Journal of neuroendovascular therapy最新文献

The Japanese Society for Neuroendovascular Therapy (JSNET) is a diverse subspecialty society based on four basic fields and is continuously growing with the advancement of neuroendovascular therapy. Despite a recent increase in the proportion of female members, awareness of diversity within JSNET remains inadequate. To foster a more mature and inclusive society, we established the JSNET-Diversity Promotion Committee in 2021, which has actively engaged in various initiatives aimed at promoting the inclusion of minorities such as female physicians as well as minority fields. Our objective is to continue in our initiative, anticipating that JSNET will evolve into an even more ideal organization in the future.

This short report describes my personal experience of 1-month neurointerventional training at Ramathibodi Hospital in Thailand, supported by a women's observership grant from the World Federation of Interventional and Therapeutic Neuroradiology, in which many interventional neuroradiology (INR) fellows from various regions of Thailand also participated. The training program allowed me to experience numerous neurointerventional cases and to acquire skills on how to function as a member of the INR team. This experience prompts me to contemplate the significance of team-based medicine and the role of women in the field of neurosurgery and INR.

Objective: Dural arteriovenous fistula (dAVF) is generally treated by endovascular therapy, but transarterial embolization (TAE) carries the risk of potential complications, including distal migration of embolic material, brain infarction, and venous congestion. Intracranial hemorrhage is infrequent but remains a considerable concern.

Case presentation: A man in the seventh decade presented with left hemiparesis. Brain MRI revealed right corona radiata infarction and incidentally identified a left transverse sigmoid sinus dAVF. Under a diagnosis of Borden type III and Cognard type IIb, an endovascular treatment plan was initiated. After an unsuccessful attempt at transvenous embolization, TAE with Onyx (Medtronic, Minneapolis, MN, USA) successfully resolved the dAVF. However, immediate post-treatment CT revealed subarachnoid hemorrhage, leading to decompressive craniotomy. Follow-up DSA showed no residual shunts, and the cause of the bleeding remained unknown.

Conclusion: Despite the unknown cause of bleeding, a thorough evaluation of preoperative hemodynamics and diligent postoperative examination is crucial in managing dAVF cases. Further pathological investigations are needed to gain a comprehensive understanding of such occurrences.

Flow diverter (FD) devices are new-generation stents placed in the parent artery at the aneurysmal neck to obstruct intra-aneurysmal blood flow, thus favoring intra-aneurysmal thrombosis. In Japan, about eight years have passed since health insurance approval was granted for FD devices, and FD placement to treat aneurysms has become widespread. Treatment indications have also been expanded with the introduction of novel devices. At present, three types of FD (Pipeline, FRED, and Surpass Streamline) are available in Japan. This report represents a compilation of available FD technologies and describes the current consensus on this treatment.

Objective: LEONIS Mova (SB-KAWASUMI LABORATORIES, Kanagawa, Japan, hereinafter called LEONIS Mova) is a steerable microcatheter (MC) that enables angle adjustment of the catheter tip using a hand-operated dial. LEONIS Mova may be useful for flow diverter placement when access to the distal parent artery with a conventional MC and microguidewire (MGW) is considered difficult or impossible. Here, we report three such cases encountered during flow diverter placement in large and giant internal carotid artery aneurysms.

Case presentation: In Case 1, a strong S-shaped curve was observed in the proximal parent artery of a giant cerebral aneurysm, and the luminal structure of the parent artery was lost within the aneurysm. It was anticipated that the distal side of the parent artery would be difficult to access with conventional MC and MGW. By adjusting the tip of the LEONIS Mova toward the aneurysm outlet beyond the S-shaped curve, it was possible to induce the MGW to secure the distal parent artery easily. In Case 2, the inflow and outflow axes of the parent artery were completely misaligned at the site of the aneurysm, and stenosis was present in the distal parent artery. Firmly bending the catheter tip increased accommodation for the catheter, enabling the induction of an MGW to access the distal parent artery without kicking back. In Case 3, the lesion extended from the cavernous portion to the petrosal portion; however, by adjusting the tip of the LEONIS Mova toward the aneurysm outlet, it was possible to induce the MGW to secure the distal parent artery easily. In each case, the LEONIS Mova enabled more secure and prompt access to the parent artery than anticipated and facilitated flow diverter placement.

Conclusion: Encountering difficult-to-access lesions is one reason endovascular treatment may be unsuccessful. The LEONIS Mova is an excellent device that can overcome this obstacle, and its utility in certain applications should be recognized.

Objective: The double origin of the posterior inferior cerebellar artery (DOPICA) is a rare variant of PICA. Vertebral artery dissecting aneurysm (VADA) with DOPICA is an extremely rare occurrence. Herein, we report a case of VADA located between DOPICA that was successfully treated with endovascular internal trapping.

Case presentation: A 48-year-old male, found collapsed at his workplace, was admitted to our hospital for emergency medical assistance. Head CT revealed a subarachnoid hemorrhage (Fisher group 3), and cerebral angiography revealed right VADA with DOPICA. The VADA was located distal to the proximal component of the posterior inferior cerebellar artery (PCPICA) and just proximal to the hypoplastic distal component of PICA (DCPICA). Emergency endovascular internal trapping was performed using a total of 13 coils from the distal end of the VADA to just the distal of the branching point of PCPICA. VADA was not visualized, and antegrade flow through DOPICA to the basilar artery was confirmed. Head magnetic resonance angiography (MRA) showed antegrade flow via DOPICA, and the patient was discharged home on Day 46 with a modified Rankin Scale 0.

Conclusion: Endovascular internal trapping for VADA with DOPICA was considered useful, especially when VADA is distal to PCPICA and proximal to DCPICA.

Objective: Reperfusion therapy, such as intravenous tissue-plasminogen activator (IV-tPA) and mechanical thrombectomy (MT) for acute ischemic stroke, may increase the incidence of acute symptomatic seizure (ASS) and post-stroke epilepsy (PSE). This study aimed to analyze the effect and predictors of reperfusion therapy for ASS and PSE limited to large-vessel occlusions (LVOs).

Methods: This retrospective study classified 237 subjects with LVO into four groups: (1) IV-tPA + MT+ (n = 74 cases, (2) MT only (n = 82), (3) tissue-plasminogen activator (tPA) only (n = 28), and (4) IV-tPA - MT- (n = 53). The incidences of ASS and PSE were assessed. Potential predictors, such as etiology, functional disability, neuroimaging findings, and the SeLECT score, were statistically analyzed.

Results: There were 12 (5.1%) subjects with ASS and 10 subjects (4.2%) with PSE. The IV-tPA and MT groups had significantly high reperfusion rates, with a Thrombolysis in Cerebral Infarction score ≥2c (p = 0.01) but there were no significant differences in the increases of hemorrhagic transformation, ASS, and PSE. An Alberta Stroke Program Early Computed Tomography Score <6 was a significant predictor of ASS (p = 0.01), and an infarct volume >60 ml was a significant predictor of PSE (p = 0.01).

Conclusion: Reperfusion therapy for acute LVO was not found to increase the risk of ASS and PSE. Large-sized infarctions should be treated with care in PSE.

Objective: Intraorbital dural arteriovenous fistula (IO-dAVF) is a rare condition, and treatment options vary from case to case. We report a case of transarterial embolization (TAE) for IO-dAVF.

Case presentation: A 62-year-old male complained of gradually worsening pain, hyperemia, and visual impairment in the right eye. He did not exhibit diplopia or exophthalmos. Cerebral angiography revealed an arteriovenous fistula in the right orbit. The feeding arteries were the ophthalmic artery (OphA) and the artery of the superior orbital fissure (ASOF), with the superior ophthalmic vein (SOV) as the main draining vein. The venous pathway from the SOV was not clearly visible, and considering the risk of blindness with TAE from the OphA, TAE from the ASOF was performed. Onyx 18 was selected as the liquid embolic material and injected through a microcatheter placed in the internal maxillary artery. Occlusion up to the SOV was achieved, and the shunt flow completely disappeared. Normal blood flow in the OphA was maintained, hyperemia improved, and no complications were observed.

Conclusion: In cases of IO-dAVF, when transvenous embolization is difficult to perform, TAE using Onyx from the vessel of the external carotid artery system may be preferred over OphA.

Wide-neck bifurcation aneurysms (WNBAs) are sometimes challenging to treat. During endovascular treatment, it is important to prevent coil deviation and preserve normal vessels. Adjunctive balloon- and stent-assisted techniques have been developed. A meta-analysis of endovascular treatments of WNBAs revealed that only 40% of patients had complete occlusion. Recently, novel devices have been developed to expand the range of treatment options. Flow-diverter stents and intra-aneurysmal flow disruption devices do not require coils; however, coil embolization remains the standard procedure used by many neurointerventionists. This review describes the recent trends in adjunctive techniques for supporting coil embolization for WNBAs. We referred to literature on balloon-assisted techniques, stent-assisted techniques, Y-stenting, PulseRider, Barrel stents, Comaneci temporary stents, pCONUS, and eCLIPs. These reports showed that adequate embolization rates were generally greater than 80%, and the complete occlusion rate was as high as 94.6%. All devices had a relatively high occlusion rate; however, it may be inaccurate to simply compare each device because of the heterogeneity of the studies. It is important to select the best treatment for each individual case by considering not only literature-based efficacy and safety but also patient background, aneurysm characteristics, and operator experience.

Objective: Although embolization of cerebral arteriovenous malformations (AVM) is widely performed as an adjunctive therapy before microsurgery or radiosurgery, there is no high-level evidence to ascertain its effectiveness. However, the technology for endovascular devices has improved. Therefore, this study aimed to identify the chronological changes in AVM embolization due to advances in endovascular treatment devices.

Methods: This retrospective study included 24 patients who underwent 31 embolization procedures between January 2018 and August 2023. Embolization plus microsurgery, embolization plus radiosurgery, and embolization alone were performed in 15 (62.5%) patients and 21 embolization procedures, 2 (8.3%) patients and 2 procedures, and 7 (29.2%) patients and 8 procedures, respectively. We assessed chronological changes in endovascular treatment devices and evaluated clinical outcomes (ideal position of microcatheter, vessel perforations, symptomatic complications) from January 2018 to December 2020 and from January 2021 to August 2023 based on the chronological changes in endovascular treatment devices.

Results: Intermediate catheters were employed in 29 (93.5%) procedures. Brands of intermediate catheters and microcatheters significantly changed around 2021. No differences were observed in the embolic materials. The ideal position of the microcatheter was achieved significantly more in 2021-2023 than in 2018-2020 (72.1% vs. 48.4%, p = 0.04). Vessel perforation by microcatheters in 2018-2020 and 2021-2023 occurred in 3 (18.8%) and 1 (6.7%) procedures (p = 0.32), respectively. Symptomatic complications in 2018-2020 and 2021-2023 occurred in 3 (18.8%) and 0 (p = 0.08) procedures, respectively. Complete obliteration was achieved in 18 of 24 patients (75.0%). Favorable clinical outcomes (modified Rankin Scale score 0-2) were observed in 20 of 24 (83.3%) patients at the final follow-up.

Conclusion: The advancement in endovascular devices for AVM has enabled effective and safe embolization, potentially enhancing the outcomes of microsurgical interventions.