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Application of Cutaneous Nerve Block in Balloon Percutaneous Transluminal Angioplasty for Vascular Access Stenosis: A Pain Management Strategy. 皮神经阻滞在球囊经皮腔内血管成形术治疗血管通路狭窄中的应用:一种疼痛管理策略。
IF 0.8 Pub Date : 2025-12-29 eCollection Date: 2025-01-01 DOI: 10.22575/interventionalradiology.2025-0063
Akira Morimoto, Midori Yamamura, Yuko Miki, Ichiro Fujiwara, Akira Yamamoto, Yoshihiro Tsujimoto

Purpose: Percutaneous transluminal angioplasty for forearm arteriovenous fistula stenosis is frequently associated with significant pain, which may hinder patient cooperation. Ultrasound-guided cutaneous nerve blocks were evaluated as an alternative analgesic method for percutaneous transluminal angioplasty in forearm arteriovenous fistula, with the aim of reducing pain without motor paralysis or systemic complications.

Material and methods: This retrospective, single-center study included 77 patients who underwent percutaneous transluminal angioplasty for forearm arteriovenous fistula stenosis with ultrasound-guided cutaneous nerve block using lidocaine in October 2024. Target nerves included the lateral antebrachial cutaneous nerves, the superficial branch of the radial nerve, and/or the medial antebrachial cutaneous nerves. We retrospectively collected data on block time, percutaneous transluminal angioplasty duration, lidocaine volume, complications, presence or absence of postanesthetic motor paralysis, and analgesic efficacy. Analgesic efficacy was graded as excellent, good, or poor, with "poor" defined as pain necessitating supplemental local infiltration anesthesia for adequate relief.

Results: The mean block preparation time was 2.1 ± 0.5 min, and the percutaneous transluminal angioplasty duration was 27.3 ± 9.2 min. The mean volume of 1% lidocaine used was 2.6 ± 1.1 mL. Minor hematomas were observed in eight cases. No patient experienced postanesthetic motor paralysis. Analgesia was rated excellent in 57.1% of patients and good in 29.9%, while poor analgesia occurred in only 12.9%. A superficial branch of the radial nerve block improved outcomes in distal forearm lesions.

Conclusions: Ultrasound-guided cutaneous nerve blocks provide rapid, effective, and motor-sparing analgesia for percutaneous transluminal angioplasty of forearm arteriovenous fistula stenosis, making them suitable for outpatient use and warranting further prospective evaluation.

目的:经皮腔内血管成形术治疗前臂动静脉瘘狭窄常伴有明显的疼痛,这可能会阻碍患者的合作。超声引导下皮神经阻滞作为前臂动静脉瘘经皮腔内血管成形术的替代镇痛方法,目的是减轻疼痛,无运动麻痹或全身并发症。材料和方法:本回顾性单中心研究纳入了77例于2024年10月行超声引导下皮神经阻滞治疗前臂动静脉瘘狭窄的经皮腔内血管成形术患者。目标神经包括臂前外侧皮神经、桡神经浅支和/或臂前内侧皮神经。我们回顾性收集阻滞时间、经皮腔内血管成形术持续时间、利多卡因用量、并发症、有无麻醉后运动麻痹和镇痛效果的数据。镇痛效果分为极好、良好和差,“差”定义为疼痛需要补充局部浸润麻醉以充分缓解。结果:平均阻滞准备时间为2.1±0.5 min,经皮腔内血管成形术时间为27.3±9.2 min。1%利多卡因平均用量2.6±1.1 mL, 8例出现轻微血肿。无患者出现觉后运动麻痹。57.1%的患者镇痛评分为优,29.9%的患者镇痛评分为良,而不良镇痛评分仅为12.9%。桡神经浅支阻滞改善了前臂远端病变的预后。结论:超声引导下皮神经阻滞对前臂动静脉瘘狭窄的经皮腔内血管成形术提供了快速、有效和不影响运动的镇痛,适合门诊使用,值得进一步的前瞻性评价。
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引用次数: 0
Direct Oral Anticoagulants for Treating Fibrin Sheath-induced Central Venous Port System Dysfunction. 直接口服抗凝剂治疗纤维蛋白鞘诱导的中心静脉口系统功能障碍。
IF 0.8 Pub Date : 2025-12-29 eCollection Date: 2025-01-01 DOI: 10.22575/interventionalradiology.2025-0057
Shoma Nagata, Hiroshi Kawada, Mizuki Hirata, Shigeru Kiyama, Yoshifumi Noda, Nobuyuki Kawai, Tomohiro Ando, Tetsuro Kaga, Taketo Suto, Masashi Asano, Takuya Seko, Hiroki Kato, Nobuhisa Matsuhashi, Masayuki Matsuo

Purpose: To retrospectively evaluate the safety and efficacy of direct oral anticoagulant therapy for fibrin sheath-induced central venous port system dysfunction.

Material and methods: Between May 2023 and February 2024, patients who underwent direct oral anticoagulant therapy for fibrin sheath-induced central venous port system dysfunction were included. The clinical effectiveness, flow confirmation study, central venous port function, and adverse events according to the Common Terminology Criteria for Adverse Events classification were retrospectively reviewed.

Results: Nine patients were included in the study. The catheter types were open-ended (n = 8) and Groshong (n = 1). All patients had difficulty with aspiration, and one exhibited injection resistance. All patients received edoxaban as direct oral anticoagulant, at doses of 30 mg (n = 3) or 60 mg (n = 6) based on their body weights. After direct oral anticoagulant administration, complete fibrin sheath resolution was confirmed by a flow confirmation study in all cases, with a mean duration of 29 ± 21 days. Concurrently, the central venous port system dysfunction was restored in eight cases. In the remaining one case, direct oral anticoagulant administration was suspended on day 26 due to grade 1 epistaxis; therefore, central venous port system dysfunction remained despite the disappearance of the fibrin sheath. Thus, the clinical success rate was 88.9% (8/9) and fibrin sheath disappearance rate was 100% (9/9), respectively. No grade 3 or higher adverse effect was observed. No recurrence of fibrin sheath-induced central venous port system dysfunction was observed during the mean follow-up period of 133 ± 98 days.

Conclusions: Direct oral anticoagulant administration can be a potentially effective and safe strategy for managing fibrin sheath-induced central venous port system dysfunction formation.

目的:回顾性评价直接口服抗凝治疗纤维蛋白鞘性中心静脉口系统功能障碍的安全性和有效性。材料和方法:纳入2023年5月至2024年2月期间,因纤维蛋白鞘诱导的中心静脉口系统功能障碍而接受直接口服抗凝治疗的患者。回顾性回顾了临床疗效、血流确认研究、中心静脉端口功能和不良事件分类通用术语标准。结果:9例患者纳入研究。导管类型为开放式(n = 8)和Groshong (n = 1)。所有患者均有吸痰困难,1例出现注射阻力。所有患者均接受依多沙班作为直接口服抗凝剂,剂量根据体重分别为30mg (n = 3)或60mg (n = 6)。直接口服抗凝剂后,所有病例均通过血流确认研究证实纤维蛋白鞘完全溶解,平均持续时间为29±21天。同时,8例中心静脉口系统功能障碍得以恢复。其余1例患者因1级鼻出血,于第26天暂停直接口服抗凝药;因此,尽管纤维蛋白鞘消失,中心静脉端口系统功能障碍仍然存在。临床成功率为88.9%(8/9),纤维蛋白鞘消失率为100%(9/9)。未观察到3级或以上的不良反应。平均随访133±98天,未见纤维蛋白鞘诱导的中心静脉口系统功能障碍复发。结论:直接口服抗凝剂是治疗纤维蛋白鞘诱导的中心静脉口系统功能障碍形成的一种潜在有效和安全的策略。
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引用次数: 0
A Case of a Right Gastric Artery Aneurysm Caused by the Collateral Flow Changes Due to the Coexistence of Median Arcuate Ligament Syndrome and a Celiac Artery Anomaly. 腹正中弓状韧带综合征伴腹腔动脉异常并发侧支血流改变致右胃动脉瘤1例。
IF 0.8 Pub Date : 2025-12-29 eCollection Date: 2025-01-01 DOI: 10.22575/interventionalradiology.2025-0025
Yamato Tsunoda, Hirotatsu Sato, Tetsuo Sonomura, Yuichi Miyake, Naoki Nishioka, Fumihiro Tanaka, Kodai Fukuda, Ryuta Okuhira, Nobuyuki Higashino, Atsufumi Kamisako, Akira Ikoma, Hiroki Minamiguchi

A man in his 60s presented with severe epigastric pain. Abdominal computed tomography revealed an aneurysm of the right gastric artery, which branched from an aberrant gastroduodenal artery originating from the axis of the splenic artery. Other vascular anomalies included a left gastric artery arising directly from the aorta and several additional arterial variations. Computed tomography also revealed stenosis of the axes of the celiac artery and left gastric artery. The aneurysm was thought to be caused by the stenosis due to median arcuate ligament syndrome. Transcatheter arterial embolization was successfully performed. This case highlights that median arcuate ligament syndrome combined with vascular anomalies can alter hemodynamics and lead to the development of uncommon gastric artery aneurysms.

一名60多岁的男子出现严重的上腹部疼痛。腹部计算机断层扫描显示右胃动脉动脉瘤,该动脉瘤由起源于脾动脉轴的异常胃十二指肠动脉分支。其他血管异常包括直接源自主动脉的左胃动脉和其他一些动脉变异。计算机断层扫描也显示腹腔动脉和胃左动脉轴狭窄。动脉瘤被认为是由中间弓状韧带综合征引起的狭窄引起的。经导管动脉栓塞成功。本病例强调正中弓韧带综合征合并血管异常可改变血流动力学并导致不常见的胃动脉瘤的发展。
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引用次数: 0
Is Saline Sealing of Needle Tract Effective to Prevent Pneumothorax after Computed Tomography-guided Lung Biopsy? 盐水封针对预防ct引导下肺活检后气胸有效吗?
IF 0.8 Pub Date : 2025-12-29 eCollection Date: 2025-01-01 DOI: 10.22575/interventionalradiology.2025-0068
Soichiro Okamoto, Yusuke Matsui, Koji Tomita, Kazuaki Munetomo, Noriyuki Umakoshi, Toshiharu Mitsuhashi, Toshihiro Iguchi, Takao Hiraki

Purpose: To evaluate the efficacy of needle tract sealing using normal saline instillation for decreasing the risk of pneumothorax after computed tomography-guided lung biopsy.

Material and methods: This retrospective, single-institution study included 391 computed tomography-guided lung biopsies performed by 12 operators between January 2022 and October 2024. After exclusion, 298 biopsies were analyzed by comparing the saline seal (n = 138) and control (n = 160) groups. A 17/18-gauge or 19/20-gauge coaxial biopsy system was used, and tract sealing was performed by instilling 1-5 mL of normal saline during the withdrawal of the introducer needle in the saline seal group; tract sealing was not performed in the control group. After 1:1 propensity score matching was performed to balance baseline characteristics, the incidences of pneumothorax and chest tube placement were compared between the two groups using Fisher's exact test.

Results: After propensity score matching, 108 pairs (mean lesion size: 17 mm) were well balanced. The incidence of pneumothorax did not differ significantly between the control and saline seal groups (50.0% vs. 60.2%, respectively; p = 0.171). Similarly, the incidence of chest tube placement was not significantly different between the two groups (7.4% vs. 13.0%, respectively; p = 0.260).

Conclusions: According to the propensity score-matched analysis, normal saline instillation for tract sealing did not significantly reduce the incidence of pneumothorax or chest tube placement. In our cohort, which had a high prevalence of small lesions, saline sealing alone may be insufficient to reduce post-biopsy pneumothorax risk. Hence, combined strategies require further investigation.

目的:评价生理盐水灌注封堵针道对降低ct引导下肺活检术后气胸风险的作用。材料和方法:这项回顾性的单机构研究纳入了2022年1月至2024年10月期间由12名操作员进行的391例计算机断层扫描引导的肺活检。排除后对298例活检组织进行分析,比较生理盐水密封组(n = 138)和对照组(n = 160)。采用17/18号或19/20号同轴活检系统,生理盐水密封组在拔针时灌注1-5 mL生理盐水进行尿道密封;对照组不进行尿道封闭。在进行1:1倾向评分匹配以平衡基线特征后,使用Fisher精确检验比较两组之间气胸和胸管置入的发生率。结果:经倾向评分匹配后,108对(平均病变大小为17 mm)平衡良好。对照组和盐水密封组的气胸发生率无显著差异(50.0% vs. 60.2%, p = 0.171)。同样,两组患者放置胸管的发生率无显著差异(分别为7.4%比13.0%,p = 0.260)。结论:根据倾向评分匹配分析,生理盐水滴注用于气道密封并没有显著降低气胸或胸管置入的发生率。在我们的队列中,小病变的患病率很高,单纯的生理盐水密封可能不足以降低活检后气胸的风险。因此,需要进一步研究联合策略。
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引用次数: 0
A Case of Superior Mesenteric Artery Occlusion Caused by Portal Vein Stenting. 门静脉支架置入术致肠系膜上动脉闭塞1例。
IF 0.8 Pub Date : 2025-12-29 eCollection Date: 2025-01-01 DOI: 10.22575/interventionalradiology.2024-0059
Kenji Takata, Toyohiko Sakai, Midori Ueda, Kiyotaka Takeuchi, Hideaki Komiya, Daisuke Yoshikawa, Satomi Kanai, Tasuku Wakabayashi, Ayaki Kitano, Mariko Toyooka, Tetsuya Tsujikawa

Portal vein stenting treats stenosis or thrombosis of the portal venous system with relatively high technical and clinical success rates. However, complications have been reported. We present a case of a 58-year-old woman with a history of pancreatic head cancer surgery who developed superior mesenteric vein occlusion owing to recurrent mesenteric lesions. Portal vein stenting was performed; however, it resulted in superior mesenteric artery occlusion, which caused extensive intestinal ischemia. Gas from the intestinal necrosis migrated into the superior mesenteric artery and superior mesenteric vein, and thrombotic occlusion of the portal vein stent was observed. This complication, which is characterized by superior mesenteric artery occlusion induced by portal vein stenting, is unique. Furthermore, this case highlights the need for a thorough preoperative evaluation and careful consideration to avoid such a rare but severe complication.

门静脉支架置入术治疗门静脉系统狭窄或血栓形成具有较高的技术和临床成功率。然而,也有并发症的报道。我们提出一个58岁的女性胰脏头癌手术史谁发展上肠系膜静脉闭塞,由于肠系膜病变复发。行门静脉支架植入术;然而,它导致肠系膜上动脉闭塞,引起广泛的肠道缺血。肠坏死气体迁移到肠系膜上动脉和肠系膜上静脉,观察到门静脉支架血栓闭塞。这种并发症的特点是门静脉支架置入引起肠系膜上动脉闭塞,是独特的。此外,该病例强调了术前全面评估和仔细考虑的必要性,以避免这种罕见但严重的并发症。
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引用次数: 0
Emergency Plug-assisted Retrograde Transvenous Obliteration Using an Optimo 9-Fr Balloon Guiding Catheter: A Case Report. 使用Optimo 9-Fr球囊导尿管急诊栓辅助逆行经静脉闭塞术1例报告。
IF 0.8 Pub Date : 2025-12-29 eCollection Date: 2025-01-01 DOI: 10.22575/interventionalradiology.2025-0083
Yohei Takeshita, Junji Moriya, Yo Matsui, Shintaro Chiba

Gastric variceal rupture requires rapid hemostasis. When an abdominal balloon catheter is unavailable, alternatives are needed. We report emergency plug-assisted retrograde transvenous obliteration performed with a 9-Fr Optimo balloon-guiding catheter in a 59-year-old man with alcoholic cirrhosis and fundal gastric varices. Under balloon occlusion, balloon-occluded retrograde transvenous venography delineated the variceal complex. A 10-mm Amplatzer Vascular Plug II was deployed via the Optimo, followed by stepwise injection of gelatin sponge particles through a high-flow microcatheter. Complete occlusion was achieved without complications. Follow-up computed tomography and endoscopy confirmed improvement. The Optimo enabled single-system balloon-occluded retrograde transvenous venography, plug deployment, and embolic delivery through one venous access, offering a practical option for urgent hemostasis when inventory constraints exist, provided that preprocedural computed tomography confirms device compatibility.

胃静脉曲张破裂需要快速止血。当不能使用腹部球囊导管时,需要使用其他方法。我们报告了一名59岁的酒精性肝硬化和胃底静脉曲张患者使用9-Fr Optimo球囊引导导管进行急诊塞辅助逆行经静脉闭塞术。在球囊阻断下,球囊阻断逆行经静脉造影显示静脉曲张复合体。通过Optimo部署10mm Amplatzer血管塞II,然后通过高流量微导管逐步注射明胶海绵颗粒。完全闭塞无并发症。随访的计算机断层扫描和内窥镜检查证实改善。Optimo实现了单系统球囊闭塞逆行经静脉造影、栓塞部署和单静脉通道栓塞输送,在库存受限的情况下,提供了紧急止血的实用选择,前提是术前计算机断层扫描确认设备兼容性。
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引用次数: 0
Salvage of a Blocked Nephrostomy Catheter Using Needle Recanalization-SURE (Sharp Urologic REcanalization) Technique. 针刺再通术- sure(锐尿路再通)技术抢救阻塞肾造口导管。
IF 0.8 Pub Date : 2025-12-02 eCollection Date: 2025-01-01 DOI: 10.22575/interventionalradiology.2025-0058
Kai Seng Loi, Ridzuan Abdul Rahim

We present a novel salvage technique for managing a completely occluded percutaneous nephrostomy catheter in a patient with metastatic cervical cancer and bilateral obstructive uropathy. While the left nephrostomy catheter was exchanged uneventfully, the right was entirely blocked, preventing standard guidewire passage. Using the Accustick II Introducer System (Boston Scientific, Spencer, IN, USA), a 21-gauge needle was advanced through the cut percutaneous nephrostomy lumen to traverse the obstruction, penetrating the catheter sidewall and access the renal collecting system. This allowed sequential guidewire and sheath introduction, enabling successful percutaneous nephrostomy replacement through the existing tract. Termed the Sharp Urologic Recanalization technique, this method modernizes traditional sharp recanalization strategies and offers a less invasive alternative when conventional techniques fail.

我们提出了一种新的抢救技术,用于治疗转移性宫颈癌和双侧梗阻性尿路病变患者的完全闭塞的经皮肾造瘘导管。当左侧肾造瘘导管顺利更换时,右侧完全阻塞,阻止标准导丝通过。使用accutick II导入系统(Boston Scientific, Spencer, IN, USA), 21号针头通过切开的经皮肾造瘘管腔穿过阻塞,穿透导管侧壁,进入肾收集系统。这允许连续引入导丝和鞘,使经皮肾造口术通过现有的肾道成功替代。这种方法被称为尖锐泌尿系统再通技术,它使传统的尖锐再通策略现代化,并在传统技术失败时提供了一种侵入性较小的替代方法。
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引用次数: 0
Transarterial Embolization for Ruptured Esophageal Artery Aneurysm Associated with Median Arcuate Ligament Syndrome: A Case Report. 经动脉栓塞治疗食管动脉瘤破裂合并正中弓状韧带综合征1例报告。
IF 0.8 Pub Date : 2025-12-02 eCollection Date: 2025-01-01 DOI: 10.22575/interventionalradiology.2025-0059
Takayuki Sanomura, Takashi Norikane, Katsuya Mitamura, Riku Morita, Hajime Shishido, Keiichi Okano, Yoshihiro Nishiyama

Median arcuate ligament syndrome is a rare condition that can lead to aneurysm formation in collateral vessels due to celiac artery compression. While pancreaticoduodenal artery aneurysms are common, esophageal artery aneurysms are extremely rare. We report a case of a ruptured proper esophageal artery aneurysm associated with median arcuate ligament syndrome in a 61-year-old woman. Emergency transarterial embolization using N-butyl 2-cyanoacrylate was performed successfully via the afferent artery. Follow-up imaging confirmed effective embolization with preserved esophageal perfusion and no signs of ischemia. This case highlights the importance of recognizing rare aneurysm sites in median arcuate ligament syndrome, and supports N-butyl 2-cyanoacrylate embolization as a safe and effective treatment for esophageal artery aneurysms.

中弓状韧带综合征是一种罕见的疾病,可导致侧支血管动脉瘤的形成,由于腹腔动脉的压迫。胰十二指肠动脉瘤很常见,而食道动脉瘤则极为罕见。我们报告一例破裂的食管固有动脉瘤合并正中弓状韧带综合征在一个61岁的妇女。紧急经动脉栓塞使用2-氰基丙烯酸酯正丁酯经传入动脉成功。随访影像证实栓塞有效,保留了食管灌注,无缺血迹象。本病例强调了在正中弓状韧带综合征中识别罕见动脉瘤部位的重要性,并支持n -丁基- 2-氰基丙烯酸酯栓塞作为一种安全有效的治疗食管动脉瘤的方法。
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引用次数: 0
Successful Transarterial Embolisation for Recurrent Subacromial-subdeltoid Bursitis: Case Report. 成功经动脉栓塞治疗复发性肩峰下-三角下滑囊炎1例报告。
IF 0.8 Pub Date : 2025-12-02 eCollection Date: 2025-01-01 DOI: 10.22575/interventionalradiology.2024-0055
Jun Kiat Ho, Jasmine Ming Er Chua, Damian Ong, Chow Wei Too

An 83-year-old man presented with chronic right shoulder pain and stiffness from recurrent subacromial-subdeltoid bursitis associated with rotator cuff tears, despite initial conservative measures. He refused surgery but agreed to transarterial embolization. The first transarterial embolization was performed with 1:1 lipiodol:iohexol emulsion, but provided no significant symptom relief. A repeat transarterial embolization demonstrated recanalization in several branches and new neovascularity. These were successfully embolized with 100 μm embozene particles. Post-procedure, his pain score on the numerical rating scale improved from 6 to 2 at rest and 7 to 3 during motion, no longer requiring regular analgesics. Follow-up ultrasound showed sustained resolution of bursal effusion up to 18 months. This case suggests the efficacy of transarterial embolization in treating recurrent subacromial-subdeltoid bursitis.

一名83岁男性,尽管最初采取了保守措施,但仍因复发性肩峰下-三角下滑囊炎伴肩袖撕裂引起慢性右肩疼痛和僵硬。他拒绝手术,但同意经动脉栓塞。第一次经动脉栓塞使用1:1的碘己醇乳剂,但没有明显的症状缓解。重复经动脉栓塞显示在几个分支和新的新血管再通。用100 μm的embozene颗粒成功栓塞。术后,患者的疼痛评分从静止时的6分提高到2分,运动时的7分提高到3分,不再需要常规止痛药。随访超声显示法囊积液持续消退达18个月。本病例提示经动脉栓塞治疗复发性肩峰下-三角下滑囊炎的疗效。
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引用次数: 0
Bilateral Subcutaneous Rat Tumor Model Perfused by the Iliolumbar Artery: A Simplified and Versatile Platform for Transarterial Therapy Studies. 髂腰动脉灌注双侧皮下大鼠肿瘤模型:经动脉治疗研究的简化和通用平台。
IF 0.8 Pub Date : 2025-12-02 eCollection Date: 2025-01-01 DOI: 10.22575/interventionalradiology.2025-0054
Takeshi Suzuki, Kenkichi Michimoto, Todd Graham, Maofeng Gong, Prem Singh, Oleh Taratula, Khashayar Farsad, Kentaro Yamada

Purpose: To evaluate the feasibility of a bilateral flank subcutaneous rat tumor model perfused by the iliolumbar artery, as a reproducible platform for preclinical transarterial therapy research. Material and Methods: Eighteen male Lewis rats (median body weight: 295 g; interquartile range: 289-301 g) received bilateral flank implantation of tumor fragments from a pancreatic ductal adenocarcinoma (DSL-6A/C1) that had developed subcutaneously in a donor rat. Upon reaching ≥8 mm in diameter, rats underwent angiography via tail artery access. A microcatheter was advanced into the iliolumbar artery through the aorta, and digital subtraction angiography was used to assess tumor staining. In two animals, either isosulfan blue or fluorescent-labeled nanoparticles were selectively injected via the iliolumbar artery to corroborate radiographic assessment of tumor perfusion. The animal that received fluorescent-labeled nanoparticles was euthanized 24 hours after injection for near-infrared imaging. The remaining rats underwent embolization and were monitored for 72 hours to assess safety. Results: The tumor engraftment rate was 97.2% (35/36). Selective iliolumbar artery catheterization was successful in all rats (100%), with a median procedure time of 20 minutes (interquartile range: 15-25). Digital subtraction angiography confirmed tumor staining in all of the evaluable tumors. Isosulfan blue injection via the iliolumbar artery resulted in whole-tumor staining. Fluorescence imaging revealed higher fluorescent signal intensity in the treated tumor compared with the contralateral side. No major complications, including skin ischemia, claudication, or paralysis were observed. Conclusions: This minimally-invasive model allows for highly reproducible subcutaneous tumor engraftment and reliable selective iliolumbar artery catheterization, providing a straightforward, technically feasible, and practical platform for transarterial therapy studies in rats.

目的:探讨髂腰动脉灌注双侧皮下大鼠肿瘤模型作为临床前经动脉治疗研究的可重复性平台的可行性。材料和方法:18只雄性Lewis大鼠(中位体重295 g,四分位数范围289-301 g)接受双侧侧胰腺导管腺癌(DSL-6A/C1)肿瘤碎片植入,该肿瘤已在供体大鼠皮下形成。当直径≥8mm时,经尾动脉通道行血管造影。微导管经主动脉进入髂腰动脉,采用数字减影血管造影评估肿瘤染色。在两只动物中,异硫丹蓝或荧光标记的纳米颗粒通过髂腰动脉选择性注射,以证实肿瘤灌注的放射学评估。注射荧光标记纳米颗粒后24小时安乐死,进行近红外成像。其余大鼠进行栓塞并监测72小时以评估安全性。结果:肿瘤植入率为97.2%(35/36)。选择性髂腰动脉插管在所有大鼠中均成功(100%),中位手术时间为20分钟(四分位数范围:15-25)。数字减影血管造影证实所有可评估的肿瘤均有肿瘤染色。经髂腰动脉注射异硫丹蓝,呈全瘤染色。荧光成像显示治疗后肿瘤荧光信号强度高于对侧。无主要并发症,包括皮肤缺血、跛行或瘫痪。结论:该微创模型允许高度可重复性的皮下肿瘤植入和可靠的选择性髂腰动脉插管,为大鼠经动脉治疗研究提供了一个简单、技术可行、实用的平台。
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引用次数: 0
期刊
Interventional radiology (Higashimatsuyama-shi (Japan)
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