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The long-term efficacy of tetracycline class antimicrobials as local adjuncts in the treatment of chronic periodontitis: a systematic review and meta-analysis. 四环素类抗菌剂作为局部辅助治疗慢性牙周炎的长期疗效:一项系统综述和荟萃分析。
IF 1.8 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-09-26 eCollection Date: 2025-01-01 DOI: 10.3389/fdmed.2025.1658720
Niroshani S Soysa, Samadhi L Jayakody, C N R A Alles
<p><strong>Introduction: </strong>This systematic review assesses the long-term efficacy of tetracycline-class local antimicrobials as adjuncts to scaling and root planing (SRP) in chronic periodontitis. It focuses on improvements in primary outcomes such as probing pocket depth (PPD) and clinical attachment level (CAL), with particular attention to differences in treatment outcomes between smokers and non-smokers. Moreover, the assessed secondary outcomes encompassed bleeding on probing (BOP), gingival index (GI), and plaque index (PI).</p><p><strong>Method: </strong>A systematic search of PubMed, Cochrane Central, Scopus, and Embase identified randomized controlled trials (RCTs) published up to 2024 with ≥6 months follow-up. Long-term efficacy of local tetracyclines was assessed from the selected studies. Meta-analysis calculated weighted mean differences (WMDs) and 95% CIs for the selected periodontal indices using R software. Meta-regression evaluated the impact of study design, assessment approach, treatment phase, and smoking status.</p><p><strong>Results: </strong>This systematic review included 52 RCTs assessing the efficacy of adjunctive locally delivered antimicrobials in periodontal therapy. Meta-analysis showed significant benefits in both medium-term (6-9 months) and long-term (12 +  months) outcomes. Medium-term results demonstrated significant PPD reduction (WMD 0.516 mm, 95% CI 0.413; 0.620, <i>P</i> = 0.0001) and CAL gain (WMD 0.336 mm, 95% CI 0.204; 0.467, <i>P</i> = 0.0001), while long-term studies showed sustained improvements (PPD: WMD 0.371 mm, 95% CI 0.181; 0.560, <i>P</i> = 0.0001; CAL: WMD 0.310 mm, 95% CI 0.240; 0.381, <i>P</i> = 0.0001). Tetracycline fibers showed the greatest medium-term PPD reduction (0.705 mm), followed by minocycline ointment (0.580 mm). Long-term follow-up also demonstrated significant improvements in BOP, PI, and GI (WMD = 0.1-0.3, <i>P</i> < 0.05). Subgroup analysis revealed non-smokers had greater PPD reduction (0.630 mm vs. 0.112 mm) and CAL gain (0.715 mm vs. 0.464 mm) than smokers (<i>P</i> < 0.05) in long-term. Meta-regression indicated study design influenced outcomes, with split-mouth designs showing significantly greater improvements [<i>β</i> = 0.422, 95% CI (0.231; 0.613), <i>P</i> = 0.0001].</p><p><strong>Discussion: </strong>Sustained-release tetracyclines with SRP improve long-term outcomes in chronic periodontitis. Non-smokers exhibit greater clinical gains, though smokers also benefit. These results support tailored adjunctive local tetracycline use to optimize outcomes across patient groups. Further large-scale, long-term RCTs are needed to confirm efficacy and refine delivery formulations.</p><p><strong>Conclusion: </strong>Locally delivered tetracycline-class antimicrobials significantly improve periodontal outcomes, with minocycline showing the most consistent benefits. These findings support the integration of tetracycline-class agents into treatment protocols, with special co
简介:本系统综述评估了四环素类局部抗菌剂作为慢性牙周炎刮治和牙根刨治(SRP)辅助治疗的长期疗效。它侧重于主要结果的改善,如探查口袋深度(PPD)和临床依恋水平(CAL),特别关注吸烟者和非吸烟者之间治疗结果的差异。此外,评估的次要结果包括探查出血(BOP)、牙龈指数(GI)和菌斑指数(PI)。方法:系统检索PubMed、Cochrane Central、Scopus和Embase,确定截至2024年发表的随机对照试验(rct),随访≥6个月。从选定的研究中评估局部四环素的长期疗效。meta分析使用R软件计算所选牙周指标的加权平均差异(wmd)和95% ci。meta回归评估了研究设计、评估方法、治疗阶段和吸烟状况的影响。结果:本系统综述包括52项随机对照试验,评估辅助局部给药抗菌剂在牙周治疗中的疗效。meta分析显示中期(6-9个月)和长期(12个月以上)结果均有显著益处。中期结果显示PPD显著降低(WMD 0.516 mm, 95% CI 0.413; 0.620, P = 0.0001), CAL增加(WMD 0.336 mm, 95% CI 0.204; 0.467, P = 0.0001),而长期研究显示持续改善(PPD: WMD 0.371 mm, 95% CI 0.181; 0.560, P = 0.0001; CAL: WMD 0.310 mm, 95% CI 0.240; 0.381, P = 0.0001)。四环素纤维中期PPD降低幅度最大(0.705 mm),二甲胺环素软膏次之(0.580 mm)。长期随访也显示BOP、PI和GI有显著改善(WMD = 0.1-0.3, P P β = 0.422, 95% CI (0.231; 0.613), P = 0.0001)。讨论:缓释四环素与SRP改善慢性牙周炎的长期预后。不吸烟者表现出更大的临床收益,尽管吸烟者也受益。这些结果支持量身定制的局部辅助四环素使用,以优化患者群体的结果。需要进一步的大规模、长期随机对照试验来确认疗效并完善给药配方。结论:局部使用四环素类抗菌剂可显著改善牙周预后,其中米诺环素表现出最一致的益处。这些发现支持将四环素类药物纳入治疗方案,并特别考虑高危患者,如吸烟者。未来的研究应强调成本效益、比较疗效和长期效益,包括分叉病变的挑战性管理,以更好地指导临床决策和优化患者预后。
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引用次数: 0
The effects of magnesium-containing coatings on the healing of soft tissues surrounding oral titanium abutments: a narrative review. 含镁涂层对口腔钛基牙周围软组织愈合的影响
IF 1.8 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-09-25 eCollection Date: 2025-01-01 DOI: 10.3389/fdmed.2025.1638027
Hongya Zheng, Chenxi Shang, Ping Li, Wenjie Zhao, Yumei Niu, Shuang Pan, Shuang Zhang

The inherent limitations of smooth titanium abutments-particularly inadequate soft tissue sealing that predisposes implants to infection and inflammation-underscore the need for surface modifications. This review synthesizes evidence on magnesium-containing coatings as a bioactive solution to enhance peri-implant soft tissue healing. Through 1) modifying the surface properties of the implant abutment to promote better cell adhesion and proliferation; 2) releasing Mg2+ to promote fibroblast migration, collagen synthesis, and angiogenesis; and 3) exerting antimicrobial effects and regulating inflammatory responses, these coatings establish a microenvironment conducive to robust tissue integration. This helps prevent peri-implant infections and inflammation, strengthens soft tissue attachment, and improves the long-term stability of dental implants, providing a new direction for the development of biomedical materials.

光滑钛基牙的固有局限性——尤其是软组织密封不足,容易导致植入物感染和炎症——强调了表面修饰的必要性。本文综述了含镁涂层作为生物活性溶液促进种植体周围软组织愈合的证据。通过1)改变种植基牙的表面特性,促进更好的细胞粘附和增殖;2)释放Mg2+促进成纤维细胞迁移、胶原合成和血管生成;3)发挥抗菌作用和调节炎症反应,这些涂层建立了一个有利于组织整合的微环境。这有助于防止种植体周围的感染和炎症,加强软组织附着,提高种植体的长期稳定性,为生物医学材料的发展提供了新的方向。
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引用次数: 0
Impact of implant surface modifications on long-term outcome of surgical peri-implantitis treatment: a systematic review. 种植体表面修饰对手术治疗种植体周围炎长期疗效的影响:一项系统综述。
IF 1.8 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-09-24 eCollection Date: 2025-01-01 DOI: 10.3389/fdmed.2025.1661369
Panagiotis Gardelis, Catherine Giannopoulou, Andreas Stavropoulos, Alkisti Zekeridou

Introduction: Peri-implantitis is an inflammatory disease that compromises peri-implant tissues and supporting bone, potentially leading to implant loss. Although several surgical treatment strategies have been proposed, it remains unclear whether implant surface characteristics (smooth vs. rough) influence long-term treatment outcomes.

Methods: A systematic review was conducted to evaluate clinical studies with a minimum follow-up of 3 years that assessed the outcomes of surgical treatment of peri-implantitis in relation to implant surface type. Data extraction focused on recurrence of peri-implantitis, implant survival, clinical parameters, radiographic outcomes, and the type of surgical approach used (reconstructive vs. non-reconstructive).

Results: Seventeen clinical studies were included. Outcomes varied according to implant surface characteristics. Rough (modified) surfaces were generally associated with a higher risk of recurrence of peri-implantitis and implant loss compared with smooth (machined/turned) surfaces. Reconstructive surgical approaches, especially those involving bone grafts and membranes, demonstrated more favorable outcomes compared with non-reconstructive approaches.

Discussion: Despite observed trends, the certainty of the evidence remains low due to heterogeneity between studies, small sample sizes, and methodological limitations. Further well-designed long-term clinical trials are needed to clarify the role of implant surface characteristics in the long-term success of peri-implantitis surgical treatment.

Systematic review registration: PROSPERO (CRD420251129791).

简介:种植体周围炎是一种损害种植体周围组织和支撑骨的炎症性疾病,可能导致种植体丢失。虽然已经提出了几种手术治疗策略,但尚不清楚种植体表面特征(光滑与粗糙)是否会影响长期治疗结果。方法:系统回顾了至少3年随访的临床研究,评估了手术治疗种植体周围炎与种植体表面类型的关系。数据提取的重点是种植体周围炎的复发、种植体存活、临床参数、影像学结果和采用的手术方式(重建与非重建)。结果:纳入17项临床研究。结果因种植体表面特征而异。与光滑(加工/翻转)表面相比,粗糙(修饰)表面通常与种植体周围炎复发和种植体丢失的风险更高相关。与非重建入路相比,重建手术入路,特别是涉及骨移植物和膜的手术入路,显示出更有利的结果。讨论:尽管观察到趋势,但由于研究之间的异质性、小样本量和方法学的局限性,证据的确定性仍然很低。需要进一步精心设计的长期临床试验来阐明种植体表面特征在种植体周围炎手术治疗的长期成功中的作用。系统评价注册:PROSPERO (CRD420251129791)。
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引用次数: 0
Incidence and risk factors of postoperative complications following periodontal flap surgery: a retrospective study. 牙周皮瓣术后并发症发生率及危险因素的回顾性研究。
IF 1.8 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-09-24 eCollection Date: 2025-01-01 DOI: 10.3389/fdmed.2025.1668844
Hongjiang Gu, Wei Liu, Xiaoyu Xu, Yinjie Shen

Background: Periodontal flap surgery is a common procedure for treating advanced periodontal disease, but postoperative complications such as pain, infection, and delayed healing are frequent. This study aims to investigate the incidence of postoperative complications and identify key risk factors, contributing to more personalized surgical management.

Methods: A retrospective analysis was conducted on 121 patients who underwent periodontal flap surgery. Patient demographics, clinical data (e.g., age, probing depth, clinical attachment loss), and surgical variables (e.g., incision type, surgery duration) were collected. Logistic regression analysis was performed to identify significant predictors of postoperative complications. The complications analyzed included dentin hypersensitivity, excessive pain, infection, and gingival bleeding.

Results: Postoperative complications occurred in 44.63% of patients. Age was a significant predictor, with each additional year increasing the risk of complications by 12% (p < 0.001). Clinical attachment loss was strongly associated with complications (p = 0.009). Semilunar incisions, typically used in localized mild cases, were associated with a lower incidence of complications compared to trapezoidal incisions (p < 0.001). Smoking also significantly increased the risk of complications in both the univariate and multivariate analyses (p < 0.05). In the univariate analysis, both preoperative antibiotics and preoperative analgesics were associated with a reduced risk of complications (p < 0.05), but these effects were not significant in the multivariate analysis (p > 0.05).

Conclusion: This study highlights age, clinical attachment loss, smoking, and surgical incision type as significant predictors of postoperative complications following periodontal flap surgery. The findings underscore the need for personalized surgical approaches, particularly in older patients and those with severe periodontal disease.

背景:牙周皮瓣手术是治疗晚期牙周病的常用方法,但术后并发症如疼痛、感染和延迟愈合是常见的。本研究旨在调查术后并发症的发生率,识别关键危险因素,为更个性化的手术管理做出贡献。方法:对121例行牙周皮瓣手术的患者进行回顾性分析。收集患者人口统计学、临床数据(如年龄、探查深度、临床附着丧失)和手术变量(如切口类型、手术时间)。进行Logistic回归分析以确定术后并发症的重要预测因素。分析的并发症包括牙本质过敏、过度疼痛、感染和牙龈出血。结果:术后并发症发生率为44.63%。年龄是一个重要的预测因素,每增加一年并发症的风险增加12% (p p = 0.009)。半月切口通常用于局部轻度病例,与梯形切口相比,并发症发生率较低(p p p p > 0.05)。结论:本研究强调年龄、临床附着丧失、吸烟和手术切口类型是牙周皮瓣术后并发症的重要预测因素。研究结果强调了个性化手术方法的必要性,特别是对于老年患者和那些患有严重牙周病的患者。
{"title":"Incidence and risk factors of postoperative complications following periodontal flap surgery: a retrospective study.","authors":"Hongjiang Gu, Wei Liu, Xiaoyu Xu, Yinjie Shen","doi":"10.3389/fdmed.2025.1668844","DOIUrl":"10.3389/fdmed.2025.1668844","url":null,"abstract":"<p><strong>Background: </strong>Periodontal flap surgery is a common procedure for treating advanced periodontal disease, but postoperative complications such as pain, infection, and delayed healing are frequent. This study aims to investigate the incidence of postoperative complications and identify key risk factors, contributing to more personalized surgical management.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 121 patients who underwent periodontal flap surgery. Patient demographics, clinical data (e.g., age, probing depth, clinical attachment loss), and surgical variables (e.g., incision type, surgery duration) were collected. Logistic regression analysis was performed to identify significant predictors of postoperative complications. The complications analyzed included dentin hypersensitivity, excessive pain, infection, and gingival bleeding.</p><p><strong>Results: </strong>Postoperative complications occurred in 44.63% of patients. Age was a significant predictor, with each additional year increasing the risk of complications by 12% (<i>p</i> < 0.001). Clinical attachment loss was strongly associated with complications (<i>p</i> = 0.009). Semilunar incisions, typically used in localized mild cases, were associated with a lower incidence of complications compared to trapezoidal incisions (<i>p</i> < 0.001). Smoking also significantly increased the risk of complications in both the univariate and multivariate analyses (<i>p</i> < 0.05). In the univariate analysis, both preoperative antibiotics and preoperative analgesics were associated with a reduced risk of complications (<i>p</i> < 0.05), but these effects were not significant in the multivariate analysis (<i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>This study highlights age, clinical attachment loss, smoking, and surgical incision type as significant predictors of postoperative complications following periodontal flap surgery. The findings underscore the need for personalized surgical approaches, particularly in older patients and those with severe periodontal disease.</p>","PeriodicalId":73077,"journal":{"name":"Frontiers in dental medicine","volume":"6 ","pages":"1668844"},"PeriodicalIF":1.8,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mesiodistal width correlation between primary and successor mandibular teeth: implication for early orthodontic diagnosis. 下颌主牙和后继牙的中远端宽度相关性:对早期正畸诊断的意义。
IF 1.8 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-09-24 eCollection Date: 2025-01-01 DOI: 10.3389/fdmed.2025.1659242
Aleyna Cakir, Annika Both, Christian Kirschneck, Nikolaos Daratsianos, Cristiano Miranda de Araújo, Juliane Corá, Erika Calvano Küchler, Svenja Beisel-Memmert

Background: Most studies on permanent tooth width prediction focus on the predictive value of permanent teeth, however only a few studies examine the predictive value of primary teeth. The aim of this study was to investigate the correlation between the mesiodistal widths of the mandibular primary canines and molars and those of their permanent successors. In addition, the study evaluated whether the mesiodistal width of the primary canines and molars can serve as reliable predictors for the width of the permanent mandibular first molars.

Methods: This cross-sectional study analyzed records from 143 orthodontic patients (78 males and 65 females) who had digitized dental models in the mixed and in the permanent dentition stage. Mesiodistal measurements were performed on left-sided mandibular permanent teeth (canines, first and second premolars, first molar), and primary teeth (canines, first and second molars). The Pearson correlation coefficient test was used to determine the correlation strength between the mesiodistal dimensions of primary and permanent teeth (p < 0.05).

Results: Significant correlations were found between second primary molars and second premolars (Pearson r = 0.400-0.461) as well as between primary and permanent canines (Pearson r = 0.462-0.512), across the total sample and within both sexes. The dimensions of all three evaluated primary teeth were correlated with first permanent molar with r ranging from 0.402 to 0.625. The primary first molar showed a weak correlation with the first premolar for the total sample (Pearson r = 0.240) and males (Pearson r = 0.302), and none was observed for female patients (Pearson r = 0.048).

Conclusions: A link between primary and permanent tooth width of canines and posterior dentition was observed, but a difference between sexes exists. Therefore, primary teeth may offer early insight into future space requirements, however their predictive strength is influenced by tooth type and sex.

背景:恒牙宽度预测的研究大多集中在恒牙的预测价值上,而对乳牙的预测价值的研究很少。本研究的目的是探讨下颌初级犬齿和磨牙的中远端宽度与它们的永久继承者的相关性。此外,本研究还评估了初生犬齿和磨牙的近远端宽度是否可以作为恒颌第一磨牙宽度的可靠预测指标。方法:横断面分析143例正畸患者(男78例,女65例)混合牙列和恒牙列阶段的数字化牙模型。对左侧下颌恒牙(犬齿,第一和第二前磨牙,第一磨牙)和乳牙(犬齿,第一和第二磨牙)进行中远端测量。使用Pearson相关系数检验来确定乳牙和恒牙中远端尺寸之间的相关强度(p)结果:在整个样本和两性中,第二乳牙和第二前磨牙之间(Pearson r = 0.400-0.461)以及乳牙和恒牙之间(Pearson r = 0.462-0.512)均存在显著相关性。三颗乳牙的尺寸与第一恒磨牙的相关系数r在0.402 ~ 0.625之间。乳牙第一磨牙与第一前磨牙的相关性在总体(Pearson r = 0.240)和男性(Pearson r = 0.302)中呈弱相关性,而在女性患者中无相关性(Pearson r = 0.048)。结论:观察到犬科动物和后牙列的乳牙和恒牙宽度之间存在联系,但存在性别差异。因此,乳牙可以提供对未来空间需求的早期洞察,但其预测强度受牙齿类型和性别的影响。
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引用次数: 0
Water sorption of gingiva-shade composites and its influence on color stability. 牙龈色复合材料的吸水性及其对颜色稳定性的影响。
IF 1.8 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-09-23 eCollection Date: 2025-01-01 DOI: 10.3389/fdmed.2025.1671386
Shivaughn M Marchan, Kelee Bascombe, Samiyah Suliman, Reisha N Rafeek

Background: This study aimed to ascertain the water sorption of three gingival shade esthetic materials and understand the correlation between water sorption and color change when immersed in common food colorants.

Methods: Disc-shaped composites were fabricated and subjected to immersion in distilled water, followed by desiccation to ascertain water sorption values. Simultaneously, similarly shaped specimens were fabricated, measured for total color using a spectrophotometer before and after immersion in various colorant solutions. Pearson's correlation was used to ascertain if there was a positive linear relationship between values for water sorption and change in total color.

Results: There was a statistically significant difference in mean water sorption data between the tested composites (p = 0.02, F value = 5.6). No correlation coefficients between water sorption and any tested composites in any colorant solutions were statistically significant (p ≥ 0.05), with the exception of PermaFlow Pink immersed in coffee (r = -0.635, p = 0.05).

Conclusions: All the tested composites exhibited favorable values for water sorption. Over the studied period, water immersion produced a negligible change in color among all the tested specimens. All composites exhibited changes in color when exposed to food colorants with the largest relative change occurring for immersion in curry. There was no positive correlation between water sorption values and change in color.

背景:本研究旨在确定三种牙龈色度美学材料的吸水率,了解浸泡在常见食用色素中吸水率与颜色变化的关系。方法:制备圆盘状复合材料,经蒸馏水浸泡,干燥测定吸水性。同时,制作形状相似的标本,用分光光度计测量浸入各种着色剂溶液前后的总颜色。采用Pearson相关法确定吸水性值与总色变化之间是否存在正线性关系。结果:两种复合材料的平均吸水率差异有统计学意义(p = 0.02, F值= 5.6)。除PermaFlow Pink浸在咖啡中(r = -0.635, p = 0.05)外,在任何着色剂溶液中,吸水率与任何测试复合材料的相关系数均无统计学意义(p≥0.05)。结论:所测复合材料均具有良好的吸水性能。在研究期间,在所有的测试样本中,水浸产生的颜色变化可以忽略不计。当暴露于食用色素时,所有复合材料的颜色都发生了变化,其中浸泡在咖喱中的相对变化最大。吸水率与颜色变化无正相关关系。
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引用次数: 0
Evaluation of color stability on resin composite specimens using different polishing kits: an in vitro study. 使用不同抛光套件评估树脂复合材料样品的颜色稳定性:体外研究。
IF 1.8 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-09-23 eCollection Date: 2025-01-01 DOI: 10.3389/fdmed.2025.1669071
Hamed S Alghamdi, Hanan Z Alosaimi, Demah E Kaki, Amani H Majrashi, Ayah I Rassas, Ghena AlHumaid, Turki Alshehri, Abdulrahman A Balhaddad, Mohammed A Barashi, Rashed A Alsahafi, Hesham A Alhazmi

Objectives: Modern dentistry has introduced color-matching restorations along with commercial finishing/polishing kits to improve color stability. This study aims to evaluate the effect of three finishing and polishing kits on the color stability of Filtek™ Z250 resin composite.

Methods: This study involved 140 resin composite discs categorized into three experimental groups: Sof-Lex, Super-Snap, and OptiDisc (40 discs each), along with a control group of 20 discs. Each disc was exposed to either coffee or cola after finishing or following both finishing and polishing. Mean color change was computed for each group. A One-Way ANOVA was conducted to compare mean color changes among the finishing kits.

Results: Super-Snap demonstrated the highest color stability among different finishing kits for Filtek™ Z250 resin composites in coffee staining, with a mean color change of 10.7. After finishing and polishing, its color stability improved to 10.2. For cola staining, Super-Snap had a mean color stability of 2.98, which decreased to 2.07 after polishing. However, there were no significant differences between the kits (p > 0.05). Furthermore, immersion in coffee resulted in significantly greater color changes compared to cola for all tested groups (p < 0.05).

Conclusion: The three multi-step finishing and polishing kits for Filtek™ Z250 demonstrated similar color stability, with coffee showing a higher staining potential than cola. Patients with anterior composite restorations may require education about the risk of staining and the importance of dental follow-ups to maintain the aesthetic quality of their restorations.

目的:现代牙科已经引入了颜色匹配修复以及商业精加工/抛光套件,以提高颜色稳定性。本研究旨在评估三种精加工和抛光套件对Filtek™Z250树脂复合材料颜色稳定性的影响。方法:140个树脂复合椎间盘分为sofo - lex、Super-Snap和OptiDisc三组(每组40个),对照组20个。在完成或完成和抛光后,每个光盘都暴露在咖啡或可乐中。计算各组的平均颜色变化。采用单因素方差分析比较整理套件的平均颜色变化。结果:Super-Snap在不同的整理套件中对Filtek™Z250树脂复合材料在咖啡染色中表现出最高的颜色稳定性,平均颜色变化为10.7。经整理抛光后,其颜色稳定性提高到10.2。对于可乐染色,Super-Snap的平均颜色稳定性为2.98,抛光后下降到2.07。两组间差异无统计学意义(p < 0.05)。此外,与可乐相比,浸泡在咖啡中会导致所有测试组的颜色变化明显更大(p结论:Filtek™Z250的三个多步骤整理和抛光套件显示出相似的颜色稳定性,咖啡比可乐显示出更高的染色潜力。使用前牙复合修复体的患者可能需要接受有关染色风险的教育,以及牙科随访以保持修复体美学质量的重要性。
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引用次数: 0
An integrated approach to tracking mandibular position relative to incisal and condylar envelopes of motion during intraoral clinical procedures: a new look at TMJ movements. 在口腔内临床手术中,追踪下颌位置相对于切牙和髁突包膜运动的综合方法:TMJ运动的新视角。
IF 1.8 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-09-17 eCollection Date: 2025-01-01 DOI: 10.3389/fdmed.2025.1654118
Jing-Sheng Li, Douglas S Ramsay, Andrea B Burke, Greg J Huang, Fritzie I Arce-McShane

Current methods for tracking temporomandibular joint (TMJ) movements are difficult to perform during dental procedures. Yet precise and accurate quantification of mandibular movements is critical for understanding temporomandibular biomechanics and how certain movements may contribute to temporomandibular dysfunction. This is particularly relevant to clinical procedures that might move the mandible near or beyond its functional range of motion. We present a novel approach that integrates cone-beam computed tomography, optical intra-oral scans, and six degree-of-freedom electromagnetic sensor data to quantify mandibular movements. This method employs rigid body transformations to generate subject-specific three-dimensional (3D) envelopes of motion and assess whether incisal and condylar landmarks remain within their functional 3D envelopes of motion. We demonstrate the clinical utility of this approach through simulated mandibular poses presented relative to the limits of incisal and condylar envelopes created from that individual's voluntary border movements. Our findings reveal that condylar or incisal points in simulated mandibular poses are located beyond their normal motion envelopes, highlighting the importance of simultaneous monitoring of incisal and condylar landmarks. This methodology provides a clinically relevant tool for understanding temporomandibular biomechanics and it has the potential to signal clinicians when jaw movements during dental and oral surgical procedures approach or exceed the jaw's functional range of motion and such corrective feedback could prevent adverse effects on the TMJ.

目前追踪颞下颌关节(TMJ)运动的方法在牙科手术中很难执行。然而,精确和准确的量化下颌运动对于理解颞下颌生物力学以及某些运动如何导致颞下颌功能障碍至关重要。这对于可能使下颌骨接近或超出其功能活动范围的临床手术尤为重要。我们提出了一种整合锥形束计算机断层扫描,光学口腔内扫描和六自由度电磁传感器数据的新方法来量化下颌运动。该方法采用刚体变换来生成受试者特定的三维(3D)运动包络,并评估切骨和髁突标志是否保持在其功能的三维运动包络内。我们通过模拟下颌骨姿势来展示这种方法的临床实用性,这些姿势相对于由个体自愿边界运动产生的切牙和髁包膜的限制。我们的研究结果表明,模拟下颌姿势的髁突或切突点位于其正常运动包膜之外,突出了同时监测切突和髁突标志的重要性。该方法为理解颞下颌生物力学提供了临床相关的工具,并且有可能在牙科和口腔外科手术过程中,当颌骨运动接近或超过颌骨的功能运动范围时,向临床医生发出信号,这种纠正反馈可以防止对TMJ的不良影响。
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引用次数: 0
Filling the gaps sustainably: an island case study of rural dental workforce challenges. 填补差距可持续:农村牙科劳动力挑战的岛屿案例研究。
IF 1.8 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-09-17 eCollection Date: 2025-01-01 DOI: 10.3389/fdmed.2025.1640643
Silvana Bettiol, Arish Naresh, Shahrukh Khan

Tasmania faces ongoing challenges in providing equitable oral health care across its geographically dispersed and ageing population. Tasmania has the lowest dental practitioner-to-population ratio in Australia, alongside long wait times and limited access to care in rural and regional areas. This perspective explores the demographic and workforce distribution trends that influence oral health service delivery in Tasmania using Census data, regulatory records, and key public sector audits. We highlight critical gaps in service provision and policy, reflect on the implications of the workforce maldistribution, argue for expanding the oral health therapy workforce and explore the transdisciplinary approaches currently implemented that prioritise sustainable, community-integrated oral health care. Such models align with the United Nations Sustainable Development Goals (SDGs), particularly SDG 3 (Good Health and Well-being), but also encompass SDGs 4, 5, 6, 8, 9, 10, 13 and 17, which respond to environmental and social contexts. This perspective highlights the intersections of planetary health, oral health, and community well-being, arguing that sustainable, health-centred solutions must address both human and environmental health outcomes.

塔斯马尼亚在为其地理分散和老龄化人口提供公平的口腔保健方面面临着持续的挑战。塔斯马尼亚州的牙科医生与人口比例是澳大利亚最低的,而且在农村和偏远地区,等待时间长,获得护理的机会有限。这个观点探讨人口和劳动力分布趋势,影响口腔卫生服务提供在塔斯马尼亚使用人口普查数据,监管记录,和关键的公共部门审计。我们强调了服务提供和政策方面的关键差距,反思了劳动力分布不均的影响,主张扩大口腔健康治疗劳动力,并探索目前实施的跨学科方法,优先考虑可持续的、社区综合的口腔卫生保健。这些模式与联合国可持续发展目标(SDG),特别是可持续发展目标3(良好健康和福祉)相一致,但也包括可持续发展目标4、5、6、8、9、10、13和17,这些目标是针对环境和社会背景的。这一观点强调了地球健康、口腔健康和社区福祉的交叉点,认为以健康为中心的可持续解决办法必须兼顾人类和环境健康结果。
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引用次数: 0
Mineralization, anti-demineralization, and antibacterial effects of novel Bioactive Universal Bond with calcium salt monomers on dental caries. 新型生物活性万能键与钙盐单体对龋的矿化、抗脱矿和抗菌作用。
IF 1.8 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-09-15 eCollection Date: 2025-01-01 DOI: 10.3389/fdmed.2025.1633158
Bayarchimeg Altankhishig, Yasuhiro Matsuda, Yaxin Rao, Takashi Saito

This study investigated the mineralization, anti-demineralization, and antibacterial properties of a novel bioactive universal adhesive containing the calcium salt of 4-methacryloxyethyl trimellitate acid (CMET). Four adhesives were evaluated: Bioactive Universal Bond with CMET (BA), Clearfil Universal Bond Quick (CU), Prime & Bond Universal (PB), and Scotchbond Universal Plus Adhesive (SUB). To assess mineralization properties, BA specimens were immersed in simulated body fluid (SBF) at 37°C, in line with ISO 23317, and the induced crystals were analyzed using scanning electron microscopy and energy dispersive x-ray spectroscopy. Anti-demineralization was evaluated by applying each adhesive to polished bovine dentin, followed by a one-week pH cycling protocol. Transverse microradiography (TMR) was used to quantify the integrated mineral loss. The antibacterial activity was assessed using eluates prepared by immersing the cured specimens in distilled water for seven days, followed by serial dilutions (10%, 5%, 1%, and 0.5%). These eluates were incubated with Streptococcus mutans, Actinomyces viscosus, and Lactobacillus casei for 24 h at 37°C. Viable bacterial counts were determined using the quantitative polymerase chain reaction following propidium monoazide treatment. BA exhibited distinct mineralization in SBF, likely attributable to CMET, and was characterized by the formation of octacalcium-phosphate-like crystals. TMR analysis showed that BA significantly suppressed demineralization at the dentin-material interface in relation to the other adhesives. In antibacterial assays, 5% and 10% BA eluates markedly suppressed the growth of S. mutans and A. viscosus, whereas CU, PB, and SUB exhibited inhibitory effects at only 10% concentration for S. mutans and had no impact on A. viscosus. Notably, only the 10% BA eluate significantly inhibited L. casei growth. Despite the limitations of the in vitro experiments, these findings suggest that BA possesses multifunctional properties, supporting its potential as an effective adhesive system for the prevention and treatment of caries. Furthermore, its demonstrated bioactivity suggests promising applications across various biomedical fields, such as antibacterial coatings for medical devices, bone-regenerative scaffolds, and bioactive interfaces in tissue engineering and regenerative medicine.

研究了含4-甲基丙烯氧乙基三ellitate acid (CMET)钙盐的新型生物活性通用胶粘剂的矿化、抗脱矿和抗菌性能。对四种胶粘剂进行了评价:Bioactive Universal Bond with CMET (BA)、Clearfil Universal Bond Quick (CU)、Prime & Bond Universal (PB)和Scotchbond Universal Plus Adhesive (SUB)。为了评估BA样品的矿化性质,将BA样品浸入模拟体液(SBF)中,温度为37°C,符合ISO 23317标准,并使用扫描电镜和能量色散x射线能谱分析诱导晶体。通过将每种粘合剂应用于抛光的牛牙本质,然后进行一周的pH循环方案来评估抗脱矿性。横向显微放射照相(TMR)用于量化综合矿物质损失。将固化后的标本在蒸馏水中浸泡7天,然后依次稀释(10%、5%、1%和0.5%),以洗脱液评估其抗菌活性。这些洗脱液与变形链球菌、粘放线菌和干酪乳杆菌在37℃下孵育24小时。采用单叠氮丙啶处理后的定量聚合酶链反应测定活菌数。BA在SBF中表现出明显的矿化,可能与CMET有关,其特征是形成八磷酸钙样晶体。TMR分析表明,与其他黏合剂相比,BA明显抑制了牙本质-材料界面的脱矿。在抗菌实验中,5%和10% BA洗脱液能明显抑制变形链球菌和粘单胞菌的生长,而只有10%浓度的CU、PB和SUB对变形链球菌有抑制作用,对粘单胞菌没有影响。值得注意的是,只有10%的BA洗脱液能显著抑制干酪乳杆菌的生长。尽管体外实验存在局限性,但这些发现表明BA具有多功能特性,支持其作为预防和治疗龋齿的有效粘接系统的潜力。此外,其已证明的生物活性表明其在各种生物医学领域的应用前景广阔,如医疗设备的抗菌涂层、骨再生支架、组织工程和再生医学中的生物活性界面。
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引用次数: 0
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Frontiers in dental medicine
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