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Introduction of a new stroke lipid specialist nurse to improve lipid optimisation for acute ischaemic stroke patients 引进新的卒中脂质专科护士，以改善急性缺血性卒中患者的脂质优化
IF 2.1 Q3 PERIPHERAL VASCULAR DISEASE
Atherosclerosis plus
Pub Date : 2025-12-01 DOI: 10.1016/j.athplu.2025.10.021
Aravind Udayan , Lucy Barton , Soma Banerjee , Joseph Kwan , Jaimini Cegla
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引用次数: 0
Polygenic predisposition to increased LDL-cholesterol concentration and Carotid Artery Intima Media Thickness in childhood and early adulthood 儿童期和成年早期ldl -胆固醇浓度和颈动脉内膜中层厚度增加的多基因易感性
IF 2.1 Q3 PERIPHERAL VASCULAR DISEASE
Atherosclerosis plus
Pub Date : 2025-12-01 DOI: 10.1016/j.athplu.2025.10.004
M. Futema , T. Ingegneri , M. Sharifi , F. Drenos , S.E. Humphries
{"title":"Polygenic predisposition to increased LDL-cholesterol concentration and Carotid Artery Intima Media Thickness in childhood and early adulthood","authors":"M. Futema , T. Ingegneri , M. Sharifi , F. Drenos , S.E. Humphries","doi":"10.1016/j.athplu.2025.10.004","DOIUrl":"10.1016/j.athplu.2025.10.004","url":null,"abstract":"","PeriodicalId":72324,"journal":{"name":"Atherosclerosis plus","volume":"62 ","pages":"Page 3"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145808510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paediatric Familial Hypercholesterolaemia database at a single tertiary centre: a review of patients managed under the paediatric lipid clinic at Hammersmith Hospital 单一三级中心的儿科家族性高胆固醇血症数据库：对哈默史密斯医院儿科脂质诊所管理的患者的回顾
IF 2.1 Q3 PERIPHERAL VASCULAR DISEASE
Atherosclerosis plus
Pub Date : 2025-12-01 DOI: 10.1016/j.athplu.2025.10.015
P. Chua, L. Barton, C. Neuwirth, J. Cegla, A. David, S. Walji
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引用次数: 0
Genetic Diagnosis of Familial Hypercholesterolemia in Residual Newborn Dried Blood Spots 新生儿残留干血斑家族性高胆固醇血症的遗传诊断
IF 2.1 Q3 PERIPHERAL VASCULAR DISEASE
Atherosclerosis plus
Pub Date : 2025-12-01 DOI: 10.1016/j.athplu.2025.10.007
A.L. Peterson , V. Horner , M.R. Lasarev , X. Zhang , S.E. Humphries , R.D. Steiner , M. Benoy , J. Tumolo , P.K. Held , X. Shao
{"title":"Genetic Diagnosis of Familial Hypercholesterolemia in Residual Newborn Dried Blood Spots","authors":"A.L. Peterson , V. Horner , M.R. Lasarev , X. Zhang , S.E. Humphries , R.D. Steiner , M. Benoy , J. Tumolo , P.K. Held , X. Shao","doi":"10.1016/j.athplu.2025.10.007","DOIUrl":"10.1016/j.athplu.2025.10.007","url":null,"abstract":"","PeriodicalId":72324,"journal":{"name":"Atherosclerosis plus","volume":"62 ","pages":"Page 4"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145808467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HEART UK 38th Annual Medical & Scientific conference 英国心脏协会第38届年度医学与科学会议
IF 2.1 Q3 PERIPHERAL VASCULAR DISEASE
Atherosclerosis plus
Pub Date : 2025-12-01 DOI: 10.1016/j.athplu.2025.10.002
{"title":"HEART UK 38th Annual Medical & Scientific conference","authors":"","doi":"10.1016/j.athplu.2025.10.002","DOIUrl":"10.1016/j.athplu.2025.10.002","url":null,"abstract":"","PeriodicalId":72324,"journal":{"name":"Atherosclerosis plus","volume":"62 ","pages":"Page 1"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145808508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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IF 2.1 Q3 PERIPHERAL VASCULAR DISEASE
Atherosclerosis plus
Pub Date : 2025-12-01 DOI: 10.1016/S2667-0895(25)00060-4
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引用次数: 0
Layered plaque in patients with chronic coronary syndrome 慢性冠脉综合征患者的层状斑块
IF 2.1 Q3 PERIPHERAL VASCULAR DISEASE
Atherosclerosis plus
Pub Date : 2025-12-01 DOI: 10.1016/j.athplu.2025.11.002
Takafumi Mito , Daisuke Kinoshita , Yoichiro Otaki , Jun Goto , Seisei Ra , Hiroe Ono , Taku Shikama , Shingo Tachibana , Shigehiko Kato , Tetsu Watanabe , Ik-Kyung Jang , Masafumi Watanabe

Background

Plaque disruption exposes thrombogenic substrates and triggers local thrombosis. When a fresh thrombus forms, endogenous antithrombotic mechanisms activate. The balance between these two pro- and antithrombotic mechanisms determines the outcome of plaque disruption. When thrombogenic stimuli outweigh the antithrombotic mechanisms, an occlusive thrombus forms, leading to acute coronary syndromes. When antithrombotic mechanisms dominate, a non-occlusive thrombus forms, contributing to the rapid progression of atherosclerosis. A layered or healed plaque can be identified using optical coherence tomography (OCT).

Purpose

The study aimed to investigate the association between atherothrombotic biomarkers and layered plaque at culprit lesions.

Methods

We analyzed 119 lesions in patients with chronic coronary syndrome who underwent OCT prior to percutaneous coronary intervention. Four groups of biomarkers were studied: antithrombotic, atherogenic, prothrombotic, and inflammatory. The layer index, defined as the mean layer arc multiplied by the layer length, was assessed using OCT.

Results

Patients were divided into tertiles based on each of the four groups. Among the four groups, only the antithrombotic biomarkers were significantly associated with the layer index (low vs. moderate vs. high: 0 vs. 517 vs. 719, p for trend = 0.037). This positive correlation remained significant after adjusting for confounders. In contrast, no association was found between the layer index and atherogenic, prothrombotic, or inflammatory biomarkers.

Conclusions

The antithrombotic mechanism appears to play a key role in layered plaque formation.
斑块破坏暴露血栓形成底物并引发局部血栓形成。当新血栓形成时，内源性抗血栓机制被激活。这两种促血栓和抗血栓机制之间的平衡决定了斑块破裂的结果。当血栓形成的刺激超过抗血栓机制，闭塞血栓形成，导致急性冠状动脉综合征。当抗血栓机制占主导地位时，非闭塞性血栓形成，促进动脉粥样硬化的快速进展。层状或愈合的斑块可以使用光学相干断层扫描（OCT）识别。目的研究动脉粥样硬化血栓生物标志物与罪魁祸首病变层状斑块之间的关系。方法分析119例经皮冠状动脉介入治疗前行OCT检查的慢性冠状动脉综合征病变。研究了四组生物标志物：抗血栓、致动脉粥样硬化、促血栓和炎症。层指数定义为平均层弧乘以层长，使用oct进行评估。结果根据四组的每一组将患者分为三层。在四组中，只有抗血栓生物标志物与层指数显著相关（低、中、高：0、517、719，p为趋势= 0.037）。在调整混杂因素后，这种正相关仍然显著。相反，没有发现层指数与动脉粥样硬化、血栓形成前或炎症生物标志物之间的关联。结论抗血栓机制在层状斑块形成中起关键作用。
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引用次数: 0
Hypertriglyceridemia and pancreatitis: Prevention success with older lipid lowering medication in a case with comorbidities 高甘油三酯血症和胰腺炎：有合并症的老年降脂药物预防成功
IF 2.1 Q3 PERIPHERAL VASCULAR DISEASE
Atherosclerosis plus
Pub Date : 2025-12-01 DOI: 10.1016/j.athplu.2025.10.012
E. Mohamed, I. Boughazi, E. Ward, A. Theodoraki, M. Feher
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引用次数: 0
Clinical trial experience using in vivo base editing medicines for cardiovascular disease that aim to durably lower LDL cholesterol after a single treatment 使用体内碱基编辑药物治疗心血管疾病的临床试验经验，旨在单次治疗后持久降低LDL胆固醇
IF 2.1 Q3 PERIPHERAL VASCULAR DISEASE
Atherosclerosis plus
Pub Date : 2025-12-01 DOI: 10.1016/j.athplu.2025.10.010
S.B. Vafai
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引用次数: 0
Lomitapide in paediatric patients with homozygous familial hypercholesterolaemia (HoFH) – Analysis of long-term (104-week) safety and efficacy from the APH-19 study 洛米他啶在纯合子家族性高胆固醇血症（HoFH）患儿中的应用——APH-19研究的长期（104周）安全性和有效性分析
IF 2.1 Q3 PERIPHERAL VASCULAR DISEASE
Atherosclerosis plus
Pub Date : 2025-12-01 DOI: 10.1016/j.athplu.2025.10.016
Phil Dawson , Luis Masana , Alberto Zambon , Claus Peter Schmitt , Christina Taylan , Joenna Driemeyer , Hofit Cohen , Paola Sabrina Buonuomo , Abdullah Alashwal , Mohammed Al-Dubayee , Naji Kholaif , José Luis Diaz-Diaz , Faouzi Maatouk , Sergio Martinez-Hervas , Brian Mangal , Sandra Löwe , Zsuzsanna Tamas
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引用次数: 0
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