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Opportunities and trends of transcutaneous auricular vagus nerve stimulation 经皮耳廓迷走神经刺激疗法的机遇与趋势
Pub Date : 2024-06-06 DOI: 10.54844/gmiw.2024.0519
Chen Xin, Yuzhengheng Zhang, Jing Guo, Yu Wang, Yifei Wang, Ya’nan Zhao, Ningyi Zou, Shaoyuan Li, Peijing Rong
Background: After more than two decades of development, transcutaneous auricular vagus nerve stimulation (taVNS) has surpassed its role as a mere alternative to VNS and is now applied to various disorders. This study presents a bibliometric analysis to evaluate the global scientific output of taVNS research, aiming to describe its current status and identify potential future trends. Methods: We conducted a systematic retrieval of taVNS-related studies published between 2000 and 2022 from the Web of Science database. VOSviewer was used to construct networks based on country/institution/author co-authorship, journal/reference co-citation analysis, literature citation analysis and keyword co-occurrence. Results: A total of 523 relevant articles and reviews were included. Since 2012, there has been a rapid increase in publications and citations. China emerged as the leading contributor in terms of publication output, while Germany had the highest number of citations. Interestingly, research groups from different countries exhibited distinct research ideas and characteristics concerning taVNS, yet collaboration between these groups remained limited. Through a focused examination of key aspects in this field, we identified significant opportunities for the future advancement of taVNS. Conclusion: This bibliometric analysis emphasizes the interest in and recognition of taVNS as a therapeutic intervention and identifies broader clinical applications, more precise stimulation, and the development and commercialization of wearable devices as key opportunities and challenges for the future.
背景:经过二十多年的发展,经皮耳廓迷走神经刺激术(taVNS)已不再仅仅是迷走神经刺激术的替代疗法,而是被应用于各种疾病的治疗。本研究通过文献计量学分析评估了全球 taVNS 研究的科学成果,旨在描述其现状并确定潜在的未来趋势。方法:我们从科学网数据库中对 2000 年至 2022 年间发表的 taVNS 相关研究进行了系统检索。使用 VOSviewer 根据国家/机构/作者共同署名、期刊/参考文献共同引用分析、文献引用分析和关键词共同出现构建网络。结果:共纳入了 523 篇相关文章和综述。自 2012 年以来,论文发表量和被引用次数迅速增加。中国在论文发表量方面居首位,而德国的论文被引用次数最多。有趣的是,不同国家的研究小组在 taVNS 方面表现出不同的研究思路和特点,但这些小组之间的合作仍然有限。通过对这一领域关键方面的重点研究,我们发现了未来推动 taVNS 发展的重要机遇。结论:这项文献计量分析强调了人们对 taVNS 作为一种治疗干预手段的兴趣和认可,并将更广泛的临床应用、更精确的刺激以及可穿戴设备的开发和商业化确定为未来的主要机遇和挑战。
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引用次数: 0
Bioelectronic medicine for restoring autonomic balance in autoimmune diseases. 用于恢复自身免疫性疾病自律神经平衡的生物电子医学。
Pub Date : 2023-02-21 Epub Date: 2023-03-30 DOI: 10.54844/gmiw.2022.0182
Victor Pikov

The aim of this mini-review is to introduce most prevalent autoimmune diseases, emphasize the importance of sympatho-parasympathetic imbalance in these autoimmune diseases, demonstrate how such imbalance can be effectively treated using the bioelectronic medicine, and describe potential mechanisms of bioelectronic medicine effects on the autoimmune activity at the cellular and molecular levels.

这篇微型综述旨在介绍最常见的自身免疫性疾病,强调交感-副交感神经失衡在这些自身免疫性疾病中的重要性,展示如何利用生物电子医学有效治疗这种失衡,并描述生物电子医学在细胞和分子水平上影响自身免疫活动的潜在机制。
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引用次数: 0
Gut microbiota and human wellness: Start from the integrated medicine model 肠道菌群与人体健康:从综合医学模式出发
Pub Date : 2023-02-21 DOI: 10.54844/gmiw.2022.0084
Bin Cong, Jiande D. Z. Chen, Wei Wei
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引用次数: 0
Neuromodulation for functional upper gastrointestinal diseases. 神经调节治疗功能性上消化道疾病。
Pub Date : 2023-01-01 Epub Date: 2023-04-28 DOI: 10.54844/gmiw.2022.0087
Jiande Chen

Neuromodulation has recently received a great deal of attention among academic institutions, government funding agents and industries. This mini-review focuses on methods and applications as well as mechanisms of various neuromodulation methods in treating functional diseases of the upper gastrointestinal tract. First, the methods of various neuromodulation are introduced, including direct electrical stimulation at various peripheral nerves, such as the vagus nerve, sacral nerve and spinal cord, direct gastrointestinal electrical stimulation and noninvasive/transcutaneous electrical stimulation. Then, literature search was performed on the clinical applications of these neuromodulation methods for treating gastroesophageal reflux disease, functional dyspepsia and gastroparesis. Due to nature of the mini-review, the search results are selectively presented based on the expert opinions. Finally, a perspective is provided based on the author's own experience in this field of research.

最近,神经调控受到了学术机构、政府资助机构和工业界的广泛关注。这篇微型综述主要介绍各种神经调控方法在治疗上消化道功能性疾病中的方法和应用以及机制。首先,介绍了各种神经调控方法,包括直接电刺激各种外周神经,如迷走神经、骶神经和脊髓,直接胃肠电刺激和无创/经皮电刺激。然后,对这些神经调控方法在治疗胃食管反流病、功能性消化不良和胃痉挛方面的临床应用进行了文献检索。由于微型综述的性质,搜索结果将根据专家意见有选择性地呈现。最后,作者根据自己在这一研究领域的经验提出了自己的观点。
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引用次数: 0
Clinical application of acupuncture and Chinese materia medica in the treatment of gastrointestinal dysfunction under the mode of traditional Chinese medicine 中医模式下针灸与中药结合治疗胃肠功能障碍的临床应用
Pub Date : 2022-06-16 DOI: 10.54844/gmiw.2022.0090
Jing-jun Zhao, Cuiling Feng, Peijing Rong
In China, Chinese materia medica and acupuncture have been applied as effective methods for the treatment of gastrointestinal dysfunction for several thousand years. In fact, traditional Chinese medicine (TCM), especially acupuncture, has been gradually accepted by practitioners and patients all over the world. However, due to lack of systematic and comprehensive review articles, the effects of acupuncture and Chinese materia medica under the TCM mode have not been clearly elaborated. Therefore, in this review, we discussed the potential clinical value of acupuncture and Chinese materia medica in the treatment of gastrointestinal dysfunction under the TCM model. Articles published in the past 10 years were searched with "acupuncture," "gastrointestinal dysfunction," "gastrointestinal disorders," and other relevant keywords. In the following review, the author expounded the effects of TCM on gastrointestinal function and its potential value from the perspective of acupuncture for gastrointestinal dysfunction, Chinese materia medica for gastrointestinal dysfunction, and the combination of acupuncture and Chinese materia medica.
在中国,中药和针灸作为治疗胃肠功能障碍的有效方法已有几千年的历史。事实上,中医,尤其是针灸,已经逐渐被世界各地的医生和患者所接受。然而,由于缺乏系统、全面的综述文章,针灸与中药在中医模式下的作用尚未得到明确阐述。因此,本文就中医模式下针灸与中药联合治疗胃肠功能障碍的潜在临床价值进行探讨。用“针灸”、“胃肠功能障碍”、“胃肠疾病”等相关关键词搜索近10年发表的文章。本文将从针灸治疗胃肠功能障碍、中药治疗胃肠功能障碍、针灸与中药结合等方面阐述中药对胃肠功能的影响及其潜在价值。
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引用次数: 0
Association of reduced renal function with different phase of chronic hepatitis B virus infection 不同阶段慢性乙型肝炎病毒感染与肾功能下降的关系
Pub Date : 2022-06-16 DOI: 10.54844/gmiw.2022.0181
Guangdong Tong, W. Zhong, Deti Peng, Xiaoyan Jiang, Tianran Zhou, Furong Huang, C. Tian, Chunshan Wei, Y. Xing, Jing Yuan, Jian Yang, Jin Wu, Jiong Yang, Che-ching Huang, Zhijun Qu
Background: The association between chronic hepatitis B virus (HBV) infection and the development of chronic kidney disease (CKD) remains controversial, and whether the cause is related to the different phases of chronic HBV infection remains unclear. Methods: A large cross-sectional study was performed to show the prevalence of reduced renal function during chronic HBV infection in adults from 7 multi-centers of Shenzhen City in China. Estimated glomerular filtration rate (eGFR) was used to evaluate the effect of HBV infection on the risk of renal impairment. Results: 33.04% HBsAg (+) patients had eGFR < 90, while patients without HBV exposure, 32.73% had eGFR < 90, showing no significant difference. There was no significant difference between those with elevated and normal alanine aminotransferase (ALT) in chronic hepatitis B (CHB) groups. Moreover, according to stratified statistics of different phases of the disease, liver cirrhosis, especially decompensated liver cirrhosis, hepatocellular carcinoma (HCC) showed a significant decrease in renal function compared with CBH (P = 0). Multivariate logistic regression analysis showed that liver disease different phases independently associated with reduced renal function. Conclusion: During the early CHB phase of chronic HBV infection (either elevated ALT or normal) did not increase the risk of renal dysfunction compares no exposure to HBV. However, when CHB progress to end-stage liver disease were associated with reduced kidney function. Additionally, Hoek formula should be recommended for patients with end-stage liver disease.
背景:慢性乙型肝炎病毒(HBV)感染与慢性肾脏疾病(CKD)发展之间的关系仍然存在争议,其原因是否与慢性HBV感染的不同阶段有关尚不清楚。方法:进行了一项大型横断面研究,以显示中国深圳市7个多中心成人慢性HBV感染期间肾功能下降的患病率。估计肾小球滤过率(eGFR)被用来评估HBV感染对肾损害风险的影响。结果:33.04% HBsAg(+)患者eGFR < 90, 32.73%无HBV暴露患者eGFR < 90,差异无统计学意义。慢性乙型肝炎(CHB)组丙氨酸转氨酶(ALT)升高与正常之间无显著差异。此外,根据不同阶段疾病的分层统计,肝硬化,特别是失代偿期肝硬化,肝细胞癌(HCC)与CBH相比肾功能明显下降(P = 0),多因素logistic回归分析显示肝脏疾病不同阶段与肾功能下降独立相关。结论:慢性乙型肝炎早期阶段慢性乙型肝炎感染(无论是ALT升高还是正常)与未接触乙型肝炎相比,不会增加肾功能障碍的风险。然而,当慢性乙型肝炎进展为终末期肝病时,与肾功能下降有关。此外,Hoek方应推荐用于终末期肝病患者。
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引用次数: 0
Helicobacter pylori interpretation in 2022 2022年幽门螺杆菌解读
Pub Date : 2022-06-16 DOI: 10.54844/gmiw.2022.0089
A. Tay, B. Marshall
Helicobacter pylori, or formally known as Campylobacter pylori, is a Gram negative, micro-aerophilic, spiral microorganism that can colonise the healthy stomach lining. It is associated with gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric cancer.[1–3] At least 50% of the world population is still infected with H. pylori and about 1 million new gastric cancer cases are reported annually.[4] In 1994 and 2017, the WHO classified H. pylori as a Class I carcinogen[5,6] and listed it as one of the most important (priority high) pathogens for emerging antibiotic resistance alarm,[7,8] respectively.
幽门螺杆菌,或正式称为幽门弯曲杆菌,是一种革兰氏阴性,微嗜气的螺旋微生物,可以在健康的胃粘膜上定植。它与胃炎、消化性溃疡疾病、粘膜相关淋巴组织淋巴瘤和胃癌有关。[1 - 3]世界上至少有50%的人口仍然感染幽门螺杆菌,每年约有100万新的胃癌病例报告1994年和2017年,WHO分别将幽门螺杆菌列为一级致癌物[5,6],并将其列为新兴抗生素耐药性警报的最重要(优先级高)病原体之一[7,8]。
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引用次数: 0
Practice and thinking on the traditional Chinese medicine treatment of chronic atrophic gastritis based on pathological evaluation 基于病理评价的慢性萎缩性胃炎中医治疗的实践与思考
Pub Date : 2022-06-16 DOI: 10.54844/gmiw.2022.0091
Yang Yang, Zijing Tao, Shuangshuang Fang, Ping Zhang, Wei Wei
Chronic atrophic gastritis is a precancerous gastric disease with intestinal epithelial hyperplasia and heterogeneous proliferation based on mucosal atrophy. In recent years, the international guidelines and consensus on the treatment of precancerous gastric disease have been gradually updated, emphasizing the treatment of precancerous gastric disease and lesions based on the pathological changes as the outcome. Chinese medicine is widely used in the clinical treatment of chronic atrophic gastritis, but there are fewer research ideas of Chinese medicine based on the pathological evaluation of the results. In this article, the pathological concepts related to chronic atrophic gastritis and the clinical research ideas and practice strategies of traditional Chinese medicine based on the evaluation of pathological outcomes are compiled.
慢性萎缩性胃炎是一种以肠上皮增生和粘膜萎缩为基础的胃癌前病变。近年来,国际上关于胃癌前病变治疗的指南和共识逐渐更新,强调以病理改变为结局治疗胃癌前病变和病变。中医在慢性萎缩性胃炎的临床治疗中应用广泛,但基于病理评价结果的中医研究思路较少。本文就慢性萎缩性胃炎的相关病理概念以及基于病理结果评价的中医临床研究思路和实践策略进行综述。
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引用次数: 0
Multi-targeting regulation of auricular vagus nerve stimulation on gastric hypersensitivity and gastric dysmotility in a rodent model of functional dyspepsia 耳迷走神经刺激对功能性消化不良鼠模型胃超敏反应和胃动力障碍的多靶点调控
Pub Date : 2022-06-16 DOI: 10.54844/gmiw.2022.0088
Peijing Rong, Liwei Hou, Yang Yang, Xiaoying Luo, Junying Wang, Jinling Zhang, Jiande D. Z. Chen, Wei Wei
Background: Evidences have shown the auricular vagus nerve stimulation (aVNS) is effective for functional dyspepsia (FD) recently. This study aimed to observe the mechanism of aVNS on facilitatory mediators of the inflammation in a rat model of functional dyspepsia. Methods: Thirty-six 5 d-old male Sprague Dawley rats were randomly divided into control groups (n = 12), model group (n = 12), aVNS group (n = 6) and sham-aVNS group (n = 6). Except for the control rats, all other rats were treated with iodoacetamide gavage. After the model was developed successfully, rats in aVNS group and sham-aVNS group received aVNS and sham-aVNS respectively, 30 min/1 time per day for 14 consecutive days. The control group and model group received no intervention. Gastric sensitivity after 1-week of intervention and gastric emptying after 2-week of intervention were adopted to assess the effect of aVNS. Brain-gut peptides, facilitatory mediators of the inflammation in serum were tested by ELISA, and α7 nicotinic acetylcholine receptor (α7-nAchR) in antrum tissue were tested by Immunohistochemistry to explore the mechanism of aVNS. Results: Compared with the control group, the gastric sensitivity was increased, gastric emptying decreased, and there was no structural damage in the gastric antrum in the model group. aVNS reduced visceral hypersensitivity and improved gastric emptying but not sham-aVNS. cholecystokinin, glucagon-like peptide-1, peptide, tumor necrosis factorα and interleukin 6 were all increased, while ghrelin and α7-nAchR decreased in model rats (P < 0.01 for all, compared with the control group). aVNS can normalize them. Conclusion: The aVNS can decrease the gastric sensitivity and increase gastric emptying, the mechanism was related to its regulation of brain-gut peptides and facilitatory mediators of the inflammation. The ameliorating effect was related to cholinergic mechanism.
背景:耳穴迷走神经刺激(aVNS)是治疗功能性消化不良(FD)的有效方法。本研究旨在观察aVNS对功能性消化不良大鼠模型炎症促进介质的作用机制。方法:将36只5 d龄雄性Sprague Dawley大鼠随机分为对照组(n = 12)、模型组(n = 12)、aVNS组(n = 6)和假aVNS组(n = 6),除对照组外,其余大鼠均灌胃碘乙酰胺。造模成功后,aVNS组和假aVNS组大鼠分别给予aVNS和假aVNS,每天30 min/1次,连续14天。对照组和模型组不进行干预。采用干预1周后胃敏感性和干预2周后胃排空情况评价aVNS的效果。采用ELISA法检测血清炎症促进剂脑肠肽,免疫组化法检测上颌窦组织α7烟碱胆碱受体(α7- nachr)水平,探讨aVNS发生的机制。结果:与对照组比较,模型组大鼠胃敏感性增强,胃排空减少,胃窦未见结构性损伤。aVNS减少内脏过敏和改善胃排空,但假aVNS没有。模型大鼠胆囊收缩素、胰高血糖素样肽-1、肽、肿瘤坏死因子α、白细胞介素6均升高,胃饥饿素、α7-nAchR均降低(与对照组比较,P < 0.01)。aVNS可以使它们正常化。结论:aVNS具有降低胃敏感性、增加胃排空的作用,其机制与其调节脑肠肽和炎症促进介质有关。其改善作用与胆碱能机制有关。
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Gut microbiota and integrative wellness
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