Pub Date : 2021-01-01DOI: 10.23937/2469-5726/1510091
Cipriani Luiza M, Campos Ana PB, Simioni Juliana, Nisihara Renato, Skare Thelma L
Objectives: Comorbidities are common in psoriatic arthritis patients, including mood disorders. We aimed to study the prevalence of anxiety and depression in psoriatic arthritis patients from Brazil and its association with epidemiological, clinical and treatment data. Methods: Fifty-four psoriatic arthritis patients were interviewed using Becks’ anxiety inventory, CES-D (Center for Epidemiologic Studies Depression Scale) and the SF-12 (Short Form Health Survey). Simultaneously the disease activity was measured using ASDAS (Ankylosing Spondylitis Disease Activity Score)-ESR (erythrocyte sedimentation rate) and ASDAS-CRP (C reactive protein) for the joint domain and PASI (Psoriasis Area Severity Index) for the skin domain. Epidemiological, clinical and treatment data were obtained through chart review. Results: Anxiety was found in 62.9% and depression in 51.8% of the sample. Anxiety correlated with ASDAS-ESR (p = 0.003), PASI (p = 0.001) and SF-12 (P < 0.0001). Depression correlated with PASI and SF-12 (p < 0.0001). All patients with depression also had anxiety. No associations were found with epidemiological data, treatment or psoriatic arthritis subset (all with p > 0.05). Conclusion: There was a high frequency of anxiety and depression in this psoriatic arthritis sample that correlated with the degree of skin involvement and had a negative impact in quality of life. Anxiety also correlated with joint disease activity measured by ASDAS-ESR.
{"title":"Anxiety and Depression in Psoriatic Arthritis: A Cross Sectional Study in Brazilian Patients","authors":"Cipriani Luiza M, Campos Ana PB, Simioni Juliana, Nisihara Renato, Skare Thelma L","doi":"10.23937/2469-5726/1510091","DOIUrl":"https://doi.org/10.23937/2469-5726/1510091","url":null,"abstract":"Objectives: Comorbidities are common in psoriatic arthritis patients, including mood disorders. We aimed to study the prevalence of anxiety and depression in psoriatic arthritis patients from Brazil and its association with epidemiological, clinical and treatment data. Methods: Fifty-four psoriatic arthritis patients were interviewed using Becks’ anxiety inventory, CES-D (Center for Epidemiologic Studies Depression Scale) and the SF-12 (Short Form Health Survey). Simultaneously the disease activity was measured using ASDAS (Ankylosing Spondylitis Disease Activity Score)-ESR (erythrocyte sedimentation rate) and ASDAS-CRP (C reactive protein) for the joint domain and PASI (Psoriasis Area Severity Index) for the skin domain. Epidemiological, clinical and treatment data were obtained through chart review. Results: Anxiety was found in 62.9% and depression in 51.8% of the sample. Anxiety correlated with ASDAS-ESR (p = 0.003), PASI (p = 0.001) and SF-12 (P < 0.0001). Depression correlated with PASI and SF-12 (p < 0.0001). All patients with depression also had anxiety. No associations were found with epidemiological data, treatment or psoriatic arthritis subset (all with p > 0.05). Conclusion: There was a high frequency of anxiety and depression in this psoriatic arthritis sample that correlated with the degree of skin involvement and had a negative impact in quality of life. Anxiety also correlated with joint disease activity measured by ASDAS-ESR.","PeriodicalId":73938,"journal":{"name":"Journal of rheumatic diseases and treatment","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85138777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-30DOI: 10.23937/2469-5726/1510087
A. EspinoAdrianRonald, D. AngMariaCarmen, P. FortinezJudyTheresa
{"title":"Hughes Syndrome Preceding Systemic Lupus Erythematosus for 8 Years in a 30-Year-Old Filipino Female Patient: A Case Report","authors":"A. EspinoAdrianRonald, D. AngMariaCarmen, P. FortinezJudyTheresa","doi":"10.23937/2469-5726/1510087","DOIUrl":"https://doi.org/10.23937/2469-5726/1510087","url":null,"abstract":"","PeriodicalId":73938,"journal":{"name":"Journal of rheumatic diseases and treatment","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89603575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-27DOI: 10.23937/2469-5726/1510082
Alrehaili Amani A., I. Khadiga A., Alshehri Afrah A., Fadel Salwa M., Alharthi Morouj M., Alqurashi Nada S., Ajmani Seham H. Al, Gharib Amal F.
Background: Tumor Necrosis Factor-α (TNF-α) is coded and regulated by TNF-α gene which is implicated in the predisposition of Rheumatoid Arthritis (RA). This study aims to detect TNF-α (G-308Α) promoter polymorphism and evaluate its association with susceptibility to Rheumatoid Arthritis. Methods: In the present study, 50 patients with RA and 50 healthy individual were included and evaluated for the C-reactive protein, rheumatoid factor, and TNF-α were evaluated by ELISA, Erythrocyte Sedimentation Rate (ESR) by Westergren method and for TNF-α -308 G > A polymorphism by polymerase chain reaction with amplification refractory mutation system (PCR-ARMS). Results: The CRP, RF, ESR and TNF-α were significantly elevated in RA patients relative to controls. The serum level TNF-α was also significantly elevated in female patients and in patients ≥ 50 years. Analysis of TNF-308 gene polymorphism revealed that GG genotypes were more common in RA than in the controls and that GG genotype may be a risk factor to RA. The G allele was more frequent in RA than in the control. Elevated TNF-α serum levels were significantly associated the GG genotype and functional disability in RA patients. Conclusion: TNF-α promoter 308 polymorphism GG genotype may be considered as a risk factor for RA and the TNF-α serum level was significantly related to the functional disability in the disease.
背景:肿瘤坏死因子-α (TNF-α)是由TNF-α基因编码和调控的，与类风湿关节炎(RA)的易感性有关。本研究旨在检测TNF-α (G-308Α)启动子多态性并评估其与类风湿关节炎易感性的关系。方法:选取50例RA患者和50例健康人，采用ELISA法检测c反应蛋白、类风湿因子、TNF-α， Westergren法检测红细胞沉降率(ESR)， PCR-ARMS法检测TNF-α -308 G > A多态性。结果:RA患者CRP、RF、ESR、TNF-α水平明显高于对照组。血清TNF-α水平在女性患者和≥50岁患者中也显著升高。TNF-308基因多态性分析显示，GG基因型在RA中较对照组更为常见，GG基因型可能是RA的危险因素。G等位基因在RA中比在对照组中更常见。血清TNF-α水平升高与RA患者GG基因型及功能失能显著相关。结论:TNF-α启动子308多态性GG基因型可能是RA的危险因素，血清TNF-α水平与RA的功能障碍有显著相关性。
{"title":"Association of TNF-α Promoter Polymorphisms and Some Inflammatory Cytokines with Susceptibility to Rheumatoid Arthritis in Saudi Population","authors":"Alrehaili Amani A., I. Khadiga A., Alshehri Afrah A., Fadel Salwa M., Alharthi Morouj M., Alqurashi Nada S., Ajmani Seham H. Al, Gharib Amal F.","doi":"10.23937/2469-5726/1510082","DOIUrl":"https://doi.org/10.23937/2469-5726/1510082","url":null,"abstract":"Background: Tumor Necrosis Factor-α (TNF-α) is coded and regulated by TNF-α gene which is implicated in the predisposition of Rheumatoid Arthritis (RA). This study aims to detect TNF-α (G-308Α) promoter polymorphism and evaluate its association with susceptibility to Rheumatoid Arthritis. Methods: In the present study, 50 patients with RA and 50 healthy individual were included and evaluated for the C-reactive protein, rheumatoid factor, and TNF-α were evaluated by ELISA, Erythrocyte Sedimentation Rate (ESR) by Westergren method and for TNF-α -308 G > A polymorphism by polymerase chain reaction with amplification refractory mutation system (PCR-ARMS). Results: The CRP, RF, ESR and TNF-α were significantly elevated in RA patients relative to controls. The serum level TNF-α was also significantly elevated in female patients and in patients ≥ 50 years. Analysis of TNF-308 gene polymorphism revealed that GG genotypes were more common in RA than in the controls and that GG genotype may be a risk factor to RA. The G allele was more frequent in RA than in the control. Elevated TNF-α serum levels were significantly associated the GG genotype and functional disability in RA patients. Conclusion: TNF-α promoter 308 polymorphism GG genotype may be considered as a risk factor for RA and the TNF-α serum level was significantly related to the functional disability in the disease.","PeriodicalId":73938,"journal":{"name":"Journal of rheumatic diseases and treatment","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84138583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Our goal was to evaluate prevalence of foot pain and lesions in patients with systemic sclerosis (SSc) and their association with other organ involvements. Materials and methods: In this cross-section study 133 scleroderma patients were probed throughout a survey in which both forms of digital and non-digital plantar lesions were included. Chi-square test and student’s t-test were used to determine the associations of foot pain and lesion with clinical features and serologic findings of the disease. multivariate analysis was used for determining independent factors associated with foot lesion and pain. Results: Of all patients, 119 (89%) were women with a mean age +Standard Deviation (SD) of 39.3 + 13.1 years, 32 (24.1%) patients had foot pain, and 40.6% were classified as having diffuse cutaneous SSc. Mean disease duration was 6.7 ± 5.8 years. Foot lesions were found in 47 (35%) of patients; from which 30 (93.8%) patients reported foot pain. In univariate analysis, Foot lesion were associated with vascular lesion, such as Raynaud ‘s phenomenon on the foot (p < 0.001), digital ulcer/gangrene (p < 0.005), calcinosis (p < 0.00 1), and high pulmonary arterial pressure on echocardiography (PAP), (p < 0.05). Additionally, we noticed the association of foot lesion with inflammatory disease, such as arthritis (p < 0.001), tendon friction rub (p < 0.004), pericardial effusion (p < 0.003), and esophageal dysmotility (p < 0.03) for vascular foot lesion. In the multivariate model, the diffuse subtype of the disease, presence of telangiectasia, calcinosis and Raynaud’s on foot showed a significant association with vascular foot lesion. Conclusion: Foot pain and lesion are common in Scleroderma patients, the diffuse subtype of the diseases, foot’s Raynaud’s, calcinosis, and telangiectasia were independently associated factors with foot lesion.
{"title":"Foot Pain and Lesions in Systemic Sclerosis: Prevalence and Association with Organ Involvement","authors":"Poormoghim Hadi, Andalib Elham, J. Arash, Salimi Maryam, Ghafarpour Gholam Hossein","doi":"10.23937/2469-5726/1510076","DOIUrl":"https://doi.org/10.23937/2469-5726/1510076","url":null,"abstract":"Objective: Our goal was to evaluate prevalence of foot pain and lesions in patients with systemic sclerosis (SSc) and their association with other organ involvements. Materials and methods: In this cross-section study 133 scleroderma patients were probed throughout a survey in which both forms of digital and non-digital plantar lesions were included. Chi-square test and student’s t-test were used to determine the associations of foot pain and lesion with clinical features and serologic findings of the disease. multivariate analysis was used for determining independent factors associated with foot lesion and pain. Results: Of all patients, 119 (89%) were women with a mean age +Standard Deviation (SD) of 39.3 + 13.1 years, 32 (24.1%) patients had foot pain, and 40.6% were classified as having diffuse cutaneous SSc. Mean disease duration was 6.7 ± 5.8 years. Foot lesions were found in 47 (35%) of patients; from which 30 (93.8%) patients reported foot pain. In univariate analysis, Foot lesion were associated with vascular lesion, such as Raynaud ‘s phenomenon on the foot (p < 0.001), digital ulcer/gangrene (p < 0.005), calcinosis (p < 0.00 1), and high pulmonary arterial pressure on echocardiography (PAP), (p < 0.05). Additionally, we noticed the association of foot lesion with inflammatory disease, such as arthritis (p < 0.001), tendon friction rub (p < 0.004), pericardial effusion (p < 0.003), and esophageal dysmotility (p < 0.03) for vascular foot lesion. In the multivariate model, the diffuse subtype of the disease, presence of telangiectasia, calcinosis and Raynaud’s on foot showed a significant association with vascular foot lesion. Conclusion: Foot pain and lesion are common in Scleroderma patients, the diffuse subtype of the diseases, foot’s Raynaud’s, calcinosis, and telangiectasia were independently associated factors with foot lesion.","PeriodicalId":73938,"journal":{"name":"Journal of rheumatic diseases and treatment","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88803484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-07DOI: 10.23937/2469-5726/1510075
E. BrawerArthur
Over the past five years clinicians from numerous countries have implicated human papillomavirus (HPV) immunizations as the cause of diverse systemic ailments, egregious injuries, and even death. Vaccine ingredients in Gardasil and Cervarix contain hidden organosiloxanes (organosilicones) and silica (silicon dioxide), all of which are capable of creating biochemical disturbances that are strikingly similar to the metabolic disruptions identified in both chronic fatigue syndrome and the recurrent public health debacle of silicone gel-filled breast implant toxicity.
{"title":"Hidden Toxicity of Human Papillomavirus Vaccine Ingredients","authors":"E. BrawerArthur","doi":"10.23937/2469-5726/1510075","DOIUrl":"https://doi.org/10.23937/2469-5726/1510075","url":null,"abstract":"Over the past five years clinicians from numerous countries have implicated human papillomavirus (HPV) immunizations as the cause of diverse systemic ailments, egregious injuries, and even death. Vaccine ingredients in Gardasil and Cervarix contain hidden organosiloxanes (organosilicones) and silica (silicon dioxide), all of which are capable of creating biochemical disturbances that are strikingly similar to the metabolic disruptions identified in both chronic fatigue syndrome and the recurrent public health debacle of silicone gel-filled breast implant toxicity.","PeriodicalId":73938,"journal":{"name":"Journal of rheumatic diseases and treatment","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84753751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-03DOI: 10.23937/2469-5726/1510074
F. LeebBurkhard, Lunzer Raimund, Fasching Peter, H. Manfred, Zamani Omid, Riedlmair Ute, Schimetta Wolfgang, B. GraningerWinfried
Background: As data on the efficacy of biologics in patients with mild/moderate rheumatoid arthritis are limited, this study was performed to assess the efficacy and safety of tocilizumab plus methotrexate versus tocilizumab monotherapy on disease activity. Methods: Seventy-seven patients with mild/moderate rheumatoid arthritis and an inadequate response (Disease Activity Score 28 > 3.2) to methotrexate were initially enrolled (mean Disease Activity Score 28 3.91 +/0.54) and received three infusions of tocilizumab 8 mg/kg every 4 weeks plus methotrexate. Subjects achieving a good/moderate European League Against Rheumatism response after three months of open-label treatment were randomised to Group A (tocilizumab plus methotrexate) or Group B (tocilizumab plus placebo methotrexate). The primary endpoint was the Disease Activity Score 28 change from week 12 to 24. The secondary endpoints included the proportion of patients achieving remission according to the Disease Activity Score 28 and various disease activity indices at week 24. Results: Sixty-five patients were included in the blinded trial phase. At week 12, the mean Disease Activity Score 28 was 1.51 in Group A (n = 32) and 1.72 in Group B (n = 33). The Disease Activity Score 28 difference between the groups was not statistically significant (p = 0.19). No substantial differences were seen with regard to the secondary endpoints. Conclusions: Additional tocilizumab treatment led to improvement in patients with mild/moderate rheumatoid arthritis. The study results give no indication that the combination of Tocilizumab with Methotrexate induces a better outcome (preserving the level of disease activity achieved at week 12) in comparison with Tocilizumab monotherapy in patients corresponding to those included into the study.
{"title":"Optimise: An Austrian Multicentre Study on the Effectiveness and Safety of Tocilizumab in Combination with Methotrexate versus Tocilizumab for Mild/Moderate Rheumatoid Arthritis and an Inadequate Response to Methotrexate","authors":"F. LeebBurkhard, Lunzer Raimund, Fasching Peter, H. Manfred, Zamani Omid, Riedlmair Ute, Schimetta Wolfgang, B. GraningerWinfried","doi":"10.23937/2469-5726/1510074","DOIUrl":"https://doi.org/10.23937/2469-5726/1510074","url":null,"abstract":"Background: As data on the efficacy of biologics in patients with mild/moderate rheumatoid arthritis are limited, this study was performed to assess the efficacy and safety of tocilizumab plus methotrexate versus tocilizumab monotherapy on disease activity. Methods: Seventy-seven patients with mild/moderate rheumatoid arthritis and an inadequate response (Disease Activity Score 28 > 3.2) to methotrexate were initially enrolled (mean Disease Activity Score 28 3.91 +/0.54) and received three infusions of tocilizumab 8 mg/kg every 4 weeks plus methotrexate. Subjects achieving a good/moderate European League Against Rheumatism response after three months of open-label treatment were randomised to Group A (tocilizumab plus methotrexate) or Group B (tocilizumab plus placebo methotrexate). The primary endpoint was the Disease Activity Score 28 change from week 12 to 24. The secondary endpoints included the proportion of patients achieving remission according to the Disease Activity Score 28 and various disease activity indices at week 24. Results: Sixty-five patients were included in the blinded trial phase. At week 12, the mean Disease Activity Score 28 was 1.51 in Group A (n = 32) and 1.72 in Group B (n = 33). The Disease Activity Score 28 difference between the groups was not statistically significant (p = 0.19). No substantial differences were seen with regard to the secondary endpoints. Conclusions: Additional tocilizumab treatment led to improvement in patients with mild/moderate rheumatoid arthritis. The study results give no indication that the combination of Tocilizumab with Methotrexate induces a better outcome (preserving the level of disease activity achieved at week 12) in comparison with Tocilizumab monotherapy in patients corresponding to those included into the study.","PeriodicalId":73938,"journal":{"name":"Journal of rheumatic diseases and treatment","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77129308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-11DOI: 10.23937/2469-5726/1510073
M. Magerl, R. F. Gandra, R. A. Menolli
{"title":"ANA-Hep2 Positive with Anti-Rods and Rings Pattern in a Child without Hepatitis C under Treatment: Case Report","authors":"M. Magerl, R. F. Gandra, R. A. Menolli","doi":"10.23937/2469-5726/1510073","DOIUrl":"https://doi.org/10.23937/2469-5726/1510073","url":null,"abstract":"","PeriodicalId":73938,"journal":{"name":"Journal of rheumatic diseases and treatment","volume":"1931 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91091048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-04DOI: 10.23937/2469-5726/1510072
Klara Nypelius Standley, I. Gjertsson, A. Winkvist, H. Lindqvist
Nutritional status of patients with rheumatoid arthritis (RA) is often poor. In addition, popular trends in avoiding certain foods have been noted among patients with RA yet recent data on dietary intake is lacking. The aim of the present study was to examine possible differences in food intake between Swedish women with and without RA. In total 150 women with RA, selected from the Swedish Rheumatology Quality Register, and 163 women without RA, answered a postal food frequency questionnaire including questions on 45 food items, food choices, age, weight, height, educational level and serious illness. Women with RA consumed red meat and nuts less frequently and did not eat any butter/ margarine on sandwiches or chose low fat varieties to a higher extent than women without RA. Background characteristics differed between the groups and were adjusted for in the analyses. To conclude, habits of women with RA differ to some extent from that of women without the disease; most importantly many women with RA exclude red meat. Future studies should include meal patterns and amounts of food consumed to obtain a wider, more accurate understanding of food consumption patterns of women with RA and to link this with concurrent disease activity.
{"title":"Dietary Habits of Women with Rheumatoid Arthritis Differ from that of Women without the Disease: Results from a Population-Based Study","authors":"Klara Nypelius Standley, I. Gjertsson, A. Winkvist, H. Lindqvist","doi":"10.23937/2469-5726/1510072","DOIUrl":"https://doi.org/10.23937/2469-5726/1510072","url":null,"abstract":"Nutritional status of patients with rheumatoid arthritis (RA) is often poor. In addition, popular trends in avoiding certain foods have been noted among patients with RA yet recent data on dietary intake is lacking. The aim of the present study was to examine possible differences in food intake between Swedish women with and without RA. In total 150 women with RA, selected from the Swedish Rheumatology Quality Register, and 163 women without RA, answered a postal food frequency questionnaire including questions on 45 food items, food choices, age, weight, height, educational level and serious illness. Women with RA consumed red meat and nuts less frequently and did not eat any butter/ margarine on sandwiches or chose low fat varieties to a higher extent than women without RA. Background characteristics differed between the groups and were adjusted for in the analyses. To conclude, habits of women with RA differ to some extent from that of women without the disease; most importantly many women with RA exclude red meat. Future studies should include meal patterns and amounts of food consumed to obtain a wider, more accurate understanding of food consumption patterns of women with RA and to link this with concurrent disease activity.","PeriodicalId":73938,"journal":{"name":"Journal of rheumatic diseases and treatment","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82921830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-05-15DOI: 10.23937/2469-5726/1510071
Nazri Siti Khadijah SM, Ghazali Wan Syamimee W, Ashari Noor Suryani M, Hamid Wan Zuraida WA
Introduction: So far, there is no conventional parameters that have been proven to possess the ability to predict the histology of systemic lupus erythematosus (SLE). A few autoimmune serology markers of SLE including anti-dsDNA antibodies, complement C3 and C4, and anti-nucleosome could be helpful clinically, but the correlation between those and lupus renal disease is still imperfect. Recently, the urinary vascular cell adhesion molecule-1 (VCAM-1), kidney injury molecule-1 (KIM-1) and endothelin-1 (ET-1) have been studied for the diagnosis of lupus nephritis (LN). Nevertheless, it is still unknown whether the urinary VCAM1, KIM-1 and ET-1 could be used as disease monitoring and flare predictor tools for LN. Objective: To evaluate the levels of VCAM-1, KIM-1, and ET-1 in active LN, inactive LN and controls, cut-off points and diagnostic accuracy and their correlation with SLE Disease Activity Index (SLEDAI), renal SLEDAI (rSLEDAI), and the standard immunological markers. Methods: This study involved 60 LN patients and 30 controls conducted in the Hospital Universiti Sains Malaysia (Hospital USM) from September 2016 to February 2018. All three biomarkers were determined by enzyme-linked immunosorbent assay (ELISA) in urine samples of patients. Receiver operating characteristic analysis was performed to obtain the best cut-off values and to calculate the performance of these markers. The correlation was done between urinary biomarkers and immunological parameters. Statistical analysis was performed using SPSS software, version 22.0. Results: Urinary VCAM-1, KIM-1, and ET-1 levels were significantly higher in active LN patients compared to inactive LN patients and controls. These markers correlated significantly with anti-dsDNA, complement C3, complement C4, urine protein/urine creatinine (Uprot/Ucreat), SLE disease activity index (SLEDAI), and renal SLEDAI scores. The urinary KIM-1 significantly correlated with all the immunological parameters except for complement C4. Urinary ET-1 showed higher specificity and sensitivity in differentiating LN patients and healthy controls (AUC 0.809) than urinary VCAM-1 (AUC 0.725) and urinary KIM-1 (AUC 0.640). Conclusions: Our study demonstrated that urinary VCAM1, KIM-1, and ET-1 might be potential biomarkers specific for the lupus renal disease.
{"title":"Urinary VCAM-1, KIM-1, and ET-1 as Biomarkers of Lupus Nephritis: Correlation with Immunological Parameters in Hospital USM","authors":"Nazri Siti Khadijah SM, Ghazali Wan Syamimee W, Ashari Noor Suryani M, Hamid Wan Zuraida WA","doi":"10.23937/2469-5726/1510071","DOIUrl":"https://doi.org/10.23937/2469-5726/1510071","url":null,"abstract":"Introduction: So far, there is no conventional parameters that have been proven to possess the ability to predict the histology of systemic lupus erythematosus (SLE). A few autoimmune serology markers of SLE including anti-dsDNA antibodies, complement C3 and C4, and anti-nucleosome could be helpful clinically, but the correlation between those and lupus renal disease is still imperfect. Recently, the urinary vascular cell adhesion molecule-1 (VCAM-1), kidney injury molecule-1 (KIM-1) and endothelin-1 (ET-1) have been studied for the diagnosis of lupus nephritis (LN). Nevertheless, it is still unknown whether the urinary VCAM1, KIM-1 and ET-1 could be used as disease monitoring and flare predictor tools for LN. Objective: To evaluate the levels of VCAM-1, KIM-1, and ET-1 in active LN, inactive LN and controls, cut-off points and diagnostic accuracy and their correlation with SLE Disease Activity Index (SLEDAI), renal SLEDAI (rSLEDAI), and the standard immunological markers. Methods: This study involved 60 LN patients and 30 controls conducted in the Hospital Universiti Sains Malaysia (Hospital USM) from September 2016 to February 2018. All three biomarkers were determined by enzyme-linked immunosorbent assay (ELISA) in urine samples of patients. Receiver operating characteristic analysis was performed to obtain the best cut-off values and to calculate the performance of these markers. The correlation was done between urinary biomarkers and immunological parameters. Statistical analysis was performed using SPSS software, version 22.0. Results: Urinary VCAM-1, KIM-1, and ET-1 levels were significantly higher in active LN patients compared to inactive LN patients and controls. These markers correlated significantly with anti-dsDNA, complement C3, complement C4, urine protein/urine creatinine (Uprot/Ucreat), SLE disease activity index (SLEDAI), and renal SLEDAI scores. The urinary KIM-1 significantly correlated with all the immunological parameters except for complement C4. Urinary ET-1 showed higher specificity and sensitivity in differentiating LN patients and healthy controls (AUC 0.809) than urinary VCAM-1 (AUC 0.725) and urinary KIM-1 (AUC 0.640). Conclusions: Our study demonstrated that urinary VCAM1, KIM-1, and ET-1 might be potential biomarkers specific for the lupus renal disease.","PeriodicalId":73938,"journal":{"name":"Journal of rheumatic diseases and treatment","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84837833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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