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What delirium follow-up is routinely offered after elective arthroplasty surgery? A survey of UK and Irish clinicians. 择期关节置换术后谵妄的常规随访是什么?一项对英国和爱尔兰临床医生的调查。
Pub Date : 2023-07-05 DOI: 10.56392/001c.74538
Jordan Walker, Emily M. L. Bowman, E. Cunningham, S. O’Brien, Owen Diamon
Postoperative delirium (POD) is a serious complication occurring after approximately 17% of elective arthroplasty surgeries. However, it is unclear if any routine clinical follow-up services are available to patients post-discharge. This study aims to determine what routine postoperative delirium screening and documentation processes are in place and what follow-up services are currently offered. A brief online survey of multiple-choice and free-text questions was devised for clinicians in the United Kingdom (UK) and Republic of Ireland (ROI). An email invitation to complete the survey was sent to relevant clinicians in the UK and ROI by non-NHS professional bodies. Twitter was used to highlight and disseminate the survey. Of the 43 participating clinicians, 18 (42%) respondents indicated that delirium is routinely screened for after elective arthroplasty and 17 respondents stated that the 4AT tool is used. Most respondents (62%) indicated that delirium is documented upon discharge to patients’ GPs. Only 11 respondents (26%) describe routine clinical follow-up practices. These included a joint arthroplasty clinic, geriatric outpatient department and liaison psychiatry. Results of this survey suggest that a) post-arthroplasty delirium screening and documentation is not widespread and b) clinical follow-up services for delirium in the UK and ROI are neither standardised nor routine.
术后谵妄(POD)是约17%的选择性关节置换术后发生的严重并发症。然而,目前尚不清楚是否有任何常规的临床随访服务提供给出院后的患者。本研究旨在确定常规的术后谵妄筛查和记录流程,以及目前提供的随访服务。为英国(UK)和爱尔兰共和国(ROI)的临床医生设计了一个简短的选择题和自由文本问题的在线调查。通过非nhs专业机构向英国和ROI的相关临床医生发送了电子邮件邀请完成调查。Twitter被用来突出和传播这项调查。在43名参与调查的临床医生中,18名(42%)受访者表示,在选择性关节置换术后,谵妄是常规筛查,17名受访者表示使用了4AT工具。大多数应答者(62%)表示,出院时向全科医生记录谵妄。只有11名受访者(26%)描述了常规的临床随访实践。其中包括关节成形术诊所、老年门诊部和联络精神病学。这项调查的结果表明:a)关节置换术后谵妄的筛查和记录并不普遍;b)在英国和ROI,谵妄的临床随访服务既不标准化也不常规。
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引用次数: 0
Delirium is under-reported in discharge summaries and in hospital administrative systems: a systematic review. 出院总结和医院管理系统中谵妄的报告不足:一项系统回顾
Pub Date : 2023-05-15 DOI: 10.56392/001c.74541
Temi Ibitoye, Sabrina So, Susan D Shenkin, Atul Anand, Matthew J Reed, Emma R L C Vardy, Sarah T Pendelbury, Alasdair M J MacLullich

Background: Accurate recording of delirium in discharge summaries (DS) and hospital administrative systems (HAS) is critical for patient care.

Objective: To systematically review studies reporting the frequency of delirium documentation and coding in DS and HAS, respectively.

Method: We searched Medline, Embase, PsycINFO and Web of Science databases from inception to 23 June 2021. Eligibility criteria included requiring the term delirium in DS or HAS. Screening and full-text reviews were performed independently by two reviewers. Risk of bias (RoB) was assessed using the Effective Public Health Practice Project tool.

Results: The search yielded 7,910 results; 24 studies were included. The studies were heterogeneous in design and size (N=25 to 809,512). Mean age ranged from 57 to 84 years. Four studies reported only overall DS documentation and HAS coding in whole hospital or healthcare databases. Twenty studies used additional delirium ascertainment methods (e.g. chart review) in smaller patient subsets. Studies reported either DS figures only (N=8), HAS figures only (N=11), or both (N=5). Documentation rates in DS ranged from 0.1% to 64%. Coding rates in HAS ranged from 1.5% to 49%. Some studies explored the impact of race, and nurse versus physician practice. No significant differences were reported for race; one study reported that nurses showed higher documentation rates in DS relative to physicians. Most studies (N=22) had medium to high RoB.

Conclusion: Delirium is a common and serious medical emergency, yet studies show considerable under-documentation and under-coding in healthcare systems. This has important implications for patient care and service planning. Healthcare systems need to take action to reach satisfactory delirium documentation and coding rates.

在出院总结(DS)和医院管理系统(HAS)中准确记录谵妄对患者护理至关重要。系统地回顾研究报告谵妄记录和编码的频率分别在DS和HAS。我们检索了Medline, Embase, PsycINFO和Web of Science数据库,从成立到2021年6月23日。资格标准包括在DS或HAS中需要谵妄一词。筛选和全文评审由两名审稿人独立进行。使用有效公共卫生实践项目工具评估偏倚风险(RoB)。搜索产生了7910个结果;纳入了24项研究。这些研究在设计和规模上存在异质性(N=25至809,512)。平均年龄57 - 84岁。四项研究仅报告了整个医院或医疗保健数据库中DS文档和HAS编码的总体情况。20项研究在较小的患者亚群中使用了额外的谵妄确定方法(如图表回顾)。研究报告仅DS病例(N=8),仅HAS病例(N=11),或两者兼有(N=5)。DS的记录率从0.1%到64%不等。HAS的编码率从1.5%到49%不等。一些研究探讨了种族的影响,以及护士与医生的执业。种族间无显著差异;一项研究报告称,与医生相比,护士在退行性椎体滑移中显示出更高的记录率。大多数研究(N=22)的RoB为中至高。谵妄是一种常见而严重的医疗紧急情况,但研究表明,在医疗保健系统中存在相当大的文献和编码不足。这对病人护理和服务规划具有重要意义。医疗保健系统需要采取行动,以达到令人满意的谵妄记录和编码率。
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引用次数: 0
Factors associated with cognitive decline and delirium after transcatheter aortic valve implantation: Preliminary evidence 经导管主动脉瓣植入术后认知能力下降和谵妄的相关因素:初步证据
Pub Date : 2023-05-12 DOI: 10.56392/001c.74542
E. Ghezzi, P. Psaltis, T. Loetscher, Daniel Davis, M. Boord, D. Greaves, J. Montarello, S. Delacroix, J. Lau, Alice Bourke, J. McLoughlin, Megan Keage, H. Keage
Transcatheter aortic valve implantation (TAVI) has become the standard for treating severe symptomatic aortic stenosis in those with prohibitive surgical risk. Cognitive complications, including delirium and cognitive decline are common following TAVI, yet an understanding of pre-procedural factors associated with these outcomes is lacking. This prospective observational study set out to identify geriatric pre-procedural factors associated with post-procedural delirium and cognitive decline in patients undergoing TAVI. Cognitive outcomes of TAVI patients aged ≥60 years (N=32) were measured over one-year post-TAVI. Pre-procedural measures included frailty, gait, visual symptoms, voice pitch, dysphagia, blink rate, mood, and sleep. Primary outcomes were post-procedural delirium and cognitive decline. Delirium was present in 25% of patients over two days following TAVI and 26% experienced cognitive decline in the year post-TAVI. Daily physical activity was a protective factor against cognitive decline, and worse baseline visual memory was associated with delirium. While non-significant and with very large confidence intervals, moderate to large effect sizes were found for associations between slowed gait speed, pre-existing atrial fibrillation, and dysphagia for delirium, and slower gait speed, higher blink rate, pre-existing atrial fibrillation for cognitive decline. Though underpowered, measures of considerable effect size were identified (although non-significant and with large variability). In larger studies, these novel geriatric factors could further be explored for predicting cognitive complications following TAVI. Improvement of risk prediction for cognitive decline and delirium following TAVI could assist with early identification of those at risk, informing clinical decision-making and allowing for targeted intervention to reduce post-procedural incidence of these complications.
经导管主动脉瓣植入术(TAVI)已成为治疗重度症状性主动脉瓣狭窄患者手术风险过高的标准。认知并发症,包括谵妄和认知能力下降是TAVI后常见的,但对与这些结果相关的手术前因素的了解尚缺乏。这项前瞻性观察性研究旨在确定与TAVI患者术后谵妄和认知能力下降相关的老年术前因素。年龄≥60岁的TAVI患者(N=32)在TAVI后1年内测量认知结果。术前测量包括虚弱、步态、视觉症状、音高、吞咽困难、眨眼频率、情绪和睡眠。主要结局为术后谵妄和认知能力下降。25%的患者在TAVI后两天内出现谵妄,26%的患者在TAVI后一年出现认知能力下降。日常体育活动是防止认知能力下降的保护因素,而较差的基线视觉记忆与谵妄有关。虽然没有显著性和非常大的置信区间,但中等到较大的效应大小发现了步态速度减慢、先前存在的房颤和谵妄的吞咽困难与步态速度减慢、更高的眨眼频率、先前存在的房颤之间的关联。虽然动力不足,但确定了相当大的效应量(尽管不显著且具有很大的可变性)。在更大规模的研究中,这些新的老年因素可以进一步用于预测TAVI后的认知并发症。改善TAVI术后认知能力下降和谵妄的风险预测有助于早期识别高危人群,为临床决策提供信息,并允许有针对性的干预,以减少术后这些并发症的发生率。
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引用次数: 0
Delirium, polypharmacy and adverse outcomes: findings from a hospital in Kerala, India 谵妄、多种用药和不良后果:来自印度喀拉拉邦一家医院的调查结果
Pub Date : 2023-04-14 DOI: 10.56392/001c.74100
Steve Manjaly, Aqueen Joju, Anu Francis
Delirium is an acute disorder of attention and awareness, a medical emergency associated with increased morbidity and mortality. Delirium remains under-recognised, and few studies are from India. This study aimed to estimate the prevalence of delirium and its risk factors among hospitalised older patients admitted to medical and surgical wards in a teaching hospital in Central South India. We performed a retrospective cross-sectional study on 100 older patients admitted to medical and surgical wards in April-October, 2020. Patient data were obtained from a record review, extracting information on comorbidities, medications, and terms indicating delirium. Delirium was present in 39% of the study population and was significantly associated with older age (88%), abnormal electrolytes (59%), and polypharmacy (87%). Delirium was also significantly associated with mortality (28%) and prolonged hospital stay. (36%) The prevalence of delirium is high among older hospitalised patients and is significantly related to adverse hospital outcomes. The findings of this study could trigger changes in hospital policies in screening for delirium in older persons for its prompt recognition and prevention of adverse health outcomes.
谵妄是一种急性注意力和意识障碍,是一种发病率和死亡率增高的医学急症。谵妄症仍未得到充分认识,而且很少有研究来自印度。本研究旨在评估印度中南部一家教学医院内科和外科病房住院的老年患者谵妄的患病率及其危险因素。我们对2020年4月至10月住院的100名内科和外科老年患者进行了回顾性横断面研究。患者数据从记录回顾中获得,提取有关合并症、药物和指示谵妄的术语的信息。39%的研究人群存在谵妄,与老年(88%)、电解质异常(59%)和多药(87%)显著相关。谵妄也与死亡率(28%)和住院时间延长显著相关。(36%)谵妄的患病率在老年住院患者中很高,并与不良的医院预后显著相关。这项研究的发现可能会引发医院政策的变化,以筛查老年人谵妄及时识别和预防不良健康后果。
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引用次数: 0
Reporting Essentials for DElirium bioMarker Studies (REDEEMS): Explanation and Elaboration 谵妄生物标志物研究报告要点(REDEEMS):解释和阐述
Pub Date : 2022-12-21 DOI: 10.56392/001c.57389
Ingrid Amgarth-Duff, Annemarie Hosie, G. Caplan, D. Adamis, L. O. Watne, C. Cunningham, E. Oh, Sophia Wang, H. Lindroth, Robert D. Sanders, B. Olofsson, T. Girard, L. Steiner, S. Vasunilashorn, M. Agar
Despite many studies of potential delirium biomarkers, delirium pathophysiology remains unclear. Evidence shows that the quality of reporting delirium biomarker studies is sub-optimal. Better reporting of delirium biomarker studies is needed to understand delirium pathophysiology better. To improve robustness, transparency and uniformity of delirium biomarker study reports, the REDEEMS (Reporting Essentials for DElirium bioMarker Studies) guideline was developed by an international group of delirium researchers through a three-stage process, including a systematic review, a three-round Delphi study, and a follow-up consensus meeting. This process resulted in a 9-item guideline to inform delirium fluid biomarker studies. To enhance implementation of the REDEEMS guideline, this Explanation and Elaboration paper provides a detailed explanation of each item. We anticipate that the REDEEMS guideline will help to accelerate our understanding of delirium pathophysiology by improving the reporting of delirium biomarker research and, consequently the capacity to synthesise results across studies.
尽管对谵妄的潜在生物标志物进行了许多研究,但谵妄的病理生理仍不清楚。证据表明,报告谵妄生物标志物研究的质量是次优的。为了更好地了解谵妄的病理生理,需要更好地报道谵妄的生物标志物研究。为了提高谵妄生物标志物研究报告的稳健性、透明度和统一性,一个国际谵妄研究小组通过三个阶段的过程制定了REDEEMS(谵妄生物标志物研究报告要点)指南,包括系统综述、三轮德尔菲研究和后续共识会议。这一过程产生了9项指导方针,为谵妄液生物标志物研究提供信息。为加强REDEEMS指引的实施,本解释及阐述文件对每一项都作了详细的解释。我们预计REDEEMS指南将通过改进谵妄生物标志物研究的报告,从而提高综合研究结果的能力,从而有助于加速我们对谵妄病理生理学的理解。
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引用次数: 1
Assessing Recovery from Delirium: An International Survey of Healthcare Professionals Involved in Delirium Care. 评估谵妄的恢复:参与谵妄护理的医疗保健专业人员的国际调查。
Pub Date : 2022-12-19 DOI: 10.56392/001c.56675
Erin Noble, Haruno McCartney, Alasdair M MacLullich, Susan D Shenkin, Graciela Muniz-Terrera, Jonathan J Evans, Daniel Davis, Daisy Sandeman, Zoë Tieges

Background: A crucial part of delirium care is determining if the delirium episode has resolved. Yet, there is no clear evidence or consensus on which assessments clinicians should use to assess for delirium recovery.

Objective: To evaluate current opinions from delirium specialists on assessment of delirium recovery.

Design: Online questionnaire-based survey distributed internationally to healthcare professionals involved in delirium care.

Methods: The survey covered methods for assessing recovery, the importance of different symptom domains for capturing recovery, and local guidance or pathways that recommend monitoring for delirium recovery.

Results: Responses from 199 clinicians were collected. Respondents were from the UK (51%), US (13%), Australia (9%), Canada (7%), Ireland (7%) and 16 other countries. Most respondents were doctors (52%) and nurses (27%). Clinicians worked mostly in geriatrics (52%), ICUs (21%) and acute assessment units (17%). Ninety-four percent of respondents indicated that they conduct repeat delirium assessments (i.e., on ≥2 occasions) to monitor delirium recovery. The symptom domains considered most important for capturing recovery were: arousal (92%), inattention (84%), motor disturbance (84%), and hallucinations and delusions (83%). The most used tool for assessing recovery was the 4 'A's Test (4AT, 51%), followed by the Confusion Assessment Method (CAM, 26%), the CAM for the ICU (CAM-ICU, 17%) and the Single Question in Delirium (SQiD, 11%). Twenty-eight percent used clinical features only. Less than half (45%) of clinicians reported having local guidance that recommends monitoring for delirium recovery.

Conclusions: The survey results suggest a lack of standardisation regarding tools and methods used for repeat delirium assessment, despite consensus surrounding the key domains for capturing delirium recovery. These findings emphasise the need for further research to establish best practice for assessing delirium recovery.

背景:谵妄护理的一个关键部分是确定谵妄发作是否已经消退。然而,对于临床医生应该使用何种评估来评估谵妄恢复,尚无明确的证据或共识。目的:评价目前谵妄专家对谵妄恢复评估的看法。设计:以在线问卷为基础的调查,向参与谵妄护理的国际医疗保健专业人员分发。方法:调查涵盖了评估恢复的方法,不同症状域对捕获恢复的重要性,以及推荐监测谵妄恢复的局部指导或途径。结果:收集了199名临床医生的反馈。受访者分别来自英国(51%)、美国(13%)、澳大利亚(9%)、加拿大(7%)、爱尔兰(7%)和其他16个国家。大多数受访者是医生(52%)和护士(27%)。临床医生主要在老年科(52%)、icu(21%)和急性评估单位(17%)工作。94%的应答者表示,他们进行重复谵妄评估(即,≥2次)以监测谵妄恢复。被认为对捕获恢复最重要的症状域是:觉醒(92%)、注意力不集中(84%)、运动障碍(84%)、幻觉和妄想(83%)。评估恢复最常用的工具是4a测试(4AT, 51%),其次是混淆评估法(CAM, 26%), ICU的CAM (CAM-ICU, 17%)和谵妄中的单一问题(SQiD, 11%)。28%的人只使用临床特征。不到一半(45%)的临床医生报告有建议监测谵妄恢复的当地指导。结论:调查结果表明,尽管围绕捕获谵妄恢复的关键领域达成共识,但用于重复谵妄评估的工具和方法缺乏标准化。这些发现强调需要进一步的研究来建立评估谵妄恢复的最佳实践。
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引用次数: 1
Pilot testing of a new electronic diagnostic support tool (AiD-DST) designed to identify the cause(s) of delirium 一种新的电子诊断支持工具(AiD-DST)的试点测试,旨在确定谵妄的原因
Pub Date : 2022-08-11 DOI: 10.56392/001c.37365
E. Eeles, Peter Worthy, A. Teodorczuk, Paven Kaur, N. Dissanayaka
Delirium is frequently multifactorial, and causes are often missed in clinical practice. The Aetiology in Delirium - Diagnostic Support Tool (AiD-DST) was developed to improve recognition of the causes. We undertook an evaluation of an electronic version of AiD-DST. A development and evaluation life cycle of improvement was used. In phase 1, alpha testing among the development group evaluated technical performance of AiD-DST. In phase 2, we performed a cycle of beta testing among junior doctors to assess impressions of AiD-DST using Think Aloud methodology. We grouped responses into themes and made changes to AiD-DST by the development group accordingly. In phase 3, usability and acceptance of AiD-DST was assessed using the mHealth App Usability Questionnaire (MAUQ). In phase 1, software issues were identified, and modifications made. In phase 2, feedback was obtained from 29 junior doctors. Three cycles of feedback were obtained. The number of items identified after each cycle were 20, 12 and 7, respectively. Content was grouped into themes of; ‘style and grammar’, ‘formatting’, ‘IT’, ‘missed diagnosis’ and ‘other concerns.’ In phase 3, 20 participants completed MAUQ questionnaire. Overall, the average score was 6.36 (SD=0.8) with 7 as the highest attainable score. This translates to agreement up to strong agreement concerning usability of AiD-DST. After a process of optimisation, AiD-DST has been shown to be a usable and potentially useful diagnostic support tool to help junior doctors identify cause(s) of delirium. An implementation study is planned.
谵妄常常是多因素的,在临床实践中常常遗漏病因。谵妄的病因诊断支持工具(AiD-DST)是为了提高对病因的认识而开发的。我们对一个电子版的AiD-DST进行了评估。采用了改进的开发和评价生命周期。在第1阶段,开发小组之间的alpha测试评估了AiD-DST的技术性能。在第二阶段,我们在初级医生中进行了一轮beta测试,以评估使用Think Aloud方法对AiD-DST的印象。我们将响应分组为主题,并由开发小组对AiD-DST进行相应的更改。在第三阶段,使用移动健康应用可用性问卷(MAUQ)评估AiD-DST的可用性和接受度。在阶段1中,确定了软件问题,并进行了修改。在第二阶段,获得了29名初级医生的反馈。得到了三个反馈周期。每个周期后确定的项目数量分别为20、12和7个。内容分为主题;“风格和语法”、“格式”、“IT”、“漏诊”和“其他问题”。在第三阶段,20名参与者完成了MAUQ问卷。总体而言,平均得分为6.36 (SD=0.8),最高得分为7分。这就转化为关于AiD-DST可用性的强有力的协议。经过一个优化的过程,AiD-DST已被证明是一个可用的和潜在有用的诊断支持工具,帮助初级医生确定谵妄的原因。计划进行一项实施研究。
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引用次数: 0
Development of the Reporting Essentials for DElirium bioMarker Studies (REDEEMS) guideline 谵妄生物标志物研究(REDEEMS)指南报告要点的制定
Pub Date : 2022-07-19 DOI: 10.56392/001c.36531
Ingrid Amgarth-Duff, Annmarie Hosie, G. Caplan, M. Agar
Delirium is a serious and distressing neurocognitive condition manifesting as an acute change in mental status due to medical illness, injury and/or treatment. The understanding of delirium pathophysiology is limited and largely hypothetical and this evidence gap impedes the development of effective therapies. Delirium biomarker studies have a key role in building knowledge of the pathophysiology of delirium, subject to the robustness of their methods and reporting. Our objective was to describe the multi-method development and finalisation of a new reporting guideline for delirium fluid biomarker studies: REDEEMS. A previously published systematic review on delirium and advanced cancer biomarkers informed a three-round modified Delphi study with international experts in delirium research in 2019. We held a follow-up consensus meeting with a newly configured expert panel of 12 delirium researchers in June, 2020 to determine the inclusion or exclusion of 16 items that achieved 70-80% (i.e., borderline) consensus in the Delphi study. Of the 16 items presented at the consensus meeting, seven were excluded, six remained as discrete items, and three were merged with another item. The final REDEEMS guideline contained nine items specific to reporting delirium biomarker studies. The REDEEMS guideline was developed through a rigorously conducted Delphi and follow-up consensus meeting with international experts in delirium research. The REDEEMS will support the improved reporting rigour and synthesis of future delirium biomarker research. The next step is dissemination to promote uptake of the guideline and evaluate the influence on improved study methods and capacity to address research hypotheses.
谵妄是一种严重的、令人痛苦的神经认知疾病,表现为由于医学疾病、损伤和/或治疗而导致的精神状态的急性改变。对谵妄病理生理的理解是有限的,很大程度上是假设的,这种证据差距阻碍了有效治疗的发展。谵妄生物标志物研究在建立谵妄病理生理学知识方面起着关键作用,这取决于其方法和报告的稳健性。我们的目的是描述谵妄液体生物标志物研究的多方法发展和最终确定的新报告指南:REDEEMS。此前发表的一项关于谵妄和晚期癌症生物标志物的系统综述为2019年谵妄研究领域的国际专家进行的三轮改良德尔福研究提供了信息。2020年6月,我们与新组建的12名谵妄研究人员专家小组举行了后续共识会议,以确定德尔福研究中达到70-80%(即边缘性)共识的16个项目的纳入或排除。在协商一致会议上提出的16个项目中,有7个被排除,6个保留为独立项目,3个与另一个项目合并。最终的REDEEMS指南包含9个项目,专门报道谵妄生物标志物研究。REDEEMS指南是通过与谵妄研究方面的国际专家进行严格的德尔菲和后续共识会议制定的。REDEEMS将支持未来谵妄生物标志物研究的报告精确性和合成的改进。下一步是传播,以促进指南的吸收,并评估对改进研究方法和处理研究假设的能力的影响。
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引用次数: 2
期刊
Delirium communications
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