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Journal of allergy and infectious diseases最新文献

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Heparin binding proteins on monocyte cell surfaces regulates pre-inflammatory responses in diabetes 单核细胞表面的肝素结合蛋白调节糖尿病的炎症前反应
Journal of allergy and infectious diseases
Pub Date : 2023-09-14 DOI: 10.46439/allergy.4.037
Andrew Jun Wang, Aimin Wang, Vincent Hascall
Many diabetic complications, such as renal and cardiovascular disease, share a common association with extensive and chronic inflammation due to infiltration by activated leukocytes that originate from the bone marrow (BM). Our previous study demonstrated that macrophage progenitor cells that divided in hyperglycemia induced intracellular synthesis of hyaluronan and became pro-inflammatory macrophages (Mpi), and that the presence of low concentrations of heparin (~50 nM) prevented the intracellular HA synthesis and promoted the formation of tissue repair macrophages (Mtr). However, the molecular mechanism underlying heparin’s role is still unknown. This study showed that heparin can be internalized by dividing monocyte progenitor cells. Further, there are two most abundant heparin binding proteins, alpha-enolase (ENO-1) and cofilin-1, identified on monocyte cell surfaces. In addition to their conventional roles inside of cells, ENO-1 and cofilin-1 can be found on cell surfaces and are also involved in autoimmune diseases. Thus, this study provides new insight into heparin’s role in regulating monocyte and macrophage function.
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引用次数: 0
Short commentary on fractional model for Middle East Respiratory Syndrome Coronavirus on a complex heterogeneous network 中东呼吸综合征冠状病毒复杂异质网络分数模型述评
Journal of allergy and infectious diseases
Pub Date : 2023-09-14 DOI: 10.46439/allergy.4.038
Ibrahim Obaya, H. A. A. El-Saka
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引用次数: 0
Multisystem inflammatory syndrome in Adults (MIS-A) 成人多系统炎症综合征(MIS-A)
Journal of allergy and infectious diseases
Pub Date : 2021-09-19 DOI: 10.46439/allergy.2.023
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引用次数: 9
COVID-19: Aspects of outpatient treatment COVID-19:门诊治疗的各个方面
Journal of allergy and infectious diseases
Pub Date : 2021-09-19 DOI: 10.46439/allergy.2.024
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引用次数: 0
Women who have sex with women (WSW) and women who have sex with women and men (WSWM) in the HIV-AIDS prevention campaigns 在预防艾滋病毒/艾滋病运动中，与妇女发生性关系的妇女(WSW)和与男女发生性关系的妇女(wsm)
Journal of allergy and infectious diseases
Pub Date : 2021-07-13 DOI: 10.46439/allergy.2.021
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引用次数: 5
Possible therapeutic targets for SARS-CoV-2 infection and COVID-19. SARS-CoV-2感染和COVID-19可能的治疗靶点。
Journal of allergy and infectious diseases
Pub Date : 2021-01-01 DOI: 10.46439/allergy.2.028
Nabab Khan, Nirmal Kumar, Jonathan D Geiger

SARS-CoV-2 infection causes COVID-19, which has emerged as a health emergency worldwide. SARS-CoV-2 infects cells by binding to ACE2 receptors and enters into the cytoplasm following its escape from endolysosomes. Once in the cytoplasm, the virus replicates and eventually causes various pathological conditions including acute respiratory distress syndrome (ARDS) that is caused by pro-inflammatory cytokine storms. Thus, endolysosomes and cytokine storms are important therapeutic targets to suppress SARS-CoV-2 infection and COVID-19. Here, we discuss therapeutic targets of SARS-CoV-2 infection and available drugs that could be helpful in the suppression of the SARS-CoV-2 infection and pathological condition COVID-19. The urgency of the COVID-19 pandemic precludes the development of new drugs and increased focus on drug repurposing might provide the quickest way to finding effective medicines.

SARS-CoV-2感染导致COVID-19, COVID-19已成为全球卫生紧急事件。SARS-CoV-2通过与ACE2受体结合感染细胞，并在从内溶酶体逃逸后进入细胞质。一旦进入细胞质，病毒复制并最终引起各种病理状况，包括由促炎细胞因子风暴引起的急性呼吸窘迫综合征(ARDS)。因此，内溶酶体和细胞因子风暴是抑制SARS-CoV-2感染和COVID-19的重要治疗靶点。在这里，我们讨论了SARS-CoV-2感染的治疗靶点以及可能有助于抑制SARS-CoV-2感染和COVID-19病理状态的现有药物。COVID-19大流行的紧迫性阻碍了新药的开发，加强对药物再利用的关注可能是找到有效药物的最快方法。
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引用次数: 0
Monitoring clinical trials in infectious diseases. 监测传染病的临床试验。
Journal of allergy and infectious diseases
Pub Date : 2021-01-01 DOI: 10.46439/allergy.2.019
David L DeMets, Thomas R Fleming, Susan S Ellenberg
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引用次数: 0
Hyponatremia in COVID-19 infection: possible causal factors and management COVID-19感染的低钠血症:可能的病因和管理
Journal of allergy and infectious diseases
Pub Date : 2020-12-31 DOI: 10.46439/allergy.1.012
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引用次数: 0
The impact of HIV and HAART in the pathogenesis of COPD HIV和HAART在COPD发病机制中的影响
Journal of allergy and infectious diseases
Pub Date : 2020-12-31 DOI: 10.46439/allergy.1.013
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引用次数: 0
Period-varying confirmed case-fatality risk still being depicted 仍在描述时期变化的确诊病死率风险
Journal of allergy and infectious diseases
Pub Date : 2020-12-31 DOI: 10.46439/allergy.1.014
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引用次数: 0
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