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Atlanta medical and surgical journal最新文献

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The Heatonian Method for the Radical Cure of Hernia. 热疗法根治疝。
Pub Date : 1881-05-01
W H Heath
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引用次数: 0
Cancer of the Cervix Uteri. 子宫颈癌。
Pub Date : 1881-05-01
John G Blake
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引用次数: 0
New York Academy of Medicine 纽约医学院
Pub Date : 1881-05-01 DOI: 10.1136/ard.9.3.252
The author reviews the effects of treating 169 cases of chronic rheumatic disease with cortisone and 175 with ACTH (the total so far treated in America). Cortisone and ACTH are effective in the treatment of rheumatoid arthritis, rheumatoid spondylitis, Still's disease, and psoriasis with arthritis. The average dosage for cortisone is 100 mg. daily, in one injection, until a remission is induced, and then 100 mg. thrice weekly. With ACTH it seems preferable to give small doses (generally 25 mg. of standard preparation) four times daily. Relapse after cessation of treatment usually occurs rapidly. Complications include: oedema from sodium retention, hypopotassiumaemia, partial hypercortico-adrenalism, menstrual disorders, diabetic carbohydrate metabolism, insomnia, tachycardia, excitability, and mental depression. They occur more frequently in women, particularly those of premenopausal age, and in children, who require comparatively larger doses. Substances chemically similar to cortisone studied to date, include compound S, progesterone, 1 7-hydroxyprogesterone, pregnenolone, acetoxy-pregnenolone and testosterone, but all are ineffective. In conclusion it is emphasized that, since prolonged administration of cortisone may lead to adrenal atrophy and that of ACTH to pituitary atrophy with adrenal hyperplasia, further research on this problem is required before the hormones can be considered for practical therapy. It remains, however, the greatest advance in the treatment of rheumatic diseases.
作者回顾了可的松治疗慢性风湿病169例,促肾上腺皮质激素治疗慢性风湿病175例(美国迄今治疗总数)的疗效。可的松和促肾上腺皮质激素对类风湿关节炎、类风湿脊柱炎、斯蒂尔氏病和伴有关节炎的牛皮癣有效。可的松的平均剂量为100毫克。每日一次注射,直到诱导缓解,然后再注射100毫克。三次每周。对于促肾上腺皮质激素,小剂量(一般为25毫克)似乎更可取。(指标准制剂)每日四次。停止治疗后复发通常发生得很快。并发症包括:钠潴留引起的水肿、低钾血症、部分肾上腺皮质亢进、月经紊乱、糖尿病性碳水化合物代谢、失眠、心动过速、兴奋性和精神抑郁。它们更常发生在妇女,特别是绝经前年龄的妇女和儿童中,他们需要相对较大的剂量。迄今为止研究的化学性质与可的松相似的物质包括化合物S、黄体酮、17 -羟基黄体酮、孕烯醇酮、乙酰羟孕烯醇酮和睾酮,但都是无效的。总之,需要强调的是,由于长期使用可的松可能导致肾上腺萎缩,而ACTH可能导致垂体萎缩伴肾上腺增生,因此在考虑使用可的松进行实际治疗之前,还需要进一步研究这一问题。然而,它仍然是风湿病治疗方面的最大进步。
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引用次数: 0
Medico-Chirurgical Society of Louisville, Ky. 肯塔基州路易斯维尔市医学Chirourgical Society。
Pub Date : 1881-05-01
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引用次数: 0
Mechanical Atresia Vaginæ. 机械性阴道闭锁。
Pub Date : 1881-05-01
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引用次数: 0
West Chicago Medical Society. 西芝加哥医学协会
Pub Date : 1881-05-01
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引用次数: 0
Philadelphia Academy of Surgery. 费城外科学会。
Pub Date : 1881-05-01
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引用次数: 0
Reflex Nervous Disturbances. 反射性神经紊乱。
Pub Date : 1881-05-01
Robt W Westmoreland
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引用次数: 0
Philadelphia County Medical Society. 费城县医学会
Pub Date : 1881-05-01
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引用次数: 0
New York Academy of Medicine. 纽约医学院。
Pub Date : 1881-05-01
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引用次数: 0
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Atlanta medical and surgical journal
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