Pub Date : 2024-02-06DOI: 10.1007/s44178-024-00073-0
Lei Wang, Yanqun Na, Gangzhi Zhu
{"title":"Application of holographic imaging in partial nephrectomy: a literature review","authors":"Lei Wang, Yanqun Na, Gangzhi Zhu","doi":"10.1007/s44178-024-00073-0","DOIUrl":"https://doi.org/10.1007/s44178-024-00073-0","url":null,"abstract":"","PeriodicalId":73245,"journal":{"name":"Holistic integrative oncology","volume":"82 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139801149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-06DOI: 10.1007/s44178-024-00073-0
Lei Wang, Yanqun Na, Gangzhi Zhu
{"title":"Application of holographic imaging in partial nephrectomy: a literature review","authors":"Lei Wang, Yanqun Na, Gangzhi Zhu","doi":"10.1007/s44178-024-00073-0","DOIUrl":"https://doi.org/10.1007/s44178-024-00073-0","url":null,"abstract":"","PeriodicalId":73245,"journal":{"name":"Holistic integrative oncology","volume":"20 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139860915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-05DOI: 10.1007/s44178-023-00067-4
X. Zhi, Zhibo Zhang, Weiwei Li, Zhouhuan Dong, Xiaodong Wu, X. Ge, Jin-Hai Zhai, D. Lu, Xiang Yan, Jinliang Wang
{"title":"Correlation of lung immune prognostic index with the efficacy of immune checkpoint inhibitors in Chinese patients with advanced non-small cell lung cancer","authors":"X. Zhi, Zhibo Zhang, Weiwei Li, Zhouhuan Dong, Xiaodong Wu, X. Ge, Jin-Hai Zhai, D. Lu, Xiang Yan, Jinliang Wang","doi":"10.1007/s44178-023-00067-4","DOIUrl":"https://doi.org/10.1007/s44178-023-00067-4","url":null,"abstract":"","PeriodicalId":73245,"journal":{"name":"Holistic integrative oncology","volume":"45 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139382315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-04DOI: 10.1007/s44178-023-00068-3
Lei Li, Jinghe Lang
{"title":"Recent advances in the treatment for gynecologic oncology","authors":"Lei Li, Jinghe Lang","doi":"10.1007/s44178-023-00068-3","DOIUrl":"https://doi.org/10.1007/s44178-023-00068-3","url":null,"abstract":"","PeriodicalId":73245,"journal":{"name":"Holistic integrative oncology","volume":"51 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139385075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01Epub Date: 2024-03-11DOI: 10.1007/s44178-024-00077-w
Yihai Cao
Cancer provokes systemic diseases through three possible mechanisms: 1) Distal metastasis in multiple tissues and organs, which directly causes functional damage and impairment of involved organs; 2) Paraneoplastic syndrome (PNS) that affects multiple organ systems, including the endocrine, gastrointestinal, hematologic, neurologic, dermatologic, and ophthalmologic systems; and 3) Cancer cachexia (CCA) or self-wasting syndrome characterized by anorexia, progressive bodyweight loss, adipose atrophy, and muscle atrophy. While cancer metastasis has received considerable attention for comprehensive research, PNS and CCA remain relatively overlooked. At the time of this writing, effective treatments of PNS and CCA in human cancer patients are lacking. This review focuses on discussing mechanistic insights into PNA and CCA and current advances in development of new possible therapeutic interventions.
癌症通过三种可能的机制引发全身性疾病：1) 多个组织和器官的远端转移，直接导致受累器官的功能损伤和功能障碍；2) 癌旁综合征（PNS），影响多个器官系统，包括内分泌、胃肠道、血液、神经、皮肤和眼科系统；以及 3) 癌症恶病质（CCA）或自我消耗综合征，其特征为厌食、进行性体重减轻、脂肪萎缩和肌肉萎缩。虽然癌症转移的综合研究受到了相当大的关注，但 PNS 和 CCA 仍相对被忽视。在撰写本文时，还缺乏针对人类癌症患者的 PNS 和 CCA 的有效治疗方法。本综述将重点讨论对 PNA 和 CCA 的机理认识，以及目前在开发可能的新治疗干预措施方面取得的进展。
{"title":"Cancer-triggered systemic disease and therapeutic targets.","authors":"Yihai Cao","doi":"10.1007/s44178-024-00077-w","DOIUrl":"10.1007/s44178-024-00077-w","url":null,"abstract":"<p><p>Cancer provokes systemic diseases through three possible mechanisms: 1) Distal metastasis in multiple tissues and organs, which directly causes functional damage and impairment of involved organs; 2) Paraneoplastic syndrome (PNS) that affects multiple organ systems, including the endocrine, gastrointestinal, hematologic, neurologic, dermatologic, and ophthalmologic systems; and 3) Cancer cachexia (CCA) or self-wasting syndrome characterized by anorexia, progressive bodyweight loss, adipose atrophy, and muscle atrophy. While cancer metastasis has received considerable attention for comprehensive research, PNS and CCA remain relatively overlooked. At the time of this writing, effective treatments of PNS and CCA in human cancer patients are lacking. This review focuses on discussing mechanistic insights into PNA and CCA and current advances in development of new possible therapeutic interventions.</p>","PeriodicalId":73245,"journal":{"name":"Holistic integrative oncology","volume":"3 1","pages":"11"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10927837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140121499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To compare effectiveness of topical 5-aminolevulinic acid-mediated photodynamic therapy (5-ALA PDT) and loop electrosurgical excision procedure (LEEP) among patients with cervical intraepithelial neoplasia (CIN).
Methods: We retrospectively identified patients who underwent either 5-ALA PDT or LEEP from Sep. 2012 to Dec. 2019 in Chinese PLA general hospital. Patients' outcomes were compared according to the HPV genotyping, cytological tests within 3-6-month follow-up post-treatment, the pathological examination would be performed if the cytological results indicated the risk of CIN. Propensity score matching (PSM) was adapted to pair the baseline. Complete remission (CR), partial remission (PR) and the remission rate of HPV infections were used to evaluate the efficacy of 5-ALA PDT versus LEEP.
Results: In total, 30 pairs were matched as the matching tolerance was set as 0.03. There was no significant difference about the CR and PR between 5-ALA PDT and LEEP group (73.33% vs 84.00%, P = 0.340; 3.33% vs 4.00%, P = 1.000). Among different CIN group, there was no statistic difference between 5-ALA PDT and LEEP. Moreover, in terms of HPV remission rate, 5-ALA PDT showed the same efficacy as LEEP (59.26% vs 53.85%, P = 0.691).
Conclusions: In essence, topical 5-ALA PDT emerges as a non-invasive, repeatable procedure with minimal side effects for cervical lesions, preserving cervical structure. Overall, the efficacy of 5-ALA PDT is comparable to LEEP in achieving successful outcomes.
目的：比较外用5-氨基乙酰丙酸介导的光动力疗法（5-ALA PDT）和环形电切术（LEEP）治疗宫颈上皮内瘤变（CIN）的疗效。方法：回顾性分析2012年9月至2019年12月在中国人民解放军总医院接受5-ALA PDT或LEEP治疗的患者。根据HPV基因分型、治疗后随访3-6个月细胞学检查比较患者结局，细胞学结果提示有CIN风险时行病理检查。采用倾向评分匹配（PSM）对基线进行配对。用HPV感染完全缓解（CR）、部分缓解（PR）和缓解率来评价5-ALA PDT与LEEP的疗效。结果：共匹配30对，匹配公差设为0.03。5-ALA PDT组与LEEP组CR、PR差异无统计学意义(73.33% vs 84.00%, P = 0.340；3.33% vs 4.00%, P = 1.000)。不同CIN组间5-ALA PDT与LEEP差异无统计学意义。在HPV缓解率方面，5-ALA PDT与LEEP的疗效相同（59.26% vs 53.85%, P = 0.691）。结论：从本质上讲，局部5-ALA PDT是一种无创、可重复的手术，对宫颈病变的副作用最小，保留了宫颈结构。总体而言，5-ALA PDT在获得成功结果方面的疗效与LEEP相当。
{"title":"Topical 5-aminolevulinic acid-mediated photodynamic therapy versus loop electrosurgical excision procedure in the treatment of cervical intraepithelial neoplasia.","authors":"Yidi Liu, Yi Li, Huan Wu, Ying Wang, Jing Zeng, Hui Li, Haixia Qiu, Ying Gu","doi":"10.1007/s44178-024-00127-3","DOIUrl":"https://doi.org/10.1007/s44178-024-00127-3","url":null,"abstract":"<p><strong>Objective: </strong>To compare effectiveness of topical 5-aminolevulinic acid-mediated photodynamic therapy (5-ALA PDT) and loop electrosurgical excision procedure (LEEP) among patients with cervical intraepithelial neoplasia (CIN).</p><p><strong>Methods: </strong>We retrospectively identified patients who underwent either 5-ALA PDT or LEEP from Sep. 2012 to Dec. 2019 in Chinese PLA general hospital. Patients' outcomes were compared according to the HPV genotyping, cytological tests within 3-6-month follow-up post-treatment, the pathological examination would be performed if the cytological results indicated the risk of CIN. Propensity score matching (PSM) was adapted to pair the baseline. Complete remission (CR), partial remission (PR) and the remission rate of HPV infections were used to evaluate the efficacy of 5-ALA PDT versus LEEP.</p><p><strong>Results: </strong>In total, 30 pairs were matched as the matching tolerance was set as 0.03. There was no significant difference about the CR and PR between 5-ALA PDT and LEEP group (73.33% vs 84.00%, <i>P</i> = 0.340; 3.33% vs 4.00%, <i>P</i> = 1.000). Among different CIN group, there was no statistic difference between 5-ALA PDT and LEEP. Moreover, in terms of HPV remission rate, 5-ALA PDT showed the same efficacy as LEEP (59.26% vs 53.85%, <i>P</i> = 0.691).</p><p><strong>Conclusions: </strong>In essence, topical 5-ALA PDT emerges as a non-invasive, repeatable procedure with minimal side effects for cervical lesions, preserving cervical structure. Overall, the efficacy of 5-ALA PDT is comparable to LEEP in achieving successful outcomes.</p>","PeriodicalId":73245,"journal":{"name":"Holistic integrative oncology","volume":"3 1","pages":"56"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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