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Clinical Characteristics and Imaging Findings of Adult COVID-19 and Influenza-related Pulmonary Complications due to Methicillin-susceptible <i>Staphylococcus </i><i>aure</i><i>u</i><i>s</i> 甲氧西林敏感型葡萄球菌&lt;i&gt; &lt;i&gt;金黄色&lt;/i&gt;&lt;i&gt;u&lt;/i&gt;&lt;i&gt; &lt;i&gt; &lt;i&gt; &lt;i&gt; &lt;
Pub Date : 2023-10-16 DOI: 10.31586/gjeidd.2023.798
Masafumi Seki, Daishi Shimada
Background: The pulmonary characteristics of Staphylococcus aureus (S. aureus) co-infection with respiratory viruses, such as SARS-CoV-2 and influenza virus, are still unclear. Case series: Two patients with methicillin-susceptible S. aureus (MSSA) infection in the lungs co-infected with either SARS-CoV-2 or influenza virus are reported. Case 1 was a 66-year-old woman who was admitted with SARS-CoV-2 infection. Her chest X-ray and computed tomography (CT) showed multiple cavity formations with infiltration shadows, and MSSA was detected from her sputum and blood, suggesting COVID-19-related bacterial pneumonia and pulmonary embolism. No catheters had been used, but she had skin eruptions and a history of SARS-CoV-2 vaccination. Ampicillin/sulbactam (ABPC/SBT) was administered, and she finally improved. Case 2 was an 87-year-old man with a history of atopic dermatitis who was admitted with moderate pneumonia, and influenza virus co-infection was found. He showed multiple cavitary shadows, and MSSA was isolated from both his sputum and blood. He was diagnosed with influenza-related bacterial pulmonary embolism. No catheters had been used, but he had a history of influenza vaccination. He was also treated by ABPC/SBT and finally improved. Conclusions: These cases suggest that MSSA showed affinity to the lungs when co-infected with either SARS-CoV-2 or influenza virus, and it presented as septic emboli without catheter use. We should consider MSSA infection when patients have SARS-CoV-2 or influenza virus co-infection, and multiple cavity formation and skin disorders are seen, even though they were vaccinated and no catheters were used.
背景:金黄色葡萄球菌(S. aureus)合并呼吸道病毒(如SARS-CoV-2和流感病毒)感染的肺部特征尚不清楚。病例系列:报告2例肺部甲氧西林敏感金黄色葡萄球菌(MSSA)感染患者同时感染SARS-CoV-2或流感病毒。病例1为一名66岁妇女,因感染SARS-CoV-2入院。胸部x线及CT示多腔形成伴浸润影,痰及血液中检出MSSA,提示新冠肺炎相关细菌性肺炎及肺栓塞。没有使用导管,但她有皮肤皮疹和SARS-CoV-2疫苗接种史。给予氨苄西林/舒巴坦(ABPC/SBT)治疗,最终病情好转。病例2为87岁男性,有特应性皮炎病史,入院时伴有中度肺炎,并发流感病毒感染。他表现出多个空洞阴影,痰和血中均分离出MSSA。他被诊断为流感相关的细菌性肺栓塞。没有使用导尿管,但他有流感疫苗接种史。同时行ABPC/SBT治疗,病情好转。结论:这些病例提示MSSA在与SARS-CoV-2或流感病毒共感染时均与肺部有亲和力,且在不使用导管的情况下表现为脓毒性栓塞。当患者同时感染SARS-CoV-2或流感病毒时,即使接种疫苗且未使用导管,也出现多发腔形成和皮肤病变,应考虑MSSA感染。
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引用次数: 0
Epidemiological and Clinical Profile of Deaths due to COVID-19 among Hospitalized Patients in Sidama Region, Ethiopia 埃塞俄比亚西达马地区住院患者COVID-19死亡的流行病学和临床概况
Pub Date : 2022-08-25 DOI: 10.31586/gjeid.2022.402
Kibruyisfaw Weldeab Abore, Ashagre Beyene Barasa, Amsalu Midaso Titole
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引用次数: 2
Women’s socio-demographic and cultural factors influencing unmet need for family planning in rural areas of The Gambia: Evidence from a population-based analytical cross-sectional study 影响冈比亚农村地区未满足的计划生育需求的妇女社会人口和文化因素:来自基于人口的分析横断面研究的证据
Pub Date : 2022-06-05 DOI: 10.31586/gjeid.2022.304
A. Barrow, E. Isah, E. Reynolds, A. Aisien
{"title":"Women’s socio-demographic and cultural factors influencing unmet need for family planning in rural areas of The Gambia: Evidence from a population-based analytical cross-sectional study","authors":"A. Barrow, E. Isah, E. Reynolds, A. Aisien","doi":"10.31586/gjeid.2022.304","DOIUrl":"https://doi.org/10.31586/gjeid.2022.304","url":null,"abstract":"","PeriodicalId":73167,"journal":{"name":"Global journal of epidemiology and infectious disease","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45204370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence and predictors of physical activity among female high school students in The Gambia: an institutional-based cross-sectional study 冈比亚女高中生体育活动的流行程度和预测因素:一项基于机构的横断面研究
Pub Date : 2022-05-23 DOI: 10.31586/gjeid.2022.300
A. Barrow, Balla Jammeh, Mansour Badjie
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引用次数: 0
Healthcare Workers Should Receive Seasonal Influenza Vaccine during COVID-19 Pandemic? COVID-19大流行期间医护人员是否应接种季节性流感疫苗?
Pub Date : 2022-03-27 DOI: 10.31586/gjeid.2022.215
Hadir Fathy Abdel-Rahman Ibrahim, A. A. Fotouh, M. Allam
{"title":"Healthcare Workers Should Receive Seasonal Influenza Vaccine during COVID-19 Pandemic?","authors":"Hadir Fathy Abdel-Rahman Ibrahim, A. A. Fotouh, M. Allam","doi":"10.31586/gjeid.2022.215","DOIUrl":"https://doi.org/10.31586/gjeid.2022.215","url":null,"abstract":"","PeriodicalId":73167,"journal":{"name":"Global journal of epidemiology and infectious disease","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45837884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of Ivermectin in Management of COVID-19 伊维菌素在新冠肺炎管理中的作用
Pub Date : 2022-03-27 DOI: 10.31586/gjeid.2022.238
Areej Mohamed Abdelhady Ahmed Helaly, G. Amin, S. A. Rahman, M. Allam
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引用次数: 0
Prevalence and Determinants of Acute Respiratory Infections among Children under Five Years in Rural Settings of The Gambia: Evidence from a National Survey 冈比亚农村地区5岁以下儿童急性呼吸道感染的患病率和决定因素:来自全国调查的证据
Pub Date : 2022-02-25 DOI: 10.31586/gjeid.2022.247
A. Barrow, Afape Ayobami, Precious Chidozie Azubuike, D. Cham
{"title":"Prevalence and Determinants of Acute Respiratory Infections among Children under Five Years in Rural Settings of The Gambia: Evidence from a National Survey","authors":"A. Barrow, Afape Ayobami, Precious Chidozie Azubuike, D. Cham","doi":"10.31586/gjeid.2022.247","DOIUrl":"https://doi.org/10.31586/gjeid.2022.247","url":null,"abstract":"","PeriodicalId":73167,"journal":{"name":"Global journal of epidemiology and infectious disease","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48701403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Melatonin could be used for Treatment of COVID-19? 褪黑素可用于治疗COVID-19?
Pub Date : 2022-02-22 DOI: 10.31586/gjeid.2022.188
Rehab Mohamed Ali Mohamed, Ghada Essam El-Din Amin, Salwa Mostafa Mohammad Abdel Rahman, Mohamed Farouk Allam
{"title":"Melatonin could be used for Treatment of COVID-19?","authors":"Rehab Mohamed Ali Mohamed, Ghada Essam El-Din Amin, Salwa Mostafa Mohammad Abdel Rahman, Mohamed Farouk Allam","doi":"10.31586/gjeid.2022.188","DOIUrl":"https://doi.org/10.31586/gjeid.2022.188","url":null,"abstract":"","PeriodicalId":73167,"journal":{"name":"Global journal of epidemiology and infectious disease","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46864190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Retrospective, Cross-sectional Hospital-based Study to Determine the Epidemiological, Clinical and Comorbidity Characteristics in Older Adults with Psoriasis 一项以医院为基础的回顾性横断面研究,以确定老年银屑病的流行病学、临床和合并症特征
Pub Date : 2022-02-10 DOI: 10.31586/gjeid.2022.182
K. Minni, M. Rajagopalan
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引用次数: 0
Role of Colchicine in Management of COVID-19? 秋水仙碱在新冠肺炎治疗中的作用?
Pub Date : 2021-12-16 DOI: 10.31586/gjeid.2022.177
Kholoud Mohamed Elawady Elhefnawy Elshiwy, Ghada Essam El-Din Amin, M. Nazmy, R. Samir, Mohamed Farouk Allam
: CoV-2 disease 2019 (COVID-19) pandemic has exerted a great burden on the health and economic systems worldwide. One of the most important factors that affect the severity and prognosis of COVID-19 is the occurrence of hyperstimulation of the immune system resulting in “cytokine storm”. Similar to SARS -CoV, an intracellular complex called nod like receptor family pyrin domain containing 3 (NLRP3) inflammasome was found to be activated by SARS-CoV-2, then in turn stimulates several interleukins and initiates the inflammatory cascade. In addition, other inflammatory mediators such as interferons e.g., IFN- α, and IFN - γ, interleukins e.g., IL - 1β, IL-12, IL-18, tumor necrosis factor- α (TNF - α), and chemokines e.g., CCL2, CXCL10 have been reported in severely ill patients. These mediators represent the corner stone in developing cytokine storm that results in uncontrolled systemic inflammatory reaction with subsequent acute respiratory distress syndrome (ARDS), multiple organ failure and eventually death. Based on its an-ti-inflammatory effects, colchicine has also gained attention to be utilized in the management of COVID-19 patient. Colchicine exerts its anti-inflammatory effect through inhibition of formation of microtubules which is considered an essential step in several cellular processes such as division, signalling, and migration. Also, colchicine affects the cytokine cascade by inhibiting IL- 1β leading to reduction in neutrophils recruitment, free radicles production and inflammasome stimulation. This raises the concerns about the effectiveness of colchicine in COVID-19 treatment and the possibility of providing an improvement of the clinical course of the disease.
2019年新型冠状病毒病(COVID-19)大流行给全球卫生和经济系统带来了巨大负担。影响COVID-19病情严重程度和预后的重要因素之一是免疫系统的过度刺激导致“细胞因子风暴”的发生。与SARS-CoV类似,发现一种称为含有3 (NLRP3)炎性体的淋巴结样受体家族pyrin结构域的细胞内复合体被SARS-CoV-2激活,然后反过来刺激几种白细胞介素并启动炎症级联反应。此外,其他炎症介质如干扰素,如IFN- α和IFN- γ,白细胞介素,如IL- 1β, IL-12, IL-18,肿瘤坏死因子- α (TNF - α)和趋化因子,如CCL2, CXCL10已在重症患者中报道。这些介质是细胞因子风暴发生的基础,导致不受控制的全身炎症反应,随后出现急性呼吸窘迫综合征(ARDS)、多器官衰竭和最终死亡。由于秋水仙碱的抗炎作用,在COVID-19患者的治疗中也得到了关注。秋水仙碱通过抑制微管的形成发挥其抗炎作用,微管的形成被认为是细胞分裂、信号传导和迁移等过程中必不可少的一步。此外,秋水仙碱通过抑制IL- 1β导致中性粒细胞募集、自由基产生和炎性小体刺激减少,从而影响细胞因子级联。这引起了人们对秋水仙碱在COVID-19治疗中的有效性以及改善该疾病临床病程的可能性的担忧。
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引用次数: 0
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Global journal of epidemiology and infectious disease
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