Pub Date : 2023-10-01DOI: 10.1089/ct.2023;35.395-397
Jan Wolff, Michael M. Kaplan, Arthur B. Schneider
Clinical Thyroidology®Vol. 35, No. 10 ATA Centennial Anniversary SeriesFree AccessJan Wolff Reflects on His Career as He Approaches His 99th BirthdayJan Wolff, Michael M. Kaplan, and Arthur B. SchneiderJan Wolff National Institutes of Health (Emeritus), Bethesda, Maryland, U.S.A.Search for more papers by this author, Michael M. Kaplan Associated Endocrinologists, Farmington Hills, Michigan, U.S.A.Search for more papers by this author, and Arthur B. Schneider College of Medicine (Emeritus), University of Illinois at Chicago, Chicago, Illinois, U.S.A.Search for more papers by this authorPublished Online:5 Oct 2023https://doi.org/10.1089/ct.2023;35.395-397AboutSectionsPDF/EPUB Permissions & CitationsPermissionsDownload CitationsTrack CitationsAdd to favorites Back To Publication ShareShare onFacebookTwitterLinked InRedditEmail Jan Wolff in 2022In celebration of the American Thyroid Association's centennial anniversary this year, the journal is pleased to share this special interview with the thyroid giant, Dr. Jan Wolff. Dr. Wolff, along with Dr. Israel Chaikoff, are the pair for whom the term the Wolff–Chaikoff effect was coined.TRANSCRIPTION OF THE FIRESIDE CHATMichael Kaplan and Arthur Schneider:What was the path that led you from Germany, where you were born, to the University of California (UC) Berkeley, where you met Israel Chaikoff?Jan Wolff:Hitler forced the path. My father was a pediatrician and my mother, Dutch, was a professional violinist. When my father was prevented from practicing in Germany, we went to Holland, where I attended an English boarding school from 1935 to 1937 and then, at age 12, warned of what was coming, we moved to San Francisco. After high school I went to UC Berkeley for my undergraduate, masters, and PhD studies. It is there where I met Israel Chaikoff.Michael Kaplan and Arthur Schneider:What were you and Chaikoff trying to do when you observed the “Wolff–Chaikoff effect”? When did you realize your names would endure as a permanent eponym for this phenomenon?Jan Wolff:We initially got radioiodine from tellurium bombardment in the cyclotron and later from what was then called “the pile.” Our project was to see how much T4 (as T3 had not been discovered) could be made by thyroid slices under an iodide load. That is when we bumped into the inhibitory iodide effect on hormone synthesis and later various nonhormone functions (1). Rats showed the same phenomenon in vivo, although it was difficult to maintain high iodide levels in that system. Sid Ingbar and Lew Braverman called this the Wolff–Chaikoff effect. The chemical nature of the iodine-induced effect has still not been settled. An iodination product of the omega-3 fatty acid docosahexaenoic acid has been proposed, but this possible mechanism requires further work.Michael Kaplan and Arthur Schneider:After medical school and internship in Boston, you went to the NIH [National Institutes of Health], leaving clinical practice behind. How did this happen? During your m
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