"Thiago Fernandes Negris Lima, Sirpi Nackeeran, Evgeniya Rakitina, Gustavo Fernandes Negris Lima, Himanshu Arora, Atil Y Kargi, Ranjith Ramasamy","doi":"10.1089/andro.2020.0007","DOIUrl":"https://doi.org/10.1089/andro.2020.0007","url":null,"abstract":"<p><strong>Introduction: </strong>Obese men can have testosterone deficiency (TD) but the etiology is uncertain. Leptin is a 16-kDa protein produced primarily by adipose tissue and, therefore, is positively associated with the amount of body fat and can affect testosterone (T) production. We hypothesized that increased leptin can be independently associated with low T.</p><p><strong>Materials and methods: </strong>We performed a cross-sectional analysis of men from National Health and Nutrition Examination III database to evaluate the association of leptin with serum T and calculated free testosterone (cFT). Linear regression was performed with leptin, age, waist circumference, hypertension, and diabetes as independent variables predicting cFT/T. Multiple linear regression was used to determine predictors for cFT and T using variables previously significant in the univariate analysis.</p><p><strong>Results: </strong>A total of 1193 men were analyzed. As expected, older and obese men were associated with having lower T. Interestingly, increasing leptin levels were an independent predictor of decreasing T and cFT on multivariable analysis. Increasing 1ng/mL in leptin resulted in a decrease of 5.13 and 0.11 ng/dL of T and cFT, respectively (<i>p</i> < 0.05). Also, every additional year of life led to a T and cFT reduction of 2.87 and 0.13 ng/dL, respectively, and increasing 1 cm in waist circumference corresponded to decrease of 4ng/dL in T (<i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>We concluded that increasing leptin, age, and waist circumference were associated with decreasing of T and cFT. Elevated leptin levels could be one of the potential etiologies of TD.</p>","PeriodicalId":72197,"journal":{"name":"Androgens: clinical research and therapeutics","volume":"1 1","pages":"94-100"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/andro.2020.0007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38592202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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