Acta Pharmaceutica Sinica B最新文献
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Controlling tumor progression and recurrence in mice through combined treatment with a PD-L1 inhibitor and a designer Salmonella strain that delivers GM-CSF
通过联合使用 PD-L1 抑制剂和可提供 GM-CSF 的沙门氏菌株，控制小鼠的肿瘤进展和复发
Pub Date : 2024-07-01
DOI: 10.1016/j.apsb.2024.07.011
H. Jeon, Daejin Lim, EunA. So, Solbi Kim, J. Jeong, Miryoung Song, Hyojin Lee
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Discovery of a novel exceptionally potent and orally active Nur77 ligand NB1 with a distinct binding mode for cancer therapy
发现一种新型特效口服活性 Nur77 配体 NB1，其独特的结合模式可用于癌症治疗
Pub Date : 2024-07-01
DOI: 10.1016/j.apsb.2024.07.012
Jun Chen, Taige Zhao, Wenbin Hong, Hongsheng Li, Mingtao Ao, Yijing Zhong, Xiaoya Chen, Yingkun Qiu, Xiumin Wang, Zhen Wu, Tianwei Lin, Baicun Li, Xueqin Chen, M. Fang
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Natural product mediated mesenchymal–epithelial remodeling by covalently binding ENO1 to degrade m6A modified β-catenin mRNA
天然产物通过共价结合 ENO1 来降解 m6A 修饰的 β-catenin mRNA，从而介导间充质-上皮重塑
Pub Date : 2024-07-01
DOI: 10.1016/j.apsb.2024.07.013
Tianyang Chen, Guangju Liu, Sisi Chen, Fengyuan Zhang, Shuoqian Ma, Yongping Bai, Quan Zhang, Yahui Ding
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{"title":"Natural product mediated mesenchymal–epithelial remodeling by covalently binding ENO1 to degrade m6A modified β-catenin mRNA","authors":"Tianyang Chen, Guangju Liu, Sisi Chen, Fengyuan Zhang, Shuoqian Ma, Yongping Bai, Quan Zhang, Yahui Ding","doi":"10.1016/j.apsb.2024.07.013","DOIUrl":"https://doi.org/10.1016/j.apsb.2024.07.013","url":null,"abstract":"","PeriodicalId":7314,"journal":{"name":"Acta Pharmaceutica Sinica B","volume":"77 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141696062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Development of a bacteria-nanosapper for the active delivery of ZIF-8 particles containing therapeutic genes for cancer immune therapy
开发一种细菌-纳米贴片机，用于将含有治疗基因的 ZIF-8 颗粒主动投递到癌症免疫疗法中
Pub Date : 2024-07-01
DOI: 10.1016/j.apsb.2024.07.020
Yiting Qiao, Miao Luo, Yufei Wang, Haoxiang Qi, Menglan Wang, Yunxin Pei, Mengqing Sun, Zhengguo Zhang, Jiacheng Huang, Pengyu Gong, Shusen Zheng, Jianxiang Chen
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Avenanthramide A potentiates Bim-mediated antineoplastic properties of 5-fluorouracil via targeting KDM4C/MIR17HG/GSK-3β negative feedback loop in colorectal cancer
金刚烷胺 A 在结直肠癌中通过靶向 KDM4C/MIR17HG/GSK-3β 负反馈环增强了 Bim 介导的 5-氟尿嘧啶抗肿瘤特性
Pub Date : 2024-07-01
DOI: 10.1016/j.apsb.2024.07.018
Rong Fu, Zhangfeng Dou, Ning Li, Xueyuan Fan, Sajid Amin, Jinqi Zhang, Yuqing Wang, Zongwei Li, Zhuoyu Li, Peng Yang
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{"title":"Avenanthramide A potentiates Bim-mediated antineoplastic properties of 5-fluorouracil via targeting KDM4C/MIR17HG/GSK-3β negative feedback loop in colorectal cancer","authors":"Rong Fu, Zhangfeng Dou, Ning Li, Xueyuan Fan, Sajid Amin, Jinqi Zhang, Yuqing Wang, Zongwei Li, Zhuoyu Li, Peng Yang","doi":"10.1016/j.apsb.2024.07.018","DOIUrl":"https://doi.org/10.1016/j.apsb.2024.07.018","url":null,"abstract":"","PeriodicalId":7314,"journal":{"name":"Acta Pharmaceutica Sinica B","volume":"8 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141843416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Intravenous delivery of STING agonists using acid-sensitive polycationic polymer-modified lipid nanoparticles for enhanced tumor immunotherapy
利用酸敏感聚阳离子聚合物修饰的脂质纳米粒子静脉注射 STING 激动剂，增强肿瘤免疫疗法的效果
Pub Date : 2024-06-01
DOI: 10.1016/j.apsb.2024.06.004
Ying He, Ke Zheng, Xifeng Qin, Siyu Wang, Xuejing Li, Huiwen Liu, Mingyang Liu, Ruizhe Xu, Shaojun Peng, Zhiqing Pang
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{"title":"Intravenous delivery of STING agonists using acid-sensitive polycationic polymer-modified lipid nanoparticles for enhanced tumor immunotherapy","authors":"Ying He, Ke Zheng, Xifeng Qin, Siyu Wang, Xuejing Li, Huiwen Liu, Mingyang Liu, Ruizhe Xu, Shaojun Peng, Zhiqing Pang","doi":"10.1016/j.apsb.2024.06.004","DOIUrl":"https://doi.org/10.1016/j.apsb.2024.06.004","url":null,"abstract":"","PeriodicalId":7314,"journal":{"name":"Acta Pharmaceutica Sinica B","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141392949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Synthesis and evaluation of TSPO-targeting radioligand [18F]F-TFQC for PET neuroimaging in epileptic rats
合成和评估用于癫痫大鼠 PET 神经成像的 TSPO 靶向放射性配体 [18F]F-TFQC
Pub Date : 2024-06-01
DOI: 10.1016/j.apsb.2024.05.031
Wenhui Fu, Qingyu Lin, Zhequan Fu, Tingting Yang, Dai Shi, Pengcheng Ma, Hongxing Su, Yunze Wang, Guobing Liu, Jing Ding, Hongcheng Shi, Dengfeng Cheng
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{"title":"Synthesis and evaluation of TSPO-targeting radioligand [18F]F-TFQC for PET neuroimaging in epileptic rats","authors":"Wenhui Fu, Qingyu Lin, Zhequan Fu, Tingting Yang, Dai Shi, Pengcheng Ma, Hongxing Su, Yunze Wang, Guobing Liu, Jing Ding, Hongcheng Shi, Dengfeng Cheng","doi":"10.1016/j.apsb.2024.05.031","DOIUrl":"https://doi.org/10.1016/j.apsb.2024.05.031","url":null,"abstract":"","PeriodicalId":7314,"journal":{"name":"Acta Pharmaceutica Sinica B","volume":"56 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141276973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Counteracting Alzheimer’s disease via normalizing neurovascular unit with a self-regulated multi-functional nano-modulator
通过自调节多功能纳米调节器使神经血管正常化来对抗阿尔茨海默病
Pub Date : 2024-05-01
DOI: 10.1016/j.apsb.2024.05.017
Xue Xia, Ya Wei, Qianqian Huang, Yang Zhou, Xiaorong Wang, Yulong Shi, Xiaotong Yang, Wenqin Yang, Yiwei Zhang, Ting Lei, Yuan Huang, Hanmei Li, Meng Qin, Huile Gao
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{"title":"Counteracting Alzheimer’s disease via normalizing neurovascular unit with a self-regulated multi-functional nano-modulator","authors":"Xue Xia, Ya Wei, Qianqian Huang, Yang Zhou, Xiaorong Wang, Yulong Shi, Xiaotong Yang, Wenqin Yang, Yiwei Zhang, Ting Lei, Yuan Huang, Hanmei Li, Meng Qin, Huile Gao","doi":"10.1016/j.apsb.2024.05.017","DOIUrl":"https://doi.org/10.1016/j.apsb.2024.05.017","url":null,"abstract":"","PeriodicalId":7314,"journal":{"name":"Acta Pharmaceutica Sinica B","volume":" 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141131798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Rhizoma Drynariae-derived nanovesicles reverse osteoporosis by potentiating osteogenic differentiation of human bone marrow mesenchymal stem cells via targeting ERα signaling
通过靶向ERα信号传导促进人骨髓间充质干细胞的成骨分化，从而逆转骨质疏松症
Pub Date : 2024-02-01
DOI: 10.1016/j.apsb.2024.02.005
Qing Zhao, Junjie Feng, Fubin Liu, Qianxin Liang, Manlin Xie, Jiaming Dong, Yanfang Zou, J. Ye, Guilong Liu, Yue Cao, Zhaodi Guo, Hongzhi Qiao, Lei Zheng, Kewei Zhao
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ALS-linked C9orf72 dipeptide repeats inhibit starvation-induced autophagy through modulating BCL2-BECN1 interaction
与ALS相关的C9orf72二肽重复序列通过调节BCL2-BECN1的相互作用抑制饥饿诱导的自噬作用
Pub Date : 2024-02-01
DOI: 10.1016/j.apsb.2024.02.004
Shiqiang Xu, Qilian Ma, Junwen Shen, Ningning Li, Shan Sun, Na-na Wang, Yang Chen, Chunsheng Dong, Kin Yip Tam, Jochen H.M. Prehn, Hongfeng Wang, Zheng Ying
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{"title":"ALS-linked C9orf72 dipeptide repeats inhibit starvation-induced autophagy through modulating BCL2-BECN1 interaction","authors":"Shiqiang Xu, Qilian Ma, Junwen Shen, Ningning Li, Shan Sun, Na-na Wang, Yang Chen, Chunsheng Dong, Kin Yip Tam, Jochen H.M. Prehn, Hongfeng Wang, Zheng Ying","doi":"10.1016/j.apsb.2024.02.004","DOIUrl":"https://doi.org/10.1016/j.apsb.2024.02.004","url":null,"abstract":"","PeriodicalId":7314,"journal":{"name":"Acta Pharmaceutica Sinica B","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139893152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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