Pub Date : 2023-11-14DOI: 10.1007/s43152-023-00049-8
Leila Jahangiri
Abstract Purpose of Review Gastrointestinal cancers are a major health concern worldwide and include oesophageal, gastric, colorectal, liver, and pancreatic cancers that may have unfavourable patient prognoses and frequently lead to death due to cancer. The function of cancer stem cells (CSCs) in tumour growth, propagation, migration, metastasis, and recurrence has been reported in the literature, and finding effective markers for these cells is highly desirable. Recent Findings These cells may display properties such as self-renewal, symmetric and asymmetric divisions, low reactive oxygen species, efflux of compounds and toxins, heightened capacity for DNA damage repair, and tumour growth and propagation in immunodeficient mouse models. Furthermore, CSCs dynamically interact with the tumour microenvironment and, in addition, may impact processes like tumour progression, aggressive behaviour, migration, disease relapse, and recurrence, hence becoming clinically important. Summary Based on this background, this review aimed to obtain a deeper understanding of the properties of CSCs across five gastrointestinal cancers and to discuss their specific characteristics and markers. A better understanding of CSCs may ultimately contribute to improving patient prognoses and treatment outcomes and ultimately enhance the quality of life of gastrointestinal cancer sufferers.
{"title":"Cancer Stem Cell Markers and Properties Across Gastrointestinal Cancers","authors":"Leila Jahangiri","doi":"10.1007/s43152-023-00049-8","DOIUrl":"https://doi.org/10.1007/s43152-023-00049-8","url":null,"abstract":"Abstract Purpose of Review Gastrointestinal cancers are a major health concern worldwide and include oesophageal, gastric, colorectal, liver, and pancreatic cancers that may have unfavourable patient prognoses and frequently lead to death due to cancer. The function of cancer stem cells (CSCs) in tumour growth, propagation, migration, metastasis, and recurrence has been reported in the literature, and finding effective markers for these cells is highly desirable. Recent Findings These cells may display properties such as self-renewal, symmetric and asymmetric divisions, low reactive oxygen species, efflux of compounds and toxins, heightened capacity for DNA damage repair, and tumour growth and propagation in immunodeficient mouse models. Furthermore, CSCs dynamically interact with the tumour microenvironment and, in addition, may impact processes like tumour progression, aggressive behaviour, migration, disease relapse, and recurrence, hence becoming clinically important. Summary Based on this background, this review aimed to obtain a deeper understanding of the properties of CSCs across five gastrointestinal cancers and to discuss their specific characteristics and markers. A better understanding of CSCs may ultimately contribute to improving patient prognoses and treatment outcomes and ultimately enhance the quality of life of gastrointestinal cancer sufferers.","PeriodicalId":72757,"journal":{"name":"Current tissue microenvironment reports","volume":"29 29","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134954645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-10DOI: 10.1007/s43152-023-00046-x
Abhijit Chakraborty, Preyangsee Dutta, Dwaipayan Saha, Mayank Singh, C. P. Prasad, D. Pushpam, A. Shankar, D. Saini
{"title":"Chimeric Antigen Receptor CAR-T Therapy on the Move: Current Applications and Future Possibilities","authors":"Abhijit Chakraborty, Preyangsee Dutta, Dwaipayan Saha, Mayank Singh, C. P. Prasad, D. Pushpam, A. Shankar, D. Saini","doi":"10.1007/s43152-023-00046-x","DOIUrl":"https://doi.org/10.1007/s43152-023-00046-x","url":null,"abstract":"","PeriodicalId":72757,"journal":{"name":"Current tissue microenvironment reports","volume":"4 1","pages":"29-40"},"PeriodicalIF":0.0,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43081051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-12DOI: 10.1007/s43152-023-00044-z
Sunanda R Singh, Samara P Singh, A. Parihar
{"title":"Application of Nano-Antibodies for Cancer Immunotherapy","authors":"Sunanda R Singh, Samara P Singh, A. Parihar","doi":"10.1007/s43152-023-00044-z","DOIUrl":"https://doi.org/10.1007/s43152-023-00044-z","url":null,"abstract":"","PeriodicalId":72757,"journal":{"name":"Current tissue microenvironment reports","volume":"1 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41955266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-01DOI: 10.1007/s43152-023-00043-0
Dilara Sahan Khankishiyev, Gamze Gulden, Berranur Sert, Cihan Tastan
{"title":"Current Challenges and Potential Strategies for Designing a New Generation of Chimeric Antigen Receptor-T cells with High Anti-tumor Activity in Solid Tumors","authors":"Dilara Sahan Khankishiyev, Gamze Gulden, Berranur Sert, Cihan Tastan","doi":"10.1007/s43152-023-00043-0","DOIUrl":"https://doi.org/10.1007/s43152-023-00043-0","url":null,"abstract":"","PeriodicalId":72757,"journal":{"name":"Current tissue microenvironment reports","volume":"4 1","pages":"1-16"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46261997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01Epub Date: 2022-07-13DOI: 10.1007/s43152-022-00040-9
Eric Engelbrecht, Tristan Kooistra, Rachel S Knipe
Purpose of review: The current paradigm of idiopathic pulmonary fibrosis (IPF) pathogenesis involves recurrent injury to a sensitive alveolar epithelium followed by impaired repair responses marked by fibroblast activation and deposition of extracellular matrix. Multiple cell types are involved in this response with potential roles suggested by advances in single-cell RNA sequencing and lung developmental biology. Notably, recent work has better characterized the cell types present in the pulmonary endothelium and identified vascular changes in patients with IPF.
Recent findings: Lung tissue from patients with IPF has been examined at single-cell resolution, revealing reductions in lung capillary cells and expansion of a population of vascular cells expressing markers associated with bronchial endothelium. In addition, pre-clinical models have demonstrated a fundamental role for aging and vascular permeability in the development of pulmonary fibrosis.
Summary: Mounting evidence suggests that the endothelium undergoes changes in the context of fibrosis, and these changes may contribute to the development and/or progression of pulmonary fibrosis. Additional studies will be needed to further define the functional role of these vascular changes.
{"title":"The Vasculature in Pulmonary Fibrosis.","authors":"Eric Engelbrecht, Tristan Kooistra, Rachel S Knipe","doi":"10.1007/s43152-022-00040-9","DOIUrl":"10.1007/s43152-022-00040-9","url":null,"abstract":"<p><strong>Purpose of review: </strong>The current paradigm of idiopathic pulmonary fibrosis (IPF) pathogenesis involves recurrent injury to a sensitive alveolar epithelium followed by impaired repair responses marked by fibroblast activation and deposition of extracellular matrix. Multiple cell types are involved in this response with potential roles suggested by advances in single-cell RNA sequencing and lung developmental biology. Notably, recent work has better characterized the cell types present in the pulmonary endothelium and identified vascular changes in patients with IPF.</p><p><strong>Recent findings: </strong>Lung tissue from patients with IPF has been examined at single-cell resolution, revealing reductions in lung capillary cells and expansion of a population of vascular cells expressing markers associated with bronchial endothelium. In addition, pre-clinical models have demonstrated a fundamental role for aging and vascular permeability in the development of pulmonary fibrosis.</p><p><strong>Summary: </strong>Mounting evidence suggests that the endothelium undergoes changes in the context of fibrosis, and these changes may contribute to the development and/or progression of pulmonary fibrosis. Additional studies will be needed to further define the functional role of these vascular changes.</p>","PeriodicalId":72757,"journal":{"name":"Current tissue microenvironment reports","volume":"3 4","pages":"83-97"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10597084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-28DOI: 10.1007/s43152-022-00042-7
Eric Engelbrecht, T. Kooistra, R. Knipe
{"title":"Correction to: The Vasculature in Pulmonary Fibrosis","authors":"Eric Engelbrecht, T. Kooistra, R. Knipe","doi":"10.1007/s43152-022-00042-7","DOIUrl":"https://doi.org/10.1007/s43152-022-00042-7","url":null,"abstract":"","PeriodicalId":72757,"journal":{"name":"Current tissue microenvironment reports","volume":"3 1","pages":"99"},"PeriodicalIF":0.0,"publicationDate":"2022-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47871247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-26DOI: 10.1007/s43152-022-00041-8
S. Negri, Zhao Li, Yiyun Wang, Masnsen Cherief, Qizhi Qin, Jiajia Xu, Mario Armando Gomez Salazar, G. Hsu, A. James
{"title":"The Role of Pericytes in the Articular Environment—a Review","authors":"S. Negri, Zhao Li, Yiyun Wang, Masnsen Cherief, Qizhi Qin, Jiajia Xu, Mario Armando Gomez Salazar, G. Hsu, A. James","doi":"10.1007/s43152-022-00041-8","DOIUrl":"https://doi.org/10.1007/s43152-022-00041-8","url":null,"abstract":"","PeriodicalId":72757,"journal":{"name":"Current tissue microenvironment reports","volume":"3 1","pages":"77-82"},"PeriodicalIF":0.0,"publicationDate":"2022-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46371122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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