Pub Date : 2021-12-31DOI: 10.46439/neurobiology.3.014
Thomas Varkey, T. Varkey
{"title":"“I’m Feeling Blue”: Depression as a presenting symptom of Normal Pressure Hydrocephalus","authors":"Thomas Varkey, T. Varkey","doi":"10.46439/neurobiology.3.014","DOIUrl":"https://doi.org/10.46439/neurobiology.3.014","url":null,"abstract":"","PeriodicalId":73855,"journal":{"name":"Journal of neurobiology and physiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45724656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-31DOI: 10.46439/neurobiology.3.018
{"title":"Parkinson’s disease pathogeny and treatments: A narrative review","authors":"","doi":"10.46439/neurobiology.3.018","DOIUrl":"https://doi.org/10.46439/neurobiology.3.018","url":null,"abstract":"","PeriodicalId":73855,"journal":{"name":"Journal of neurobiology and physiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48260666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-31DOI: 10.46439/neurobiology.3.015
{"title":"Commentary on adrenarche and middle childhood","authors":"","doi":"10.46439/neurobiology.3.015","DOIUrl":"https://doi.org/10.46439/neurobiology.3.015","url":null,"abstract":"","PeriodicalId":73855,"journal":{"name":"Journal of neurobiology and physiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43402948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-30DOI: 10.46439/neurobiology.2.006
{"title":"EBV-positive Intravascular Large B-cell Lymphoma","authors":"","doi":"10.46439/neurobiology.2.006","DOIUrl":"https://doi.org/10.46439/neurobiology.2.006","url":null,"abstract":"","PeriodicalId":73855,"journal":{"name":"Journal of neurobiology and physiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46002986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-30DOI: 10.46439/neurobiology.2.005
{"title":"Clopidogrel pharmacogenetics in patients undergoing percutaneous neurointervention","authors":"","doi":"10.46439/neurobiology.2.005","DOIUrl":"https://doi.org/10.46439/neurobiology.2.005","url":null,"abstract":"","PeriodicalId":73855,"journal":{"name":"Journal of neurobiology and physiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45845217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-30DOI: 10.46439/neurobiology.2.007
{"title":"Inflammation in the olfactory bulb: A new mechanism of olfactory dysfunction in T2D?","authors":"","doi":"10.46439/neurobiology.2.007","DOIUrl":"https://doi.org/10.46439/neurobiology.2.007","url":null,"abstract":"","PeriodicalId":73855,"journal":{"name":"Journal of neurobiology and physiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46057977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-30DOI: 10.31080/asne.2020.03.0173
Y. Razvodovsky, Smirnov Vy, E. I. Troyan, Maksimovich N. Ye, I. Semenenya
{"title":"Interhemispheric Asymmetry in the Pool of Amino Acids during Subtotal Cerebral Ischemia","authors":"Y. Razvodovsky, Smirnov Vy, E. I. Troyan, Maksimovich N. Ye, I. Semenenya","doi":"10.31080/asne.2020.03.0173","DOIUrl":"https://doi.org/10.31080/asne.2020.03.0173","url":null,"abstract":"","PeriodicalId":73855,"journal":{"name":"Journal of neurobiology and physiology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42242091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.46439/neurobiology.2.008
Shaoxun Wang, Richard J Roman, Fan Fan
Individuals with spinal cord injury (SCI) have a significantly increased risk for cognitive impairment that is associated with cerebrovascular remodeling and endothelial dysfunction. The sub-acute stage following high thoracic SCI is characterized by increased fibrosis and stiffness of cerebral arteries. However, a more prolonged duration after SCI exacerbates cerebrovascular injury by damaging endothelium. Endothelial dysfunction is associated with reduced expression of transient receptor potential cation channel 4 that mediates the production of nitric oxide and epoxyeicosatrienoic acids following shear stress and the response to carbachol and other endothelium-dependent vasodilators. Reduced expression of CD31 in cerebral arteries also suggests the loss of endothelial cell integrity following chronic SCI. Repetitively transient hypertension and intermittent hypotension contribute to cerebrovascular endothelial dysfunction in the animals with a sub-acute stage of high thoracic SCI. The increase in vascular remodeling and endothelial dysfunction ultimately reduce cerebral blood flow, which promotes cerebral hypoperfusion and cognitive dysfunction in the chronic phase of SCI. In conclusion, the duration and magnitude of fluctuations in blood pressure after SCI play a vital role in the onset and progress of cerebrovascular dysfunction, which promotes the development of cognitive impairment.
{"title":"Duration and magnitude of bidirectional fluctuation in blood pressure: the link between cerebrovascular dysfunction and cognitive impairment following spinal cord injury.","authors":"Shaoxun Wang, Richard J Roman, Fan Fan","doi":"10.46439/neurobiology.2.008","DOIUrl":"https://doi.org/10.46439/neurobiology.2.008","url":null,"abstract":"<p><p>Individuals with spinal cord injury (SCI) have a significantly increased risk for cognitive impairment that is associated with cerebrovascular remodeling and endothelial dysfunction. The sub-acute stage following high thoracic SCI is characterized by increased fibrosis and stiffness of cerebral arteries. However, a more prolonged duration after SCI exacerbates cerebrovascular injury by damaging endothelium. Endothelial dysfunction is associated with reduced expression of transient receptor potential cation channel 4 that mediates the production of nitric oxide and epoxyeicosatrienoic acids following shear stress and the response to carbachol and other endothelium-dependent vasodilators. Reduced expression of CD31 in cerebral arteries also suggests the loss of endothelial cell integrity following chronic SCI. Repetitively transient hypertension and intermittent hypotension contribute to cerebrovascular endothelial dysfunction in the animals with a sub-acute stage of high thoracic SCI. The increase in vascular remodeling and endothelial dysfunction ultimately reduce cerebral blood flow, which promotes cerebral hypoperfusion and cognitive dysfunction in the chronic phase of SCI. In conclusion, the duration and magnitude of fluctuations in blood pressure after SCI play a vital role in the onset and progress of cerebrovascular dysfunction, which promotes the development of cognitive impairment.</p>","PeriodicalId":73855,"journal":{"name":"Journal of neurobiology and physiology","volume":"2 1","pages":"15-18"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/39/35/nihms-1630837.PMC7739907.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38387210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-31DOI: 10.46439/neurobiology.1.001
{"title":"Neurobiological And Physiological Aspects Of Disease-Brain As A Key With Multiple Links, a new medical hypothesis","authors":"","doi":"10.46439/neurobiology.1.001","DOIUrl":"https://doi.org/10.46439/neurobiology.1.001","url":null,"abstract":"","PeriodicalId":73855,"journal":{"name":"Journal of neurobiology and physiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44336566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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