John-Henry L. Dean, Mayank P. Patel, William T. Williams, Michael N. Moulton, Michael S. Cahil, Bryan C. Ramsey
{"title":"Near-Simultaneous Development of Coronary and Pulmonary Thrombosis in a Patient With COVID-19","authors":"John-Henry L. Dean, Mayank P. Patel, William T. Williams, Michael N. Moulton, Michael S. Cahil, Bryan C. Ramsey","doi":"10.7326/aimcc.2022.1314","DOIUrl":"https://doi.org/10.7326/aimcc.2022.1314","url":null,"abstract":"","PeriodicalId":72222,"journal":{"name":"Annals of internal medicine. Clinical cases","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135809941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Simon Stutz, Roberto Buonomano, Alain Rudiger, Elias Bodendoerfer, Thomas Herren
Infectious tenosynovitis as a presenting symptom of infective endocarditis (IE) is unusual. We report the case of a 65-year-old man admitted for surgical aortic valve replacement 6 years previously who presented with ankle pain. Targeted imaging revealed septic emboli in the tibialis posterior tendon, kidney, and the brain. Cardiobacterium hominis was identified in blood cultures, and the diagnosis of IE was confirmed by echocardiography. Portal of entry was a fractured and infected tooth, which was removed. Antibiotic treatment with ceftriaxone was successful. Atraumatic infectious tenosynovitis caused by hematogenous spread should raise the suspicion of IE.
{"title":"A Rare Cause of Infectious Tenosynovitis: <i>Cardiobacterium hominis</i> Endocarditis","authors":"Simon Stutz, Roberto Buonomano, Alain Rudiger, Elias Bodendoerfer, Thomas Herren","doi":"10.7326/aimcc.2023.0328","DOIUrl":"https://doi.org/10.7326/aimcc.2023.0328","url":null,"abstract":"Infectious tenosynovitis as a presenting symptom of infective endocarditis (IE) is unusual. We report the case of a 65-year-old man admitted for surgical aortic valve replacement 6 years previously who presented with ankle pain. Targeted imaging revealed septic emboli in the tibialis posterior tendon, kidney, and the brain. Cardiobacterium hominis was identified in blood cultures, and the diagnosis of IE was confirmed by echocardiography. Portal of entry was a fractured and infected tooth, which was removed. Antibiotic treatment with ceftriaxone was successful. Atraumatic infectious tenosynovitis caused by hematogenous spread should raise the suspicion of IE.","PeriodicalId":72222,"journal":{"name":"Annals of internal medicine. Clinical cases","volume":"142 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134931111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Husam El Sharu, Sinda Hidri, Joshua Peltz, Mohammad Alqaisieh
Incretin-based medications are well-established agents used for glycemic control in patients with type 2 diabetes mellitus. Of these medications, glucagon-like peptide 1 agonists have a well-known association with pancreatitis. However, controversy still exists about a similar association with dipeptidyl peptidase 4 inhibitors. Linagliptin, in particular, has not been studied thoroughly. Therefore, to the best of our knowledge, we report linagliptin-induced pancreatitis, the fourth case reported in the medical literature, that resolved after stopping the medication and did not recur with the resumption of all of the other patient's medications.
{"title":"Linagliptin-Induced Pancreatitis","authors":"Husam El Sharu, Sinda Hidri, Joshua Peltz, Mohammad Alqaisieh","doi":"10.7326/aimcc.2023.0316","DOIUrl":"https://doi.org/10.7326/aimcc.2023.0316","url":null,"abstract":"Incretin-based medications are well-established agents used for glycemic control in patients with type 2 diabetes mellitus. Of these medications, glucagon-like peptide 1 agonists have a well-known association with pancreatitis. However, controversy still exists about a similar association with dipeptidyl peptidase 4 inhibitors. Linagliptin, in particular, has not been studied thoroughly. Therefore, to the best of our knowledge, we report linagliptin-induced pancreatitis, the fourth case reported in the medical literature, that resolved after stopping the medication and did not recur with the resumption of all of the other patient's medications.","PeriodicalId":72222,"journal":{"name":"Annals of internal medicine. Clinical cases","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134934817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gabriela Szuman, Lama Amer, Robert Hamilton, Ur Metser, Sylvia L. Asa, Ozgur Mete, Shereen Ezzat
Paragangliomas emerging in unusual locations may represent a diagnostic pitfall. We report clinical, genetic, imaging, and histopathologic features of succinate dehydrogenase–deficient paraganglioma arising within the prostate gland. This patient had multiple and recurrent paragangliomas since the age of 18 years. During the course of surveillance for a pathogenic germline SDHB variant, he developed 2 separate foci of disease in the prostate and retroperitoneum. Both lesions were gallium 68 DOTATATE positron emission tomography–avid and proved to be separate paragangliomas histologically. We emphasize that the prostate represents a site for paragangliomas, particularly in genetically predisposed patients who develop enlargement of the gland with normal prostatic-specific antigen.
{"title":"Succinate Dehydrogenase–Deficient Paraganglioma of the Prostate","authors":"Gabriela Szuman, Lama Amer, Robert Hamilton, Ur Metser, Sylvia L. Asa, Ozgur Mete, Shereen Ezzat","doi":"10.7326/aimcc.2023.0361","DOIUrl":"https://doi.org/10.7326/aimcc.2023.0361","url":null,"abstract":"Paragangliomas emerging in unusual locations may represent a diagnostic pitfall. We report clinical, genetic, imaging, and histopathologic features of succinate dehydrogenase–deficient paraganglioma arising within the prostate gland. This patient had multiple and recurrent paragangliomas since the age of 18 years. During the course of surveillance for a pathogenic germline SDHB variant, he developed 2 separate foci of disease in the prostate and retroperitoneum. Both lesions were gallium 68 DOTATATE positron emission tomography–avid and proved to be separate paragangliomas histologically. We emphasize that the prostate represents a site for paragangliomas, particularly in genetically predisposed patients who develop enlargement of the gland with normal prostatic-specific antigen.","PeriodicalId":72222,"journal":{"name":"Annals of internal medicine. Clinical cases","volume":"159 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135809930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rania Al Asmar, Rabia Cheema, Samera Vaseer, Ira Targoff, Mary Beth Humphrey
Antisynthetase syndrome is a distinct entity of overlap myositis in adults and is characterized by muscle weakness, arthritis, mechanic's hands, interstitial lung disease, and Raynaud phenomenon. Despite several published cases and cohorts, myocarditis is an underrecognized disease manifestation, which often presents as acute chest pain or progressive shortness of breath and heart failure. Identifying myocardial involvement as a potential feature of antisynthetase syndrome is crucial to using the correct treatments. We present 2 patients with antisynthetase syndrome and myocarditis, their hospital courses, and treatments as well as a literature review. Early diagnosis of myocarditis in antisynthetase syndrome patients can be life-saving.
{"title":"Anti–Jo-1–Positive Antisynthetase Syndrome and Myocarditis: An Underrecognized Clinical Presentation","authors":"Rania Al Asmar, Rabia Cheema, Samera Vaseer, Ira Targoff, Mary Beth Humphrey","doi":"10.7326/aimcc.2023.0262","DOIUrl":"https://doi.org/10.7326/aimcc.2023.0262","url":null,"abstract":"Antisynthetase syndrome is a distinct entity of overlap myositis in adults and is characterized by muscle weakness, arthritis, mechanic's hands, interstitial lung disease, and Raynaud phenomenon. Despite several published cases and cohorts, myocarditis is an underrecognized disease manifestation, which often presents as acute chest pain or progressive shortness of breath and heart failure. Identifying myocardial involvement as a potential feature of antisynthetase syndrome is crucial to using the correct treatments. We present 2 patients with antisynthetase syndrome and myocarditis, their hospital courses, and treatments as well as a literature review. Early diagnosis of myocarditis in antisynthetase syndrome patients can be life-saving.","PeriodicalId":72222,"journal":{"name":"Annals of internal medicine. Clinical cases","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134931110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Affan Rizwan, Robert C. Long, Michael E. Hall, Brandon W. Lennep
{"title":"Septic Diffuse Left Ventricular Calcification With Reversibility","authors":"Affan Rizwan, Robert C. Long, Michael E. Hall, Brandon W. Lennep","doi":"10.7326/aimcc.2023.0457","DOIUrl":"https://doi.org/10.7326/aimcc.2023.0457","url":null,"abstract":"","PeriodicalId":72222,"journal":{"name":"Annals of internal medicine. Clinical cases","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134934816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Benjamin J. McCormick, Rex K. Siu, Eric Eggenberger, Ronald R. Butendieck, Michael J. Maniaci
Giant cell arteritis is a systemic granulomatous vasculitis commonly involving the temporal artery and associated with visual deficits. The most common ocular presentation of giant cell arteritis involves anterior ischemic ocular neuropathy with sudden unilateral vision loss. We present a rare case of alternating painless monocular vision loss in an older man who responded clinically to prolonged glucocorticoid therapy, tocilizumab, and intraocular pressure–lowering ophthalmic medications.
{"title":"Alternating Transient Monocular Vision Loss Due to Giant Cell Arteritis","authors":"Benjamin J. McCormick, Rex K. Siu, Eric Eggenberger, Ronald R. Butendieck, Michael J. Maniaci","doi":"10.7326/aimcc.2023.0639","DOIUrl":"https://doi.org/10.7326/aimcc.2023.0639","url":null,"abstract":"Giant cell arteritis is a systemic granulomatous vasculitis commonly involving the temporal artery and associated with visual deficits. The most common ocular presentation of giant cell arteritis involves anterior ischemic ocular neuropathy with sudden unilateral vision loss. We present a rare case of alternating painless monocular vision loss in an older man who responded clinically to prolonged glucocorticoid therapy, tocilizumab, and intraocular pressure–lowering ophthalmic medications.","PeriodicalId":72222,"journal":{"name":"Annals of internal medicine. Clinical cases","volume":"116 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134935071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Prutha Pathak, Siddharth Patel, Brendan Gaylord, Punuru J. Reddy
Fatigue, fever, localized soreness, urticaria, and rash are common adverse reactions of COVID-19 vaccines. However, the occurrence of serious autoimmune reactions is quite rare. Cutaneous small-vessel vasculitis is an autoimmune disorder that manifests with palpable purpura and petechiae involving extremities. It results from neutrophilic inflammation within and around dermal vessels and is usually self-limited. We report a 55-year-old woman presenting with a rash 48 hours after receiving the third (Moderna) COVID-19 vaccine dose. Blood investigations and a skin punch biopsy confirmed the diagnosis of COVID-19 vaccine–induced cutaneous small-vessel vasculitis. The patient ultimately improved after inpatient treatment with systemic steroids.
{"title":"Vasculitis After a Vaccine: Rare Adverse Reaction Following a COVID-19 Vaccine","authors":"Prutha Pathak, Siddharth Patel, Brendan Gaylord, Punuru J. Reddy","doi":"10.7326/aimcc.2022.1043","DOIUrl":"https://doi.org/10.7326/aimcc.2022.1043","url":null,"abstract":"Fatigue, fever, localized soreness, urticaria, and rash are common adverse reactions of COVID-19 vaccines. However, the occurrence of serious autoimmune reactions is quite rare. Cutaneous small-vessel vasculitis is an autoimmune disorder that manifests with palpable purpura and petechiae involving extremities. It results from neutrophilic inflammation within and around dermal vessels and is usually self-limited. We report a 55-year-old woman presenting with a rash 48 hours after receiving the third (Moderna) COVID-19 vaccine dose. Blood investigations and a skin punch biopsy confirmed the diagnosis of COVID-19 vaccine–induced cutaneous small-vessel vasculitis. The patient ultimately improved after inpatient treatment with systemic steroids.","PeriodicalId":72222,"journal":{"name":"Annals of internal medicine. Clinical cases","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135809932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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