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Acta Pharmaceutica Sinica B最新文献

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Controlling tumor progression and recurrence in mice through combined treatment with a PD-L1 inhibitor and a designer Salmonella strain that delivers GM-CSF 通过联合使用 PD-L1 抑制剂和可提供 GM-CSF 的沙门氏菌株，控制小鼠的肿瘤进展和复发
Acta Pharmaceutica Sinica B
Pub Date : 2024-07-01 DOI: 10.1016/j.apsb.2024.07.011
H. Jeon, Daejin Lim, EunA. So, Solbi Kim, J. Jeong, Miryoung Song, Hyojin Lee
{"title":"Controlling tumor progression and recurrence in mice through combined treatment with a PD-L1 inhibitor and a designer Salmonella strain that delivers GM-CSF","authors":"H. Jeon, Daejin Lim, EunA. So, Solbi Kim, J. Jeong, Miryoung Song, Hyojin Lee","doi":"10.1016/j.apsb.2024.07.011","DOIUrl":"https://doi.org/10.1016/j.apsb.2024.07.011","url":null,"abstract":"","PeriodicalId":7314,"journal":{"name":"Acta Pharmaceutica Sinica B","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141690009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discovery of a novel exceptionally potent and orally active Nur77 ligand NB1 with a distinct binding mode for cancer therapy 发现一种新型特效口服活性 Nur77 配体 NB1，其独特的结合模式可用于癌症治疗
Acta Pharmaceutica Sinica B
Pub Date : 2024-07-01 DOI: 10.1016/j.apsb.2024.07.012
Jun Chen, Taige Zhao, Wenbin Hong, Hongsheng Li, Mingtao Ao, Yijing Zhong, Xiaoya Chen, Yingkun Qiu, Xiumin Wang, Zhen Wu, Tianwei Lin, Baicun Li, Xueqin Chen, M. Fang
{"title":"Discovery of a novel exceptionally potent and orally active Nur77 ligand NB1 with a distinct binding mode for cancer therapy","authors":"Jun Chen, Taige Zhao, Wenbin Hong, Hongsheng Li, Mingtao Ao, Yijing Zhong, Xiaoya Chen, Yingkun Qiu, Xiumin Wang, Zhen Wu, Tianwei Lin, Baicun Li, Xueqin Chen, M. Fang","doi":"10.1016/j.apsb.2024.07.012","DOIUrl":"https://doi.org/10.1016/j.apsb.2024.07.012","url":null,"abstract":"","PeriodicalId":7314,"journal":{"name":"Acta Pharmaceutica Sinica B","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141704479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Natural product mediated mesenchymal–epithelial remodeling by covalently binding ENO1 to degrade m6A modified β-catenin mRNA 天然产物通过共价结合 ENO1 来降解 m6A 修饰的 β-catenin mRNA，从而介导间充质-上皮重塑
Acta Pharmaceutica Sinica B
Pub Date : 2024-07-01 DOI: 10.1016/j.apsb.2024.07.013
Tianyang Chen, Guangju Liu, Sisi Chen, Fengyuan Zhang, Shuoqian Ma, Yongping Bai, Quan Zhang, Yahui Ding
{"title":"Natural product mediated mesenchymal–epithelial remodeling by covalently binding ENO1 to degrade m6A modified β-catenin mRNA","authors":"Tianyang Chen, Guangju Liu, Sisi Chen, Fengyuan Zhang, Shuoqian Ma, Yongping Bai, Quan Zhang, Yahui Ding","doi":"10.1016/j.apsb.2024.07.013","DOIUrl":"https://doi.org/10.1016/j.apsb.2024.07.013","url":null,"abstract":"","PeriodicalId":7314,"journal":{"name":"Acta Pharmaceutica Sinica B","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141696062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanomedicine regulating PSC-mediated intercellular crosstalk: Mechanisms and therapeutic strategies 调节 PSC 介导的细胞间串扰的纳米药物：机制和治疗策略
Acta Pharmaceutica Sinica B
Pub Date : 2024-07-01 DOI: 10.1016/j.apsb.2024.07.007
Hui Wang, Liang Qi, Han Han, Xuena Li, Mengmeng Han, Lei Xing, Ling Li, Hulin Jiang
{"title":"Nanomedicine regulating PSC-mediated intercellular crosstalk: Mechanisms and therapeutic strategies","authors":"Hui Wang, Liang Qi, Han Han, Xuena Li, Mengmeng Han, Lei Xing, Ling Li, Hulin Jiang","doi":"10.1016/j.apsb.2024.07.007","DOIUrl":"https://doi.org/10.1016/j.apsb.2024.07.007","url":null,"abstract":"","PeriodicalId":7314,"journal":{"name":"Acta Pharmaceutica Sinica B","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141697144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Precise targeting of lipid metabolism in the era of immuno-oncology and the latest advances in nano-based drug delivery systems for cancer therapy 免疫肿瘤学时代脂质代谢的精确靶向以及用于癌症治疗的纳米给药系统的最新进展
Acta Pharmaceutica Sinica B
Pub Date : 2024-07-01 DOI: 10.1016/j.apsb.2024.07.021
Hongyan Zhang, Yujie Li, Jingyi Huang, Limei Shen, Yang Xiong
{"title":"Precise targeting of lipid metabolism in the era of immuno-oncology and the latest advances in nano-based drug delivery systems for cancer therapy","authors":"Hongyan Zhang, Yujie Li, Jingyi Huang, Limei Shen, Yang Xiong","doi":"10.1016/j.apsb.2024.07.021","DOIUrl":"https://doi.org/10.1016/j.apsb.2024.07.021","url":null,"abstract":"","PeriodicalId":7314,"journal":{"name":"Acta Pharmaceutica Sinica B","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141839184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The microneedle bandages provide new hope for healing diabetic wounds 微针绷带为糖尿病伤口愈合带来新希望
Acta Pharmaceutica Sinica B
Pub Date : 2024-07-01 DOI: 10.1016/j.apsb.2024.07.010
Saadullah Khattak, Hong-Tao Xu, Jianliang Shen
{"title":"The microneedle bandages provide new hope for healing diabetic wounds","authors":"Saadullah Khattak, Hong-Tao Xu, Jianliang Shen","doi":"10.1016/j.apsb.2024.07.010","DOIUrl":"https://doi.org/10.1016/j.apsb.2024.07.010","url":null,"abstract":"","PeriodicalId":7314,"journal":{"name":"Acta Pharmaceutica Sinica B","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141701243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a bacteria-nanosapper for the active delivery of ZIF-8 particles containing therapeutic genes for cancer immune therapy 开发一种细菌-纳米贴片机，用于将含有治疗基因的 ZIF-8 颗粒主动投递到癌症免疫疗法中
Acta Pharmaceutica Sinica B
Pub Date : 2024-07-01 DOI: 10.1016/j.apsb.2024.07.020
Yiting Qiao, Miao Luo, Yufei Wang, Haoxiang Qi, Menglan Wang, Yunxin Pei, Mengqing Sun, Zhengguo Zhang, Jiacheng Huang, Pengyu Gong, Shusen Zheng, Jianxiang Chen
{"title":"Development of a bacteria-nanosapper for the active delivery of ZIF-8 particles containing therapeutic genes for cancer immune therapy","authors":"Yiting Qiao, Miao Luo, Yufei Wang, Haoxiang Qi, Menglan Wang, Yunxin Pei, Mengqing Sun, Zhengguo Zhang, Jiacheng Huang, Pengyu Gong, Shusen Zheng, Jianxiang Chen","doi":"10.1016/j.apsb.2024.07.020","DOIUrl":"https://doi.org/10.1016/j.apsb.2024.07.020","url":null,"abstract":"","PeriodicalId":7314,"journal":{"name":"Acta Pharmaceutica Sinica B","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141852275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Avenanthramide A potentiates Bim-mediated antineoplastic properties of 5-fluorouracil via targeting KDM4C/MIR17HG/GSK-3β negative feedback loop in colorectal cancer 金刚烷胺 A 在结直肠癌中通过靶向 KDM4C/MIR17HG/GSK-3β 负反馈环增强了 Bim 介导的 5-氟尿嘧啶抗肿瘤特性
Acta Pharmaceutica Sinica B
Pub Date : 2024-07-01 DOI: 10.1016/j.apsb.2024.07.018
Rong Fu, Zhangfeng Dou, Ning Li, Xueyuan Fan, Sajid Amin, Jinqi Zhang, Yuqing Wang, Zongwei Li, Zhuoyu Li, Peng Yang
{"title":"Avenanthramide A potentiates Bim-mediated antineoplastic properties of 5-fluorouracil via targeting KDM4C/MIR17HG/GSK-3β negative feedback loop in colorectal cancer","authors":"Rong Fu, Zhangfeng Dou, Ning Li, Xueyuan Fan, Sajid Amin, Jinqi Zhang, Yuqing Wang, Zongwei Li, Zhuoyu Li, Peng Yang","doi":"10.1016/j.apsb.2024.07.018","DOIUrl":"https://doi.org/10.1016/j.apsb.2024.07.018","url":null,"abstract":"","PeriodicalId":7314,"journal":{"name":"Acta Pharmaceutica Sinica B","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141843416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intravenous delivery of STING agonists using acid-sensitive polycationic polymer-modified lipid nanoparticles for enhanced tumor immunotherapy 利用酸敏感聚阳离子聚合物修饰的脂质纳米粒子静脉注射 STING 激动剂，增强肿瘤免疫疗法的效果
Acta Pharmaceutica Sinica B
Pub Date : 2024-06-01 DOI: 10.1016/j.apsb.2024.06.004
Ying He, Ke Zheng, Xifeng Qin, Siyu Wang, Xuejing Li, Huiwen Liu, Mingyang Liu, Ruizhe Xu, Shaojun Peng, Zhiqing Pang
{"title":"Intravenous delivery of STING agonists using acid-sensitive polycationic polymer-modified lipid nanoparticles for enhanced tumor immunotherapy","authors":"Ying He, Ke Zheng, Xifeng Qin, Siyu Wang, Xuejing Li, Huiwen Liu, Mingyang Liu, Ruizhe Xu, Shaojun Peng, Zhiqing Pang","doi":"10.1016/j.apsb.2024.06.004","DOIUrl":"https://doi.org/10.1016/j.apsb.2024.06.004","url":null,"abstract":"","PeriodicalId":7314,"journal":{"name":"Acta Pharmaceutica Sinica B","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141392949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and evaluation of TSPO-targeting radioligand [18F]F-TFQC for PET neuroimaging in epileptic rats 合成和评估用于癫痫大鼠 PET 神经成像的 TSPO 靶向放射性配体 [18F]F-TFQC
Acta Pharmaceutica Sinica B
Pub Date : 2024-06-01 DOI: 10.1016/j.apsb.2024.05.031
Wenhui Fu, Qingyu Lin, Zhequan Fu, Tingting Yang, Dai Shi, Pengcheng Ma, Hongxing Su, Yunze Wang, Guobing Liu, Jing Ding, Hongcheng Shi, Dengfeng Cheng
{"title":"Synthesis and evaluation of TSPO-targeting radioligand [18F]F-TFQC for PET neuroimaging in epileptic rats","authors":"Wenhui Fu, Qingyu Lin, Zhequan Fu, Tingting Yang, Dai Shi, Pengcheng Ma, Hongxing Su, Yunze Wang, Guobing Liu, Jing Ding, Hongcheng Shi, Dengfeng Cheng","doi":"10.1016/j.apsb.2024.05.031","DOIUrl":"https://doi.org/10.1016/j.apsb.2024.05.031","url":null,"abstract":"","PeriodicalId":7314,"journal":{"name":"Acta Pharmaceutica Sinica B","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141276973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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