International journal of clinical endocrinology and metabolism最新文献

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Recombinant Growth hormone response in Indian girls with Turner syndrome 重组生长激素对印度特纳综合征女孩的影响

International journal of clinical endocrinology and metabolism

Pub Date : 2018-10-29 DOI: 10.17352/ijcem.000029

Kochar Inderpal Singh

Diabetes Mellitus (DM) is widely recognized as a major cause of blindness, with Diabetic Retinopathy (DR) being the most frequently cited underlying pathophysiologic mechanism. This makes DR, among all ocular manifestations of diabetes, the focus of most diagnostic as well as therapeutic interventions. However, diabetic neurotrophic keratopathy, a common ocular complication of diabetes that is caused by corneal nerve fiber damage, is a diagnostic entity that generated a lot of attention recently in the ophthalmology community for being largely unrecognized, underdiagnosed and generally not treated, rendering a large number of the growing population susceptible to this serious ocular complication. This is largely because of the challenge in diagnosis and management of diabetic neurotrophic keratopathy. In this manuscript, we discuss the epidemiology, pathophysiologic mechanisms, diagnostic challenges and the innovative therapeutic interventions of diabetic neurotrophic keratopathy, an entity with potentially serious implications for diabetic patients, both type 1 as well as type 2 alike.

引用次数: 3

Closing the Mortality Gap in Diabetic Ketoacidosis and Hyperosmolar Hyperglycemic State: Implications of a Clinical Decision Support App. 缩小糖尿病酮症酸中毒和高渗性高血糖状态的死亡率差距:临床决策支持应用程序的意义。

International journal of clinical endocrinology and metabolism

Pub Date : 2018-01-01 DOI: 10.17352/ijcem.000031

Yair Saperstein, Joongheum Park, Samy I McFarlane

Diabetes is a major public health issue affecting millions of people in the United States and worldwide. In the United States alone, about 30.3 million people (9.4% of the population) have diabetes [1]. Worldwide, a staggering 422 million have diabetes according to 2014 estimates [2]. Diabetes complications over years of exposure include cardiovascular disease -- stroke and myocardial infarction -- and microvascular disorders -- kidney failure, blindness and amputation [3]. Acute and potentially fatal complications of diabetes include hyperglycemic crises, specifically diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar state (HHS) [4].

引用次数: 3

Diabetic Retinopathy: Focus on Minority Populations. 糖尿病视网膜病变：关注少数民族人群。

International journal of clinical endocrinology and metabolism

Pub Date : 2017-01-01 Epub Date: 2017-11-11 DOI: 10.17352/ijcem.000027

Arpine Barsegian, Boleslav Kotlyar, Justin Lee, Moro O Salifu, Samy I McFarlane

Diabetic retinopathy is a major cause of blindness in the United States. With rise of the epidemic of obesity and diabetes in the USA and around the globe, serious and common diabetic complications are evolving as a major public health problem, particularly among minority populations. These populations are disproportionately affected by diabetes and 2-3 times more likely to develop visually significant complications. In this highly illustrated review article, we discuss the diabetic epidemic, highlighting the biology and the pathophysiologic mechanisms of this disorder on the anatomy of the eye. We also discuss the risk factors and the implications for minority populations. For the health care providers, we provide cutting edge information and imminently relevant information to help evaluate, manage, and know when to refer their patients to a specialist in ophthalmology to quell the tide of the epidemic.

糖尿病视网膜病变是美国失明的主要原因。随着肥胖症和糖尿病在美国和全球的流行，严重和常见的糖尿病并发症正在演变成一个主要的公共健康问题，尤其是在少数群体中。这些人群受糖尿病的影响尤为严重，出现视觉上严重并发症的几率是普通人的 2-3 倍。在这篇图文并茂的综述文章中，我们讨论了糖尿病的流行，重点介绍了这种疾病对眼部解剖结构的生物学和病理生理机制。我们还讨论了风险因素和对少数群体的影响。对于医疗服务提供者，我们提供了最前沿的信息和迫在眉睫的相关信息，以帮助评估、管理和了解何时将患者转诊给眼科专科医生，从而平息疫情。

引用次数: 0

Hepatitis B Vaccination Rate in Patients with Diabetes: Assessment of Racial and Socioeconomic Disparity 糖尿病患者的乙肝疫苗接种率:种族和社会经济差异的评估

International journal of clinical endocrinology and metabolism

Pub Date : 2016-12-30 DOI: 10.17352/IJCEM.000018

A. Aytaman, N. Ojike, Samantha Zizi, S. Pandi-Perumal, I. Lukolic, A. Bhanvadia, F. Nwamaghinna, H. Kamran, A. Akivis, Olusegun Bankole, M. Salifu, Samy I McFarlane

Introduction Less hygienic use of blood glucose monitoring equipment such as blood glucose meters, lancets, finger stick devices or other diabetes-care equipment such as syringes or insulin pens by self-administration often exposes the diabetic patient to Hepatitis B infection. This study evaluates hepatitis B vaccination among individuals with diabetes. Methods The study used data from the 2000–2013 National Health Interview Survey (NHIS). Vaccination rates among adult individuals with diabetes of various ethnic backgrounds was accessed and compared using chis-square tests. Multivariable logistic regression model was used to compare factors affecting hepatitis B vaccination among individuals with diabetes. Results The crude rate of diabetes in this population was 5.4%. The rate of vaccination among individuals with diabetes differed across racial groups (Asians 31.8% vs. blacks 30.7%; and whites 26.5%; p<0.01). After multivariate regression, the leading factors affecting hepatitis B vaccination included Age (40–60 years) (OR=0.51, 95% CI=0.47–0.57, p<0.01), lack of college education (OR=0.71,95% CI=0.64–0.79, p<0.01), foreign birth (OR=0.83, 95% CI=0.72–0.95, p<0.01), and Hispanic ethnicity (OR=0.88, 95% CI=0.78–1.00, P<0.05). Conclusion Social and economic factors-education, insurance status, age, poverty level, and place of birth affect rates of vaccination among individuals with diabetes.

不卫生地使用血糖监测设备，如血糖仪、刺刀、指棒装置或其他糖尿病护理设备，如注射器或胰岛素笔，往往使糖尿病患者暴露于乙型肝炎感染。本研究评估了糖尿病患者接种乙肝疫苗的情况。方法采用2000-2013年全国健康访谈调查(NHIS)数据。不同种族背景的成人糖尿病患者的疫苗接种率被访问并使用卡方检验进行比较。采用多变量logistic回归模型比较糖尿病患者接种乙肝疫苗的影响因素。结果该人群糖尿病粗患病率为5.4%。糖尿病患者的疫苗接种率因种族而异(亚洲人31.8% vs黑人30.7%;白人26.5%;p < 0.01)。多因素回归后，影响乙肝疫苗接种的主要因素包括年龄(40-60岁)(OR=0.51, 95% CI= 0.47-0.57, p<0.01)、缺乏大学教育(OR=0.71,95% CI= 0.64-0.79, p<0.01)、外国出生(OR=0.83, 95% CI= 0.72-0.95, p<0.01)、西班牙裔(OR=0.88, 95% CI= 0.78-1.00, p< 0.05)。结论社会经济因素——教育程度、保险状况、年龄、贫困程度和出生地影响糖尿病患者的疫苗接种率。

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引用次数: 2

Hepatitis B Vaccination Rate in Patients with Diabetes: Assessment of Racial and Socioeconomic Disparity. 糖尿病患者的乙肝疫苗接种率:种族和社会经济差异的评估。

International journal of clinical endocrinology and metabolism

Pub Date : 2016-01-01 Epub Date: 2016-12-30

Ayse Aytaman, Nwakile Ojike, Samantha Zizi, S R Pandi-Perumal, Ismet Lukolic, Amit Bhanvadia, Felix Nwamaghinna, Haroon Kamran, Alla Akivis, Olusegun Bankole, Moro O Salifu, Samy I McFarlane

Introduction: Less hygienic use of blood glucose monitoring equipment such as blood glucose meters, lancets, finger stick devices or other diabetes-care equipment such as syringes or insulin pens by self-administration often exposes the diabetic patient to Hepatitis B infection. This study evaluates hepatitis B vaccination among individuals with diabetes.

Methods: The study used data from the 2000-2013 National Health Interview Survey (NHIS). Vaccination rates among adult individuals with diabetes of various ethnic backgrounds was accessed and compared using chis-square tests. Multivariable logistic regression model was used to compare factors affecting hepatitis B vaccination among individuals with diabetes.

Results: The crude rate of diabetes in this population was 5.4%. The rate of vaccination among individuals with diabetes differed across racial groups (Asians 31.8% vs. blacks 30.7%; and whites 26.5%; p<0.01). After multivariate regression, the leading factors affecting hepatitis B vaccination included Age (40-60 years) (OR=0.51, 95% CI=0.47-0.57, p<0.01), lack of college education (OR=0.71,95% CI=0.64-0.79, p<0.01), foreign birth (OR=0.83, 95% CI=0.72-0.95, p<0.01), and Hispanic ethnicity (OR=0.88, 95% CI=0.78-1.00, P<0.05).

Conclusion: Social and economic factors-education, insurance status, age, poverty level, and place of birth affect rates of vaccination among individuals with diabetes.

导语:不卫生地使用血糖监测设备，如血糖仪、刺刀、指棒装置或其他糖尿病护理设备，如注射器或胰岛素笔，往往使糖尿病患者暴露于乙型肝炎感染。本研究评估了糖尿病患者接种乙肝疫苗的情况。方法:采用2000-2013年全国健康访谈调查(NHIS)数据。不同种族背景的成人糖尿病患者的疫苗接种率被访问并使用卡方检验进行比较。采用多变量logistic回归模型比较糖尿病患者接种乙肝疫苗的影响因素。结果:该人群糖尿病粗患病率为5.4%。糖尿病患者的疫苗接种率因种族而异(亚洲人31.8% vs黑人30.7%;白人26.5%;结论:受教育程度、保险状况、年龄、贫困程度和出生地等社会经济因素影响糖尿病患者的疫苗接种率。

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引用次数: 0

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