Pub Date : 2020-01-01DOI: 10.25082/ccr.2020.02.001
L. Marinova, B. Yordanova, D. Malinova
We present here a rare case of primary mammary angiosarcoma in 48-year-old female patient. After 3 years without treatment, the woman presented to the hospital with locally advanced tumor in right mammary gland, involving the overlying skin and bleeding. Radical mastectomy was performed with axillary lymph-node dissection. The CT scan revealed solitary liver metastasis. After an overview of different cases of primary angiosarcoma of the breast published in the literature, we discuss the importance of histological criteria and immunohistochemical methods, as well as the optimal multimodal treatment in these patients. Poorly differentiated primary mammary angiosarcoma (grade 3) is an invasive neoplasm with high risk of local recurrence and distant metastases. The multimodal treatment involves radical mastectomy with or without axillary lymph-node dissection. Adjuvant radiotherapy and adjuvant chemotherapy help the local tumor control, reduce recurrences and increase overall survival.
{"title":"Primary angiosarcoma of the breast: A clinical case and review of the literature","authors":"L. Marinova, B. Yordanova, D. Malinova","doi":"10.25082/ccr.2020.02.001","DOIUrl":"https://doi.org/10.25082/ccr.2020.02.001","url":null,"abstract":"We present here a rare case of primary mammary angiosarcoma in 48-year-old female patient. After 3 years without treatment, the woman presented to the hospital with locally advanced tumor in right mammary gland, involving the overlying skin and bleeding. Radical mastectomy was performed with axillary lymph-node dissection. The CT scan revealed solitary liver metastasis. After an overview of different cases of primary angiosarcoma of the breast published in the literature, we discuss the importance of histological criteria and immunohistochemical methods, as well as the optimal multimodal treatment in these patients. Poorly differentiated primary mammary angiosarcoma (grade 3) is an invasive neoplasm with high risk of local recurrence and distant metastases. The multimodal treatment involves radical mastectomy with or without axillary lymph-node dissection. Adjuvant radiotherapy and adjuvant chemotherapy help the local tumor control, reduce recurrences and increase overall survival.","PeriodicalId":72728,"journal":{"name":"Current cancer reports","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69216271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-24DOI: 10.25082/ccr.2019.01.004
S. Bouomrani, Mesfar Rim, Amri DhiaEddine, N. Belgacem, A. Hammami, W. Mahdhaoui, Ali Naffati
The occurrence of hepatocellular carcinoma (HCC) on a healthy liver is exceptional and represents a real diagnosis challenge for the clinician. Recently a particularly increased risk of cancer during Behc¸et’s disease (BD) was reported by several studies. Only a few sporadic cases of liver cancer associated with this vascultis have been reported. We report an original observation of non-fibrolamellar HCC occurring on healthy liver in a Tunisian patient followed for BD. A 43-year-old man, followed since the age of 25 for BD with isolated cutaneous and mucosal involvement, and treated by colchicine, was admitted for exploration of a pain of the right hypochondrium evolving since a few months associated with an important slimming, anorexia, and evening fever. The clinical examination noted a firm and painful hepatomegaly. Radiological exploration (ultrasonography, computed tomography (CT), and magnetic resonance imaging (MRI)) showed a bulky hepatic tumor with highly developed arterial blood supply. Ultrasound-guided biopsy concluded at HCC without signs of fibrolamellar type or cirrhosis. Biological tests were without abnormalities and specific investigations eliminated underlying chronic hepatopathy (chronic viral hepatitis B or C, hemochromatosis, Wilson’s disease or autoimmune hepatitis). The patient was treated symptomatically given the advanced stage of cancer. He quickly died after a month because of a multi-organ failure. HCC on healthy liver is exceptional and BD was suggested as a possible contributing factor. Thus, regular radiological monitoring seems to be recommended in any patient followed for BD, especially those with hepatic veins thrombosis.
{"title":"Hepatocellular carcinoma associated to Behçet's disease","authors":"S. Bouomrani, Mesfar Rim, Amri DhiaEddine, N. Belgacem, A. Hammami, W. Mahdhaoui, Ali Naffati","doi":"10.25082/ccr.2019.01.004","DOIUrl":"https://doi.org/10.25082/ccr.2019.01.004","url":null,"abstract":"The occurrence of hepatocellular carcinoma (HCC) on a healthy liver is exceptional and represents a real diagnosis challenge for the clinician. Recently a particularly increased risk of cancer during Behc¸et’s disease (BD) was reported by several studies. Only a few sporadic cases of liver cancer associated with this vascultis have been reported. We report an original observation of non-fibrolamellar HCC occurring on healthy liver in a Tunisian patient followed for BD. A 43-year-old man, followed since the age of 25 for BD with isolated cutaneous and mucosal involvement, and treated by colchicine, was admitted for exploration of a pain of the right hypochondrium evolving since a few months associated with an important slimming, anorexia, and evening fever. The clinical examination noted a firm and painful hepatomegaly. Radiological exploration (ultrasonography, computed tomography (CT), and magnetic resonance imaging (MRI)) showed a bulky hepatic tumor with highly developed arterial blood supply. Ultrasound-guided biopsy concluded at HCC without signs of fibrolamellar type or cirrhosis. Biological tests were without abnormalities and specific investigations eliminated underlying chronic hepatopathy (chronic viral hepatitis B or C, hemochromatosis, Wilson’s disease or autoimmune hepatitis). The patient was treated symptomatically given the advanced stage of cancer. He quickly died after a month because of a multi-organ failure. HCC on healthy liver is exceptional and BD was suggested as a possible contributing factor. Thus, regular radiological monitoring seems to be recommended in any patient followed for BD, especially those with hepatic veins thrombosis.","PeriodicalId":72728,"journal":{"name":"Current cancer reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46874372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-05DOI: 10.25082/CCR.2019.01.003
S. Mhamdi, R. Fessi, S. Daboussi, A. Hedhli, Z. Moetamri, C. Aichaouia, M. Khadhraoui, R. Cheikh, S. Bouomrani
The overall prognosis in patients with advanced and metastatic lung cancer is poor, however a subset of these patients has durable survival and they are called long-term survivors (LS). The definition of LS varies in published series from 18 months to 5 years. Few studies have focused on them. We report six cases of LS patients: three cases of non-small- cell lung cancer (stage IIIB and stage IV), two case of small cell lung cancer, and a case of composite carcinoma (small cell carcinoma and squamous carcinoma), all having a survival of five years or more. Our patients show clinical and evolutionary similarities with LS in the literature regarding the prognostic factors associated with prolonged survival namely performance status and good response to first-line chemotherapy.
{"title":"Long-term survivors of advanced and metastatic lung cancer","authors":"S. Mhamdi, R. Fessi, S. Daboussi, A. Hedhli, Z. Moetamri, C. Aichaouia, M. Khadhraoui, R. Cheikh, S. Bouomrani","doi":"10.25082/CCR.2019.01.003","DOIUrl":"https://doi.org/10.25082/CCR.2019.01.003","url":null,"abstract":"The overall prognosis in patients with advanced and metastatic lung cancer is poor, however a subset of these patients has durable survival and they are called long-term survivors (LS). The definition of LS varies in published series from 18 months to 5 years. Few studies have focused on them. We report six cases of LS patients: three cases of non-small- cell lung cancer (stage IIIB and stage IV), two case of small cell lung cancer, and a case of composite carcinoma (small cell carcinoma and squamous carcinoma), all having a survival of five years or more. Our patients show clinical and evolutionary similarities with LS in the literature regarding the prognostic factors associated with prolonged survival namely performance status and good response to first-line chemotherapy.","PeriodicalId":72728,"journal":{"name":"Current cancer reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46336085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-30DOI: 10.25082/CCR.2019.01.002
S. Coughlin, L. Caplan, R. Stone, J. Stewart
As breast cancer relative survival continues to increase, many breast cancer patients face many issues, including recurrence of cancer and cancer-related side effects that impact several aspects of their quality of life. With breast cancer patients living longer, there is more of a concern for negative breast cancer outcomes. Although physical activity is an affordable and relatively convenient way to improve breast cancer outcomes, only about one-third of breast cancer survivors engage in the recommended level of physical activity. This article reviews articles published to date to examine whether home-based physical activity interventions are effective in improving physical activity and other outcomes among breast cancer survivors who have completed primary therapy for the disease. The present review is based upon bibliographic searches in PubMed and CINAHL and relevant search terms. Articles published in English from 1980 through February 28, 2019 were identified. A total of 360 article citations were identified in PubMed and non-duplicates in CINAHL. After screening the abstracts or full texts of these articles and reviewing the references of previous review articles, 20 studies that met the eligibility criteria. Three of the studies were pre-/post-test trials and 17 were randomized controlled trials. home-based exercise programs are effective in improving physical activity among breast cancer survivors who have completed primary therapy for the disease. Home-based exercise programs such as walking programs offer a convenient and affordable option for women who wish to increase their physical activity and maintain a healthy lifestyle.
{"title":"A review of home-based physical activity interventions for breast cancer survivors","authors":"S. Coughlin, L. Caplan, R. Stone, J. Stewart","doi":"10.25082/CCR.2019.01.002","DOIUrl":"https://doi.org/10.25082/CCR.2019.01.002","url":null,"abstract":"As breast cancer relative survival continues to increase, many breast cancer patients face many issues, including recurrence of cancer and cancer-related side effects that impact several aspects of their quality of life. With breast cancer patients living longer, there is more of a concern for negative breast cancer outcomes. Although physical activity is an affordable and relatively convenient way to improve breast cancer outcomes, only about one-third of breast cancer survivors engage in the recommended level of physical activity. This article reviews articles published to date to examine whether home-based physical activity interventions are effective in improving physical activity and other outcomes among breast cancer survivors who have completed primary therapy for the disease. The present review is based upon bibliographic searches in PubMed and CINAHL and relevant search terms. Articles published in English from 1980 through February 28, 2019 were identified. A total of 360 article citations were identified in PubMed and non-duplicates in CINAHL. After screening the abstracts or full texts of these articles and reviewing the references of previous review articles, 20 studies that met the eligibility criteria. Three of the studies were pre-/post-test trials and 17 were randomized controlled trials. home-based exercise programs are effective in improving physical activity among breast cancer survivors who have completed primary therapy for the disease. Home-based exercise programs such as walking programs offer a convenient and affordable option for women who wish to increase their physical activity and maintain a healthy lifestyle.","PeriodicalId":72728,"journal":{"name":"Current cancer reports","volume":"1 1","pages":"6 - 12"},"PeriodicalIF":0.0,"publicationDate":"2019-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46149014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-14DOI: 10.25082/CCR.2019.01.001
Yingyu Cui
Cancer, or malignant tumour, is a group of diseases defined by the uncontrollable growth of the transformed cells, and their capabilities of invasion into surrounding healthy tissues and metastasis to remote sites in the body of organisms[1, 2]. According to different origins, it can be further divided into five subtypes: carcinoma, adenocarcinoma, sarcoma, lymphoma/leukemia and myeloma. Cancer is the second leading cause of death worldwide after cardiovascular disease (GBD 2013 Mortality and Causes of Death Collaborators 2015)[3]. Usually, scientists attribute tumorigenesis to the control loss of cell proliferation, inhibition of cell differentiation and blockade of cell senescence and death at cellular level; chromosome aneuploidy[4, 5] and hyperactive telomerase[6] at sub-cellular level; excessive activation of oncogenes and excessive inhibition of anti-oncogenes, gene mutation and epigenetic modification (DNA methylation and histone acetylation, etc.)[7] at molecular level, respectively. Mutagens in in vitro environment, including physical carcinogens (UV, X-rays, etc.), chemical carcinogens (Benzopyrene, Aflatoxin B1, etc.) and biological carcinogens (DNA viruses, RNA retroviruses) can promote the transformation of benign tumours to malignant tumours with the help of factors in in vivo envi-
{"title":"Cancer, Mankind′s Challenge","authors":"Yingyu Cui","doi":"10.25082/CCR.2019.01.001","DOIUrl":"https://doi.org/10.25082/CCR.2019.01.001","url":null,"abstract":"Cancer, or malignant tumour, is a group of diseases defined by the uncontrollable growth of the transformed cells, and their capabilities of invasion into surrounding healthy tissues and metastasis to remote sites in the body of organisms[1, 2]. According to different origins, it can be further divided into five subtypes: carcinoma, adenocarcinoma, sarcoma, lymphoma/leukemia and myeloma. Cancer is the second leading cause of death worldwide after cardiovascular disease (GBD 2013 Mortality and Causes of Death Collaborators 2015)[3]. Usually, scientists attribute tumorigenesis to the control loss of cell proliferation, inhibition of cell differentiation and blockade of cell senescence and death at cellular level; chromosome aneuploidy[4, 5] and hyperactive telomerase[6] at sub-cellular level; excessive activation of oncogenes and excessive inhibition of anti-oncogenes, gene mutation and epigenetic modification (DNA methylation and histone acetylation, etc.)[7] at molecular level, respectively. Mutagens in in vitro environment, including physical carcinogens (UV, X-rays, etc.), chemical carcinogens (Benzopyrene, Aflatoxin B1, etc.) and biological carcinogens (DNA viruses, RNA retroviruses) can promote the transformation of benign tumours to malignant tumours with the help of factors in in vivo envi-","PeriodicalId":72728,"journal":{"name":"Current cancer reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44509425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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