Cutaneous squamous cell carcinoma (SCC) is the second most common nonmelanoma skin cancer. The clinical features of SCC typically include scaly, crusted, nonhealing, ulcerative lesions in sun-exposed areas of the body. We present here the interesting case of a patient who was diagnosed with extremely severe SCC, keratoacanthoma-type (KA; SCC-KA type) with multiple annular, crusted, papular lesions (8-20 mm) on the dorsal aspect of his hands and forearms. The patient was successfully treated with cetuximab over 78 days, with complete resolution.
{"title":"A severe case of cutaneous squamous cell carcinoma keratoacanthoma type in a 55-year-old man","authors":"Nabeel Ahmad, N. Alkhouri","doi":"10.12788/J.CMONC.0008","DOIUrl":"https://doi.org/10.12788/J.CMONC.0008","url":null,"abstract":"Cutaneous squamous cell carcinoma (SCC) is the second most common nonmelanoma skin cancer. The clinical features of SCC typically include scaly, crusted, nonhealing, ulcerative lesions in sun-exposed areas of the body. We present here the interesting case of a patient who was diagnosed with extremely severe SCC, keratoacanthoma-type (KA; SCC-KA type) with multiple annular, crusted, papular lesions (8-20 mm) on the dorsal aspect of his hands and forearms. The patient was successfully treated with cetuximab over 78 days, with complete resolution.","PeriodicalId":72649,"journal":{"name":"Community oncology","volume":"10 1","pages":"128-130"},"PeriodicalIF":0.0,"publicationDate":"2013-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66797541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
W. Gradishar, J. Gralow, Stephen N. Jones, H. Collins
Bone metastasis is a serious complication of advanced cancer. It is most commonly observed in patients with metastatic breast and prostate cancers, but also occurs in most other metastatic solid cancers. Without treatment, patients may experience complications including intractable bone pain, hypercalcemia, fracture, spinal cord compression and/or a requirement for surgical or radiotherapeutic intervention. In 2010, denosumab, a fully human monoclonal antibody that inhibits RANK ligand (RANKL) and subsequent osteoclast-mediated bone destruction, was approved by the Food and Drug Administration for the prevention of skeletal-related events (SREs) in patients with bone metastases from solid tumors. This article reviews the role of denosumab in preventing SREs due to bone metastases, treating bone loss due to hormone-ablative cancer therapies, and describes denosumab’s safety profile and potential future indications under investigation.
{"title":"Minimizing cancer's impact on bone with denosumab: Current and future perspectives","authors":"W. Gradishar, J. Gralow, Stephen N. Jones, H. Collins","doi":"10.12788/J.CMONC.0024","DOIUrl":"https://doi.org/10.12788/J.CMONC.0024","url":null,"abstract":"Bone metastasis is a serious complication of advanced cancer. It is most commonly observed in patients with metastatic breast and prostate cancers, but also occurs in most other metastatic solid cancers. Without treatment, patients may experience complications including intractable bone pain, hypercalcemia, fracture, spinal cord compression and/or a requirement for surgical or radiotherapeutic intervention. In 2010, denosumab, a fully human monoclonal antibody that inhibits RANK ligand (RANKL) and subsequent osteoclast-mediated bone destruction, was approved by the Food and Drug Administration for the prevention of skeletal-related events (SREs) in patients with bone metastases from solid tumors. This article reviews the role of denosumab in preventing SREs due to bone metastases, treating bone loss due to hormone-ablative cancer therapies, and describes denosumab’s safety profile and potential future indications under investigation.","PeriodicalId":72649,"journal":{"name":"Community oncology","volume":"50 1","pages":"235-243"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66797960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-12-01DOI: 10.1016/J.CMONC.2012.11.004
Matthew E. Brow, T. Okon, E. George, D. Eagle, D. Patt, Bruce J Gould, B. Brooks, P. Cobb, S. Charles, Scott Tetrault, R. Beveridge
{"title":"Thoughts and recommendations on cancer care site of service","authors":"Matthew E. Brow, T. Okon, E. George, D. Eagle, D. Patt, Bruce J Gould, B. Brooks, P. Cobb, S. Charles, Scott Tetrault, R. Beveridge","doi":"10.1016/J.CMONC.2012.11.004","DOIUrl":"https://doi.org/10.1016/J.CMONC.2012.11.004","url":null,"abstract":"","PeriodicalId":72649,"journal":{"name":"Community oncology","volume":"9 1","pages":"382-388"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54038654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-12-01DOI: 10.1016/J.CMONC.2012.11.005
H. Hamann, L. Robinson, Amy Moldrem, Elisabeth P Golden, Julie A. Mook, W. Bishop, C. Skinner, D. Euhus
{"title":"BRCA1/2 testing and cancer risk management in underserved women at a public hospital","authors":"H. Hamann, L. Robinson, Amy Moldrem, Elisabeth P Golden, Julie A. Mook, W. Bishop, C. Skinner, D. Euhus","doi":"10.1016/J.CMONC.2012.11.005","DOIUrl":"https://doi.org/10.1016/J.CMONC.2012.11.005","url":null,"abstract":"","PeriodicalId":72649,"journal":{"name":"Community oncology","volume":"9 1","pages":"369-376"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54038724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-12-01DOI: 10.1016/j.cmonc.2012.09.019
Loretta J Nastoupil, Christopher R Flowers
{"title":"Management of relapsed chronic lymphocytic leukemia: applying guidelines to practice.","authors":"Loretta J Nastoupil, Christopher R Flowers","doi":"10.1016/j.cmonc.2012.09.019","DOIUrl":"10.1016/j.cmonc.2012.09.019","url":null,"abstract":"","PeriodicalId":72649,"journal":{"name":"Community oncology","volume":"9 12","pages":"S85-S92"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541037/pdf/nihms417520.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31159717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-12-01DOI: 10.1016/J.CMONC.2012.07.008
N. Mar, D. Askin, J. George, C. Spaccavento, R. Graham, L. Ratner
{"title":"Challenges in managing a patient with multiple primary malignancies","authors":"N. Mar, D. Askin, J. George, C. Spaccavento, R. Graham, L. Ratner","doi":"10.1016/J.CMONC.2012.07.008","DOIUrl":"https://doi.org/10.1016/J.CMONC.2012.07.008","url":null,"abstract":"","PeriodicalId":72649,"journal":{"name":"Community oncology","volume":"9 1","pages":"377-381"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54036899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-12-01DOI: 10.1016/J.CMONC.2012.11.003
J. Abraham
{"title":"Everolimus in renal angiomyolipoma and SEGA associated with tuberous sclerosis complex","authors":"J. Abraham","doi":"10.1016/J.CMONC.2012.11.003","DOIUrl":"https://doi.org/10.1016/J.CMONC.2012.11.003","url":null,"abstract":"","PeriodicalId":72649,"journal":{"name":"Community oncology","volume":"9 1","pages":"365-368"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54038611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-12-01DOI: 10.1016/J.CMONC.2012.11.006
S. Matin
{"title":"Everolimus for the treatment of TSC-associated tumors","authors":"S. Matin","doi":"10.1016/J.CMONC.2012.11.006","DOIUrl":"https://doi.org/10.1016/J.CMONC.2012.11.006","url":null,"abstract":"","PeriodicalId":72649,"journal":{"name":"Community oncology","volume":"9 1","pages":"361-362"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54038917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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