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Non-penetrating chest blows and sudden death in the young. 非穿透性胸部打击和年轻人猝死。
Pub Date : 2000-11-01 DOI: 10.1136/emj.17.6.421
S Thakore, M Johnston, E Rogena, Z Peng, D Sadler

Sudden death in the young after low energy anterior chest wall impact is an under-recognised phenomenon in this country. Review of the literature yields several American references to commotio cordis, mainly in the context of sporting events. Two cases are reported of sudden death in young men as a result of blunt impact anterior chest wall trauma. It is suggested that these cases draw attention to a lethal condition of which many practitioners are unaware.

在这个国家,低能量前胸壁撞击后的年轻人猝死是一种未被充分认识的现象。回顾文献,我们发现了一些美国人对交通事故的参考,主要是在体育赛事的背景下。本文报告两例年轻男性因钝性冲击前胸壁创伤而猝死的病例。有人建议,这些案件提请注意致命的条件,许多从业者都不知道。
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引用次数: 0
The Millennium Scientific Meeting, Manchester, 9–11 October 2000 (Hosted by the Faculty of Accident and Emergency Medicine) 千年科学会议,曼彻斯特,2000年10月9日至11日(由事故和急诊医学院主办)
Pub Date : 2000-11-01 DOI: 10.1136/emj.17.6.434
N. Hjelm, R. Cocks
The Millennium Scientific Meeting, Manchester, 9–11 October 2000 (Hosted by the Faculty of Accident and Emergency Medicine) EMRS/SSL International plc Prize Session Use of plasma DNA analysis to derive early prediction rules for post-traumatic organ failure T H RAINER, Y M D LO, L Y S CHAN, P K W LAM, E K WONG, N M HJELM, R A COCKS Accident and Emergency Medicine Academic Unit and Department of Chemical Pathology,The Chinese University of Hong Kong and Prince of Wales Hospital, Hong Kong Background—The discovery of eVective treatments preventing or mimising post-traumatic complications may be hampered by our inability to target high risk patients early after injury. The purpose of this study was to derive a guideline for the prediction of posttraumatic organ failure using cell free (plasma) DNA and other predictors of post-traumatic complications. Methods—The research ethics committee approved a prospective, observational study investigating molecular responses of patients to injury. Plasma DNA was measured using a real time, quantitative, polymerase chain reaction assay for the â globin gene in 84 patients (mean age 38 (SD 16) years; 83% male) triaged to an emergency department resuscitation room within a median time of 60 minutes (interquartile range 50, 90; range 30–240) from injury. Other variables were injury severity scores, white cell count (WCC) and shock index (SI). Organ failure (OF) and multiple organ dysfunction syndrome (MODS) occurred in 21 of 84 (25%) and 9 of 84 (11%) cases respectively. After univariate and receiver operator curve analysis, data were further analysed using a classification and regression tree. Results—Within four hours of injury, OF could be correctly predicted (predictive value positive, PV+) in 85.7% cases (n = 18 of 21; 95%CI 62.6% to 96.2%) by: (1) cell free DNA > 140 000 genome equivalents/ml, (2) injury severity score (ISS) > 27 and (3) WCC > 13.4 (×10/l). OF could be correctly excluded (predictive value negative, PV−) in 95.2% cases (n = 60 of 63; 95%CI 85.8% to 98.8%) by (1) cell free DNA < 141 000 genome equivalents/ml, (2) ISS < 27 and (3) WCC < 13.4. Sensitivity and specificity were 85.7% (95%CI, 62.6% to 96.2%) and 95.2% (95% CI, 85.8% to 98.8%) respectively. MODS could be correctly predicted (PV+) in 87.5% cases (n = 7 of 8; 95%CI 46.7% to 99.3%) by: (1) cell free DNA > 108 000 copies/ml, (2) maximal abbreviated injury score (MAIS) > 3, and (3) SI > 0.72. MODS could be correctly excluded (PV−) in 97.3% cases (n = 71 of 73; 95%CI 89.6% to 99.5%) by (1) cell free DNA < 108 000 copies/ml, (2) MAIS < 3.0 and (3) SI < 0.72. Sensitivity and specificity were 77.8% (95%CI, 40.2% to 96.1%) and 98.6% (95% CI, 91.5% to 99.9%) respectively. Conclusion—Plasma DNA analysis allows the development of early accurate guidelines for the prediction of post-traumatic OF and MODS. These guidelines now require prospective validation. The eVects of in vivo haemodilution with 0.9% sodium chloride and Gelofusine on whole bloo
千禧科学会议,曼彻斯特,2000年10月9 - 11(学院主办的事故和急诊医学)电子病历国际plc奖/ SSL会话使用等离子体DNA分析获得早期预测创伤后T H RAINER器官衰竭,规则Y M D, L Y S CHAN P K W LAM E K黄,N M HJELM, R旋塞事故和急诊医学学术单位和化学病理学系,香港中文大学的威尔士亲王医院香港背景-由于我们无法在伤后早期针对高危患者,因此发现预防或减少创伤后并发症的有效治疗方法可能会受到阻碍。本研究的目的是利用游离细胞(血浆)DNA和其他创伤后并发症的预测指标来预测创伤后器官衰竭。方法:研究伦理委员会批准了一项前瞻性观察性研究,调查患者对损伤的分子反应。84例患者(平均年龄38岁(SD 16)岁)采用实时、定量、聚合酶链反应法检测血浆DNA。83%男性)在平均60分钟内被分诊到急诊科复苏室(四分位数范围50,90;射程30-240)。其他变量包括损伤严重程度评分、白细胞计数(WCC)和休克指数(SI)。84例患者中有21例(25%)发生器官衰竭(OF), 9例(11%)发生多器官功能障碍综合征(MODS)。在单变量和接收算子曲线分析后,使用分类和回归树进一步分析数据。结果:损伤后4小时内,85.7%的患者能正确预测of(预测值阳性,PV+) (n = 18 / 21;95%CI 62.6%至96.2%),方法为:(1)细胞游离DNA > 140 000基因组当量/ml,(2)损伤严重程度评分(ISS) > 27和(3)WCC > 13.4 (×10/l)。95.2%的病例可以正确排除OF(预测值阴性,PV−)(n = 60 / 63;(1)细胞游离DNA < 141 000基因组当量/ml, (2) ISS < 27, (3) WCC < 13.4, 95%CI 85.8% ~ 98.8%)。敏感性和特异性分别为85.7% (95%CI, 62.6% ~ 96.2%)和95.2% (95%CI, 85.8% ~ 98.8%)。87.5%的病例能正确预测MODS (PV+) (n = 7 / 8;95%CI 46.7% ~ 99.3%),分别为:(1)细胞游离DNA > 108 000拷贝/ml,(2)最大缩短损伤评分(MAIS) > 3, (3) SI > 0.72。97.3%的病例可以正确排除MODS (PV−)(n = 71 / 73;(1)细胞游离DNA < 108,000拷贝/ml, (2) MAIS < 3.0, (3) SI < 0.72, 95%CI 89.6% ~ 99.5%)。敏感性和特异性分别为77.8% (95%CI, 40.2% ~ 96.1%)和98.6% (95%CI, 91.5% ~ 99.9%)。结论:血浆DNA分析可为创伤后of和MODS的早期准确预测提供指导。这些指南现在需要前瞻性验证。0.9%氯化钠和Gelofusine体内血液稀释对全血凝和血小板功能的影响E V BRAZIL*, U SHAH**, M MACEY**, T J COATS* *学术单位、急诊科和**血液科,伦敦,Whitechapel, London, E1 1BB引入——与生理盐水相比,Gelofusine体外血液稀释可降低血块质量,具有促凝作用。这些凝血功能的改变尚不清楚,但可能涉及血小板功能的改变。Sonoclot分析仪允许测量全血凝固的一些参数。血小板活化后,血小板表面膜上CD62P (P选择素)表达增加。CD42a (GPIX)也在血小板表面表达,CD45在白细胞表面表达,但不表达血小板。血小板-白细胞聚集(CD45-CD42a阳性事件)可能在血栓形成状态下增加。这些抗原的单克隆抗体可以结合到荧光分子上,并通过流式细胞术进行分析。目的:探讨0/9%氯化钠加格洛夫辛体内血液稀释对全血凝、血小板活化及血小板-白细胞相互作用的影响。方法本研究采用随机、对照、交叉研究。8名成年志愿者分别在30分钟内接受每种溶液1000毫升的治疗,两次测试之间有一周的洗脱期。在输液前和输液后立即从自由流动的上肢静脉进行非创伤性采血。新鲜血液用于超声凝血分析。用于血小板分析的血液被收集到含有柠檬酸钠的真空容器中,并在收集后10分钟内进行分析。结果:溶液前后平均Sonoclot值和血小板分子表达见表1。结论:Gelofusine体内血液稀释可显著延长达到最大凝块强度的时间。其他全血凝血参数不变。 与生理盐水相比,Gelofusine可使血小板活化和血小板-白细胞相互作用受损,而生理盐水可促进这些变化。一项前瞻性随机对照试验,探讨急诊物理治疗的临床和成本效益
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引用次数: 0
Emergency Medicine, Concepts and Clinical Practice. 4th Edition on CD-ROM. 急诊医学,概念和临床实践。第4版光盘。
Pub Date : 2000-11-01 DOI: 10.1136/emj.17.6.432-b
G. Johnson
Rosen's Emergency Medicine is the gold standard against which other textbooks in our specialty are compared. The current weighty and authoritative three volume, 3000 page text is now available as a single CD-ROM. The disk also contains three other Mosby products supplying prescribing information, drug interaction data, and patient handouts for prescribed drugs. These, however, will be of little interest to a UK audience.Most readers will be familiar with the excellence of the content and comprehensive coverage provided by the printed text. …
罗森的急诊医学是黄金标准,与其他教科书在我们的专业进行比较。目前的重要和权威的三卷,3000页的文本现在作为单一的CD-ROM提供。磁盘还包含另外三种莫斯比产品,提供处方信息、药物相互作用数据和处方药物的患者手册。然而,英国观众不会对这些内容感兴趣。大多数读者将熟悉印刷文本提供的内容和全面覆盖的卓越性。…
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引用次数: 9
A national census of ambulance response times to emergency calls in Ireland. 爱尔兰救护车对紧急呼叫反应时间的全国普查。
Pub Date : 2000-11-01 DOI: 10.1136/emj.17.6.392
N Breen, J Woods, G Bury, A W Murphy, H Brazier

Background: Equity of access to appropriate pre-hospital emergency care is a core principle underlying an effective ambulance service. Care must be provided within a timeframe in which it is likely to be effective. A national census of response times to emergency and urgent calls in statutory ambulance services in Ireland was undertaken to assess current service provision.

Methods: A prospective census of response times to all emergency and urgent calls was carried out in the nine ambulance services in the country over a period of one week. The times for call receipt, activation, arrival at and departure from scene and arrival at hospital were analysed. Crew type, location of call and distance from ambulance base were detailed. The type of incident leading to the call was recorded but no further clinical information was gathered. Results-2426 emergency calls were received by the services during the week. Fourteen per cent took five minutes or longer to activate (range 5-33%). Thirty eight per cent of emergencies received a response within nine minutes (range 10-47%). Only 4.5% of emergency calls originating greater than five miles from an ambulance station were responded to within nine minutes (range 0-10%). Median patient care times for "on call" crews were three times longer than "on duty" crews.

Conclusion: Without prioritized use of available resources, inappropriately delayed responses to critical incidents will continue. Recommendations are made to improve the effectiveness of emergency medical service utilisation.

背景:公平获得适当的院前急救护理是有效救护车服务的核心原则。必须在可能有效的时间范围内提供护理。对爱尔兰法定救护车服务的紧急和紧急呼叫响应时间进行了一次全国普查,以评估目前的服务提供情况。方法:在为期一周的时间内,对全国九家救护车服务机构的所有紧急和紧急呼叫的响应时间进行前瞻性普查。对呼叫接收次数、激活次数、到达和离开现场次数、到达医院次数进行了分析。机组人员类型、呼叫地点以及与救护基地的距离都有详细说明。记录了导致该呼叫的事件类型,但没有收集到进一步的临床信息。结果-在一周内,服务部门接到了2426个紧急呼叫。14%需要5分钟或更长时间才能激活(范围5-33%)。38%的紧急情况在9分钟内得到回应(范围10-47%)。在距离救护站5英里以外发出的紧急呼叫中,只有4.5%在9分钟内得到回应(范围0-10%)。“随叫随到”的医护人员护理病人的时间中位数是“值班”医护人员的三倍。结论:如果不优先使用现有资源,对关键事件的不当延迟响应将继续存在。提出了提高紧急医疗服务利用效率的建议。
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引用次数: 35
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Elastic compression stockings and the risk of post-thrombotic syndrome in patients with symptomatic proximal vein thrombosis. 以证据为基础的急诊医学:曼彻斯特皇家医院的最佳赌注。有症状的近端静脉血栓形成患者的弹性压缩袜和血栓后综合征的风险。
Pub Date : 2000-11-01 DOI: 10.1136/emj.17.6.405
B Lane, S Jones
Report by Beverley Lane, Research Nurse Search checked by Steve Jones, Research Fellow A 35 year old woman attends the emergency department with a swollen and painful left leg. A DVT is suspected and confirmed on ultrasound. You are aware of the possible risks of developing post-thrombotic …
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引用次数: 2
Brugada syndrome--the missed epidemic. 布鲁加达综合症——错过的流行病。
Pub Date : 2000-11-01 DOI: 10.1136/emj.17.6.426
J M Butler

About 10-20% of patients dying suddenly or resuscitated from ventricular fibrillation do not have demonstrable heart disease. These people are often young and tragically in some cases sudden death is the first and only clinical event. One of the three main electrophysiological diagnoses to be considered in these situations is the Brugada syndrome. A case of Brugada syndrome is described, together with an example of the classic electrocardiographic manifestations and a discussion of the possible aetiology, diagnosis and management of this condition.

因心室颤动而突然死亡或复苏的患者中约有10-20%没有明显的心脏病。这些人往往很年轻,不幸的是,在某些情况下,猝死是第一个也是唯一的临床事件。在这些情况下要考虑的三种主要电生理诊断之一是Brugada综合征。本文描述了一例Brugada综合征,并结合一个典型的心电图表现,并讨论了可能的病因、诊断和治疗。
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引用次数: 0
Posterior dislocation of hip in adolescents attributable to casual rugby. 青少年因橄榄球引起的髋后脱位。
Pub Date : 2000-11-01 DOI: 10.1136/emj.17.6.429
K Mohanty, S K Gupta, A Langston
A 17 year old boy was assaulted with a skateboard, from which he sustained a laceration to his forehead and below his left eye. His wounds were closed primarily in accident and emergency and he was given a course of oral flucloxacillin. He returned to the department two days later having become increasingly unwell with lethargy, fever, and marked swelling with tenderness over the left lower eyelid.On examination he had a tachycardia of 120 and a pyrexia of 38.9. He had mild chemosis of the left eye with a …
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引用次数: 6
Does intraosseous have to mean intramedullary? 骨内一定是指髓内吗?
Pub Date : 2000-11-01 DOI: 10.1136/emj.17.6.432-a
G McCarthy, P Buss
Editor,—Further to Foex's historical note on the intraosseous route for fluid administration1 and Lavis's recommendations regarding its use in extreme circumstances in adults,2 we would like to mention our previously reported experience where use of an intracalcaneal infusion proved very successful in the resuscitation of a seriously ill child.3 In our opinion, this case questions the assumption that it is necessary to have a functioning medullary cavity in the bone where an intraosseous needle is used. Could it just be that a bone …
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引用次数: 6
Acute medicine: the physician's role. A working party report of the Federation of Royal Colleges of Physicians of the United Kingdom. 急症医学:医生的角色。联合王国皇家医师学院联合会工作组报告。
Pub Date : 2000-11-01 DOI: 10.1136/emj.17.6.391
R D Hardern
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引用次数: 5
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. SimpliRed D-dimer assay in suspected pulmonary embolus. 以证据为基础的急诊医学:曼彻斯特皇家医院的最佳赌注。疑似肺栓塞的简易d -二聚体测定。
Pub Date : 2000-11-01 DOI: 10.1136/emj.17.6.404
M Harrison, S Jones
Report by Magnus Harrison, Research Fellow Search checked by Steve Jones, Research Fellow A 40 year old man presents with acute suspected pulmonary embolus (PE). You wonder whether a negative SimpliRed d-dimer assay is sufficient to rule out the diagnosis of PE. In [a patient suspected of having an acute pulmonary embolus] is [a …
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引用次数: 1
期刊
Journal of accident & emergency medicine
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