Current research in chemical biology最新文献

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Detecting and inactivating severe acute respiratory syndrome coronavirus-2 under the auspices of electrochemistry 在电化学的支持下检测和灭活严重急性呼吸综合征冠状病毒2

Current research in chemical biology

Pub Date : 2021-01-01 DOI: 10.1016/j.crchbi.2021.100001

Ghazala Ashraf , Ayesha Aziz , Rubina Naz Qaisrani , Wei Chen , Muhammad Asif

The recent epidemic of novel coronavirus (COVID-19) has turned out to be a huge public health concern owing to its fast transmission. Rapid and cost-effective detection of SARS-CoV-2 is crucial to classify diseased individuals. Serological examination based on antibody chromatography as a substitute to RT-PCR provides inadequate help owing to sophisticated personnel, false-positive results, special equipment and high cost. Biosensing techniques provide sensitive and specific detection, recognition and quantification of pathogens. Herein, after an introduction, we review potential electrochemical (EC) biosensors for COVID-19 diagnosis, emphasizing plasmonic, optical, colorimetric and aptamer-based sensors with a special focus on EC biosensors and point-of-care (POC) diagnostic methods. We have conferred the working principle of these biosensors, EC performance in terms of particular analytical figures of merit and their real-time applications in biological matrices. Lastly, we have described briefly the inactivation of SARS-CoV-2 by EC oxidation. In the end, we have concluded this review by clearing up the strengths and weaknesses of EC sensors and future directions. Advancement in research and technology would be our unsurpassed weapons in the fight against COVID-19 and preventing imminent pandemics.

最近，新型冠状病毒感染症(COVID-19)的传播速度很快，成为了一个巨大的公共卫生问题。快速和经济有效地检测SARS-CoV-2对于对患病个体进行分类至关重要。基于抗体层析的血清学检测作为RT-PCR的替代品，由于人员复杂、结果假阳性、设备特殊和成本高，帮助不足。生物传感技术提供了敏感和特异的检测、识别和定量病原体。在此，在介绍之后，我们回顾了用于COVID-19诊断的潜在电化学(EC)生物传感器，重点介绍了等离子体、光学、比色和基于适配体的传感器，并特别关注了EC生物传感器和护理点(POC)诊断方法。我们已经授予这些生物传感器的工作原理，EC性能在特定的分析数字方面的优点和他们在生物矩阵中的实时应用。最后，我们简要描述了EC氧化对SARS-CoV-2的灭活作用。最后，我们对EC传感器的优缺点和未来发展方向进行了总结。研究和技术的进步将是我们抗击COVID-19和预防即将到来的大流行的无与伦比的武器。

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