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The Esophagogastric Junction Integrity 食管胃交界完整性
Pub Date : 2023-06-01 DOI: 10.1177/26345161231170426
Salih Samo
To the editor, I read with great interest the article “The American Foregut Society white paper on the endoscopic classification of esophagogastric junction integrity”1 published in the journal. The newly proposed American Foregut Society (AFS) classification to grade the antireflux barrier (ARB) integrity provides more comprehensive evaluation that are relevant to the practicing clinicians in day-to-day practice. The authors appropriately call for future validation of this novel classification and its correlation with the presence and severity of gastroesophageal reflux disease, and additionally to extend the classification to assess the ARB integrity in individuals with prior antireflux interventions,1 whether surgical or endoscopic. However, the future directions fall short of addressing 2 important variables that may affect the assessment of ARB integrity by applying the AFS classification. First, the classification does not take into consideration the anesthesia effect on the ARB. The hiatal aperture tends to be larger under general anesthesia with use of paralytics as compared to conscious sedation without the use of paralytics. Second, the novel AFS classification does not take obesity into consideration either. It is common to see a large fat pad in the diaphragmatic hiatus during laparoscopy, which may prevent accurate appreciation of a hidden hiatal hernia, whether endoscopically or laparoscopically. Therefore, caution needs to be taken when evaluating for hiatal hernia in obese patients, and other modalities, such as upper gastrointestinal contrast study, should be used to assess for presence of hiatal hernias.2 Addressing these 2 important issues is of paramount importance in future studies. Declaration of Conflicting Interests
对于编辑,我怀着极大的兴趣阅读了1在杂志上发表的文章《the American Foregut Society白皮书on内镜下食管胃结完整性分类》。新提出的美国前肠学会(AFS)分类对抗反流屏障(ARB)完整性进行分级,提供了更全面的评估,与临床医生在日常实践中相关。作者适当地呼吁进一步验证这一新的分类及其与胃食管反流疾病的存在和严重程度的相关性,并进一步扩展分类以评估先前进行过抗反流干预的个体的ARB完整性,1无论是手术还是内镜。然而,未来的方向缺乏解决两个重要的变量,这两个变量可能会影响应用AFS分类对ARB完整性的评估。首先,该分类没有考虑到ARB的麻醉效果。与不使用麻痹剂的清醒镇静相比,使用麻痹剂的全身麻醉下,裂孔孔径往往更大。其次,新的AFS分类也没有考虑肥胖。腹腔镜检查时,在膈裂孔中经常看到一个大的脂肪垫,这可能会妨碍对隐藏裂孔疝的准确判断,无论是内窥镜还是腹腔镜检查。因此,在评估肥胖患者的裂孔疝时需要谨慎,并应采用其他方式,如上胃肠造影研究,来评估裂孔疝的存在在未来的研究中,解决这两个重要问题至关重要。利益冲突声明
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引用次数: 1
Sex Differences in Gastroesophageal Reflux Disease (GERD) 胃食管反流病(GERD)的性别差异
Pub Date : 2023-06-01 DOI: 10.1177/26345161231166136
Daniel Scheese, Mohamad Chehab, C. A. Puig
Gastroesophageal reflux disease (GERD) is the most commonly diagnosed digestive disorder in the United States. Higher rates of non-erosive reflux disease (NERD) are found in females while higher rates of erosive reflux disease (ERD) are found in males. Pre-menopausal females appear to be protected from esophageal mucosal damage, as they demonstrate lower rates of ERD, Barrett’s esophagus, and esophageal adenocarcinoma. A protective effect of estrogen on the esophageal mucosa is thought to contribute to this decreased prevalence. A better understanding of sex-related differences in GERD may help alleviate the reported differences in outcomes between sexes regarding medical and surgical management.
胃食管反流病(GERD)是美国最常见的消化系统疾病。非糜烂性反流病(NERD)在女性中发病率较高,而糜烂性反流病(ERD)在男性中发病率较高。绝经前女性似乎不受食管黏膜损伤的影响,因为她们患ERD、Barrett食管和食管腺癌的几率较低。雌激素对食管黏膜的保护作用被认为是导致患病率下降的原因。更好地了解反流胃食管反流的性别相关差异可能有助于减轻已报道的性别间在医疗和手术治疗方面的差异。
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引用次数: 0
Reply to the Esophagogastric Junction Integrity 对食管胃交界完整性的回答
Pub Date : 2023-06-01 DOI: 10.1177/26345161231170423
N. Nguyen, K. Chang, M. Canto, J. Lipham, R. Bell, P. Kahrilas
We thank the reader for their letter and interest in the American Foregut Society (AFS) endoscopic classification of esophagogastric junction (EGJ) integrity.1,2 The reader raised 2 issues regarding potential limitations of our approach. First, it does not consider the effect of anesthesia and the reader commented on the observation that the hiatal aperture tends to enlarge under general anesthesia with the use of paralytics as compared to conscious sedation endoscopy. While this observation is interesting, we are not advocating doing routine upper endoscopy under general anesthesia. It is also worth noting that we were more driven by endoscopic undergrading of hiatal integrity due to insufficient gastric insufflation rather than overgrading, even going so far as to advocate eliciting a hernia with a provocative endoscopic maneuver. The second observation from the reader is that obese patients commonly have a large fat pad at the level of the hiatus that may preclude an accurate depiction of the hiatal defect. We agree that this can lead to “undergrading” the EGJ and should be kept in mind with obese patients. It also emphasizes the need to utilize maximal insufflation of the stomach and provocative maneuvers to elicit a sliding hiatal hernia. However even if the fat pad leads to an underestimation of the hiatus grade, it would not obscure an AFS grade II which is a key difference between AFS grading and the Hill classification. An AFS grade II is considered pathologic, representing partial hiatus disruption with loss of the intraabdominal esophageal length along with the gastroesophageal flap valve and the angle of His. In contrast, a Hill grade II is considered to be a normal finding. We thank the reader for their interest and astute comments. Declaration of Conflicting Interests
我们感谢读者来信并对美国前肠学会(AFS)食管胃结(EGJ)完整性的内镜分类感兴趣。读者就我们的方法的潜在局限性提出了两个问题。首先,它没有考虑麻醉的影响,读者评论了与有意识镇静内窥镜相比,在全身麻醉下使用麻痹剂时,裂孔孔径倾向于扩大。虽然这个观察结果很有趣,但我们并不提倡在全身麻醉下进行常规的上消化道内窥镜检查。同样值得注意的是,我们更多的是由于胃充气性不足而导致的内镜对裂孔完整性的低估,而不是高估,甚至提倡通过挑衅性的内镜操作引发疝气。来自读者的第二个观察是,肥胖患者通常在裂孔水平有一个大的脂肪垫,这可能会妨碍对裂孔缺陷的准确描述。我们认为这可能导致EGJ“降级”,肥胖患者应牢记这一点。它还强调需要利用最大的胃和刺激的操作,以引起滑动裂孔疝。然而,即使脂肪垫导致对中断等级的低估,它也不会模糊AFS等级II,这是AFS等级与Hill等级之间的关键区别。AFS II级被认为是病理性的,表现为部分食管裂孔破裂,伴有腹内食管长度、胃食管瓣瓣和His角度的丧失。相比之下,Hill II级被认为是正常的发现。我们感谢读者的兴趣和敏锐的评论。利益冲突声明
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引用次数: 0
Analysis of Reported Adverse Events Associated With the Use of Functional Lumen Imaging Probe Devices in the Esophagus and Stomach: An FDA MAUDE Database Study 与食道和胃使用功能性管腔成像探头装置相关的不良事件分析:FDA MAUDE数据库研究
Pub Date : 2023-06-01 DOI: 10.1177/26345161231191696
F. Jaber, W. Johnson, N. Wilson, Saqr Alsakarneh, Mouhand F. H. Mohamed, K. Ahmed, Nicole Patel, B. Hanson, Mohamed Abdallah, M. Bilal
The endoscopic Functional Lumen Imaging Probe (FLIP) devices are used to evaluate pressure changes, diameter, and volume of the esophagus. We used the FDA’s MAUDE database to collect post-marketing surveillance data on these devices from January 2009 to September 2022. Forty-Five device-related events and thirty-six patient-related adverse events were analyzed. The most common device issue for the diagnostic FLIP device was therapeutic/diagnostic failure (n = 6), while the most frequent issue with the therapeutic FLIP device was adverse events without an identified device or use problem (n = 11). Patient-related adverse events were extremely rare with the diagnostic FLIP and the most common patient-related adverse event with the therapeutic FLIP was perforation (n = 11). Endoscopists need to be mindful of these potential technical issues and adverse events while using these devices.
内镜下功能管腔成像探针(FLIP)装置用于评估食管的压力变化、直径和体积。我们使用FDA的MAUDE数据库收集2009年1月至2022年9月期间这些器械的上市后监测数据。分析了45个器械相关事件和36个患者相关不良事件。诊断性FLIP设备最常见的设备问题是治疗/诊断失败(n = 6),而治疗性FLIP设备最常见的问题是没有确定设备或使用问题的不良事件(n = 11)。诊断性FLIP的患者相关不良事件极为罕见,治疗性FLIP最常见的患者相关不良事件是穿孔(n = 11)。内窥镜医师在使用这些设备时需要注意这些潜在的技术问题和不良事件。
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引用次数: 0
The Impact of Disparities on Minimally Invasive Esophagectomy After the 2014 Affordable Care Act Expansion: A Retrospective Analysis 2014年平价医疗法案扩大后微创食管切除术差异的影响:回顾性分析
Pub Date : 2023-06-01 DOI: 10.1177/26345161231178351
Avanti Badrinathan, Thomas A. Syphan, A. Bassiri, J. Linden, Christine E. Alvarado, Jillian N. Sinopoli, Leonidas Tapias Vargas, C. Towe
The effect of Affordable Care Act Medicaid expansion on access to minimally invasive esophagectomy (MIE) is unknown. We hypothesize that greater Medicaid coverage resulting from ACA expansion would be associated with improved access to MIE, and performed an analysis of the National Cancer Database, comparing MIE rates in Medicaid expansion states to non-expansion states. MIE was more common in expansion states (30.37%vs 23.88%, P < .001). A multivariable difference-in-differences analysis, however, suggested no effect in MIE rate due to Medicaid expansion. This finding suggests that access to care is more complex than access to insurance. Further study is required to characterize disparities in access to MIE.
平价医疗法案医疗补助扩大对微创食管切除术(MIE)的影响尚不清楚。我们假设ACA扩大所带来的更大的医疗补助覆盖范围将与获得MIE的改善有关,并对国家癌症数据库进行了分析,比较了医疗补助扩大州和未扩大州的MIE率。MIE多见于扩张状态(30.37%vs 23.88%, P < 0.001)。然而,一项多变量差异分析表明,由于医疗补助计划的扩大,MIE率没有影响。这一发现表明,获得医疗服务比获得保险更为复杂。需要进一步研究以确定获得MIE方面的差异。
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引用次数: 0
Disparities in Benign and Malignant Foregut Disease 良性和恶性前肠疾病的差异
Pub Date : 2023-06-01 DOI: 10.1177/26345161231175993
V. Litle
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引用次数: 0
Critical Decision Making: Endoscopic Pyloromyotomy 关键决策:内窥镜幽门切开术
Pub Date : 2023-05-30 DOI: 10.1177/26345161231178352
Lee L. Swanstöm
Endoscopic pylormyotomy is a new very minimally invasive treatment option for delayed gastric emptying—an increasingly common clinical problem. However, as with any novel procedure, critical decision-making is necessary to ensure optimal patient outcomes. In this article, we discuss the various factors that should be considered when deciding whether to perform G-POEM, including patient selection, pre-operative workup including newer dynamic test modalities, technical considerations, and post-operative management. We also highlight potential complications and their management. By understanding the critical decision-making process involved in G-POEM, physicians can optimize patient outcomes and improve overall success rates of this procedure.
胃镜幽门肌切开术是一种新的非常微创的治疗胃排空延迟的方法,这是一个越来越常见的临床问题。然而,与任何新手术一样,关键的决策是必要的,以确保最佳的患者结果。在本文中,我们讨论了在决定是否进行G-POEM时应考虑的各种因素,包括患者选择、术前检查(包括更新的动态测试模式)、技术考虑和术后管理。我们还强调了潜在的并发症及其处理。通过了解G-POEM中涉及的关键决策过程,医生可以优化患者的结果并提高该手术的总体成功率。
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引用次数: 0
Symptom Profile, Proton Pump Inhibitor Therapy, and Diagnostic Testing in Patients With Persistent Reflux-Like Symptoms: Results From a Population-Based Survey 持续反流样症状患者的症状概况、质子泵抑制剂治疗和诊断测试:一项基于人群的调查结果
Pub Date : 2023-05-27 DOI: 10.1177/26345161231173643
D. Armstrong, S. Srinivasan, Ceciel Rooker, P. Sinclair, E. Taylor, Prateek Sharma
Proton pump inhibitors (PPIs) are highly effective in treating gastroesophageal reflux disease (GERD). However, persistent, troublesome reflux symptoms despite PPI use are common, and a proportion of individuals with these persistent symptoms is considered to have refractory GERD (rGERD). There are limited data on patients’ experience with persistent reflux-like symptoms to guide healthcare professionals in managing this troublesome condition. An international, population-based, online survey was conducted among adults who reported persistent reflux-like symptoms; 24 questions were posed regarding the participants’ symptoms, diagnosis, treatment, and comorbid conditions. Descriptive analyses were performed to characterize participants’ experience with diagnosis and their satisfaction with treatment. All data were self-reported. Of 565 initial respondents, 283 (51%) answered the question regarding being formally diagnosed by a healthcare professional with GERD and/or rGERD. The 197 (70%) participants who answered “yes” made up the survey population. Heartburn (65%) and acid regurgitation (62%) were the most common troublesome symptoms. PPI use was reported by 145 (74%) respondents, but only 30% were satisfied with PPI therapy. The most common alternative therapies included antacid/alginates (63%), histamine H2-receptor antagonists (33%), mucosal protectants (25%), and lifestyle modifications (84%). In this population-based survey, nearly one-third of participants with persistent reflux-like symptoms had not received a formal diagnosis of GERD or rGERD. Although most participants diagnosed with GERD/rGERD had received PPI therapy, persistent symptoms, dissatisfaction with PPI therapy, and concerns about long-term PPI use were common. These data emphasize the need for patient input when developing management strategies for GERD and persistent reflux-like symptoms or rGERD.
质子泵抑制剂(PPIs)在治疗胃食管反流病(GERD)方面非常有效。然而,尽管使用了PPI,但持续的、麻烦的反流症状是常见的,并且有一定比例的持续症状的人被认为患有难治性胃食管反流病(rGERD)。关于患者持续性反流样症状的经验,指导医疗保健专业人员处理这种麻烦的情况的数据有限。对报告持续性反流样症状的成年人进行了一项基于人群的国际在线调查;就参与者的症状、诊断、治疗和共病情况提出了24个问题。进行描述性分析,以描述参与者的诊断经验和他们对治疗的满意度。所有数据均为自我报告。在565名初始受访者中,283人(51%)回答了由医疗专业人员正式诊断为GERD和/或rGERD的问题。197名(70%)回答“是”的参与者构成了调查人群。烧心(65%)和反酸(62%)是最常见的麻烦症状。145名(74%)受访者报告了PPI的使用情况,但只有30%的人对PPI治疗感到满意。最常见的替代疗法包括抗酸剂/藻酸盐(63%)、组胺H2受体拮抗剂(33%)、粘膜保护剂(25%)和生活方式改变(84%)。在这项基于人群的调查中,近三分之一有持续性反流样症状的参与者没有得到GERD或rGERD的正式诊断。尽管大多数被诊断为GERD/rGERD的参与者都接受了PPI治疗,但持续症状、对PPI治疗的不满以及对长期使用PPI的担忧是常见的。这些数据强调,在制定GERD和持续性反流样症状或rGERD的管理策略时,需要患者输入。
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引用次数: 0
Endoscopy and Antireflux Surgery: A Technical Review of Pre- and Postoperative Evaluation and Recognizing Patterns of Failure 内镜和抗反流手术:术前和术后评估和识别失败模式的技术综述
Pub Date : 2023-05-19 DOI: 10.1177/26345161231174246
C. Dunn, Sven E. Eriksson, B. Jobe, S. Ayazi
Endoscopic evaluation after antireflux surgery is a challenge, due to the complexity of anatomy, variations in anatomical repairs, and the various patterns of failure. Studies have demonstrated that endoscopy reports of postoperative examinations are often inaccurate and inconsistent. The key to consistent high quality endoscopic examinations of the integrity of an antireflux surgery is a sound foundation in the native anatomical gastroesophageal junction and an understanding of the anatomy of the various postoperative configurations. This review will clarify the critical details necessary to perform a detailed endoscopic evaluation of the patient with suspected gastroesophageal reflux, and highlight key features to distinguish the intact repair from the dysfunctional one. It first explores the anatomical components of the native gastroesophageal junction and the unique geometric architecture that manifests in the physiologic reflux barrier. Then details the essential structures to evaluate and techniques to perform in an endoscopic examination prior to an antireflux surgery. It then systematically examines the altered anatomy and postoperative changes in endoscopic appearance after Nissen, Toupet, and Dor fundoplication, Collis gastroplasty, magnetic sphincter augmentation, and transoral incisionless fundoplication. Finally, to aid in the endoscopic diagnosis of specific dysfunction, it discusses the various patterns of failure after antireflux surgery, their characteristic endoscopic appearances, and the most useful adjunct testing modalities to augment the endoscopic examination when diagnosis is unclear.
由于解剖结构的复杂性、解剖修复的变化和各种失败模式,抗反流手术后的内镜评估是一项挑战。研究表明,内镜术后检查报告往往不准确和不一致。对抗反流手术完整性进行一致的高质量内窥镜检查的关键是对胃食管连接的天然解剖的良好基础和对各种术后构型的解剖理解。本综述将阐明对疑似胃食管反流患者进行详细内镜评估所需的关键细节,并强调区分完整修复与功能障碍修复的关键特征。它首先探讨了天然胃食管交界处的解剖成分和独特的几何结构,体现在生理性反流屏障中。然后详细介绍在抗反流手术前进行内窥镜检查时需要评估的基本结构和技术。然后系统地检查了Nissen, Toupet和Dor底瓣置换术、Collis胃成形术、磁力括约肌增强术和经口无切口底瓣置换术后解剖结构的改变和内镜下外观的术后变化。最后,为了帮助内镜诊断特定功能障碍,本文讨论了抗反流手术后失败的各种模式,它们的特征性内镜表现,以及在诊断不明确时增强内镜检查的最有用的辅助检测方式。
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引用次数: 0
Benign Esophageal Disorders: The Thing About Race and Ethnicity 良性食道疾病:关于种族和民族的事情
Pub Date : 2023-05-18 DOI: 10.1177/26345161231171379
A. Addo, Kevin Connors, A. Park
The aim of this review is to highlight the racial and ethnic differences in the prevalence, presentation, management, and outcomes of benign foregut disorders. Gastroesophageal reflux disease and achalasia make up the most common benign esophageal disorders. There are limited data in the literature regarding racial and ethnic disparities in the care and management of these disorders. However, studies have shown that racial and ethnic disparities play a role in the management of these disorders. To minimize the impact of these disparities, more effort is needed in identifying the interplay between race, insurance status, socioeconomic status and their underlying mechanism.
本综述的目的是强调良性前肠疾病的患病率,表现,管理和结局的种族和民族差异。胃食管反流病和贲门失弛缓症是最常见的良性食管疾病。文献中关于这些疾病的护理和管理中的种族和民族差异的数据有限。然而,研究表明,种族和民族差异在这些疾病的管理中发挥了作用。为了尽量减少这些差异的影响,需要更多的努力来确定种族、保险状况、社会经济地位及其潜在机制之间的相互作用。
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引用次数: 1
期刊
Foregut (Thousand Oaks, Calif.)
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