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Spontaneous Regression of Incidental Meningioma in the Posterior Cranial Fossa: A Case Report and Literature Review. 后颅窝偶发性脑膜瘤自发性消退1例报告及文献复习。
Pub Date : 2025-10-01 DOI: 10.14791/btrt.2025.0012
Min Seok Kim, So Hee Park, Youngbeom Seo

We report a rare case of spontaneous regression of a meningioma located in the posterior cranial fossa. A 60-year-old female patient presented with a headache. Both physical and neurological examinations were normal. Her medical history included type 2 diabetes mellitus. MRI showed a homogeneously enhancing mass in the left cerebellopontine angle. The volume of the tumor was 1.673 cm³. Radiological features, including the dural tail sign and the cerebrospinal fluid cleft sign, suggested the presence of a meningioma. Given these characteristics, we recommended serial follow-up MRI examinations. Unfortunately, the patient was lost to follow-up. Ten years later, she returned with a headache to reevaluate the previously diagnosed tumor. The follow-up MRI revealed significant regression and increased intratumoral calcification, with the tumor now measuring only 0.256 cm³. This report illustrates that meningiomas diagnosed incidentally can undergo spontaneous regression, a phenomenon that clinicians should be aware of.

我们报告一例罕见的脑膜瘤自发性消退位于颅后窝。60岁女性患者,以头痛为主诉。身体和神经检查均正常。她的病史包括2型糖尿病。MRI显示左侧桥小脑角均匀增强肿块。肿瘤体积1.673 cm³。影像学表现,包括硬脑膜尾征和脑脊液裂征,提示脑膜瘤的存在。鉴于这些特点,我们建议进行连续随访MRI检查。不幸的是,患者未能随访。十年后,她带着头痛回来重新评估先前诊断的肿瘤。随访MRI显示肿瘤明显消退,瘤内钙化增加,目前肿瘤尺寸仅为0.256 cm³。本报告说明偶然诊断的脑膜瘤可发生自发消退,这是临床医生应注意的现象。
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引用次数: 0
Resolution of Hyperprolactinemia Caused by Pituitary Stalk Compression After Transsphenoidal Surgery for Pituitary Tumors. 垂体瘤经蝶窦手术后垂体柄受压所致高催乳素血症的解决。
Pub Date : 2025-10-01 DOI: 10.14791/btrt.2025.0028
Myungsuk Oh, Eui Hyun Kim

Background: Hyperprolactinemia caused by pituitary stalk compression is common in patients with pituitary tumors. There is a lack of studies investigating the resolution patterns or time course of hyperprolactinemia after surgery. We aimed to demonstrate the time course of changes in prolactin levels following successful surgical decompression of the pituitary stalk.

Methods: We retrospectively examined 201 patients with preoperative hyperprolactinemia caused by the pituitary stalk compression effect who underwent transsphenoidal surgery. Postoperative prolactin levels were assessed at the time points of 1 week; 1, 3, and 6 months; and 1 year following the surgery. As a subgroup analysis, 115 individuals underwent serial prolactin level measurements at 6, 12, 18, 24, 48, and 72 hours after surgery.

Results: Hyperprolactinemia caused by pituitary stalk compression was resolved in 71.64% of patients 1 week after surgery, 84.84% after 1 month, 89.30% after 3 months, and 92.67% after 6 months, and 92.74% eventually reached normalization 1 year after surgery. Among the 35 patients whose prolactin levels were measured in the immediate postoperative period, 26 patients (72.49%) reached remission status within 72 hours. The immediate postoperative prolactin level was most predictive at 72 hours after surgery, with an optimal cutoff of 23.10 ng/mL.

Conclusion: The postoperative resolution of hyperprolactinemia caused by stalk compression was possible in 90% within a year. The decline in serum prolactin levels typically began within the first 72 hours after surgery, indicating that the hormonal response to surgical decompression is very prompt and effective.

背景:垂体柄受压引起的高催乳素血症在垂体肿瘤患者中很常见。手术后高泌乳素血症的消退模式和时间过程缺乏研究。我们旨在证明垂体柄成功手术减压后催乳素水平变化的时间过程。方法:回顾性分析201例术前垂体柄压迫致高泌乳素血症患者行经蝶窦手术。术后1周时间点评估泌乳素水平;1、3、6个月;手术后1年。作为亚组分析,115名患者在手术后6、12、18、24、48和72小时接受了催乳素水平的连续测量。结果:垂体柄压迫引起的高催乳素血症在术后1周、1个月、3个月、6个月分别有71.64%、84.84%、89.30%和92.67%的患者得到缓解,92.74%的患者在术后1年最终恢复正常。术后即刻检测催乳素水平的35例患者中,26例(72.49%)在72小时内达到缓解状态。术后即刻催乳素水平在术后72小时最具预测性,最佳临界值为23.10 ng/mL。结论:茎部压迫引起的高催乳素血症在术后一年内有90%的可能性得到缓解。血清催乳素水平的下降通常在手术后72小时内开始,表明激素对手术减压的反应是非常迅速和有效的。
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引用次数: 0
Sonodynamic Therapy With Orally Absorbable Nanomedicine for Brain Tumor. 口服可吸收纳米药物对脑肿瘤的声动力治疗。
Pub Date : 2025-10-01 DOI: 10.14791/btrt.2025.0023
Chaerim Yoo, Jihyeon Kim, Dong Yun Lee

Glioblastoma (GBM) is an aggressive and treatment-resistant brain tumor with poor prognosis despite surgery, radiotherapy, and chemotherapy. Sonodynamic therapy (SDT), which combines low-intensity focused ultrasound with systemically or orally administered sonosensitizers, has emerged as a promising non-invasive approach to achieve localized tumor cell killing via reactive oxygen species. Recent advances in nanomedicine have enabled the development of orally absorbable, blood-brain barrier permeable delivery systems that enhance tumor targeting and ultrasound responsiveness. Preclinical studies have demonstrated consistent anti-tumor efficacy and immune activation, while early clinical trials suggest SDT is safe, feasible, and potentially effective in recurrent GBM. This review outlines recent progress in SDT-based strategies for GBM, with emphasis on mechanistic insights, delivery innovations, and clinical translation.

胶质母细胞瘤(GBM)是一种侵袭性和治疗耐药的脑肿瘤,尽管手术、放疗和化疗,预后都很差。声动力疗法(SDT)将低强度聚焦超声与系统或口服超声增敏剂相结合,已成为一种有前途的非侵入性方法,可通过活性氧实现局部肿瘤细胞杀伤。纳米医学的最新进展使口服可吸收、血脑屏障可渗透的给药系统得以发展,从而增强肿瘤靶向性和超声反应性。临床前研究显示出一致的抗肿瘤疗效和免疫激活,而早期临床试验表明SDT对复发性GBM是安全、可行和潜在有效的。本综述概述了基于sdt的GBM治疗策略的最新进展,重点是机制见解、交付创新和临床转化。
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引用次数: 0
Neural Vulnerabilities in Glioblastoma: Rethinking Therapy Through Neuroactive Drug Repurposing. 胶质母细胞瘤的神经脆弱性:通过神经活性药物再利用重新思考治疗。
Pub Date : 2025-10-01 DOI: 10.14791/btrt.2025.0024
Paola Onate Colobon, Sohyon Lee

Glioblastoma, the most common and highly aggressive brain cancer, remains challenging to treat with limited gains in patient survival despite decades of research. Significant obstacles in developing new effective therapies for glioblastoma include the blood-brain barrier impeding drug delivery, inter- and intra-tumoral patient heterogeneity, and the lack of predictive preclinical models. Emerging insights from cancer neuroscience suggest that leveraging the neurodevelopmental and neurophysiological properties of glioblastoma may offer a new therapeutic window. In this context, neuroactive drugs (NADs) that are already approved for other central nervous system indications and can readily cross the blood-brain barrier may target these neural properties of glioblastoma through still unknown mechanisms. This review discusses existing preclinical models for glioblastoma drug discovery, explores how the tumor's neural-like behavior opens new therapeutic opportunities, and highlights the recent evidence supporting the repositioning of NADs as a paradigm shift in glioblastoma treatment.

胶质母细胞瘤是最常见和高度侵袭性的脑癌,尽管数十年的研究,但治疗仍然具有挑战性,患者生存率有限。开发胶质母细胞瘤新有效疗法的重大障碍包括血脑屏障阻碍药物输送,肿瘤间和肿瘤内患者异质性,以及缺乏预测性临床前模型。来自癌症神经科学的新见解表明,利用胶质母细胞瘤的神经发育和神经生理特性可能提供一个新的治疗窗口。在这种情况下,已经被批准用于其他中枢神经系统适应症并且可以轻易穿过血脑屏障的神经活性药物(NADs)可能通过尚不清楚的机制靶向胶质母细胞瘤的这些神经特性。这篇综述讨论了胶质母细胞瘤药物发现的现有临床前模型,探讨了肿瘤的神经样行为如何开辟新的治疗机会,并强调了最近支持NADs重新定位为胶质母细胞瘤治疗范式转变的证据。
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引用次数: 0
Erdheim-Chester Disease Mimicking a Malignant Pituitary Stalk Tumor With Ventricular Dissemination: A Case Report. 厄德海姆-切斯特病模拟恶性垂体柄瘤伴室性播散一例报告。
Pub Date : 2025-10-01 DOI: 10.14791/btrt.2025.0029
Myungsuk Oh, Se Hoon Kim, Eui Hyun Kim

Erdheim-Chester disease (ECD) is a rare form of non-Langerhans cell histiocytosis characterized by multi-organ involvement, most commonly affecting the long bones, retroperitoneum, heart, lungs, skin, and central nervous system (CNS). Approximately half of reported cases exhibit CNS involvement, which may affect both intra- and extra-axial compartments. On MRI, ECD typically presents as a strongly enhancing mass lesion, often mimicking neoplastic or infectious conditions. With advances in genetic understanding, ECD is now recognized as a hematologic malignancy of histiocytic origin, driven by mutations in key components of the MAPK signaling pathway. Among these, the BRAF mutation is the most frequently observed genetic alteration and often provides a valuable clue for differential diagnosis. However, in cases lacking typical clinical features and the absence of BRAF mutation, diagnosis becomes significantly more challenging. We report the case of a 32-year-old man who presented with a pituitary stalk mass and ventricular dissemination, ultimately diagnosed with BRAF wild-type ECD harboring a CSF1R mutation, which has recently been implicated as a potential driver within the MAPK pathway. A deeper understanding of the molecular pathogenesis of ECD may not only aid in accurate diagnosis but also contribute to improved clinical outcomes.

Erdheim-Chester病(ECD)是一种罕见的非朗格汉斯细胞组织细胞增多症,其特征是多器官受累,最常影响长骨、腹膜后、心脏、肺、皮肤和中枢神经系统(CNS)。大约一半的报告病例表现出中枢神经受累,这可能影响轴内和轴外室。在MRI上,ECD通常表现为强烈增强的肿块病变,通常模仿肿瘤或感染性疾病。随着遗传学理解的进步,ECD现在被认为是一种起源于组织细胞的血液恶性肿瘤,由MAPK信号通路关键成分的突变驱动。其中,BRAF突变是最常见的基因改变,通常为鉴别诊断提供有价值的线索。然而,在缺乏典型临床特征和没有BRAF突变的病例中,诊断变得更具挑战性。我们报告了一名32岁男性的病例,他表现为垂体柄肿块和心室播散,最终被诊断为BRAF野生型ECD,其中包含CSF1R突变,该突变最近被认为是MAPK通路的潜在驱动因素。更深入地了解ECD的分子发病机制不仅有助于准确诊断,而且有助于改善临床结果。
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引用次数: 0
Correction of Content, Table, and Funding Statement of the Article "Intraoperative Language Area Mapping: Cortico-Cortical Evoked Potential". 对“术中语言区映射:皮质-皮质诱发电位”这篇文章的内容、表格和经费声明进行了更正。
Pub Date : 2025-10-01 DOI: 10.14791/btrt.2025.0008e
Tae-Min Cheon, Soo-Hyun Yoon, Myoung-Jeong Kim, Kyung-Min Kim

This corrects the article on p. 39 in vol. 13, PMID: 40347125.

这是对第13卷第39页的文章的更正,PMID: 40347125。
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引用次数: 0
Spontaneous Cranial Epidural Inflammatory Granuloma Mimicking Brain Tumor: A Case Report. 自发性脑硬膜外炎性肉芽肿模拟脑瘤1例报告。
Pub Date : 2025-10-01 DOI: 10.14791/btrt.2025.0027
Ho-Shin Gwak, June Young Chun, Na Young Han, So Hyeon Ji, Soyoung Choi, Young Joo Choi

Here, we report a case of spontaneous cranial epidural inflammatory granuloma occurring in an 87-year-old female patient. The patient had a longstanding history of diabetes, which was managed with insulin. She developed reading and speech difficulties 1 month prior to presentation, and on the day of her visit to the ER, she had a partial seizure. Non-contrast CT results showed an ill-defined iso- to mild hyperdense lesion on the left frontal lobe with severe perilesional edema, giving the impression of a brain tumor. Subsequent MRI results showed an irregular, rim-enhancing lesion involving the brain parenchyma and epidural space without diffusion restriction, suggestive of an infectious granuloma. An initial workup was performed, including various cultures and chest CT to rule out possible infectious sources, but all results were negative. Thus, an excisional biopsy was performed, and intraoperative findings revealed an epidural granulomatous lesion invading the dura and extending to the pial surface. Intraoperative tissue 16s rRNA polymerase chain reaction (PCR) was positive for Staphylococcus aureus, and tissue cultures later confirmed the strain to be methicillin-resistant S. aureus. After the PCR, the patient was additionally given vancomycin. She improved completely, regaining her previous average daily living function.

在此,我们报告一例自发性脑硬膜外炎性肉芽肿发生在一位87岁的女性患者。患者有长期的糖尿病病史,一直使用胰岛素治疗。在就诊前1个月,她出现了阅读和语言障碍,在她去急诊室的当天,她出现了部分癫痫发作。非对比CT结果显示左侧额叶有一模糊的等至轻度高密度病变,伴严重的病灶周围水肿,表现为脑肿瘤。随后的MRI结果显示不规则,边缘增强病变累及脑实质和硬膜外间隙,无扩散限制,提示感染性肉芽肿。进行了初步检查,包括各种培养和胸部CT以排除可能的感染源,但所有结果均为阴性。因此,进行了切除活检,术中发现硬膜外肉芽肿病变侵入硬脑膜并延伸到颅底。术中组织16s rRNA聚合酶链反应(PCR)金黄色葡萄球菌阳性,组织培养证实该菌株为耐甲氧西林金黄色葡萄球菌。PCR结束后,患者加用万古霉素。她完全好转了,恢复了以前的日常生活功能。
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引用次数: 0
Postoperative Seizures Can Predict Overall Survival of Patients With Newly Diagnosed Supratentorial Isocitrate Dehydrogenase-Wild Glioblastoma Treated With Radiotherapy Plus Concomitant and Adjuvant Temozolomide. 术后癫痫发作可以预测新诊断的幕上异柠檬酸脱氢酶野生胶质母细胞瘤患者放疗加伴随和辅助替莫唑胺治疗的总生存率。
Pub Date : 2025-10-01 DOI: 10.14791/btrt.2025.0022
Kengo Yamada, Ryosuke Matsuda, Ryota Sasaki, Ryosuke Maeoka, Tsutomu Nakazawa, Takayuki Morimoto, Yudai Morisaki, Shohei Yokoyama, Masashi Kotsugi, Yasuhiro Takeshima, Shuichi Yamada, Fumihiko Nishimura, Young-Soo Park, Ichiro Nakagawa

Background: We aimed to evaluate the correlation between postoperative seizures (POS) and overall survival in patients with newly diagnosed supratentorial isocitrate dehydrogenase (IDH)-wild glioblastoma treated with radiotherapy plus concomitant and adjuvant temozolomide.

Methods: This study included 122 patients with newly diagnosed supratentorial IDH-wild glioblastoma who were treated at our hospital between May 2007 and September 2022. Seizures occurring within 7 days after surgery were defined as immediate POS (iPOS). Moreover, seizures from the 8th day after the surgery were defined as delayed POS (dPOS).

Results: The median follow-up period and median survival time (MST) from surgery in the entire cohort were 19.3 and 20.4 months, respectively. The rates of iPOS and dPOS in this study were 6.6% (n=8) and 38.5% (n=47), respectively. The MST of patients with iPOS and without iPOS was 27.6 and 20 months, respectively. There was no significant difference between with iPOS and without iPOS. The median time to onset of dPOS was 126 days after surgery. The MST of patients with dPOS and without dPOS was 25.9 and 18.4 months, respectively. Patients with dPOS showed significantly longer survival than those without dPOS (p=0.024). Occurrence of seizures at the initial manifestation of disease was found to be significantly more likely to cause dPOS (p=0.044).

Conclusion: Among patients with newly diagnosed supratentorial IDH-wild glioblastoma, the prognosis of patients with seizures in the postoperative course was better than that of patients without dPOS.

背景:我们的目的是评估新诊断的幕上异柠檬酸脱氢酶(IDH)野生胶质母细胞瘤患者术后癫痫发作(POS)与总生存率的相关性,这些患者接受放疗加伴随和辅助替莫唑胺治疗。方法:本研究纳入2007年5月至2022年9月在我院治疗的122例新诊断的幕上idh野生胶质母细胞瘤患者。术后7天内癫痫发作定义为立即性POS (iPOS)。术后第8天的癫痫发作被定义为延迟性POS (dPOS)。结果:整个队列手术后的中位随访期和中位生存时间(MST)分别为19.3个月和20.4个月。本研究中ipo和dPOS的发生率分别为6.6% (n=8)和38.5% (n=47)。有iPOS和无iPOS患者的MST分别为27.6个月和20个月。参与ipo与未参与ipo之间无显著差异。dPOS发病的中位时间为术后126天。有dPOS和无dPOS患者的MST分别为25.9个月和18.4个月。dPOS患者的生存期明显长于无dPOS患者(p=0.024)。发现在疾病最初表现时发生癫痫发作更容易引起dPOS (p=0.044)。结论:在新诊断的幕上idh野生胶质母细胞瘤患者中,术后出现癫痫发作的患者预后优于无dPOS的患者。
{"title":"Postoperative Seizures Can Predict Overall Survival of Patients With Newly Diagnosed Supratentorial Isocitrate Dehydrogenase-Wild Glioblastoma Treated With Radiotherapy Plus Concomitant and Adjuvant Temozolomide.","authors":"Kengo Yamada, Ryosuke Matsuda, Ryota Sasaki, Ryosuke Maeoka, Tsutomu Nakazawa, Takayuki Morimoto, Yudai Morisaki, Shohei Yokoyama, Masashi Kotsugi, Yasuhiro Takeshima, Shuichi Yamada, Fumihiko Nishimura, Young-Soo Park, Ichiro Nakagawa","doi":"10.14791/btrt.2025.0022","DOIUrl":"10.14791/btrt.2025.0022","url":null,"abstract":"<p><strong>Background: </strong>We aimed to evaluate the correlation between postoperative seizures (POS) and overall survival in patients with newly diagnosed supratentorial isocitrate dehydrogenase (IDH)-wild glioblastoma treated with radiotherapy plus concomitant and adjuvant temozolomide.</p><p><strong>Methods: </strong>This study included 122 patients with newly diagnosed supratentorial IDH-wild glioblastoma who were treated at our hospital between May 2007 and September 2022. Seizures occurring within 7 days after surgery were defined as immediate POS (iPOS). Moreover, seizures from the 8th day after the surgery were defined as delayed POS (dPOS).</p><p><strong>Results: </strong>The median follow-up period and median survival time (MST) from surgery in the entire cohort were 19.3 and 20.4 months, respectively. The rates of iPOS and dPOS in this study were 6.6% (n=8) and 38.5% (n=47), respectively. The MST of patients with iPOS and without iPOS was 27.6 and 20 months, respectively. There was no significant difference between with iPOS and without iPOS. The median time to onset of dPOS was 126 days after surgery. The MST of patients with dPOS and without dPOS was 25.9 and 18.4 months, respectively. Patients with dPOS showed significantly longer survival than those without dPOS (<i>p</i>=0.024). Occurrence of seizures at the initial manifestation of disease was found to be significantly more likely to cause dPOS (<i>p</i>=0.044).</p><p><strong>Conclusion: </strong>Among patients with newly diagnosed supratentorial IDH-wild glioblastoma, the prognosis of patients with seizures in the postoperative course was better than that of patients without dPOS.</p>","PeriodicalId":72453,"journal":{"name":"Brain tumor research and treatment","volume":"13 4","pages":"140-146"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12621835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145497600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gamma Knife Radiosurgery for Advanced and Recurrent Juvenile Nasopharyngeal Angiofibroma: A Case Series. 伽玛刀放射治疗晚期和复发的青少年鼻咽血管纤维瘤:一个病例系列。
Pub Date : 2025-07-01 DOI: 10.14791/btrt.2025.0014
Jong Seok Lee, Jung-Il Lee

Juvenile nasopharyngeal angiofibroma (JNA) is a rare, benign, but locally aggressive tumor that typically affects adolescent males. While surgical resection is the standard treatment, achieving total resection is often challenging in advanced-stage tumors with intracranial extension, resulting in high recurrence rates. Gamma knife radiosurgery (GKRS) has been suggested as a potential adjuvant or salvage therapy, but evidence remains limited. In this study, we report three pediatric cases of advanced-stage JNA treated with GKRS following incomplete surgical resection. Two patients demonstrated durable local tumor control with a significant reduction in tumor size until 2 and 12 years after GKRS. The other patient with partial coverage of tumor by prescription isodose 12 Gy showed a reduction of tumor volume at 6 months but subsequent progression at 1 year. No GKRS-related complications were observed during the follow-up period. Our findings suggest that GKRS appears to be a potentially safe and effective treatment modality for residual or recurrent JNAs. Fractionated or staged GKRS combined with surgery may be a preferable strategy for large tumors in which extensive surgery alone, conventional radiotherapy, or single-fraction radiosurgery may be associated with increased morbidity in pediatric populations.

青少年鼻咽血管纤维瘤(JNA)是一种罕见的良性,但局部侵袭性肿瘤,通常影响青少年男性。虽然手术切除是标准的治疗方法,但对于颅内扩展的晚期肿瘤,实现完全切除往往具有挑战性,导致高复发率。伽玛刀放射外科(GKRS)被认为是一种潜在的辅助或挽救治疗,但证据仍然有限。在这项研究中,我们报告了三例晚期JNA患儿在不完全手术切除后用GKRS治疗。两名患者表现出持久的局部肿瘤控制,肿瘤大小显著减少,直到GKRS后2年和12年。另一名处方等剂量12 Gy覆盖部分肿瘤的患者在6个月时肿瘤体积缩小,但随后在1年出现进展。随访期间未见gkrs相关并发症。我们的研究结果表明,GKRS似乎是一种潜在的安全有效的治疗残留或复发JNAs的方式。分阶段或分期GKRS联合手术可能是大肿瘤的首选策略,其中单独进行广泛手术,常规放疗或单部分放射手术可能会增加儿科人群的发病率。
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引用次数: 0
MicroRNA Expression and Neurocognitive Outcomes in Children and Young People With Primary Brain Tumor in Karachi, Pakistan: A Pilot Exploratory Study. 巴基斯坦卡拉奇儿童和青少年原发性脑肿瘤患者的MicroRNA表达和神经认知预后:一项初步探索性研究。
Pub Date : 2025-07-01 DOI: 10.14791/btrt.2025.0006
Nida Zahid, Muhammad Nouman Mughal, Nick Brown, Andreas Mårtensson, Thomas Mårtensson, Muhammad Sufiyan Ibrahim, Sana Naeem, Siraj Qazi, Wajiha Amin, Iqbal Azam, Naureen Mushtaq, Mariya Moochhala, Faiza Kausar, Aneesa Hasan, Farrukh Javeed, Lal Rehman, Sadaf Altaf, Salman Kirmani, Syed Ather Enam

Background: microRNAs regulate various cellular pathways and may serve as medium-term prognostic markers in neurocognitive function, as suggested by adult studies. However, no comparable data exist for children with central nervous system tumors. This pilot study explored miRNA expression and its correlation with 12-month posttreatment neurocognitive function in children and young adults (5-21 years) with primary brain tumors.

Methods: The study was conducted at Aga Khan University Hospital and Jinnah Postgraduate Medical Center (November 2020 to July 2023). This study analyzed serum levels of miR-21, miR-146a, miR-296-5p, miR-210, and miR-10b using reverse transcriptase quantitative PCR. Neurocognitive assessments using Slosson Intelligence Test, Raven's Progressive Matrices, and Wechsler Intelligence Scale were performed at pretreatment and 12 months posttreatment. The paired t-test was used to assess miRNA expressions, and correlation analysis assessed relationships between pretreatment miRNA expression and neurocognitive outcomes.

Results: Of the 48 patients, serum samples were available for analysis from 34 (71%) patients each at pretreatment and 48 hours post-surgery, and 13 (27%) patients at 12 months posttreatment. A statistically significant negative correlation was found between pretreatment miR-210 levels and perceptual reasoning scores at 12 months posttreatment (ρ=-0.59), and a positive correlation between pretreatment miR-10b levels and processing speed scores (ρ=0.49). However, there were no differences in microRNA expressions between pretreatment and 48 hours post-surgery (n=34), pretreatment and 12 months posttreatment (n=13), or 48 hours post-surgery and 12 months posttreatment.

Conclusion: This pilot exploratory study found two statistically significant correlations: a negative correlation between pretreatment miR-210 levels and 12 months posttreatment perceptual reasoning scores and a positive correlation between miR-10b expression and 12 months posttreatment speed scores. Further studies are needed to understand the protective or restorative function of miR-10b in cognitive processes and the detrimental role of miR-210 in cognitive processes to evaluate their potential future use as prognostic biomarkers for neurocognitive outcomes in children and young people with primary brain tumors.

背景:成人研究表明,microRNAs调节多种细胞通路,并可能作为神经认知功能的中期预后标志物。然而,对于患有中枢神经系统肿瘤的儿童,没有可比较的数据。这项初步研究探讨了miRNA表达及其与原发性脑肿瘤儿童和年轻人(5-21岁)治疗后12个月神经认知功能的相关性。方法:研究于2020年11月至2023年7月在阿迦汗大学医院和真纳研究生医学中心进行。本研究使用逆转录酶定量PCR分析了miR-21、miR-146a、miR-296-5p、miR-210和miR-10b的血清水平。治疗前和治疗后12个月分别采用Slosson智力测验、Raven’s Progressive Matrices和Wechsler智力量表进行神经认知评估。采用配对t检验评估miRNA表达,并通过相关性分析评估预处理miRNA表达与神经认知结局之间的关系。结果:在48例患者中,术前和术后48小时各有34例(71%)患者的血清样本可供分析,治疗后12个月有13例(27%)患者的血清样本可供分析。预处理miR-210水平与治疗后12个月知觉推理评分呈显著负相关(ρ=-0.59),预处理miR-10b水平与处理速度评分呈正相关(ρ=0.49)。然而,预处理与术后48小时(n=34)、预处理与术后12个月(n=13)、术后48小时与术后12个月的microRNA表达均无差异。结论:本初步探索性研究发现两项具有统计学意义的相关性:预处理miR-210水平与治疗后12个月的感知推理评分呈负相关,miR-10b表达与治疗后12个月的速度评分呈正相关。需要进一步的研究来了解miR-10b在认知过程中的保护或恢复功能以及miR-210在认知过程中的有害作用,以评估其作为儿童和青少年原发性脑肿瘤患者神经认知结果的预后生物标志物的潜在未来用途。
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引用次数: 0
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Brain tumor research and treatment
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