Pub Date : 2019-12-01DOI: 10.1007/s13665-019-00242-x
C. Oberg, A. Majid
{"title":"Update on Management of Pleural Disease","authors":"C. Oberg, A. Majid","doi":"10.1007/s13665-019-00242-x","DOIUrl":"https://doi.org/10.1007/s13665-019-00242-x","url":null,"abstract":"","PeriodicalId":72745,"journal":{"name":"Current pulmonology reports","volume":"8 1","pages":"205 - 214"},"PeriodicalIF":0.6,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13665-019-00242-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44964514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-01Epub Date: 2019-11-26DOI: 10.1007/s13665-019-00238-7
Tejaswini Kulkarni, Steven R Duncan
Purpose of review: Acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF) are the most frequent cause of death among patients with IPF. Here, we review the revised definition and diagnostic criteria for AE-IPF and discuss management strategies including mechanistically targeted investigational therapies for this complex syndrome.
Recent findings: Novel therapies targeting various pathways including inflammation, autoimmunity and coagulation cascade involved in AE-IPF have recently been reported. Although most of these reports are small and uncontrolled, they have provided evidence to design larger randomized, controlled, multicenter studies to improve outcomes among patients with AE-IPF.
Summary: AE-IPF has a dismal prognosis and current treatment consists mainly of supportive care and symptom palliation. There is a lack of consensus on current therapies for AE-IPF, including corticosteroids, but current randomized control studies for newer therapeutic strategies may hold promise.
{"title":"Acute exacerbation of idiopathic pulmonary fibrosis: who to treat, how to treat.","authors":"Tejaswini Kulkarni, Steven R Duncan","doi":"10.1007/s13665-019-00238-7","DOIUrl":"https://doi.org/10.1007/s13665-019-00238-7","url":null,"abstract":"<p><strong>Purpose of review: </strong>Acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF) are the most frequent cause of death among patients with IPF. Here, we review the revised definition and diagnostic criteria for AE-IPF and discuss management strategies including mechanistically targeted investigational therapies for this complex syndrome.</p><p><strong>Recent findings: </strong>Novel therapies targeting various pathways including inflammation, autoimmunity and coagulation cascade involved in AE-IPF have recently been reported. Although most of these reports are small and uncontrolled, they have provided evidence to design larger randomized, controlled, multicenter studies to improve outcomes among patients with AE-IPF.</p><p><strong>Summary: </strong>AE-IPF has a dismal prognosis and current treatment consists mainly of supportive care and symptom palliation. There is a lack of consensus on current therapies for AE-IPF, including corticosteroids, but current randomized control studies for newer therapeutic strategies may hold promise.</p>","PeriodicalId":72745,"journal":{"name":"Current pulmonology reports","volume":"8 4","pages":"123-130"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13665-019-00238-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38707011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-01Epub Date: 2019-11-26DOI: 10.1007/s13665-019-00235-w
R Somayaji, C H Goss
Purpose of review: a)We conducted a review of the current evidence relating to antibiotic duration in the short and long-term management of non-cystic fibrosis bronchiectasis.
Recent findings: b)In non-cystic fibrosis pulmonary exacerbations, evidence is primarily based on expert consensus and recent guidelines recommend antibiotic durations of approximately 14 days. Chronic antibiotics (oral or inhaled) are recommended in patients with frequent exacerbations or with chronic Pseudomonas aeruginosa airways infection. Macrolides are the best studied therapies for long-term use with evidence for effect limited to a 12 month duration. Encouragingly, there are increased efforts to develop registries and conduct larger population level studies to improve patient care.
Summary: c)There is a paucity of evidence for optimal antibiotic strategies in exacerbations and chronic maintenance in persons with non-cystic fibrosis bronchiectasis. Rationally designed studies which utilize a registry and population-based approach will be critical to build evidence-based strategies to optimize management of non-cystic fibrosis bronchiectasis.
{"title":"Duration of antibiotic therapy in non-cystic fibrosis bronchiectasis.","authors":"R Somayaji, C H Goss","doi":"10.1007/s13665-019-00235-w","DOIUrl":"10.1007/s13665-019-00235-w","url":null,"abstract":"<p><strong>Purpose of review: </strong>a)We conducted a review of the current evidence relating to antibiotic duration in the short and long-term management of non-cystic fibrosis bronchiectasis.</p><p><strong>Recent findings: </strong>b)In non-cystic fibrosis pulmonary exacerbations, evidence is primarily based on expert consensus and recent guidelines recommend antibiotic durations of approximately 14 days. Chronic antibiotics (oral or inhaled) are recommended in patients with frequent exacerbations or with chronic <i>Pseudomonas aeruginosa</i> airways infection. Macrolides are the best studied therapies for long-term use with evidence for effect limited to a 12 month duration. Encouragingly, there are increased efforts to develop registries and conduct larger population level studies to improve patient care.</p><p><strong>Summary: </strong>c)There is a paucity of evidence for optimal antibiotic strategies in exacerbations and chronic maintenance in persons with non-cystic fibrosis bronchiectasis. Rationally designed studies which utilize a registry and population-based approach will be critical to build evidence-based strategies to optimize management of non-cystic fibrosis bronchiectasis.</p>","PeriodicalId":72745,"journal":{"name":"Current pulmonology reports","volume":"8 4","pages":"160-165"},"PeriodicalIF":1.1,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929711/pdf/nihms-1062828.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37490217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-28DOI: 10.1007/s13665-019-00241-y
J. Kurman, N. Pastis, S. Murgu
{"title":"Photodynamic Therapy and Its Use in Lung Disease","authors":"J. Kurman, N. Pastis, S. Murgu","doi":"10.1007/s13665-019-00241-y","DOIUrl":"https://doi.org/10.1007/s13665-019-00241-y","url":null,"abstract":"","PeriodicalId":72745,"journal":{"name":"Current pulmonology reports","volume":"8 1","pages":"215 - 221"},"PeriodicalIF":0.6,"publicationDate":"2019-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13665-019-00241-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44920590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-26DOI: 10.1007/s13665-019-00240-z
U. Shammi, R. Thomen
{"title":"Role of New Imaging Capabilities with MRI and CT in the Evaluation of Bronchiectasis","authors":"U. Shammi, R. Thomen","doi":"10.1007/s13665-019-00240-z","DOIUrl":"https://doi.org/10.1007/s13665-019-00240-z","url":null,"abstract":"","PeriodicalId":72745,"journal":{"name":"Current pulmonology reports","volume":"8 1","pages":"166 - 176"},"PeriodicalIF":0.6,"publicationDate":"2019-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13665-019-00240-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47328921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-01DOI: 10.1007/s13665-019-00228-9
A. Chughtai, P. Agarwal
{"title":"Tracheobronchomalacia in the Adult: Is Imaging Helpful?","authors":"A. Chughtai, P. Agarwal","doi":"10.1007/s13665-019-00228-9","DOIUrl":"https://doi.org/10.1007/s13665-019-00228-9","url":null,"abstract":"","PeriodicalId":72745,"journal":{"name":"Current pulmonology reports","volume":"1 1","pages":"1-8"},"PeriodicalIF":0.6,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13665-019-00228-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47730587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-01DOI: 10.1007/s13665-019-00230-1
E. Bedawi, Vineeth George, Najib M. Rahman
{"title":"A New Approach to Pleural Infection: Let It Be?","authors":"E. Bedawi, Vineeth George, Najib M. Rahman","doi":"10.1007/s13665-019-00230-1","DOIUrl":"https://doi.org/10.1007/s13665-019-00230-1","url":null,"abstract":"","PeriodicalId":72745,"journal":{"name":"Current pulmonology reports","volume":"8 1","pages":"112-122"},"PeriodicalIF":0.6,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13665-019-00230-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49433400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-01DOI: 10.1007/s13665-019-00232-z
J. Escalon, Daniel B. Green, T. Bang, D. Vargas
{"title":"Imaging Pulmonary Embolic Disease","authors":"J. Escalon, Daniel B. Green, T. Bang, D. Vargas","doi":"10.1007/s13665-019-00232-z","DOIUrl":"https://doi.org/10.1007/s13665-019-00232-z","url":null,"abstract":"","PeriodicalId":72745,"journal":{"name":"Current pulmonology reports","volume":"8 1","pages":"104-111"},"PeriodicalIF":0.6,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13665-019-00232-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43572705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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