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REDEFINING EXCELLENCE IN BIOMEDICAL RESEARCH: THE PLACE OF AIPM IN A 21ST CENTURY NIGERIAN TEACHING HOSPITAL. 重新定义卓越的生物医学研究:aipm在21世纪尼日利亚教学医院的地位。
Pub Date : 2024-12-31 Epub Date: 2024-12-30
D Chukwuma, H D Ogundipe, K I Egbuchulem
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引用次数: 0
ASSESSING CATASTROPHIC HEALTHCARE EXPENDITURES IN THE EMERGENCY SURGICAL CARE OF CHILDREN WITH INTUSSUSCEPTION: INSIGHTS FROM A TERTIARY HOSPITAL IN NIGERIA. 评估肠套叠儿童紧急外科护理中的灾难性医疗保健支出:来自尼日利亚一家三级医院的见解。
I Chukwu, S Ekpemo, L Okonkwo, C Uchendu, C Isaac-Chukwu, U Ezomike

Background: Emergency and essential surgery should be affordable, accessible, and timely. However, this is not the narrative in our setting as patients present late with complications requiring operative treatment which has an attendant healthcare expenditure often tending towards household income depletion. This study assessed the proportion of patients who incurred catastrophic healthcare expenditures following operative treatment for intussusception in our facility. Catastrophic healthcare expenditure was defined as spending >10% of Gross Domestic Product per capita. Health care expenditures were reported in US dollars.

Materials & methods: A prospective cohort study of children 15 years of age and younger who were operatively treated for intussusception at the Paediatric Surgery unit of Federal Medical Centre, Umuahia from January 2017 to December 2020.

Results: Sixty-six (84.6%) out of the 78 children who presented with intussusception within the period had 72 laparotomies. Only 6.1% (4/66) of the patients were enrolled in the National Health Insurance Scheme. The insured patients presented earlier than the uninsured patients (median 4 versus 6 days, p=0.04). The median total health expenditure was $458 (Inter Quartile Range $372.4 ? $707.1) for the uninsured patients. The total health expenditure exceeded 10% of GDP per capita ($209.71) for all the uninsured patients but not for any of the insured patients, giving an overall catastrophic expenditure rate of 93.9% (62/66). The median daily health expenditure was about one-third of 10% of GDP per capita for those who were uninsured.

Conclusion: All the uninsured patients experienced catastrophic health expenditures; with onset from the fourth day on admission. Financial risk protection by implementing payment strategies aimed at reducing user fees to non-catastrophe levels may help.

背景:急诊和基本手术应该是负担得起的、可获得的和及时的。然而,在我们的环境中,这并不是叙述,因为患者出现并发症较晚,需要手术治疗,随之而来的医疗保健支出往往倾向于家庭收入枯竭。本研究评估了我院肠套叠手术治疗后发生灾难性医疗支出的患者比例。灾难性医疗支出被定义为人均国内生产总值的10%。卫生保健支出以美元报告。材料与方法:2017年1月至2020年12月在Umuahia联邦医疗中心儿科外科接受肠套叠手术治疗的15岁及以下儿童的前瞻性队列研究。结果:78例出现肠套叠的患儿中有66例(84.6%)进行了72次剖腹手术。只有6.1%(4/66)的患者参加了国家健康保险计划。参保患者就诊时间早于未参保患者(中位4天vs中位6天,p=0.04)。总卫生支出中位数为458美元(四分位数间为372.4美元?707.1美元)。所有未参保患者的医疗总支出均超过人均GDP的10%(209.71美元),但参保患者的医疗总支出均未超过人均GDP的10%,总体灾难性支出率为93.9%(62/66)。对于那些没有保险的人来说,每日卫生支出中位数约为人均国内生产总值的10%的三分之一。结论:所有未参保患者均经历了灾难性的医疗支出;从入院第4天起发病。通过实施旨在将用户费用降低到非灾难水平的支付策略来保护财务风险可能会有所帮助。
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引用次数: 0
DEVELOPMENT OF TOBACCO CONTROL EDUCATIONAL MATERIALS: POSTERS AND NOTEBOOKS AMONG ADOLESCENTS IN NIGERIA. 尼日利亚儿童睾丸附属物扭转的临床病理表现:1例报告。
Omotayo F Fagbule, Mary E Osuh, Folake B Lawal, Olushola Ibiyemi

Background: Tobacco use is a leading preventable cause of morbidity and mortality and poses a significant burden on fragile health systems in low- and middleincome countries (LMICs), including Nigeria. Adolescents are particularly at risk of starting to use tobacco due to factors such as misinformation and insufficient knowledge about its harmful effects. There is an urgent need for culturally appropriate, acceptable, and sustainable interventions to enhance knowledge, correct misconceptions, and promote positive behavior change regarding tobacco use. This study describes the development and validation of culturally tailored, Health Belief Model (HBM)-based educational materials (posters and notebooks) for tobacco-related health education among adolescents in Nigeria.

Methodology: The Design-Based Research (DBR) approach was used to develop posters and notebooks featuring tobacco-related messages. These messages were adapted from the World Health Organization's (WHO) Tobacco Control Manual for Schools, based on the HBM constructs, and tailored to fit the Nigerian context. The materials underwent validation through reviews by a multidisciplinary panel of experts who assessed their clarity, cultural relevance, and theoretical alignment. Subsequently, they were pre-tested among 150 adolescents from public and private schools in Ibadan, Nigeria. Feedback from the adolescents guided iterative refinements, culminating in the development of the final versions of the materials.

Results: The educational materials conveyed information on different tobacco forms, the harmful constituents, health effects, and skills to avoid tobacco use. Expert reviewers confirmed the materials' alignment with HBM constructs. Participants in the pre-test rated the materials highly, with 89.3% describing the information as ?very good? and 80.7% supporting their integration into the school curriculum.

Conclusion: The tobacco control educational posters and notebooks were found to be contextually appropriate and addressed gaps in tobacco-related knowledge and behavior change strategies. They offer a scalable model for school-based interventions in LMICs and could contribute to broader public health education efforts.

睾丸尾包膜扭转是急性阴囊的病因之一。然而,它可以通过其潜伏的开始和局部压痛与睾丸扭转区分开来。彩色多普勒超声在莫格尼氏包虫病中有特征性表现。我们提出一例Morgagni包囊扭转是突然发作,并有临床特征模仿睾丸扭转,需要立即阴囊探查。术中发现阑尾睾丸扭转与临床表现提示睾丸扭转相反。急性阴囊是一个时间依赖性的紧急情况,可能没有时间进行多普勒超声检查,这将区分睾丸扭转和睾丸扭转,从而防止不必要的阴囊探查。
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引用次数: 0
Erratum: RE: SPECIALTY PREFERENCES AMONG UNDERGRADUATE DENTAL STUDENTS IN LAGOS STATE NIGERIA. 勘误:RE:尼日利亚拉各斯州牙科本科学生的专业偏好。

[This corrects the article PMChttps://pmc.ncbi.nlm.nih.gov/articles/PMC11848366.].

[这更正文章PMChttps://pmc.ncbi.nlm.nih.gov/articles/PMC11848366.]。]
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引用次数: 0
NUTCRACKER SYNDROME: A REPORT OF TWO CASES. 胡桃夹子综合征:附两例报告。
A A Adejumo, B E Osobu

Introduction: Nutcracker syndrome is a pathology that could pose a diagnostic conundrum to the physician as the patient could present with vague symptoms. This report brings to limelight the pathology of Nutcracker syndrome and the need for clinicians to consider this as a differential diagnosis when managing patients with non-specific abdominal pain.

Case presentation: This is a case series report of two patients that presented at the emergency unit with acute exacerbation of insidious onset of upper abdominal pain. Radiological evaluation with computerized tomography proved the presence of this pathology in both patients with reduction in aortomesenteric angles and distances. The management of this clinical entity is largely conservative with surgical intervention rarely needed.

Conclusion: Radiological evaluation is the bedrock of diagnosis of Nutcracker syndrome. The clinician should endeavor to consider this as a differential diagnosis in patients with recurrent and undefined upper abdominal symptoms.

简介:胡桃夹子综合征是一种病理,可能会造成诊断难题的医生,因为病人可以表现出模糊的症状。本报告将胡桃夹子综合征的病理和临床医生在处理非特异性腹痛患者时将其作为鉴别诊断的必要性放在了聚光灯下。病例介绍:这是一个病例系列报告的两个病人,在急诊室提出急性加重的潜伏发作的上腹部疼痛。计算机断层扫描的放射学评估证实了这种病理的存在,这两例患者都出现了主动脉肠系膜角度和距离的缩小。这种临床实体的管理基本上是保守的,很少需要手术干预。结论:影像学检查是诊断胡桃夹子综合征的基础。临床医生应努力将此作为反复出现和上腹部症状不明确患者的鉴别诊断。
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引用次数: 0
THE NATIONAL HEALTH INSURANCE AUTHORITY OF NIGERIA AND IMPLICATIONS FOR UNIVERSAL HEALTH COVERAGE. 尼日利亚国家健康保险局及其对全民健康覆盖的影响。
D A Adewole

Background: The National Health Insurance Scheme (NHIS) of Nigeria was established in the year 2005. The overall objective of the scheme was to enhance access to quality healthcare for all and minimize catastrophic health expenditures. However, since inception, the population coverage has been less than ten percent of the total. Very recently, the National Health Insurance Authority (NHIA) of Nigeria was enacted, which concomitantly repealed the NHIS Act. This article examined the design of the NHIA and other factors outside of the scheme but in the health system of Nigeria, in comparison to similar schemes in other settings. Finally, the newly implemented NHIA and the gaps it seeks to fill were examined.

Methods: Relevant literature extracted from databases such as PubMed, Google Scholar, and the ordinary Google website was reviewed. Findings from these sources were triangulated and used to write the manuscript.

Results: Compared with social health insurance schemes in other settings, the current population coverage under the NHIA of Nigeria is poor. Some of the factors that contributed to the poor performance of the NHIA were the features of the design of the scheme, which run contrary to the design of the majority of social health insurance schemes in other countries. In addition to this, the primary healthcare level that is most widespread in many countries and that was made use of as service providers in other social health insurance schemes was not made use of under the NHIA. In addition to these, and unlike in other settings, membership in the NHIA has been on a voluntary basis until very recently, when it was made mandatory.

Conclusion: Presently, population coverage under the NHIA is very poor. The informal sector, especially in rural settings, is mostly at a disadvantage. This is unlike in the majority of other countries, which encourage population coverage across both the formal and informal sectors. Stakeholders in the health insurance industry are encouraged to make the scheme mandatory and enforce it. The PHC facilities should also be engaged as service providers under the NHIA.

背景:尼日利亚国家健康保险计划(NHIS)于2005年建立。该计划的总体目标是增加所有人获得高质量医疗保健的机会,并尽量减少灾难性的医疗支出。然而,自成立以来,人口覆盖率一直不到总人口的10%。最近,尼日利亚成立了国家健康保险局(NHIA),同时废除了《国家健康保险局法》。本文研究了NHIA的设计以及该方案之外但在尼日利亚卫生系统中的其他因素,并与其他环境中的类似方案进行了比较。最后,对新实施的NHIA及其寻求填补的空白进行了审查。方法:从PubMed、谷歌Scholar、普通谷歌网站等数据库中提取相关文献进行综述。从这些来源得到的发现被三角化并用于撰写手稿。结果:与其他国家的社会健康保险制度相比,尼日利亚国家健康保险制度的人口覆盖率较低。造成全国健康保险计划表现不佳的一些因素是该计划的设计特点,这与其他国家大多数社会健康保险计划的设计背道而驰。此外,在许多国家最普遍的初级保健水平,在其他社会健康保险计划中被用作服务提供者,但在国家健康保险制度下没有得到利用。除此之外,与其他环境不同的是,NHIA的成员资格一直是自愿的,直到最近才成为强制性的。结论:目前我国国民健康保险的人口覆盖率很低。非正式部门,特别是在农村地区,大多处于不利地位。这与大多数其他国家不同,这些国家鼓励在正式和非正式部门覆盖人口。鼓励健康保险行业的利益相关者强制执行该计划。初级保健设施亦应作为服务提供者,参与“健康保障计划”。
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引用次数: 0
MULTIPLE ORO-FACIAL COMPLICATIONS OF HERPES ZOSTER INFECTION IN AN ELDERLY: A CASE REPORT. 老年人带状疱疹感染的多重口腔-面部并发症:1例报告。
A A Salami, T O Mudasiru, I Joseph, E O Abe, A O Adisa

Introduction: Herpes zoster (HZ) is a viral disease with a global health burden which significantly impacts on the quality of life. HZ is caused by reactivation of the varicella-zoster virus and its complications are dependent on multiple factors like immune suppression, psychological stress, malnutrition, co-morbidities, duration of HZ infection and old age. Some of the complications include secondary bacterial infection, post-herpetic neuralgia, scarring, nerve palsy, and viral encephalitis. These complications could present as single or rarely as multiple entities in an individual.

Materials & methods: We present a case of HZ infection affecting the mandibular division of trigeminal nerve in a 78-year-old widow. The patient presented with multiple complications including hyper- pigmented scarring, post herpetic neuralgia and chronic non-suppurative osteomyelitis of the left mandible. This case report highlights the presentation of multiple complications from HZ infection especially among the elderly.

Conclusion: Early diagnosis and prompt treatment of HZ infection are highly essential for reduced risk of complications.

带状疱疹(HZ)是一种全球性的病毒性疾病,严重影响生活质量。HZ是由水痘带状疱疹病毒的再激活引起的,其并发症取决于多种因素,如免疫抑制、心理压力、营养不良、合并症、HZ感染持续时间和年龄。一些并发症包括继发性细菌感染、疱疹后神经痛、瘢痕、神经麻痹和病毒性脑炎。这些并发症可能在个体中表现为单一或罕见的多个实体。材料与方法:我们提出一个78岁寡妇的HZ感染影响三叉神经下颌骨分裂的病例。患者表现出多种并发症,包括色素沉着疤痕,疱疹后神经痛和左下颌骨慢性非化脓性骨髓炎。本病例报告强调了HZ感染的多种并发症,特别是在老年人中。结论:早期诊断和及时治疗对降低并发症的发生至关重要。
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引用次数: 0
Erratum: RE: SPECIALTY PREFERENCES AMONG UNDERGRADUATE DENTAL STUDENTS IN LAGOS STATE NIGERIA. 勘误:RE:尼日利亚拉各斯州牙科本科学生的专业偏好。
Pub Date : 2024-12-31 Epub Date: 2024-12-30

[This corrects the article on p. 81 in vol. 22 PMChttps://pmc.ncbi.nlm.nih.gov/PMC11848366.].

[这是对第22卷第81页的文章的更正]http://pmc.ncbi.nlm.nih.gov/PMC11848366.]。
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引用次数: 0
THE PLASMA CONCENTRATIONS OF ESSENTIAL TRACE ELEMENTS IN WOMEN WITH CANCER OF BREAST- OR CERVIX. 乳癌或子宫颈癌患者血浆中必需微量元素的浓度。
M A Jimoh, B O Popoola, G O Arinola

Background: Derangement of trace elements which could be due to systemic inflammation or oxidative stress is thought to be directly or indirectly involved in carcinogenesis.

Aim: To evaluate plasma trace elements in female patients with cancer of breast- or cervix.

Material and methods: This study was carried out in the Departments of Immunology and Radiation Oncology, University of Ibadan, Nigeria. Thirty (30) patients with cervical cancer, 30 patients with breast cancer and 30 age-matched females without cancer as control were included in the study. Plasma separated from venous blood was analysed for the concentrations of zinc (Zn), iron (Fe), selenium (Se) and copper (Cu) using Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES). The sixty cancer patients were newly diagnosed and in a stable state.

Results: The mean plasma levels of Fe and Cu were significantly reduced in patients with breast cancer- or cervical cancer compared with control. The plasma concentrations of Fe, Cu, Zn and Se were significantly reduced in all patients having breast cancer and those in stage 2 compared with cervical cancer patients.

Conclusion: Available data further support a previous suggestion that blood levels of metal varies with different cancers. Thus, a need for differential supplementation based on cancer types when modulation of trace element levels becomes a therapeutic option.

背景:由于全身炎症或氧化应激引起的微量元素紊乱被认为直接或间接参与了癌变。目的:评价女性乳腺癌、宫颈癌患者血浆微量元素含量。材料和方法:本研究在尼日利亚伊巴丹大学免疫学和放射肿瘤学系进行。本研究共纳入30例宫颈癌患者、30例乳腺癌患者和30例年龄匹配的未患癌症女性作为对照。采用电感耦合等离子体光学发射光谱法(ICP-OES)分析静脉血中锌(Zn)、铁(Fe)、硒(Se)和铜(Cu)的浓度。60例癌症患者均为新诊断,病情稳定。结果:与对照组相比,乳腺癌或宫颈癌患者的平均血浆铁和铜水平显著降低。与宫颈癌患者相比,所有乳腺癌患者及2期患者血浆中Fe、Cu、Zn和Se的浓度均显著降低。结论:现有数据进一步支持先前的建议,即不同癌症的血液中金属含量不同。因此,当调节微量元素水平成为一种治疗选择时,需要根据癌症类型进行不同的补充。
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引用次数: 0
EARLY IMPACTS OF FUEL SUBSIDY REMOVAL ON MENTAL HEALTH STATUS OF PRIMARY HEALTHCARE WORKERS AND COMMUNITY MEMBERS IN NIGERIA: A CROSS-SECTIONAL STUDY. 取消燃料补贴对尼日利亚初级保健工作者和社区成员心理健康状况的早期影响:一项横断面研究。
D Bakare, J Salako, A Sogbesan, A A Bakare

Background: The abrupt removal of fuel subsidy in Nigeria led to exponential increase in fuel prices. The resultant economic pressure may have effects on the mental health status of Nigerians. The objective is to understand this impact, we assessed changes in mental health status among primary healthcare workers and community members after fuel subsidy removal.

Materials & methods: We carried out cross-sectional study in six Local Government Areas (LGA) across three Nigerian states and surveyed healthcare workers and community members. We analysed respondents' socio-demographic characteristics and their perceptions of fuel subsidies and mental health risks using summary statistics. Additionally, we evaluated depression and anxiety severity among respondents before and after the subsidy removal using the PHQ-9 and GAD-7 scales, reporting findings by state and percentage increases in the subsidy removal?s impact on healthcare workers and community members.

Results: We found a rise in depression and anxiety, particularly among younger adults. HCWs in Jigawa state faced the most severe increase, with depression rates nearly tripling. Similarly, community members across various demographics saw a significant rise in depression and anxiety after the policy change. According to state, Jigawa state bore the brunt, with depression and anxiety rising by over 200% while market women experienced the highest increase within occupational groups.

Conclusion: This study shows that younger adults, single individuals, residents of disadvantaged areas, and market women were mostly affected. The widespread mental health crisis necessitates broad interventions targeting these groups.

背景:尼日利亚突然取消燃料补贴导致燃料价格呈指数级增长。由此产生的经济压力可能对尼日利亚人的心理健康状况产生影响。为了了解这种影响,我们评估了取消燃料补贴后初级卫生保健工作者和社区成员心理健康状况的变化。材料与方法:我们在尼日利亚三个州的六个地方政府区(LGA)进行了横断面研究,并调查了卫生保健工作者和社区成员。我们使用汇总统计分析了受访者的社会人口特征以及他们对燃料补贴和心理健康风险的看法。此外,我们使用PHQ-9和GAD-7量表评估了补贴取消前后受访者的抑郁和焦虑严重程度,并按州和补贴取消的百分比报告了调查结果。对医护人员和社区成员的影响。结果:我们发现抑郁和焦虑有所增加,尤其是在年轻人中。吉加瓦州的卫生保健工作者面临着最严重的增长,抑郁症发病率几乎增加了两倍。同样,在政策改变后,不同人口统计数据的社区成员的抑郁和焦虑程度显著上升。根据各州的情况,吉加瓦州首当其冲,抑郁和焦虑上升了200%以上,而在职业群体中,市场妇女的增幅最高。结论:本研究表明,青壮年、单身、弱势地区居民和市场妇女受影响最大。广泛的精神健康危机需要针对这些群体进行广泛的干预。
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引用次数: 0
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Annals of Ibadan postgraduate medicine
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