D. Vlachakis, Aspasia Efthimiadou, F. Bacopoulou, E. Eliopoulos, G. Chrousos
{"title":"Exosomes in breast milk: a genetic trojan horse from mother to child","authors":"D. Vlachakis, Aspasia Efthimiadou, F. Bacopoulou, E. Eliopoulos, G. Chrousos","doi":"10.14806/EJ.26.A.993","DOIUrl":"https://doi.org/10.14806/EJ.26.A.993","url":null,"abstract":"","PeriodicalId":72893,"journal":{"name":"EMBnet.journal","volume":"120 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75876158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Katerina Pierouli, G. Goulielmos, E. Eliopoulos, D. Vlachakis
{"title":"Genome regulation by long non-coding RNAs","authors":"Katerina Pierouli, G. Goulielmos, E. Eliopoulos, D. Vlachakis","doi":"10.14806/EJ.26.A.962","DOIUrl":"https://doi.org/10.14806/EJ.26.A.962","url":null,"abstract":"","PeriodicalId":72893,"journal":{"name":"EMBnet.journal","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77042112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Panagouli, Athanasios Thirios, T. Psaltopoulou, F. Bacopoulou, T. Troupis, G. Chrousos, M. Tsolia, T. Sergentanis, A. Tsitsika
The purpose of the present study was to evaluate special features and probable correlations between symptoms, laboratory findings, treatment, and outcomes of COVID-19 in children and adolescents, through a systematic review and pooled analysis. Following database (Pubmed, Google Scholar, Scopus and Embase) search, forty articles were considered eligible identifying a total of 2,971 confirmed pediatric COVID-19 patients. Fever was reported in 55.1% of the cases, while 28.4% were asymptomatic. Radiological signs of pneumonia were observed in more than half of the cases and in 40.7% of asymptomatic patients. Fever showed the highest sensitivity (sensitivity: 60.3%, specificity: 48.8%), followed by cough (sensitivity: 47.4%, specificity: 76.7%), rhinorrhea (sensitivity: 21.1%, specificity: 88.4%) and diarrhea (sensitivity: 10.3%, specificity: 88.4%), in differentiating cases with positive radiological signs for pneumonia. Compared to school age children, preschoolers (adjusted OR=6.01, 95%CI: 1.73-20.91) were more prone to pneumonia findings. Various combinations of treatments were used across studies, without following any strict guidelines. Most children (>90%) had full recovery and rarely presented complications. Fever seems to be the most frequent symptom in pediatric COVID-19, but pediatricians should additionally evaluate cough, rhinorrhea, and diarrhea as indicators of SARS-CoV-2 infection. Asymptomatic cases were common, but not the majority, and a significant percentage had developed radiologic findings of pneumonia. Thorough reassessment of treatment and management guidelines should be helpful.
{"title":"COVID-19 features in children and adolescents: a systematic review and pooled analysis.","authors":"E. Panagouli, Athanasios Thirios, T. Psaltopoulou, F. Bacopoulou, T. Troupis, G. Chrousos, M. Tsolia, T. Sergentanis, A. Tsitsika","doi":"10.14806/EJ.26.1.946","DOIUrl":"https://doi.org/10.14806/EJ.26.1.946","url":null,"abstract":"The purpose of the present study was to evaluate special features and probable correlations between symptoms, laboratory findings, treatment, and outcomes of COVID-19 in children and adolescents, through a systematic review and pooled analysis. Following database (Pubmed, Google Scholar, Scopus and Embase) search, forty articles were considered eligible identifying a total of 2,971 confirmed pediatric COVID-19 patients. Fever was reported in 55.1% of the cases, while 28.4% were asymptomatic. Radiological signs of pneumonia were observed in more than half of the cases and in 40.7% of asymptomatic patients. Fever showed the highest sensitivity (sensitivity: 60.3%, specificity: 48.8%), followed by cough (sensitivity: 47.4%, specificity: 76.7%), rhinorrhea (sensitivity: 21.1%, specificity: 88.4%) and diarrhea (sensitivity: 10.3%, specificity: 88.4%), in differentiating cases with positive radiological signs for pneumonia. Compared to school age children, preschoolers (adjusted OR=6.01, 95%CI: 1.73-20.91) were more prone to pneumonia findings. Various combinations of treatments were used across studies, without following any strict guidelines. Most children (>90%) had full recovery and rarely presented complications. Fever seems to be the most frequent symptom in pediatric COVID-19, but pediatricians should additionally evaluate cough, rhinorrhea, and diarrhea as indicators of SARS-CoV-2 infection. Asymptomatic cases were common, but not the majority, and a significant percentage had developed radiologic findings of pneumonia. Thorough reassessment of treatment and management guidelines should be helpful.","PeriodicalId":72893,"journal":{"name":"EMBnet.journal","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86874029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01Epub Date: 2021-08-23DOI: 10.14806/ej.26.1.976
Katerina Sofianopoulou, Flora Bacopoulou, Dimitrios Vlachakis, Ioulia Kokka, Evaggelos Alexopoulos, Liza Varvogli, George P Chrousos, Christina Darviri
Research has shown that stress experiences begin in early stages of life. Stress management techniques have appeared to be beneficial for the development or enhancement of stress coping skills. The aim of this pilot randomised controlled trial was to assess the effect of a 12-week intervention, comprising training in diaphragmatic breathing and progressive muscular relaxation, on elementary school students’ stress levels. Outcomes on the quality of life and behavioural aspects of the students were also assessed. Standardised questionnaires were administered at baseline and after the 12-week intervention program. Fifty-two children aged 10 to 11 years were randomly assigned to intervention (n=24) and control groups (n=28). Children of the intervention group demonstrated lower levels of stress (in all three subscales of lack of well-being, distress, and lack of social support) and improved aspects of quality of life (physical, emotional, and school functioning). No significant differences were observed regarding the examined behavioural dimensions, in the intervention group. Larger randomised controlled trials with follow-up evaluations are needed to ascertain the positive outcomes of such programs on elementary school children.
{"title":"Stress Management in Elementary School Students: a Pilot Randomised Controlled Trial.","authors":"Katerina Sofianopoulou, Flora Bacopoulou, Dimitrios Vlachakis, Ioulia Kokka, Evaggelos Alexopoulos, Liza Varvogli, George P Chrousos, Christina Darviri","doi":"10.14806/ej.26.1.976","DOIUrl":"https://doi.org/10.14806/ej.26.1.976","url":null,"abstract":"Research has shown that stress experiences begin in early stages of life. Stress management techniques have appeared to be beneficial for the development or enhancement of stress coping skills. The aim of this pilot randomised controlled trial was to assess the effect of a 12-week intervention, comprising training in diaphragmatic breathing and progressive muscular relaxation, on elementary school students’ stress levels. Outcomes on the quality of life and behavioural aspects of the students were also assessed. Standardised questionnaires were administered at baseline and after the 12-week intervention program. Fifty-two children aged 10 to 11 years were randomly assigned to intervention (n=24) and control groups (n=28). Children of the intervention group demonstrated lower levels of stress (in all three subscales of lack of well-being, distress, and lack of social support) and improved aspects of quality of life (physical, emotional, and school functioning). No significant differences were observed regarding the examined behavioural dimensions, in the intervention group. Larger randomised controlled trials with follow-up evaluations are needed to ascertain the positive outcomes of such programs on elementary school children.","PeriodicalId":72893,"journal":{"name":"EMBnet.journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39498239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dimitris Triantakonstantis, Spyridon E. Detsikas, V. Kavvadias, Zoi Papadopoulou, Panagiotis Sparangis, Nikolaos Katsenios, D. Vlachakis, Aspasia Efthimiadou
Many on-site waste disposal systems fail regularly due to problems concerning suitable location and management. A potential environmental threat is inevitably propagated through on-site, off-site, downstream, soil surface and ground water pollution. Soil is a key component of land suitability for waste disposal. This paper presents a Geographic Information Systems (GIS) – based integrated multicriteria decision support system for evaluating the land suitability for olive mill wastewater (OMWW) disposal in the Mediterranean region. Two-scaled classification schemes are developed, the global scheme for Central and South Greece (scale: 1:30.000) and the local scheme for the study area in Xiromero, Aetolia-Acarnania Prefecture, Western Greece, scale 1:10.000. Constrains and factors are included into the spatial decision-making framework, where geostatistical and fuzzy set theory techniques, as well as Analytical Hierarchy Process (AHP) are appropriately integrated. Physical, chemical, and socioeconomic variables adapted to the Mediterranean soil conditions are incorporated as driving forces for the land suitability assessment and the produced maps reveal valuable results for final end-users, such as municipal authorities, agriculturalists, farmers and other national and local stakeholders.
{"title":"Land Suitability Assessment for Olive Mill Wastewater Disposal by Integrating Multicriteria Decision Support Tools","authors":"Dimitris Triantakonstantis, Spyridon E. Detsikas, V. Kavvadias, Zoi Papadopoulou, Panagiotis Sparangis, Nikolaos Katsenios, D. Vlachakis, Aspasia Efthimiadou","doi":"10.14806/ej.26.1.947","DOIUrl":"https://doi.org/10.14806/ej.26.1.947","url":null,"abstract":"Many on-site waste disposal systems fail regularly due to problems concerning suitable location and management. A potential environmental threat is inevitably propagated through on-site, off-site, downstream, soil surface and ground water pollution. Soil is a key component of land suitability for waste disposal. This paper presents a Geographic Information Systems (GIS) – based integrated multicriteria decision support system for evaluating the land suitability for olive mill wastewater (OMWW) disposal in the Mediterranean region. Two-scaled classification schemes are developed, the global scheme for Central and South Greece (scale: 1:30.000) and the local scheme for the study area in Xiromero, Aetolia-Acarnania Prefecture, Western Greece, scale 1:10.000. Constrains and factors are included into the spatial decision-making framework, where geostatistical and fuzzy set theory techniques, as well as Analytical Hierarchy Process (AHP) are appropriately integrated. Physical, chemical, and socioeconomic variables adapted to the Mediterranean soil conditions are incorporated as driving forces for the land suitability assessment and the produced maps reveal valuable results for final end-users, such as municipal authorities, agriculturalists, farmers and other national and local stakeholders.","PeriodicalId":72893,"journal":{"name":"EMBnet.journal","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88173353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01Epub Date: 2021-10-22DOI: 10.14806/ej.26.1.979
Vasiliki Efthymiou, Dimitra Kotsikogianni, Artemis K Tsitsika, Dimitrios Vlachakis, George P Chrousos, Evangelia Charmandari, Flora Bacopoulou
Transition from childhood to adolescence is known to bring about many changes in the lifestyle and psycho-emotional state of adolescents. One of the major lifestyle factors that affect adolescents' physical and mental health is sleep. The aim of this study was to validate the Adolescent Sleep Hygiene Scale (ASHS), a tool that measures sleep hygiene, in an adolescent sample living in Greece. The study's sample consisted of 146 Greek adolescents aged 12-18 years. The Adolescent Stress Questionnaire was used for convergent validity and correlation with adolescents' stress. The pilot and the main study demonstrated sufficient internal consistency. Exploratory Factor Analysis showed an adequate adaptation of the original ASHS questionnaire to the Greek adolescents. The findings of this study support the use of ASHS as a reliable and valid tool for evaluating sleep-facilitating and sleep-inhibiting practices of Greek adolescents.
{"title":"Validation of the Greek version of the Adolescent Sleep Hygiene Scale (ASHS).","authors":"Vasiliki Efthymiou, Dimitra Kotsikogianni, Artemis K Tsitsika, Dimitrios Vlachakis, George P Chrousos, Evangelia Charmandari, Flora Bacopoulou","doi":"10.14806/ej.26.1.979","DOIUrl":"https://doi.org/10.14806/ej.26.1.979","url":null,"abstract":"<p><p>Transition from childhood to adolescence is known to bring about many changes in the lifestyle and psycho-emotional state of adolescents. One of the major lifestyle factors that affect adolescents' physical and mental health is sleep. The aim of this study was to validate the Adolescent Sleep Hygiene Scale (ASHS), a tool that measures sleep hygiene, in an adolescent sample living in Greece. The study's sample consisted of 146 Greek adolescents aged 12-18 years. The Adolescent Stress Questionnaire was used for convergent validity and correlation with adolescents' stress. The pilot and the main study demonstrated sufficient internal consistency. Exploratory Factor Analysis showed an adequate adaptation of the original ASHS questionnaire to the Greek adolescents. The findings of this study support the use of ASHS as a reliable and valid tool for evaluating sleep-facilitating and sleep-inhibiting practices of Greek adolescents.</p>","PeriodicalId":72893,"journal":{"name":"EMBnet.journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8612368/pdf/nihms-1754041.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39660026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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