{"title":"Larkin: FDA Emergency Use Authorized Treatment Protocol of DeltaRex-G for Severe Covid-19 [IND# 27185]","authors":"","doi":"10.31488/ejrm.119","DOIUrl":"https://doi.org/10.31488/ejrm.119","url":null,"abstract":"","PeriodicalId":72981,"journal":{"name":"European journal of respiratory medicine","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79117208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Review of Alkaline Phosphatase in Preventing Systemic Inflammation after Cardiac Surgery","authors":"M. Library","doi":"10.31488/ejrm.115","DOIUrl":"https://doi.org/10.31488/ejrm.115","url":null,"abstract":"","PeriodicalId":72981,"journal":{"name":"European journal of respiratory medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81185437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tocilizumab’s Efficacy in Severe COVID-19 Patients: Fact or Fiction","authors":"","doi":"10.31488/ejrm.118","DOIUrl":"https://doi.org/10.31488/ejrm.118","url":null,"abstract":"","PeriodicalId":72981,"journal":{"name":"European journal of respiratory medicine","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88149823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical Features, Pathobiology, Efficacy, and Toxicity of Tenofovir Disoproxil Fumarate and Emtricitabine for Mild to Moderate SARS-CoV-2 Infections","authors":"","doi":"10.31488/ejrm.122","DOIUrl":"https://doi.org/10.31488/ejrm.122","url":null,"abstract":"","PeriodicalId":72981,"journal":{"name":"European journal of respiratory medicine","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91218924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cystic Fibrosis Therapy: From Chest Physiotherapy to Agents Targeting Specific Mutations","authors":"","doi":"10.31488/ejrm.106","DOIUrl":"https://doi.org/10.31488/ejrm.106","url":null,"abstract":"","PeriodicalId":72981,"journal":{"name":"European journal of respiratory medicine","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73787608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Lung Cancer and COVID-19: Therapeutic Implications","authors":"M. Provencio","doi":"10.31488/ejrm.109","DOIUrl":"https://doi.org/10.31488/ejrm.109","url":null,"abstract":"","PeriodicalId":72981,"journal":{"name":"European journal of respiratory medicine","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75303674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Safety and Efficacy of an Innovative Airway Clearance Device Versus Manual Chest Physiotherapy Techniques For Airway Secretion Clearance: a Feasibility Study","authors":"","doi":"10.31488/ejrm.107","DOIUrl":"https://doi.org/10.31488/ejrm.107","url":null,"abstract":"","PeriodicalId":72981,"journal":{"name":"European journal of respiratory medicine","volume":"25 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72489189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Clinical observations of breathing are rudimentary, compared with, for example, the use of ultrasound to display circulatory pathophysiology. However measurements of respiratory flow can be easily made with nasal cannula pressure, and could be displayed on a monitor screen or smartphone. Respiratory flow measurements were recorded in patients admitted to hospital with acute illness, and often showed abnormalities which might prove useful in diagnosis or prognosis. Methods: A cohort of patients had been recruited to allow assessment of a new device intended for continuous measurement of respiratory rate. The comparison was with a signal from a nasal cannula, which is minimally invasive, and gives a signal analogous to flow. Nasal flow recordings were obtained from 63 patients (35 were female), age 61 (17) (Mean, SD). On inspection, this set of records showed features of interest, so a subsequent formal analysis of abnormal patterns was done, and is reported. Results: The median respiratory rate the patients was 25 (22, 29) (median, quartiles) breath.min-1. Abnormal breathing patterns were very frequent. These included early inspiration in 82%, and also expiratory flow limitation, passive expiration, and delayed or absent active inspiration (63%). Cyclical variation in breath size was noted in 8% of the patients, indicating a minor degree of Cheynes-Stokes pattern breathing. Conclusions: In acutely ill medical patients, unexpected abnormal breathing is frequent. This can be detected by nasal pressure measurement. Some abnormalities could be useful for diagnosis and prognosis, such as incipient ventilatory failure: formal prospective study could be valuable. Received: May 20, 2019; Accepted: June 25, 2019; Published: June 27, 2019 European Journal of Respiratory Medicine 2019; 1(1): 111 115. doi: 10.31488/ejrm.103 Eur J Respir Med,1:1 European Journal of Respiratory Medicine Gordon B Drummond* Department of Anaesthesia and Pain Medicine, University of Edinburgh, UK Breathing Patterns in Acute Illness
{"title":"Breathing Patterns in Acute Illness","authors":"G. Drummond","doi":"10.31488/ejrm.103","DOIUrl":"https://doi.org/10.31488/ejrm.103","url":null,"abstract":"Background: Clinical observations of breathing are rudimentary, compared with, for example, the use of ultrasound to display circulatory pathophysiology. However measurements of respiratory flow can be easily made with nasal cannula pressure, and could be displayed on a monitor screen or smartphone. Respiratory flow measurements were recorded in patients admitted to hospital with acute illness, and often showed abnormalities which might prove useful in diagnosis or prognosis. Methods: A cohort of patients had been recruited to allow assessment of a new device intended for continuous measurement of respiratory rate. The comparison was with a signal from a nasal cannula, which is minimally invasive, and gives a signal analogous to flow. Nasal flow recordings were obtained from 63 patients (35 were female), age 61 (17) (Mean, SD). On inspection, this set of records showed features of interest, so a subsequent formal analysis of abnormal patterns was done, and is reported. Results: The median respiratory rate the patients was 25 (22, 29) (median, quartiles) breath.min-1. Abnormal breathing patterns were very frequent. These included early inspiration in 82%, and also expiratory flow limitation, passive expiration, and delayed or absent active inspiration (63%). Cyclical variation in breath size was noted in 8% of the patients, indicating a minor degree of Cheynes-Stokes pattern breathing. Conclusions: In acutely ill medical patients, unexpected abnormal breathing is frequent. This can be detected by nasal pressure measurement. Some abnormalities could be useful for diagnosis and prognosis, such as incipient ventilatory failure: formal prospective study could be valuable. Received: May 20, 2019; Accepted: June 25, 2019; Published: June 27, 2019 European Journal of Respiratory Medicine 2019; 1(1): 111 115. doi: 10.31488/ejrm.103 Eur J Respir Med,1:1 European Journal of Respiratory Medicine Gordon B Drummond* Department of Anaesthesia and Pain Medicine, University of Edinburgh, UK Breathing Patterns in Acute Illness","PeriodicalId":72981,"journal":{"name":"European journal of respiratory medicine","volume":"91 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85270026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Lung Cancer is the leading cause of cancer deaths around the world. Lung cancer accounts for 13.8% of all cancer diagnosis in India. Materials and Methods: prospective multicentric observational study conducted during July 2013 to September 2018 at bronchoscopy unit of MIMSR Medical College, and Venkatesh Chest Hospital Latur India to find role of TBNA submucosal & peribronchial lesions in confirming the diagnosis, to document additive yield of TBNA over other techniques like Bronchial Brush (BB), Bronchial wash (BW) and Forcep Biopsy (FB), and to observe any procedure related adverse events especially TBNA in peribronchial lesions. The study included 350 patients on the basis of clinical and radiological features of malignancy. Bronchoscopic lesions were categorized as submucosal lesions (SML) and peribronchial lesions (PBL). TBNA, FB, BB and BW were performed in all the cases during FOB. Results: Bronchoscopic abnormalities were documented as SML in 200 cases and PBL in 150 cases. In SML, diagnostic yield of TBNA & FB were 40.05% and 49.50% respectively. Additional diagnostic yield of other CDTs like BB and BW has nil effect on yield difference over forcep biopsy (P>0.11). In PBL, diagnostic yield of TBNA, FB & CDTs were 68.66%, 27.33% and 41.33% respectively. Additional CDTs like BB cytology and BW has additive yield to FB from 27.33% to 41.33% in PBL (P<0.00001). Sensitivity of TBNA in PBL is 96.19% while that of CDTs is 59 (P<0.00001). Conclusions: TBNA in submucosal lesions is complimentary to conventional diagnostic techniques in diagnosis of these lesions. TBNA in peribronchial lesions is most sensitive modality over conventional techniques and considered as ‘gold standard’ in these lesions. Received: May 12, 2019; Accepted: June 20, 2019; Published: June 24, 2019 European Journal of Respiratory Medicine 2019; 1(1): 105 110. doi: 10.31488/ejrm.102 Eur J Respir Med,1:1 European Journal of Respiratory Medicine Patil Shital*1 , Rajesh Patil2 , Ayachit Rujuta3 1. Associate Professor, Pulmonary Medicine, MIMSR Medical College, Latur, India 2. Associate Professor, Internal Medicine, MIMSR Medical College, Latur, India 3. Professor, Histopathology & Oncopathology, MIMSR medical College, Latur, India Transbronchial needle aspiration cytology (TBNA) in submucosal & peribronchial lesions: Sensitive, Superior & complimentary to Conventional diagnostic techniques during bronchoscopy in diagnosing lung cancer
{"title":"Transbronchial needle aspiration cytology (TBNA) in submucosal & peribronchial lesions: Sensitive, Superior & complimentary to Conventional diagnostic techniques during bronchoscopy in diagnosing lung cancer","authors":"Patil Shital, R. Patil, A. Rujuta","doi":"10.31488/ejrm.102","DOIUrl":"https://doi.org/10.31488/ejrm.102","url":null,"abstract":"Background: Lung Cancer is the leading cause of cancer deaths around the world. Lung cancer accounts for 13.8% of all cancer diagnosis in India. Materials and Methods: prospective multicentric observational study conducted during July 2013 to September 2018 at bronchoscopy unit of MIMSR Medical College, and Venkatesh Chest Hospital Latur India to find role of TBNA submucosal & peribronchial lesions in confirming the diagnosis, to document additive yield of TBNA over other techniques like Bronchial Brush (BB), Bronchial wash (BW) and Forcep Biopsy (FB), and to observe any procedure related adverse events especially TBNA in peribronchial lesions. The study included 350 patients on the basis of clinical and radiological features of malignancy. Bronchoscopic lesions were categorized as submucosal lesions (SML) and peribronchial lesions (PBL). TBNA, FB, BB and BW were performed in all the cases during FOB. Results: Bronchoscopic abnormalities were documented as SML in 200 cases and PBL in 150 cases. In SML, diagnostic yield of TBNA & FB were 40.05% and 49.50% respectively. Additional diagnostic yield of other CDTs like BB and BW has nil effect on yield difference over forcep biopsy (P>0.11). In PBL, diagnostic yield of TBNA, FB & CDTs were 68.66%, 27.33% and 41.33% respectively. Additional CDTs like BB cytology and BW has additive yield to FB from 27.33% to 41.33% in PBL (P<0.00001). Sensitivity of TBNA in PBL is 96.19% while that of CDTs is 59 (P<0.00001). Conclusions: TBNA in submucosal lesions is complimentary to conventional diagnostic techniques in diagnosis of these lesions. TBNA in peribronchial lesions is most sensitive modality over conventional techniques and considered as ‘gold standard’ in these lesions. Received: May 12, 2019; Accepted: June 20, 2019; Published: June 24, 2019 European Journal of Respiratory Medicine 2019; 1(1): 105 110. doi: 10.31488/ejrm.102 Eur J Respir Med,1:1 European Journal of Respiratory Medicine Patil Shital*1 , Rajesh Patil2 , Ayachit Rujuta3 1. Associate Professor, Pulmonary Medicine, MIMSR Medical College, Latur, India 2. Associate Professor, Internal Medicine, MIMSR Medical College, Latur, India 3. Professor, Histopathology & Oncopathology, MIMSR medical College, Latur, India Transbronchial needle aspiration cytology (TBNA) in submucosal & peribronchial lesions: Sensitive, Superior & complimentary to Conventional diagnostic techniques during bronchoscopy in diagnosing lung cancer","PeriodicalId":72981,"journal":{"name":"European journal of respiratory medicine","volume":"240 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80495495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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