AsiaIntervention最新文献

Background: Coronary artery disease (CAD) due to atherosclerosis is projected to be the leading cause of morbidity and mortality worldwide until 2040. CAD affects approximately 2.6 million people in the United Kingdom (UK), and 1 in 4 of them do not experience any symptoms.

Aims: The aim of this study was to assess the characteristics and outcomes of patients with plaque features of positive remodelling (PR) on their computed tomography coronary angiogram (CTCA) images.

Methods: Patients who were referred for CTCA from June 2018 to January 2020 were retrospectively identified. Patients underwent prospective, gated 128-slice dual-source CTCA. Patients with PR were compared to those without PR for demographics and outcomes.

Results: A total of 861 patients were included in our study; 241 (28%) had PR, and 620 (72%) had no PR. Patients with PR were older (PR: 63.9±11.0 years vs no PR: 62.1±11.2 years; p=0.04), more likely to be male (PR: 65.6% vs no PR: 55.8%; p=0.01) and underwent coronary angiography more frequently (PR: 25.7% vs no PR: 14.4%; p<0.01). There were also significant increases in subsequent acute coronary syndrome (ACS) events (PR: 2.5% vs no PR: 0.0%; p<0.01) and the need for revascularisation therapy (PR: 15.4% vs no PR: 7.8%; p<0.01) in patients with PR despite being on statins (not a high dose). There was no difference in all-cause mortality.

Conclusions: Detection of PR on CTCA is a reliable prognostic indicator of future cardiovascular events and presents a valuable opportunity for initiation of aggressive primary prevention therapy.

Background: Transcatheter tricuspid valve intervention has recently emerged as a viable alternative to surgery for patients with symptomatic severe tricuspid regurgitation (TR). Though usually performed on the basis of compassionate grounds, we are now exploring the extension of its usage as an elective option in a patient with severe atrial functional tricuspid regurgitation.

Aims: The aim of this study was to select a suitable patient and proceed with the implantation of the TricValve in order to provide symptomatic relief as well as to improve morbidity and mortality.

Methods: A 67-year-old woman had underlying atrial fibrillation and severe tricuspid regurgitation. Despite optimised medical therapy, she remained symptomatic with elevated NT-proBNP levels. As the patient refused surgery on multiple occasions, we chose a percutaneous procedure guided by transoesophageal echocardiography and fluoroscopy.

Results: The procedure was uneventful and the patient was discharged. At 3-month follow-up, there was marked improvement clinically and biochemically.

Conclusions: Bicaval valve implantation with the TricValve is a viable alternative to surgery in patients with symptomatic severe tricuspid regurgitation. This intervention is crucial as we are now able to intervene before irreversible right ventricular dysfunction sets in.

Background: There is a scarcity of data regarding the normal size of the left main stem coronary artery (LMS) in the Indian population; further data are needed to help determine the optimal device size during percutaneous coronary intervention (PCI).

Aims: The aim of our study was to determine the normal size of the LMS and to calculate the mean plaque burden (PB) in the left main arteries which are angiographically normal or insignificantly diseased, using intravascular ultrasound (IVUS). We hoped to establish a correlation between LMS size and body surface area (BSA).

Methods: We collected demographic and coronary artery data from 140 patients who underwent IVUS-guided PCI in the left anterior descending and circumflex arteries over a 2-year period from 2019 to 2020, where a pullback sequence of the LMS was available. The reference and luminal vessel diameters, the reference and luminal vessel areas and the mean plaque burden (PB) were obtained. Regression analysis was used to develop a correlation between BSA and LMS diameter.

Results: The IVUS-determined mean reference diameter of the LMS was 5.53±0.63 mm and the mean luminal diameter was 4.62±0.65 mm. The mean reference vessel area was 24.79±5.5 mm² and the luminal vessel area was 17.19±4.89 mm². The mean PB was found to be 29.21% in patients with an angiographically normal left main and 32.29% in patients with angiographically insignificant left main stenosis. A linear correlation was noted between the left main reference and luminal vessel diameters; the correlation equations derived were 3.57+1.01 BSA and 2.95+0.87 BSA, respectively.

Conclusions: The mean reference and luminal diameters of LMS in the Indian population are on par with the size of LMS in other ethnicities. The vessel compensates for up to 40% PB with vessel remodelling. Hence, a PB of 40% is a good landing zone for stent deployment.