Brain multiphysics最新文献

{"title":"Towards animal surrogates for characterising large strain dynamic mechanical properties of human brain tissue","authors":"David B. MacManus ,&nbsp;Andrea Menichetti ,&nbsp;Bart Depreitere ,&nbsp;Nele Famaey ,&nbsp;Jos Vander Sloten ,&nbsp;Michael Gilchrist","doi":"10.1016/j.brain.2020.100018","DOIUrl":"10.1016/j.brain.2020.100018","url":null,"abstract":"<div><p>The regional dynamic mechanical properties of mouse, rat, pig, and human brain tissue were compared directly in this first-of-its-kind study. Our results suggest the use of pig or mouse brain tissue as suitable surrogates to characterise human brain tissue. The importance of this work is highlighted by the extensive use of constitutive data from animal brain tissue in traumatic brain injury research in the absence of human brain tissue data without any direct evidence supporting their use. Indentation force-relaxation experiments were performed on mouse, rat, pig, and human brains at 10/s strain rate up to 35% strain to determine the dynamic mechanical properties of brain tissue. Finite element models have become useful tools to investigate the biomechanics of traumatic brain injury - a global leading cause of death and disability and a risk factor for developing neurodegenerative diseases. However, these models require accurate constitutive data for brain tissue to produce reliable results. The results presented here provide validation for the use of pig and mouse brain tissue data in such models.</p></div><div><h3>Statement of Significance</h3><p>The significance of this work is underscored by the extensive use of animal brain tissue as a surrogate for human brain tissue without any direct evidence supporting the validity of their use. For the first time ever, we demonstrate that porcine and murine brain tissue can be used as surrogates for human brain tissue under dynamic loading conditions. These findings will allow researchers to select appropriate animal surrogates for human brain tissue under dynamic loading conditions. Furthermore, our findings support the use of animal surrogate data to improve the fidelity of computational models of the human brain, and provide experimental data to develop constitutive models of brain tissue.</p></div>","PeriodicalId":72449,"journal":{"name":"Brain multiphysics","volume":"1 ","pages":"Article 100018"},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.brain.2020.100018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"93721391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aspirin for in vitro fertilisation.","authors":"Charalampos S Siristatidis, George Basios, Vasilios Pergialiotis, Paraskevi Vogiatzi","doi":"10.1002/14651858.CD004832.pub4","DOIUrl":"10.1002/14651858.CD004832.pub4","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Aspirin is used with the aim of optimising the chance of live birth in women undergoing assisted reproductive technology (ART), despite inconsistent evidence of its efficacy and safety (in terms of intraoperative bleeding during oocyte retrieval and risk of miscarriage). The most appropriate time to commence aspirin therapy and the length of treatment required are also still to be determined. This is the second update of the review first published in 2007.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;To evaluate the effectiveness and safety of aspirin in women undergoing ART.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Search methods: &lt;/strong&gt;We searched the Cochrane Gynaecology and Fertility Group Trials Register, Cochrane Central Register of Controlled Trials (CENTRAL; 2016, Issue 4) in the Cochrane Library (searched 9 May 2016); the databases MEDLINE (1946 to 9 May 2016) and Embase (1974 to 9 May 2016); and trial registers (ClinicalTrials.gov and the World Health Organization International Clinical Trials Registry Platform search portal). We also examined the reference lists of all known primary studies and review articles, citation lists of relevant publications and abstracts of major scientific meetings, combined with the Cochrane Gynaecology and Fertility Group's search strategy.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Selection criteria: &lt;/strong&gt;Randomised controlled trials on aspirin for women undergoing ART.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Data collection and analysis: &lt;/strong&gt;Two review authors independently assessed trial eligibility and risk of bias and extracted the data. The primary review outcome was live birth. Secondary outcomes included clinical pregnancy, ongoing pregnancy, multiple pregnancy, miscarriage, and other complications associated with IVF/ICSI or with pregnancy and birth. We combined data to calculate risk ratios (RRs) (for dichotomous data) and mean differences (MDs) (for continuous data) and 95% confidence intervals (CIs). Statistical heterogeneity was assessed using the I² statistic. We assessed the overall quality of the evidence for the main comparisons using GRADE methods.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Main results: &lt;/strong&gt;The search identified 13 trials as eligible for inclusion in the review, including a total of 2653 participants with a mean age of 35 years. Ten studies used a dose of 100 mg and three used 80 mg of aspirin per day. In most of them, aspirin was commenced immediately at the start of down-regulation, while the duration of treatment varied widely. Eight studies provided a placebo for the control group.There was no evidence of a difference between the aspirin group and the group receiving no treatment or placebo in rates of live birth (RR 0.91, 95% CI 0.72 to 1.15, 3 RCTs, n = 1053, I² = 15%, moderate-quality evidence). In addition, clinical pregnancy rates were also similar for the two groups (RR 1.03, 95% CI 0.91 to 1.17, 10 RCTs, n = 2142, I² = 27%, moderate-quality evidence); sensitivity analysis, excluding studies at high risk of bias, did not change th","PeriodicalId":72449,"journal":{"name":"Brain multiphysics","volume":"1 1","pages":"CD004832"},"PeriodicalIF":0.0,"publicationDate":"2016-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76263389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perspective: Challenges and opportunities in computational brain mechanics research: How can we use recent experimental data to improve models of brain mechanics?","authors":"P. Bayly","doi":"10.1016/j.brain.2023.100075","DOIUrl":"https://doi.org/10.1016/j.brain.2023.100075","url":null,"abstract":"","PeriodicalId":72449,"journal":{"name":"Brain multiphysics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54406268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive study of sex-based anatomical variations of human brain and development of sex-specific brain templates","authors":"M. Ramzanpour, Bahram Jafari, Jeremy L. Smith, Jason Allen, M. Hajiaghamemar","doi":"10.1016/j.brain.2023.100077","DOIUrl":"https://doi.org/10.1016/j.brain.2023.100077","url":null,"abstract":"","PeriodicalId":72449,"journal":{"name":"Brain multiphysics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54406365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring human brain mechanics by combining experiments, modeling, and simulation","authors":"S. Budday","doi":"10.1016/j.brain.2023.100076","DOIUrl":"https://doi.org/10.1016/j.brain.2023.100076","url":null,"abstract":"","PeriodicalId":72449,"journal":{"name":"Brain multiphysics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54406294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}