Pub Date : 2021-07-06DOI: 10.17352/2581-5407.000042
K. Francis, J. Juston
Radiotherapy (RT) can be used for primary treatment, adjuvant therapy, or for salvage of recurrences of intracranial ependymal tumors. In recent years, there is a rising trend towards reducing the adverse effects of RT by incorporation of modernized techniques.
{"title":"Patient’s experiences on receiving radiation therapy for head and neck cancer pre, pending and post treatment: A qualitative study at Bugando medical centre Mwanza, Tanzania","authors":"K. Francis, J. Juston","doi":"10.17352/2581-5407.000042","DOIUrl":"https://doi.org/10.17352/2581-5407.000042","url":null,"abstract":"Radiotherapy (RT) can be used for primary treatment, adjuvant therapy, or for salvage of recurrences of intracranial ependymal tumors. In recent years, there is a rising trend towards reducing the adverse effects of RT by incorporation of modernized techniques.","PeriodicalId":73166,"journal":{"name":"Global journal of cancer therapy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44823381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-06DOI: 10.17352/2581-5407.000041
F. Dinçoğlan, O. Sager, S. Demiral, M. Beyzadeoğlu
Objective: Radiotherapy (RT) can be used for primary treatment, adjuvant therapy, or for salvage of recurrences of intracranial ependymal tumors. In recent years, there is a rising trend towards reducing the adverse effects of RT by incorporation of modernized techniques. Accurate and precise RT treatment volume is essential for optimization of treatment results. Herein, we evaluated irradiation target designation of intracranial ependymal tumors. Materials and methods: In this study, irradiation target designation was assessed for intracranial ependymal tumors. RT target volume definition was evaluated with comparative analysis for patients receiving irradiation for intracranial ependymal tumors. Results: Optimal target coverage and minimal exposure of normal tissues was prioritized in RT treatment planning. Ground truth target volume determination was done with meticulous assessment of physicians. As the primary result, it was found that the ground truth target voume was identical with target determination with Computed Tomography (CT)-Magnetic Resonance Imaging (MRI) fusion based planning. Conclusion: Incorporation of MRI in target definition process should be suggested for improving accuracy and precision of target and treatment volume definition for successful radiotherapeutic management of intracranial ependymal tumors despite the need for further supporting evidence.
{"title":"Assessment of the role of multimodality imaging for treatment volume definition of intracranial ependymal tumors: An original article","authors":"F. Dinçoğlan, O. Sager, S. Demiral, M. Beyzadeoğlu","doi":"10.17352/2581-5407.000041","DOIUrl":"https://doi.org/10.17352/2581-5407.000041","url":null,"abstract":"Objective: Radiotherapy (RT) can be used for primary treatment, adjuvant therapy, or for salvage of recurrences of intracranial ependymal tumors. In recent years, there is a rising trend towards reducing the adverse effects of RT by incorporation of modernized techniques. Accurate and precise RT treatment volume is essential for optimization of treatment results. Herein, we evaluated irradiation target designation of intracranial ependymal tumors. \u0000Materials and methods: In this study, irradiation target designation was assessed for intracranial ependymal tumors. RT target volume definition was evaluated with comparative analysis for patients receiving irradiation for intracranial ependymal tumors. \u0000Results: Optimal target coverage and minimal exposure of normal tissues was prioritized in RT treatment planning. Ground truth target volume determination was done with meticulous assessment of physicians. As the primary result, it was found that the ground truth target voume was identical with target determination with Computed Tomography (CT)-Magnetic Resonance Imaging (MRI) fusion based planning. \u0000Conclusion: Incorporation of MRI in target definition process should be suggested for improving accuracy and precision of target and treatment volume definition for successful radiotherapeutic management of intracranial ependymal tumors despite the need for further supporting evidence.","PeriodicalId":73166,"journal":{"name":"Global journal of cancer therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47083944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-30DOI: 10.17352/2581-5407.000028
M. Lahfaoui, H. Benhaddou
Rhabdomyosarcomas are the most common soft tissue sarcomas developed in children under 15 years of age. The reported finding is a vaginal tumour developed in a 30-month-old granddaughter. This was a typical botryoid rhabdomyosarcoma that usually occurs in the hollow organs lined with mucous membrane. Rhabdomyosarcomas have multiple aspects that vary according to the degree of cellular differentiation. The majority of these tumours can be classified into four histological categories: embryonic, botryoid, alveolar or pleomorphic. Treatment involves excisional surgery combined with radiotherapy and chemotherapy. The prognosis remains bleak despite therapeutic advances in recent years.
{"title":"Rare Case Botryoid Rhabdomyosarcomas of the Genital Tract. About a case in a 30-month-old child","authors":"M. Lahfaoui, H. Benhaddou","doi":"10.17352/2581-5407.000028","DOIUrl":"https://doi.org/10.17352/2581-5407.000028","url":null,"abstract":"Rhabdomyosarcomas are the most common soft tissue sarcomas developed in children under 15 years of age. The reported finding is a vaginal tumour developed in a 30-month-old granddaughter. This was a typical botryoid rhabdomyosarcoma that usually occurs in the hollow organs lined with mucous membrane. Rhabdomyosarcomas have multiple aspects that vary according to the degree of cellular differentiation. The majority of these tumours can be classified into four histological categories: embryonic, botryoid, alveolar or pleomorphic. Treatment involves excisional surgery combined with radiotherapy and chemotherapy. The prognosis remains bleak despite therapeutic advances in recent years.","PeriodicalId":73166,"journal":{"name":"Global journal of cancer therapy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46511936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-20DOI: 10.17352/2581-5407.000025
Shahzeb Khan Shaz
Cancer is the one of most leading cause of death and fast growing disease with increase its global burden due to cancer causing behavior particularly smoking, drinking alcohol coal mining worker, consumption of non-organic foods, uses of non-food grad utensils and uses of food additives. About 13.5 million case of cancer have been reported worldwide in which 7.8 million deaths occur.
{"title":"Contribution of viruses to cancer and its global burden","authors":"Shahzeb Khan Shaz","doi":"10.17352/2581-5407.000025","DOIUrl":"https://doi.org/10.17352/2581-5407.000025","url":null,"abstract":"Cancer is the one of most leading cause of death and fast growing disease with increase its global \u0000burden due to cancer causing behavior particularly smoking, drinking alcohol coal mining worker, \u0000consumption of non-organic foods, uses of non-food grad utensils and uses of food additives. About \u000013.5 million case of cancer have been reported worldwide in which 7.8 million deaths occur.","PeriodicalId":73166,"journal":{"name":"Global journal of cancer therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43895630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-09DOI: 10.17352/2581-5407.000024
M. Roomi, B. Bhanap, A. Niedzwiecki, M. Rath
Background: Malignant mesothelioma is a highly aggressive and fatal cancer of older people. Consistently associated with asbestos exposure, mesothelioma is diagnosed when it is extensively metastasized and it has a dismal prognosis. Purpose of the study: Surgery, chemotherapy, and radiotherapy are the mainstay of treatment yet they are ineffective in increasing the mesothelioma patient survival. Therefore, a different approach is needed. A novel nutrient mixture containing green tea extract, ascorbic acid, lysine, and proline exhibited anti-cancer effects in various cancers. In our previous studies, the nutrient mixture was seen to block MMP secretion and invasion through MatrigelTM by mesothelioma cells. In the current study, we wanted to explore if the nutrient mixture could induce apoptosis in mesothelioma cells
{"title":"A Novel Nutrient Mixture Induces Apoptosis in Human Mesothelioma Cells (MSTO-211H) via Activation of Caspases","authors":"M. Roomi, B. Bhanap, A. Niedzwiecki, M. Rath","doi":"10.17352/2581-5407.000024","DOIUrl":"https://doi.org/10.17352/2581-5407.000024","url":null,"abstract":"Background: Malignant mesothelioma is a highly aggressive and fatal cancer of older people. Consistently associated with asbestos exposure, mesothelioma is diagnosed when it is extensively metastasized and it has a dismal prognosis. \u0000Purpose of the study: Surgery, chemotherapy, and radiotherapy are the mainstay of treatment yet they are ineffective in increasing the mesothelioma patient survival. Therefore, a different approach is needed. A novel nutrient mixture containing green tea extract, ascorbic acid, lysine, and proline exhibited anti-cancer effects in various cancers. In our previous studies, the nutrient mixture was seen to block MMP secretion and invasion through MatrigelTM by mesothelioma cells. In the current study, we wanted to explore if the nutrient mixture could induce apoptosis in mesothelioma cells","PeriodicalId":73166,"journal":{"name":"Global journal of cancer therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46975634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. Karaosmanoğlu, Burcu Butun, H. Dal, Hülya Sivas, K. Benkli
Benzofuwran derivatives found in several natural compounds and synthesized for various purposes. Due to their molecular structure’s electron behaviors they have several biological activities such as antitumor, cytotoxic, anticancer, antimicrobial, antifungal, ant proliferative etc. We synthesized (3-methyl-benzofuran-2-yl) ketoxime derivatives (one of them are new compound) and structure elucidation of the compounds was performed using IR, 1H-NMR, MASS spectroscopy and elemental analysis. X-Ray analysis of H2 compound was elucidated for the first time with this study in the literature. Cytotoxic activity against F2408 and HepG2 cell lines was also evaluated for the first time by MTT and NR uptake methods. Anti-microbial activity of H1, H2 and H3 was also investigated with broth micro dilution test. The results show that these ketoximes have cytotoxic and anti-microbial activity on different higher doses.
{"title":"Synthesis of Some Aryl Ketoxime Derivatives with their in vitro Anti-microbial and Cytotoxic Activity","authors":"O. Karaosmanoğlu, Burcu Butun, H. Dal, Hülya Sivas, K. Benkli","doi":"10.17352/GJCT.000023","DOIUrl":"https://doi.org/10.17352/GJCT.000023","url":null,"abstract":"Benzofuwran derivatives found in several natural compounds and synthesized for various purposes. Due to their molecular structure’s electron behaviors they have several biological activities such as antitumor, cytotoxic, anticancer, antimicrobial, antifungal, ant proliferative etc. We synthesized (3-methyl-benzofuran-2-yl) ketoxime derivatives (one of them are new compound) and structure elucidation of the compounds was performed using IR, 1H-NMR, MASS spectroscopy and elemental analysis. X-Ray analysis of H2 compound was elucidated for the first time with this study in the literature. Cytotoxic activity against F2408 and HepG2 cell lines was also evaluated for the first time by MTT and NR uptake methods. Anti-microbial activity of H1, H2 and H3 was also investigated with broth micro dilution test. The results show that these ketoximes have cytotoxic and anti-microbial activity on different higher doses.","PeriodicalId":73166,"journal":{"name":"Global journal of cancer therapy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42639294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-13DOI: 10.17352/2581-5407.000022
T. Shirakawa
Still in Japan, medical oncologists need to play a main role and work a lot of tasks by themselves in cancer chemotherapy. The situation of cancer chemotherapy has progressed day by day and considering the current environment surrounding medical oncology, we must discuss what is necessary for and establish the new concept for medical oncology.
{"title":"Total Oncology is necessary for Japanese new era","authors":"T. Shirakawa","doi":"10.17352/2581-5407.000022","DOIUrl":"https://doi.org/10.17352/2581-5407.000022","url":null,"abstract":"Still in Japan, medical oncologists need to play a main role and work a lot of tasks by themselves in cancer chemotherapy. The situation of cancer chemotherapy has progressed day by day and considering the current environment surrounding medical oncology, we must discuss what is necessary for and establish the new concept for medical oncology.","PeriodicalId":73166,"journal":{"name":"Global journal of cancer therapy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42624225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：