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A Qualitative Study of Japanese Medical Students' Perspectives on Clinical Practicum during Coronavirus Disease 2019. 2019冠状病毒病期间日本医学生临床实习态度的定性研究
IF 1.8 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-10-15 Epub Date: 2025-09-26 DOI: 10.31662/jmaj.2025-0413
Tomoko Miyoshi
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引用次数: 0
Impact of Simulation-based Learning and Previous Academic Achievement on Clinical Judgment in Nursing Students. 模拟学习与以往学业成绩对护生临床判断的影响。
IF 1.8 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-10-15 Epub Date: 2025-09-26 DOI: 10.31662/jmaj.2025-0299
Ayako Nishimura, Yuma Ota, Yasuyo Kasahara

Introduction: Clinical judgment is crucial for nurses because it directly impacts patient safety and outcomes. Simulation is an effective strategy for teaching clinical reasoning and judgment. This study investigated the relationship between simulation performance and foundational knowledge from previous academic subjects, as measured by clinical judgment performance on the Lasater Clinical Judgment Rubric (LCJR). This study aimed to determine the impact of simulation-based learning and previous academic achievement on LCJR scores among nursing students.

Methods: In this cross-sectional quantitative study, a questionnaire was administered to second-year undergraduate nursing students (n = 85) after they completed simulation-based learning. The questionnaire captured self-assessed achievement levels related to the simulation's learning objectives and previous academic subjects. Statistical analysis included normality tests, Cronbach's α, Spearman's correlation, and multiple regression, with simulation and subject achievement as independent variables and LCJR scores as the dependent variable.

Results: Achievement of learning objective 3 (the "expectation to initial grasp") within the simulation, along with self-reported achievement in physical assessment, critical thinking, and nursing processes from previous academic subjects, significantly affected the LCJR total score and the "Interpreting" dimension. Physical assessment, critical thinking, and nursing processes also significantly impacted the LCJR "Noticing" dimension. Achievement of learning objective 1 ("Gathering information from electronic medical records") and learning objective 3 affected the LCJR "Responding."

Conclusions: The achievement of physical assessment, critical thinking, and nursing process in the previous academic subjects affected the total LCJR scores and the scores of Noticing and Interpreting. Emphasizing these areas of nursing education may enhance the students' clinical judgment skills.

临床判断对护士来说是至关重要的,因为它直接影响患者的安全和预后。模拟教学是临床推理与判断教学的有效策略。本研究以Lasater临床判断量表(LCJR)的临床判断表现来衡量模拟表现与先前学术对象的基础知识之间的关系。本研究旨在探讨模拟学习与以往学业成绩对护生LCJR得分的影响。方法:在横断面定量研究中,对护理本科二年级学生(n = 85)在完成模拟学习后进行问卷调查。问卷记录了与模拟学习目标和以前的学术科目相关的自我评估成就水平。统计分析采用正态性检验、Cronbach’s α检验、Spearman’s相关检验和多元回归分析,以模拟和科目成绩为自变量,LCJR分数为因变量。结果:模拟中学习目标3(“对初步掌握的期望”)的实现,以及自我报告在身体评估、批判性思维和护理过程方面的成就,显著影响LCJR总分和“解释”维度。身体评估、批判性思维和护理过程也显著影响LCJR“注意”维度。学习目标1(“从电子病历中收集信息”)和学习目标3的实现影响了LCJR的“回应”。结论:以往学术科目的身体评估、批判性思维和护理过程的成绩影响LCJR总分和注意和解释得分。强调这些方面的护理教育可以提高学生的临床判断能力。
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引用次数: 0
Differences in Capacity for Wonder and Tolerance for Ambiguity by High School of Origin. 高中出身对惊奇能力和歧义容忍度的差异。
IF 1.8 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-10-15 Epub Date: 2025-09-19 DOI: 10.31662/jmaj.2025-0243
Hirohisa Fujikawa, Takayuki Ando, Junji Haruta
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引用次数: 0
Psychological, Cultural, and Linguistic Barriers to Presenting New Ideas. 提出新想法的心理、文化和语言障碍。
IF 1.8 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-10-15 Epub Date: 2025-09-12 DOI: 10.31662/jmaj.2025-0342
Shunsuke Koga
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引用次数: 0
Enhancing Healthcare Access for Older Adults through Innovative Mobility Solutions Leveraging Public Assets. 通过利用公共资产的创新移动解决方案提高老年人获得医疗保健的机会。
IF 1.8 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-10-15 Epub Date: 2025-10-03 DOI: 10.31662/jmaj.2024-0358
Mari Yokota, Shinji Nakahara, Masamichi Nishida

Japan's aging population and declining public transportation have reduced healthcare access, particularly for older adults in rural areas. Currently, innovative mobility services such as ridesharing, mixed cargo/passenger transport, and medical "Mobility as a Service" are being implemented or piloted alongside existing services for older adults, such as home-visit medical care and transportation subsidies. This letter highlights ongoing initiatives in Japan and their potential to improve healthcare access. It also explores opportunities to enhance these efforts by leveraging public infrastructure, such as the nationwide post office network.

日本的人口老龄化和公共交通的减少减少了获得医疗保健的机会,特别是对农村地区的老年人来说。目前,与现有的老年人服务(如家访医疗和交通补贴)一起,正在实施或试点拼车、货物/旅客混合运输和医疗“移动即服务”等创新移动服务。这封信强调了日本正在进行的举措及其改善医疗保健获取的潜力。它还探索了通过利用公共基础设施(如全国邮政网络)来加强这些努力的机会。
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引用次数: 0
Longitudinal Changes in Symptoms of Post-Intensive Care Syndrome: A Secondary Analysis of a Scoping Review. 重症监护后综合征症状的纵向变化:一项范围回顾的二次分析
IF 1.8 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-10-15 Epub Date: 2025-09-12 DOI: 10.31662/jmaj.2025-0040
Kohei Tanaka, Nobuto Nakanishi, Keibun Liu, Kyohei Miyamoto, Akira Kawauchi, Masatsugu Okamura, Sho Katayama, Kensuke Nakamura

Background: Since the increased interest in post-intensive care syndrome (PICS) and PICS-family, many studies have been conducted. However, the longitudinal changes in PICS symptoms are not clearly understood. This study aimed to summarize the longitudinal symptom changes in each PICS domain, including physical, cognitive, mental health, quality of life, and family.

Methods: In this secondary analysis study, we identified the studies that conducted longitudinal PICS assessments published between 2014 and 2022. The most frequently used assessment tools in each domain were defined as representative methods, and results of included studies were summarized by each PICS domain. The collected data were grouped by the following: within 3 months (baseline), at 3 months, 6 months, and annually thereafter. The Wilcoxon rank-sum test was used to compare changes from baseline.

Results: Of the 5,160 studies screened, 76 studies were selected in this study. The percentage predicted value of the 6-minute walk test as an indicator of physical function significantly improved from baseline to 6 months (median [interquartile range], from 45.9 [32.0-63.0] to 65.0 [57.8-72.8], p = 0.04), and continued to improve during the 5-year follow-up period. Montreal Cognitive Assessment for cognitive assessment and Impact of Event Scale-Revised for mental health assessment did not show statistically significant change. The anxiety score of the Hospital Anxiety and Depression Scale (HADS) improved from baseline to the 12-month follow-up (from 6.8 [4.0-8.5] to 4.3 [3.3-5.3], p = 0.04). The anxiety and depression scores of the HADS in family members did not show statistically significant change. The physical component summary of the Short Form-36 for quality of life assessment increased from baseline to the 12-month follow-up (from 31.3 [25.5-37.1] to 40.6 [36.9-50.0], p = 0.03); however, the mental component summary of the Short Form-36 was not changed with statistical significance.

Conclusions: Although the physical and mental domains showed significant longitudinal improvements, PICS symptoms were long-lasting in all domains with varying severity.

背景:随着人们对重症监护后综合征(PICS)和PICS家族的关注增加,进行了许多研究。然而,PICS症状的纵向变化尚不清楚。本研究旨在总结PICS各领域的纵向症状变化,包括身体、认知、心理健康、生活质量和家庭。方法:在这项二级分析研究中,我们确定了2014年至2022年间发表的进行纵向PICS评估的研究。将每个领域中最常用的评估工具定义为代表性方法,并将纳入的研究结果按每个PICS领域进行总结。收集的数据按以下方式分组:3个月内(基线)、3个月、6个月和此后每年。使用Wilcoxon秩和检验比较基线的变化。结果:在筛选的5160项研究中,本研究选择了76项研究。从基线到6个月,6分钟步行测试作为身体功能指标的百分比预测值显著提高(中位数[四分位数间距],从45.9[32.0-63.0]到65.0 [57.8-72.8],p = 0.04),并在5年随访期间继续提高。蒙特利尔认知评估对认知评估的影响和事件量表对心理健康评估的修订没有显示出统计学上的显著变化。医院焦虑抑郁量表(HADS)焦虑评分从基线到12个月随访均有改善(从6.8[4.0-8.5]到4.3 [3.3-5.3],p = 0.04)。家庭成员的焦虑和抑郁得分无统计学意义的变化。从基线到12个月随访期间,生活质量评估简表-36的物理成分总结有所增加(从31.3[25.5-37.1]增加到40.6 [36.9-50.0],p = 0.03);而简表-36的心理成分总结没有显著性变化。结论:尽管身体和精神领域表现出显著的纵向改善,但PICS症状在所有领域都是持久的,且严重程度不同。
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引用次数: 0
Primary Dural Diffuse Large B-Cell Lymphoma: A Case Report. 原发性硬脑膜弥漫性大b细胞淋巴瘤1例。
IF 1.8 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-10-15 Epub Date: 2025-09-05 DOI: 10.31662/jmaj.2025-0198
Yoshiaki Takamura, Takatoshi Fujimoto

Primary dural lymphoma is a rare subtype of primary central nervous system lymphoma that arises from the dura mater. The majority of primary dural lymphomas are histologically mucosa-associated lymphoid tissue lymphoma. We present a rare case of a 78-year-old woman with primary dural lymphoma diagnosed as diffuse large B-cell lymphoma. She was admitted with status epilepticus. Magnetic resonance imaging showed an extra-axial mass lesion in the right parieto-occipital region, which enhanced homogeneously with contrast medium. To obtain a histopathological diagnosis, resection of the lesion involving the dura mater was performed. Based on histopathological and immunohistochemical examinations, the patient was diagnosed with diffuse large B-cell lymphoma. We summarize the clinical characteristics of this unusual disease.

原发性硬脑膜淋巴瘤是一种罕见的起源于硬脑膜的原发性中枢神经系统淋巴瘤亚型。大多数原发性硬脑膜淋巴瘤在组织学上是粘膜相关淋巴组织淋巴瘤。我们报告一例罕见的78岁女性原发硬脑膜淋巴瘤,诊断为弥漫性大b细胞淋巴瘤。她以癫痫持续状态入院。磁共振成像显示右侧顶枕区轴外肿块病变,造影剂均匀增强。为了获得组织病理学诊断,切除累及硬脑膜的病变。经组织病理及免疫组化检查,诊断为弥漫性大b细胞淋巴瘤。我们总结了这种罕见疾病的临床特点。
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引用次数: 0
Serum Uric Acid as a Potential Risk Marker for Atherosclerotic Cardiovascular Disease in Japanese Adults: Using the Hisayama Study-based Prediction Model. 血清尿酸作为日本成人动脉粥样硬化性心血管疾病的潜在危险标志物:使用Hisayama研究为基础的预测模型
IF 1.8 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-10-15 Epub Date: 2025-08-01 DOI: 10.31662/jmaj.2025-0129
Takashi Matsuyama, Mito Yamawaki, Jun Furuya, Kyosuke Omata, Mai Kaneko, Ryuichi Furuya, Hideo Yasuda, Hirotaka Fukasawa

Introduction: Atherosclerotic cardiovascular disease (ASCVD) risk profiles vary among populations. In Japan, a prediction model for the 10-year estimate of ASCVD risk, integrating coronary artery disease and atherothrombotic cerebral infarct risk assessments, has been developed based on the Hisayama Study. While hyperuricemia can promote atherosclerosis, serum uric acid levels are not included as a risk factor in the 10-year ASCVD prediction model.

Methods: We investigated the association between serum uric acid levels and 10-year ASCVD risk in 5,984 Japanese adults (3,285 males, 2,699 females) aged 40-79 years who underwent health check-ups between 2020 and 2022. The 10-year ASCVD risk scores were calculated using the aforementioned prediction model.

Results: Participants in the lowest quartile of serum uric acid levels (3.8 ± 0.6 mg/dL) had a mean 10-year ASCVD risk of 2.1 ± 3.2%, while those in the highest quartile (7.2 ± 0.7 mg/dL) had a mean risk of 4.3 ± 4.6% (p < 0.001). A significant positive correlation was observed between serum uric acid levels and 10-year ASCVD risk scores (r = 0.34, p < 0.001). Multiple linear regression analysis also revealed that serum uric acid levels remained an independent predictor of 10-year ASCVD risk after adjusting for other risk factors (β = 0.02, p < 0.001).

Conclusions: This study indicates that serum uric acid levels may serve as a useful marker for ASCVD risk assessment, particularly in the Japanese population.

简介:动脉粥样硬化性心血管疾病(ASCVD)的风险概况因人群而异。日本在Hisayama研究的基础上开发了一种综合冠状动脉疾病和动脉粥样硬化性血栓性脑梗死风险评估的10年ASCVD风险预测模型。虽然高尿酸血症可以促进动脉粥样硬化,但在10年ASCVD预测模型中,血清尿酸水平并未作为一个危险因素。方法:我们调查了5984名年龄在40-79岁之间的日本成年人(3285名男性,2699名女性)在2020年至2022年期间接受健康检查的血清尿酸水平与10年ASCVD风险之间的关系。使用上述预测模型计算10年ASCVD风险评分。结果:血清尿酸水平最低四分位数(3.8±0.6 mg/dL)的参与者平均10年ASCVD风险为2.1±3.2%,而最高四分位数(7.2±0.7 mg/dL)的参与者平均风险为4.3±4.6% (p < 0.001)。血清尿酸水平与10年ASCVD风险评分呈正相关(r = 0.34, p < 0.001)。多元线性回归分析还显示,在校正其他危险因素后,血清尿酸水平仍然是10年ASCVD风险的独立预测因子(β = 0.02, p < 0.001)。结论:本研究表明血清尿酸水平可作为ASCVD风险评估的有用指标,特别是在日本人群中。
{"title":"Serum Uric Acid as a Potential Risk Marker for Atherosclerotic Cardiovascular Disease in Japanese Adults: Using the Hisayama Study-based Prediction Model.","authors":"Takashi Matsuyama, Mito Yamawaki, Jun Furuya, Kyosuke Omata, Mai Kaneko, Ryuichi Furuya, Hideo Yasuda, Hirotaka Fukasawa","doi":"10.31662/jmaj.2025-0129","DOIUrl":"10.31662/jmaj.2025-0129","url":null,"abstract":"<p><strong>Introduction: </strong>Atherosclerotic cardiovascular disease (ASCVD) risk profiles vary among populations. In Japan, a prediction model for the 10-year estimate of ASCVD risk, integrating coronary artery disease and atherothrombotic cerebral infarct risk assessments, has been developed based on the Hisayama Study. While hyperuricemia can promote atherosclerosis, serum uric acid levels are not included as a risk factor in the 10-year ASCVD prediction model.</p><p><strong>Methods: </strong>We investigated the association between serum uric acid levels and 10-year ASCVD risk in 5,984 Japanese adults (3,285 males, 2,699 females) aged 40-79 years who underwent health check-ups between 2020 and 2022. The 10-year ASCVD risk scores were calculated using the aforementioned prediction model.</p><p><strong>Results: </strong>Participants in the lowest quartile of serum uric acid levels (3.8 ± 0.6 mg/dL) had a mean 10-year ASCVD risk of 2.1 ± 3.2%, while those in the highest quartile (7.2 ± 0.7 mg/dL) had a mean risk of 4.3 ± 4.6% (p < 0.001). A significant positive correlation was observed between serum uric acid levels and 10-year ASCVD risk scores (r = 0.34, p < 0.001). Multiple linear regression analysis also revealed that serum uric acid levels remained an independent predictor of 10-year ASCVD risk after adjusting for other risk factors (β = 0.02, p < 0.001).</p><p><strong>Conclusions: </strong>This study indicates that serum uric acid levels may serve as a useful marker for ASCVD risk assessment, particularly in the Japanese population.</p>","PeriodicalId":73550,"journal":{"name":"JMA journal","volume":"8 4","pages":"1116-1123"},"PeriodicalIF":1.8,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12598214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145497768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Type of Wheelchair Used before Nursing Home Admission and Fall-Related Fractures after Nursing Home Admission. 疗养院入院前使用轮椅的类型和疗养院入院后跌倒相关骨折。
IF 1.8 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-10-15 Epub Date: 2025-09-19 DOI: 10.31662/jmaj.2025-0194
Ai Suzuki, Kazuaki Uda, Taeko Watanabe, Nanako Tamiya

Introduction: Residents who use multifunctional wheelchairs before nursing home admission often face discontinuation of such devices after nursing home admission. However, basic data on this issue remain limited. Therefore, in this study, we aimed to provide preliminary data by investigating the occurrence of fall-related fractures after nursing home admission, stratified by the type of wheelchair used before nursing home admission.

Methods: We used linked long-term care claims data, care-need certification survey data, and medical claims data from Ibaraki Prefecture, Japan. Participants were older adults who were newly admitted to nursing homes directly from home between July 2018 and February 2019 and had used wheelchair rental services before nursing home admission. We divided the wheelchairs into two types using long-term care claims data: multifunctional and standard wheelchairs. The outcomes of interest were newly occurring fall-related fractures within the first month of nursing home admission, identified from medical claims data. Fracture incidence was compared between the two wheelchair types, and information of residents with fracture were described.

Results: The study included 215 participants. The participants' median age was 88 years (interquartile range, 83-93); 153 (71.2%) were female, and 96 (44.7%) used a multifunctional wheelchair before nursing home admission. There are no fall-related fractures occurred among standard wheelchair users, whereas five fractures were observed among multifunctional wheelchair users.

Conclusions: Residents who used multifunctional wheelchairs experienced more fall-related fractures after admission than those who used standard wheelchairs before nursing home admission. Further research is needed to better understand the issue of service continuity by investigating wheelchair use after nursing home admission and the circumstances of fall-related fractures.

导言:入住养老院前使用多功能轮椅的居民往往在入住养老院后面临停用此类设备的问题。然而,关于这个问题的基本数据仍然有限。因此,在本研究中,我们旨在通过调查养老院入院后跌倒相关骨折的发生率,并根据入院前使用轮椅的类型进行分层,提供初步数据。方法:我们使用来自日本茨城县的长期护理索赔数据、护理需求认证调查数据和医疗索赔数据。参与者是2018年7月至2019年2月期间从家中直接入住养老院的老年人,并在入住养老院之前使用过轮椅租赁服务。我们使用长期护理索赔数据将轮椅分为两类:多功能轮椅和标准轮椅。我们感兴趣的结果是在疗养院入院的第一个月内新发生的跌倒相关骨折,从医疗索赔数据中确定。比较两种轮椅类型的骨折发生率,并描述骨折居民的信息。结果:该研究包括215名参与者。参与者的中位年龄为88岁(四分位数范围为83-93岁);其中女性153例(71.2%),96例(44.7%)入住前使用过多功能轮椅。在标准轮椅使用者中没有发生与跌倒相关的骨折,而在多功能轮椅使用者中观察到5例骨折。结论:使用多功能轮椅的住院患者在入院后比在入院前使用标准轮椅的患者发生更多的跌倒相关骨折。需要进一步的研究,以更好地了解服务连续性的问题,通过调查轮椅的使用后疗养院入院和摔伤相关骨折的情况。
{"title":"Type of Wheelchair Used before Nursing Home Admission and Fall-Related Fractures after Nursing Home Admission.","authors":"Ai Suzuki, Kazuaki Uda, Taeko Watanabe, Nanako Tamiya","doi":"10.31662/jmaj.2025-0194","DOIUrl":"10.31662/jmaj.2025-0194","url":null,"abstract":"<p><strong>Introduction: </strong>Residents who use multifunctional wheelchairs before nursing home admission often face discontinuation of such devices after nursing home admission. However, basic data on this issue remain limited. Therefore, in this study, we aimed to provide preliminary data by investigating the occurrence of fall-related fractures after nursing home admission, stratified by the type of wheelchair used before nursing home admission.</p><p><strong>Methods: </strong>We used linked long-term care claims data, care-need certification survey data, and medical claims data from Ibaraki Prefecture, Japan. Participants were older adults who were newly admitted to nursing homes directly from home between July 2018 and February 2019 and had used wheelchair rental services before nursing home admission. We divided the wheelchairs into two types using long-term care claims data: multifunctional and standard wheelchairs. The outcomes of interest were newly occurring fall-related fractures within the first month of nursing home admission, identified from medical claims data. Fracture incidence was compared between the two wheelchair types, and information of residents with fracture were described.</p><p><strong>Results: </strong>The study included 215 participants. The participants' median age was 88 years (interquartile range, 83-93); 153 (71.2%) were female, and 96 (44.7%) used a multifunctional wheelchair before nursing home admission. There are no fall-related fractures occurred among standard wheelchair users, whereas five fractures were observed among multifunctional wheelchair users.</p><p><strong>Conclusions: </strong>Residents who used multifunctional wheelchairs experienced more fall-related fractures after admission than those who used standard wheelchairs before nursing home admission. Further research is needed to better understand the issue of service continuity by investigating wheelchair use after nursing home admission and the circumstances of fall-related fractures.</p>","PeriodicalId":73550,"journal":{"name":"JMA journal","volume":"8 4","pages":"1220-1226"},"PeriodicalIF":1.8,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12598270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145497822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current Status of Drug Prescribing among Older Adults with Advanced-stage Cancer Receiving Home Medical Care in Japan: A Nationwide Study. 日本接受家庭医疗护理的老年晚期癌症患者的药物处方现状:一项全国性研究
IF 1.8 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-10-15 Epub Date: 2025-09-26 DOI: 10.31662/jmaj.2025-0179
Yukari Hattori, Shota Hamada, Masao Iwagami, Nobuo Sakata, Kiwami Kidana, Nanako Tamiya, Masahiro Akishita, Takashi Yamanaka

Introduction: Balancing preventive and symptomatic medications is crucial to minimizing polypharmacy in older adults with limited life expectancy. This study examined end-of-life medications among older adults with advanced-stage cancer receiving home medical care.

Methods: We conducted a retrospective cohort study using Japan's national claims database between October 2017 and September 2019 and selected adults aged ≥75 years who received comprehensive home medical care services for patients with advanced-stage cancer. We compared prescriptions for preventive and symptomatic medications during two periods: (1) within 180 days before the first claim for the service issued (index date) and (2) within 180 days after the index date or until death.

Results: Overall, the study included 8,463 participants, of whom 47% were women and 46% were aged ≥85 years. The median observation period after the index date was 57 days (interquartile range: 30-131 days). Among preventive drugs, antihypertensives were the most frequently prescribed before the index date (60.3%), followed by lipid-lowering drugs (25.4%) and antiplatelets (21.7%). Prescription of lipid-lowering drugs, vitamins, and drugs for osteoporosis decreased by approximately 70%-80% after the index date. In contrast, prescription of oral anticoagulants, antidiabetic drugs, and antidementia drugs declined by approximately 40%. Symptomatic drug prescriptions also decreased after the index date, except for opioids (from 42.2% to 51.9%).

Conclusions: This is the first nationwide study to examine the prescriptions of preventive and symptomatic drugs among older adults with advanced-stage cancer receiving end-of-life home medical care.

简介:平衡预防性和对症用药对于减少预期寿命有限的老年人的多重用药至关重要。这项研究调查了接受家庭医疗护理的晚期癌症老年人的临终药物治疗情况。方法:我们在2017年10月至2019年9月期间使用日本国家索赔数据库进行了一项回顾性队列研究,并选择了年龄≥75岁且接受晚期癌症患者综合家庭医疗护理服务的成年人。我们比较了两个时期的预防性和对症用药处方:(1)在首次提出服务索赔前180天内(索引日期)和(2)在索引日期后180天内或直到死亡。结果:总体而言,该研究包括8463名参与者,其中47%为女性,46%年龄≥85岁。指数日期后的中位观察期为57天(四分位数间距:30-131天)。在预防药物中,在指标日期前使用频率最高的是降压药(60.3%),其次是降脂药(25.4%)和抗血小板药(21.7%)。降脂药物、维生素和骨质疏松药物的处方在指数日期后减少了大约70%-80%。相比之下,口服抗凝血剂、降糖药和抗痴呆药的处方减少了大约40%。除阿片类药物处方从42.2%降至51.9%外,其他对症药物处方也有所下降。结论:这是第一个全国性的研究,检查老年晚期癌症患者接受临终家庭医疗护理的预防性和对症药物处方。
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引用次数: 0
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